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The map label for this gene is apt

Identifier: 159185114

GI number: 159185114

Start: 2207023

End: 2207565

Strand: Reverse

Name: apt

Synonym: Atu2236

Alternate gene names: 159185114

Gene position: 2207565-2207023 (Counterclockwise)

Preceding gene: 159185115

Following gene: 15889508

Centisome position: 77.69

GC content: 61.51

Gene sequence:

>543_bases
ATGACCGTTATCGCTTCGGAGCTTTCCGCTGCCATCCGTTCCATTCCCGACTATCCGAAGCCGGGCATCATCTTCCGGGA
CATCACGACGCTGCTCGGCAACCCGCGCGCATTTCGCCGCGCCGTCGATGAACTCGTGCAGCCCTATGCGGGAACGAAGA
TCGACAAGATCGCCGGCATGGAAGCGCGCGGCTTCATTCTGGGCGGGGCGGTGGCGCATCAGCTTTCGGCCGGTTTCGTG
CCGATCCGCAAGAAGGGCAAGCTGCCGCACACCACCGTGCGGGTCGCCTACAGCCTGGAATATGGTGTCGACGAAATGGA
GATGCATGTGGATGCCGTACAGCCGGGCGAGAAGGTCATTCTTGTCGACGACCTGATCGCCACCGGCGGCACCGCCGAAG
GTGCCGTGAAGCTCTTGCGACAGATGGGTGCGGAAATCGTATCCGCCTGCTTCGTCATCGACCTGCCTGATCTCGGCGGC
CGCAAGAAGCTGGAAGATCTTGGCGTCGACGTGCGCACGCTGGTAGAATTTTCTGGCCATTGA

Upstream 100 bases:

>100_bases
GTGGAATGAGTGCCGTTGCCTTTTTAGTTGGTCCACAGCCGTCAAATTGATAGGGTGGCCCGAACTTCCTGATCCATTTC
CCATTTTAACTGGAAATACC

Downstream 100 bases:

>100_bases
GGCGGTAACCGGGGCAAGTCGCGATGGTTTGCCCCAGGGCTCGTATTAATCGAATTCCAGAACCCCGCTCTGGAAGGTCA
GTACCGTTTCTCCCGACTGA

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 180; Mature: 179

Protein sequence:

>180_residues
MTVIASELSAAIRSIPDYPKPGIIFRDITTLLGNPRAFRRAVDELVQPYAGTKIDKIAGMEARGFILGGAVAHQLSAGFV
PIRKKGKLPHTTVRVAYSLEYGVDEMEMHVDAVQPGEKVILVDDLIATGGTAEGAVKLLRQMGAEIVSACFVIDLPDLGG
RKKLEDLGVDVRTLVEFSGH

Sequences:

>Translated_180_residues
MTVIASELSAAIRSIPDYPKPGIIFRDITTLLGNPRAFRRAVDELVQPYAGTKIDKIAGMEARGFILGGAVAHQLSAGFV
PIRKKGKLPHTTVRVAYSLEYGVDEMEMHVDAVQPGEKVILVDDLIATGGTAEGAVKLLRQMGAEIVSACFVIDLPDLGG
RKKLEDLGVDVRTLVEFSGH
>Mature_179_residues
TVIASELSAAIRSIPDYPKPGIIFRDITTLLGNPRAFRRAVDELVQPYAGTKIDKIAGMEARGFILGGAVAHQLSAGFVP
IRKKGKLPHTTVRVAYSLEYGVDEMEMHVDAVQPGEKVILVDDLIATGGTAEGAVKLLRQMGAEIVSACFVIDLPDLGGR
KKLEDLGVDVRTLVEFSGH

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=156, Percent_Identity=46.7948717948718, Blast_Score=151, Evalue=3e-37,
Organism=Homo sapiens, GI71773201, Length=121, Percent_Identity=49.5867768595041, Blast_Score=127, Evalue=6e-30,
Organism=Escherichia coli, GI1786675, Length=183, Percent_Identity=52.4590163934426, Blast_Score=201, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI17509087, Length=177, Percent_Identity=42.3728813559322, Blast_Score=131, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6323619, Length=164, Percent_Identity=41.4634146341463, Blast_Score=121, Evalue=5e-29,
Organism=Saccharomyces cerevisiae, GI6320649, Length=164, Percent_Identity=40.2439024390244, Blast_Score=104, Evalue=7e-24,
Organism=Drosophila melanogaster, GI17136334, Length=160, Percent_Identity=40.625, Blast_Score=122, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_AGRT5 (Q8UD91)

Other databases:

- EMBL:   AE007869
- PIR:   A97628
- PIR:   AC2851
- RefSeq:   NP_355193.2
- ProteinModelPortal:   Q8UD91
- SMR:   Q8UD91
- STRING:   Q8UD91
- GeneID:   1134274
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu2236
- eggNOG:   COG0503
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- PhylomeDB:   Q8UD91
- ProtClustDB:   PRK02304
- BioCyc:   ATUM176299-1:ATU2236-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 19339; Mature: 19208

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVIASELSAAIRSIPDYPKPGIIFRDITTLLGNPRAFRRAVDELVQPYAGTKIDKIAGM
CCEEHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHCCC
EARGFILGGAVAHQLSAGFVPIRKKGKLPHTTVRVAYSLEYGVDEMEMHVDAVQPGEKVI
CCCCEEEHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHCCCCCCEEE
LVDDLIATGGTAEGAVKLLRQMGAEIVSACFVIDLPDLGGRKKLEDLGVDVRTLVEFSGH
EEECHHHCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHCCCHHHHHHHCCC
>Mature Secondary Structure 
TVIASELSAAIRSIPDYPKPGIIFRDITTLLGNPRAFRRAVDELVQPYAGTKIDKIAGM
CEEHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHCCC
EARGFILGGAVAHQLSAGFVPIRKKGKLPHTTVRVAYSLEYGVDEMEMHVDAVQPGEKVI
CCCCEEEHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHCCCCCCEEE
LVDDLIATGGTAEGAVKLLRQMGAEIVSACFVIDLPDLGGRKKLEDLGVDVRTLVEFSGH
EEECHHHCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194