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The map label for this gene is mdh [H]

Identifier: 159185068

GI number: 159185068

Start: 2102930

End: 2104075

Strand: Reverse

Name: mdh [H]

Synonym: Atu2138

Alternate gene names: 159185068

Gene position: 2104075-2102930 (Counterclockwise)

Preceding gene: 15889420

Following gene: 15889418

Centisome position: 74.05

GC content: 60.56

Gene sequence:

>1146_bases
ATGAATATCGTCGCCAACTGGAGTTATCCCACCGCCGTCAAGCTTGGCCGTGGCCGGATCAAGGAACTGGCGGAAGCCTG
CAAAACGCTCGGCATCAGGAAGCCGCTGCTCGTCACGGATCGTGGCCTTGCCAATATGGCGATCACCGCGCATGCGCTGG
ATGTGCTGGAAGAGGCGGGTCTTGGCCGGGCGATCTTTGCCGATGTCGATCCGAACCCCAACGAAATCAACATGGAAGCC
GGCGTCAAGGCTTACCGCGATGGCGGTCATGACGGCGTCGTCGCCTTTGGCGGCGGCTCGGGCCTCGATCTCGGCAAGAT
GATCGCCTTCATGGCCGGGCAGACACGTCCGGTCTGGGATTTCGAGGATATCGGTGATTGGTGGACACGCGCTGATGCGT
CGAAGATCGCGCCCATCGTCGCAGTCCCGACGACGGCTGGCACCGGTTCGGAAGTCGGCCGCGCCAGCGTCATCACCAAT
TCGCAGACGCATGTGAAGAAGATCATCTTCCATCCCAAGCTGCTTCCCGGTGTCGTCATCTGCGATCCGGAACTGACGGT
CGGCATGCCGAAGGTCATCACGGCCGGCACCGGCATGGATGCCTTCGCCCATTGCCTCGAAGCGTATTCGTCACCGTTCT
TCCACCCGATGAGTGCTGGTGTCGCGCTTGAGGGCCTGCGTCTCGTCAAGGAATTCCTGCCGCGCGCCTATAAGGATGGC
ACGGATATCGAAGCCCGCACCAATATGATGGCGGCGGCGGCGATGGGGGCGGTTGCCTTCCAGAAGGGTCTCGGGGCCAT
TCATTCGCTCTCGCATCCGATCGGGGCGGTCTACAACACCCATCACGGCATGACCAATGCCGTCGTCATGCCGGCGGTGC
TGCGTTTCAACCGTCCTGCCATCGAAGACAAGATCGCGCGTGCTGCCGCCTATCTCGGCATTTCCGGCGGTTTTGACGGT
TTTTATGACTACGTGCTGGATCTTCGCAGGGAACTCGGCGTGCCGGAAAACCTGACCGCCATGGGCATCAAGCCTGATCG
TATCGACGAGCTGGCGGCAGAAGCGATCAAGGATCCGAGCTGCGGTGGTAATCCGGTGCCGATGACGCTTGAGAATACCA
AGGCGCTTTTTGAGGCTTGCTTTTAA

Upstream 100 bases:

>100_bases
GGACCGGCGTCAAGGAAACCGGCCGTGGCGGTTCGCTCTCCGTCCTCGGTTTCCAGAATCTGACCCGCCCGAAATCCTAC
CATCTGAAGAAAGTCACGAA

Downstream 100 bases:

>100_bases
AAGGTAGACAGAGTGACCGCGAGATTCTCACTTTTTTCGTCACTGATCGCGGTGGCGTTGTTGGGTTTGCCTGTCGTTGT
GCAGGCTGCTTCTTTTAAGG

Product: dehydrogenase

Products: NA

Alternate protein names: MEDH [H]

Number of amino acids: Translated: 381; Mature: 381

Protein sequence:

>381_residues
MNIVANWSYPTAVKLGRGRIKELAEACKTLGIRKPLLVTDRGLANMAITAHALDVLEEAGLGRAIFADVDPNPNEINMEA
GVKAYRDGGHDGVVAFGGGSGLDLGKMIAFMAGQTRPVWDFEDIGDWWTRADASKIAPIVAVPTTAGTGSEVGRASVITN
SQTHVKKIIFHPKLLPGVVICDPELTVGMPKVITAGTGMDAFAHCLEAYSSPFFHPMSAGVALEGLRLVKEFLPRAYKDG
TDIEARTNMMAAAAMGAVAFQKGLGAIHSLSHPIGAVYNTHHGMTNAVVMPAVLRFNRPAIEDKIARAAAYLGISGGFDG
FYDYVLDLRRELGVPENLTAMGIKPDRIDELAAEAIKDPSCGGNPVPMTLENTKALFEACF

Sequences:

>Translated_381_residues
MNIVANWSYPTAVKLGRGRIKELAEACKTLGIRKPLLVTDRGLANMAITAHALDVLEEAGLGRAIFADVDPNPNEINMEA
GVKAYRDGGHDGVVAFGGGSGLDLGKMIAFMAGQTRPVWDFEDIGDWWTRADASKIAPIVAVPTTAGTGSEVGRASVITN
SQTHVKKIIFHPKLLPGVVICDPELTVGMPKVITAGTGMDAFAHCLEAYSSPFFHPMSAGVALEGLRLVKEFLPRAYKDG
TDIEARTNMMAAAAMGAVAFQKGLGAIHSLSHPIGAVYNTHHGMTNAVVMPAVLRFNRPAIEDKIARAAAYLGISGGFDG
FYDYVLDLRRELGVPENLTAMGIKPDRIDELAAEAIKDPSCGGNPVPMTLENTKALFEACF
>Mature_381_residues
MNIVANWSYPTAVKLGRGRIKELAEACKTLGIRKPLLVTDRGLANMAITAHALDVLEEAGLGRAIFADVDPNPNEINMEA
GVKAYRDGGHDGVVAFGGGSGLDLGKMIAFMAGQTRPVWDFEDIGDWWTRADASKIAPIVAVPTTAGTGSEVGRASVITN
SQTHVKKIIFHPKLLPGVVICDPELTVGMPKVITAGTGMDAFAHCLEAYSSPFFHPMSAGVALEGLRLVKEFLPRAYKDG
TDIEARTNMMAAAAMGAVAFQKGLGAIHSLSHPIGAVYNTHHGMTNAVVMPAVLRFNRPAIEDKIARAAAYLGISGGFDG
FYDYVLDLRRELGVPENLTAMGIKPDRIDELAAEAIKDPSCGGNPVPMTLENTKALFEACF

Specific function: Unknown

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=415, Percent_Identity=26.9879518072289, Blast_Score=112, Evalue=4e-25,
Organism=Escherichia coli, GI48994951, Length=384, Percent_Identity=30.9895833333333, Blast_Score=196, Evalue=2e-51,
Organism=Escherichia coli, GI1789163, Length=376, Percent_Identity=30.8510638297872, Blast_Score=180, Evalue=1e-46,
Organism=Escherichia coli, GI87082107, Length=378, Percent_Identity=30.4232804232804, Blast_Score=175, Evalue=5e-45,
Organism=Escherichia coli, GI1787493, Length=409, Percent_Identity=29.3398533007335, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI1789386, Length=397, Percent_Identity=27.455919395466, Blast_Score=85, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17537053, Length=413, Percent_Identity=26.634382566586, Blast_Score=126, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6321181, Length=385, Percent_Identity=34.2857142857143, Blast_Score=222, Evalue=7e-59,
Organism=Drosophila melanogaster, GI24657991, Length=413, Percent_Identity=26.8765133171913, Blast_Score=109, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.244 [H]

Molecular weight: Translated: 40531; Mature: 40531

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS00913 ADH_IRON_1 ; PS00060 ADH_IRON_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIVANWSYPTAVKLGRGRIKELAEACKTLGIRKPLLVTDRGLANMAITAHALDVLEEAG
CCEEECCCCCCHHHHCHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHCC
LGRAIFADVDPNPNEINMEAGVKAYRDGGHDGVVAFGGGSGLDLGKMIAFMAGQTRPVWD
CCCEEEECCCCCCCEEEHHHCCHHHHCCCCCCEEEECCCCCCCHHHHHHHHCCCCCCCCC
FEDIGDWWTRADASKIAPIVAVPTTAGTGSEVGRASVITNSQTHVKKIIFHPKLLPGVVI
HHHHHHHHHHCCHHHCCCEEEECCCCCCCCCCCCEEEEECCHHHHHHHHHCCCCCCCEEE
CDPELTVGMPKVITAGTGMDAFAHCLEAYSSPFFHPMSAGVALEGLRLVKEFLPRAYKDG
ECCCCCCCCCCCEECCCCHHHHHHHHHHHCCCCCCHHHCCHHHHHHHHHHHHHHHHHCCC
TDIEARTNMMAAAAMGAVAFQKGLGAIHSLSHPIGAVYNTHHGMTNAVVMPAVLRFNRPA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCHHHHHHHHHHCCCCH
IEDKIARAAAYLGISGGFDGFYDYVLDLRRELGVPENLTAMGIKPDRIDELAAEAIKDPS
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHCCCC
CGGNPVPMTLENTKALFEACF
CCCCCCCEEEHHHHHHHHHCC
>Mature Secondary Structure
MNIVANWSYPTAVKLGRGRIKELAEACKTLGIRKPLLVTDRGLANMAITAHALDVLEEAG
CCEEECCCCCCHHHHCHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHCC
LGRAIFADVDPNPNEINMEAGVKAYRDGGHDGVVAFGGGSGLDLGKMIAFMAGQTRPVWD
CCCEEEECCCCCCCEEEHHHCCHHHHCCCCCCEEEECCCCCCCHHHHHHHHCCCCCCCCC
FEDIGDWWTRADASKIAPIVAVPTTAGTGSEVGRASVITNSQTHVKKIIFHPKLLPGVVI
HHHHHHHHHHCCHHHCCCEEEECCCCCCCCCCCCEEEEECCHHHHHHHHHCCCCCCCEEE
CDPELTVGMPKVITAGTGMDAFAHCLEAYSSPFFHPMSAGVALEGLRLVKEFLPRAYKDG
ECCCCCCCCCCCEECCCCHHHHHHHHHHHCCCCCCHHHCCHHHHHHHHHHHHHHHHHCCC
TDIEARTNMMAAAAMGAVAFQKGLGAIHSLSHPIGAVYNTHHGMTNAVVMPAVLRFNRPA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCHHHHHHHHHHCCCCH
IEDKIARAAAYLGISGGFDGFYDYVLDLRRELGVPENLTAMGIKPDRIDELAAEAIKDPS
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHCCCC
CGGNPVPMTLENTKALFEACF
CCCCCCCEEEHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1644761; 1995642 [H]