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The map label for this gene is proC [H]

Identifier: 159185101

GI number: 159185101

Start: 2178929

End: 2179747

Strand: Reverse

Name: proC [H]

Synonym: Atu2209

Alternate gene names: 159185101

Gene position: 2179747-2178929 (Counterclockwise)

Preceding gene: 159185439

Following gene: 15889485

Centisome position: 76.71

GC content: 66.18

Gene sequence:

>819_bases
ATGGTGTACAAGGCTTCCGGTCCGCTCGTCCTCGTGGGGGCCGGCAATATGGGCGGCGCCATGCTTTCGGGCTGGCTGAA
AAAGGGTGTGCCGGGATCGAAGGTCATCGTCATCGACCCTCGCCCCTCCGACGCCATGCGCACGACGATAGCGGAAGCCG
GCGCGACCCACAGCGAAAGCGTGCCTGAGGGCGTCAAGGCCGGCATTCTTTTCGTGGCGGTGAAGCCGCAGATGATGGAT
GCCATATTGCCGTCGCTGAAGCCCCTGCTGGGTCCGGAAACGGTCGTTGTCTCCATCGCGGCCGGTACCACCATCGCCAC
TTTCGTTTCGCATTTCGGTGCGGTCGCTGCCGTGCGCGCCATGCCCAATACGCCTGCCATGGTCGGCCGTGGCGTCACCG
GCGCTTATGCCAACGATCTTGTCACAGCCGAGCTGAAAACCGTTGTGGACGGGTTGCTGAAGGTCAGCGGTCCGGTCGAA
TGGGTTGAGGCCGAAAGCGACATCGACGCGGTGACCGCGGTTTCGGGAAGCGGCCCGGCCTATGTCTTCTATCTGGTGGA
ATGCATGGCGGAAGCTGGCCGCAAGGCCGGTCTGCCGGCCGACGTGGCCATGCGTCTGGCGCGCGAAACCGTGGCCGGTG
CCGGTGAACTCCTGCATCAGTCCCCCGAGGAGGCCGCGCGGCTGCGCCAGAACGTGACCTCGCCGGGTGGCACCACGGCC
GCGGCGCTGTCCGTGCTGATGGCCGAAGACGGCATGCAGCCCCTGTTCGACAGGGCCGTCGCCGCCGCGAAAACGCGCGC
CGAAGAACTGGCGGGCTGA

Upstream 100 bases:

>100_bases
AGCAATATTATCAGGCATTCCAGTTCGTCGTCTGGTCGGGGCTGGATGCCAAAAGTGCAATCGAAGCGGTCATGTTCGAG
ACCGTTGGAGAAGCTTGAGC

Downstream 100 bases:

>100_bases
AGGAGCGGGTCATGAGCGGCGAAATTTCCTATGCCGATTTCGAAAAGGTCGATATCCGCGTCGGTACGATCGTGGAGGCG
GTGCCGTTTCCGGAGGCTCG

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 272; Mature: 272

Protein sequence:

>272_residues
MVYKASGPLVLVGAGNMGGAMLSGWLKKGVPGSKVIVIDPRPSDAMRTTIAEAGATHSESVPEGVKAGILFVAVKPQMMD
AILPSLKPLLGPETVVVSIAAGTTIATFVSHFGAVAAVRAMPNTPAMVGRGVTGAYANDLVTAELKTVVDGLLKVSGPVE
WVEAESDIDAVTAVSGSGPAYVFYLVECMAEAGRKAGLPADVAMRLARETVAGAGELLHQSPEEAARLRQNVTSPGGTTA
AALSVLMAEDGMQPLFDRAVAAAKTRAEELAG

Sequences:

