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The map label for this gene is gabP [C]

Identifier: 159185071

GI number: 159185071

Start: 2107808

End: 2109322

Strand: Reverse

Name: gabP [C]

Synonym: Atu2143

Alternate gene names: 159185071

Gene position: 2109322-2107808 (Counterclockwise)

Preceding gene: 15889425

Following gene: 15889423

Centisome position: 74.23

GC content: 59.34

Gene sequence:

>1515_bases
ATGGACAGTTCATCATCGGGCGTCAGCTACAAGAAGGCTGATGCATCCTATTTCGAAAAACGCGGACTTTCCCGTTATGC
GGGGGTATGGTCGCTCTGGGCACTCGGCGTCGGAGCGGTTATTTCAGGGCATTTCTCCGGATGGAATTTCGGCTTTTCCA
CCGGCGGCTGGGGCGGCATGCTGGTGGCGGGCATCATCATCGCCATCATGTATCTCGGGCTGACATTTTCGATCGCGGAA
ATGAGCCCGGCCTTGCCGCACACGGGCGCGGCCTATTCCTTCGCCCGCACGGCCATGGGCCCGTGGGGCGGTTTCGTCAC
CGGACTTTGCGAGAATGTCGAATATGTGCTGACGCCGGCGGTCGTCGTCACCTTCATTACCGCTTATGTGAATTCCATTC
TCGGCCTTGATCCAGCCTATTCGCCGTTCGTGTGGATCGTGTTTTATGCGATTTTCCTTGCGCTCAACGTCTTCGGGCTG
GAGCTTTCCTTCAAGGTCACGCTGGTCATCACGCTGATTTCGCTTGCCGTTCTGGTGTTCTTCTGGATCAGCGCCATTCC
GAATATCGATTTTTCGCGTTTCGCGCTCAATATTGGCGTCGGACCGGACGGCAAGGCTGTGGAACTGCCGGAAGGCGGCG
GCTCCTTCTTCCCCTTTGGTTTCTCGGGCGTTCTTGCCACGCTGCCTTTCGCGGTGTGGCTGTTCCTCGCCATCGAGCAG
CTGCCGCTGGCGGCTGAAGAATCGGTGGATCCCAAGCGCGACATGCCGAAGGGCATCATTCTCGGCATGGTCACGCTGAT
GGTCTCGGCCTTCATGATCGTGCTGCTCAACCCGTCCCTGCCGGGCGTCGGCGCCTTCCATCTCAGCTCCTCGCTGGAAC
CGCTGCTGGATGGCTTCAAGGCGATCTATGGCGATGGCGGCGTGGTGCTGCTCGGTCTCGTGGCGCTCACGGGCCTGATC
GCCAGCTTCCACACGATCCTCTATGCGCAGGGCCGCCAGATCTATTCGTTGTCGCGTGCGGGTTACTTCCCGACCGTGCT
GTCCATCACCCACTCGAAATACCGCACGCCATACGTGGCCAATATTACCGGCGCCATAGTCGGGCTCGCGGTCATGCTGG
TCATCTGGTTCTCGCTGGGTGCGGAACAGGGCGGCAGCATCATCGGCAGCGTGCTTTTGAACATGGCCGTGTTCGGCGCC
ATGTTCTCCTACATCATGCAGGCGATTTCCTTCATTCTGCTGCGTAAGAACCTGCCGAATATCGAGCGGCCGTTCCGTTC
GCCTTTCGGCATTCCGGGTGCATTGCTGACGATCATCATCGCCATCGTGACGCTGCTCTACCAGATCCAAGATCCGAACT
TCACCAAGGGTGTGCTGTGGGTAGCCGTATGGTTTGCGGTTGCCATCGCGTATTTCGCCTTTGTCGGACGCCATCGCCTC
ATCCTGTCGCCGGAAGAGGAGTTCGCGCTGGAGCACAAGCAGGCTGCCGTTGCGGCAGCGGCTGCAAAGGCCTGA

Upstream 100 bases:

>100_bases
CGGCAGATCGCGGCAAACATCCGTGTGACGCTGAAAACTGGGGCACAATCGGCCAATAATGGCTGACTGGCTTGTTTTTT
TCTTATCAGGAGAGAAGGGC

Downstream 100 bases:

>100_bases
CGCTCAAATAAAACGGGCGGCCGTTTCCCGGCCGCCCTGTCTGCGCAATCAAGGGAACGGACAAAATGACGAGCTACACA
TTCGACGCACTTAAAATGGA

Product: ABC transporter, membrane spanning protein (amino acid)

Products: Proton [Cytoplasm]; 4-aminobutyrate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 504; Mature: 504

Protein sequence:

>504_residues
MDSSSSGVSYKKADASYFEKRGLSRYAGVWSLWALGVGAVISGHFSGWNFGFSTGGWGGMLVAGIIIAIMYLGLTFSIAE
MSPALPHTGAAYSFARTAMGPWGGFVTGLCENVEYVLTPAVVVTFITAYVNSILGLDPAYSPFVWIVFYAIFLALNVFGL
ELSFKVTLVITLISLAVLVFFWISAIPNIDFSRFALNIGVGPDGKAVELPEGGGSFFPFGFSGVLATLPFAVWLFLAIEQ
LPLAAEESVDPKRDMPKGIILGMVTLMVSAFMIVLLNPSLPGVGAFHLSSSLEPLLDGFKAIYGDGGVVLLGLVALTGLI
ASFHTILYAQGRQIYSLSRAGYFPTVLSITHSKYRTPYVANITGAIVGLAVMLVIWFSLGAEQGGSIIGSVLLNMAVFGA
MFSYIMQAISFILLRKNLPNIERPFRSPFGIPGALLTIIIAIVTLLYQIQDPNFTKGVLWVAVWFAVAIAYFAFVGRHRL
ILSPEEEFALEHKQAAVAAAAAKA

Sequences:

>Translated_504_residues
MDSSSSGVSYKKADASYFEKRGLSRYAGVWSLWALGVGAVISGHFSGWNFGFSTGGWGGMLVAGIIIAIMYLGLTFSIAE
MSPALPHTGAAYSFARTAMGPWGGFVTGLCENVEYVLTPAVVVTFITAYVNSILGLDPAYSPFVWIVFYAIFLALNVFGL
ELSFKVTLVITLISLAVLVFFWISAIPNIDFSRFALNIGVGPDGKAVELPEGGGSFFPFGFSGVLATLPFAVWLFLAIEQ
LPLAAEESVDPKRDMPKGIILGMVTLMVSAFMIVLLNPSLPGVGAFHLSSSLEPLLDGFKAIYGDGGVVLLGLVALTGLI
ASFHTILYAQGRQIYSLSRAGYFPTVLSITHSKYRTPYVANITGAIVGLAVMLVIWFSLGAEQGGSIIGSVLLNMAVFGA
MFSYIMQAISFILLRKNLPNIERPFRSPFGIPGALLTIIIAIVTLLYQIQDPNFTKGVLWVAVWFAVAIAYFAFVGRHRL
ILSPEEEFALEHKQAAVAAAAAKA
>Mature_504_residues
MDSSSSGVSYKKADASYFEKRGLSRYAGVWSLWALGVGAVISGHFSGWNFGFSTGGWGGMLVAGIIIAIMYLGLTFSIAE
MSPALPHTGAAYSFARTAMGPWGGFVTGLCENVEYVLTPAVVVTFITAYVNSILGLDPAYSPFVWIVFYAIFLALNVFGL
ELSFKVTLVITLISLAVLVFFWISAIPNIDFSRFALNIGVGPDGKAVELPEGGGSFFPFGFSGVLATLPFAVWLFLAIEQ
LPLAAEESVDPKRDMPKGIILGMVTLMVSAFMIVLLNPSLPGVGAFHLSSSLEPLLDGFKAIYGDGGVVLLGLVALTGLI
ASFHTILYAQGRQIYSLSRAGYFPTVLSITHSKYRTPYVANITGAIVGLAVMLVIWFSLGAEQGGSIIGSVLLNMAVFGA
MFSYIMQAISFILLRKNLPNIERPFRSPFGIPGALLTIIIAIVTLLYQIQDPNFTKGVLWVAVWFAVAIAYFAFVGRHRL
ILSPEEEFALEHKQAAVAAAAAKA

Specific function: Probable amino-acid or metabolite transport protein [H]

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI4507047, Length=448, Percent_Identity=23.2142857142857, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI258614005, Length=448, Percent_Identity=22.7678571428571, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI258614003, Length=449, Percent_Identity=22.71714922049, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI114326544, Length=445, Percent_Identity=22.247191011236, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI114326550, Length=445, Percent_Identity=22.247191011236, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI1789017, Length=296, Percent_Identity=27.7027027027027, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI87081869, Length=365, Percent_Identity=22.4657534246575, Blast_Score=66, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17533459, Length=364, Percent_Identity=24.4505494505494, Blast_Score=75, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17532491, Length=301, Percent_Identity=25.2491694352159, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI221512776, Length=375, Percent_Identity=23.2, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24666159, Length=438, Percent_Identity=22.3744292237443, Blast_Score=83, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24668806, Length=524, Percent_Identity=22.9007633587786, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21356285, Length=524, Percent_Identity=22.9007633587786, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24668802, Length=524, Percent_Identity=22.9007633587786, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI281366235, Length=431, Percent_Identity=23.6658932714617, Blast_Score=65, Evalue=9e-11,
Organism=Drosophila melanogaster, GI116007820, Length=431, Percent_Identity=23.6658932714617, Blast_Score=65, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 54005; Mature: 54005

Theoretical pI: Translated: 7.23; Mature: 7.23

Prosite motif: PS00041 HTH_ARAC_FAMILY_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSSSSGVSYKKADASYFEKRGLSRYAGVWSLWALGVGAVISGHFSGWNFGFSTGGWGGM
CCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHH
LVAGIIIAIMYLGLTFSIAEMSPALPHTGAAYSFARTAMGPWGGFVTGLCENVEYVLTPA
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHCCCHHHHHHH
VVVTFITAYVNSILGLDPAYSPFVWIVFYAIFLALNVFGLELSFKVTLVITLISLAVLVF
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FWISAIPNIDFSRFALNIGVGPDGKAVELPEGGGSFFPFGFSGVLATLPFAVWLFLAIEQ
HHHHHCCCCCHHHEEEEECCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
LPLAAEESVDPKRDMPKGIILGMVTLMVSAFMIVLLNPSLPGVGAFHLSSSLEPLLDGFK
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCHHHHHHHHH
AIYGDGGVVLLGLVALTGLIASFHTILYAQGRQIYSLSRAGYFPTVLSITHSKYRTPYVA
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEHHHCCCCHHHHHHHHHHCCCCCHH
NITGAIVGLAVMLVIWFSLGAEQGGSIIGSVLLNMAVFGAMFSYIMQAISFILLRKNLPN
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
IERPFRSPFGIPGALLTIIIAIVTLLYQIQDPNFTKGVLWVAVWFAVAIAYFAFVGRHRL
CHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCE
ILSPEEEFALEHKQAAVAAAAAKA
EECCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDSSSSGVSYKKADASYFEKRGLSRYAGVWSLWALGVGAVISGHFSGWNFGFSTGGWGGM
CCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHH
LVAGIIIAIMYLGLTFSIAEMSPALPHTGAAYSFARTAMGPWGGFVTGLCENVEYVLTPA
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHCCCHHHHHHH
VVVTFITAYVNSILGLDPAYSPFVWIVFYAIFLALNVFGLELSFKVTLVITLISLAVLVF
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FWISAIPNIDFSRFALNIGVGPDGKAVELPEGGGSFFPFGFSGVLATLPFAVWLFLAIEQ
HHHHHCCCCCHHHEEEEECCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
LPLAAEESVDPKRDMPKGIILGMVTLMVSAFMIVLLNPSLPGVGAFHLSSSLEPLLDGFK
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCHHHHHHHHH
AIYGDGGVVLLGLVALTGLIASFHTILYAQGRQIYSLSRAGYFPTVLSITHSKYRTPYVA
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEHHHCCCCHHHHHHHHHHCCCCCHH
NITGAIVGLAVMLVIWFSLGAEQGGSIIGSVLLNMAVFGAMFSYIMQAISFILLRKNLPN
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
IERPFRSPFGIPGALLTIIIAIVTLLYQIQDPNFTKGVLWVAVWFAVAIAYFAFVGRHRL
CHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCE
ILSPEEEFALEHKQAAVAAAAAKA
EECCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 4-aminobutyrate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 4-aminobutyrate [Periplasm] = Proton [Cytoplasm] + 4-aminobutyrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]