>Translated_272_residues
MVYKASGPLVLVGAGNMGGAMLSGWLKKGVPGSKVIVIDPRPSDAMRTTIAEAGATHSESVPEGVKAGILFVAVKPQMMD
AILPSLKPLLGPETVVVSIAAGTTIATFVSHFGAVAAVRAMPNTPAMVGRGVTGAYANDLVTAELKTVVDGLLKVSGPVE
WVEAESDIDAVTAVSGSGPAYVFYLVECMAEAGRKAGLPADVAMRLARETVAGAGELLHQSPEEAARLRQNVTSPGGTTA
AALSVLMAEDGMQPLFDRAVAAAKTRAEELAG
>Mature_272_residues
MVYKASGPLVLVGAGNMGGAMLSGWLKKGVPGSKVIVIDPRPSDAMRTTIAEAGATHSESVPEGVKAGILFVAVKPQMMD
AILPSLKPLLGPETVVVSIAAGTTIATFVSHFGAVAAVRAMPNTPAMVGRGVTGAYANDLVTAELKTVVDGLLKVSGPVE
WVEAESDIDAVTAVSGSGPAYVFYLVECMAEAGRKAGLPADVAMRLARETVAGAGELLHQSPEEAARLRQNVTSPGGTTA
AALSVLMAEDGMQPLFDRAVAAAKTRAEELAG

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI24797095, Length=266, Percent_Identity=34.2105263157895, Blast_Score=121, Evalue=6e-28,
Organism=Homo sapiens, GI24797097, Length=266, Percent_Identity=34.2105263157895, Blast_Score=121, Evalue=7e-28,
Organism=Homo sapiens, GI21361454, Length=266, Percent_Identity=33.4586466165414, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI198041662, Length=264, Percent_Identity=32.1969696969697, Blast_Score=113, Evalue=2e-25,
Organism=Escherichia coli, GI1786585, Length=265, Percent_Identity=36.6037735849057, Blast_Score=132, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17569021, Length=262, Percent_Identity=32.4427480916031, Blast_Score=110, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI17540664, Length=286, Percent_Identity=28.3216783216783, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6320861, Length=288, Percent_Identity=30.9027777777778, Blast_Score=97, Evalue=2e-21,
Organism=Drosophila melanogaster, GI21358587, Length=271, Percent_Identity=33.9483394833948, Blast_Score=135, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24648116, Length=272, Percent_Identity=31.9852941176471, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24647700, Length=172, Percent_Identity=39.5348837209302, Blast_Score=101, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 27706; Mature: 27706

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVYKASGPLVLVGAGNMGGAMLSGWLKKGVPGSKVIVIDPRPSDAMRTTIAEAGATHSES
CCEECCCCEEEEECCCCCHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCC
VPEGVKAGILFVAVKPQMMDAILPSLKPLLGPETVVVSIAAGTTIATFVSHFGAVAAVRA
CCCHHHCCEEEEEECHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHHHHC
MPNTPAMVGRGVTGAYANDLVTAELKTVVDGLLKVSGPVEWVEAESDIDAVTAVSGSGPA
CCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCEEEECCCCCH
YVFYLVECMAEAGRKAGLPADVAMRLARETVAGAGELLHQSPEEAARLRQNVTSPGGTTA
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHH
AALSVLMAEDGMQPLFDRAVAAAKTRAEELAG
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVYKASGPLVLVGAGNMGGAMLSGWLKKGVPGSKVIVIDPRPSDAMRTTIAEAGATHSES
CCEECCCCEEEEECCCCCHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCC
VPEGVKAGILFVAVKPQMMDAILPSLKPLLGPETVVVSIAAGTTIATFVSHFGAVAAVRA
CCCHHHCCEEEEEECHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHHHHC
MPNTPAMVGRGVTGAYANDLVTAELKTVVDGLLKVSGPVEWVEAESDIDAVTAVSGSGPA
CCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCEEEECCCCCH
YVFYLVECMAEAGRKAGLPADVAMRLARETVAGAGELLHQSPEEAARLRQNVTSPGGTTA
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHH
AALSVLMAEDGMQPLFDRAVAAAKTRAEELAG
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2107123; 10984043; 1676385 [H]