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The map label for this gene is adh [H]

Identifier: 159185013

GI number: 159185013

Start: 1983207

End: 1984253

Strand: Direct

Name: adh [H]

Synonym: Atu2022

Alternate gene names: 159185013

Gene position: 1983207-1984253 (Clockwise)

Preceding gene: 15889304

Following gene: 15889313

Centisome position: 69.79

GC content: 60.08

Gene sequence:

>1047_bases
ATGGCTATTGCAAGAGGTTATGCTGCGACCGACGCGTCGAAGCCGCTTACCCCGTTCACCTTCGAACGCCGCGAGCCGAA
TGATGACGACGTCGTCATCGATATCAAATATGCCGGCATCTGCCACTCGGACATCCACACCGTCCGCAACGAATGGCACA
ATGCCGTTTACCCGATCGTTCCGGGCCACGAAATCGCCGGTGTCGTGCGGGCCGTTGGTTCCAAGGTCACGCGGTTCAAG
GTCGGCGACCATGTCGGCGTCGGCTGCTTTGTCGATTCCTGCGTTGGCTGCGCCACCCGCGATGTCGACAATGAGCAGTA
TATGCCGGGTCTCGTGCAGACCTACAATTCCGTTGAACGGGACGGCAAGAGCGCGACCCAGGGCGGTTATTCCGACCATA
TCGTGGTCAGGGAAGACTACGTCCTGTCCATCCCGGACAACCTGCCGCTCGATGCCTCCGCGCCGCTTCTCTGCGCCGGC
ATCACGCTCTATTCGCCGCTGCAGCACTGGAATGCAGGCCCCGGCAAGAAAGTGGCTATCGTCGGCATGGGTGGCCTTGG
CCACATGGGCGTGAAGATCGGCTCGGCCATGGGCGCTGATATCACCGTTCTCTCGCAGACGCTGTCGAAGAAGGAAGACG
GCCTCAAGCTCGGCGCGAAGGAATATTACGCCACCAGCGACGCCTCGACCTTTGAGAAACTCGCCGGCACCTTCGACCTG
ATCCTGTGCACAGTCTCGGCCGAAATCGACTGGAACGCCTACCTCAACCTGCTCAAGGTCAACGGCACGATGGTTCTGCT
CGGCGTGCCGGAACATGCGATCCCGGTGCACGCATTCTCGGTCATTCCCGCCCGCCGTTCGCTCGCCGGTTCGATGATCG
GCTCGATCAAGGAAACCCAGGAAATGCTGGATTTCTGCGGCAAGCACGACATCGTTTCGGAAATCGAAACGATCGGCATC
AAGGACGTCAACGAAGCCTATGAGCGCGTGCTGAAGAGCGACGTGCGTTACCGCTTCGTCATCGACATGGCCTCGCTCGA
CGCTTGA

Upstream 100 bases:

>100_bases
TTTTTGCAGGATCGTGCAAAAAGCTCGGAGGATCGCTCTAACGCCTCTTTGCACTTCCATCGCATATTCCGCCGTCCCCA
ACTCCCGAAAGGATATTCAG

Downstream 100 bases:

>100_bases
TACGCGTAGAGACGACCAAATAAACAAGGGCGGGAAGCCATGCTTCCCGCCCTTTCCTTTGTTACTTCAGGCCTCGTCCT
TCAGCGTCTCTTTCTGGGTA

Product: NADP-dependent alcohol dehydrogenase

Products: NA

Alternate protein names: Ms-ADHC 1 [H]

Number of amino acids: Translated: 348; Mature: 347

Protein sequence:

>348_residues
MAIARGYAATDASKPLTPFTFERREPNDDDVVIDIKYAGICHSDIHTVRNEWHNAVYPIVPGHEIAGVVRAVGSKVTRFK
VGDHVGVGCFVDSCVGCATRDVDNEQYMPGLVQTYNSVERDGKSATQGGYSDHIVVREDYVLSIPDNLPLDASAPLLCAG
ITLYSPLQHWNAGPGKKVAIVGMGGLGHMGVKIGSAMGADITVLSQTLSKKEDGLKLGAKEYYATSDASTFEKLAGTFDL
ILCTVSAEIDWNAYLNLLKVNGTMVLLGVPEHAIPVHAFSVIPARRSLAGSMIGSIKETQEMLDFCGKHDIVSEIETIGI
KDVNEAYERVLKSDVRYRFVIDMASLDA

Sequences:

>Translated_348_residues
MAIARGYAATDASKPLTPFTFERREPNDDDVVIDIKYAGICHSDIHTVRNEWHNAVYPIVPGHEIAGVVRAVGSKVTRFK
VGDHVGVGCFVDSCVGCATRDVDNEQYMPGLVQTYNSVERDGKSATQGGYSDHIVVREDYVLSIPDNLPLDASAPLLCAG
ITLYSPLQHWNAGPGKKVAIVGMGGLGHMGVKIGSAMGADITVLSQTLSKKEDGLKLGAKEYYATSDASTFEKLAGTFDL
ILCTVSAEIDWNAYLNLLKVNGTMVLLGVPEHAIPVHAFSVIPARRSLAGSMIGSIKETQEMLDFCGKHDIVSEIETIGI
KDVNEAYERVLKSDVRYRFVIDMASLDA
>Mature_347_residues
AIARGYAATDASKPLTPFTFERREPNDDDVVIDIKYAGICHSDIHTVRNEWHNAVYPIVPGHEIAGVVRAVGSKVTRFKV
GDHVGVGCFVDSCVGCATRDVDNEQYMPGLVQTYNSVERDGKSATQGGYSDHIVVREDYVLSIPDNLPLDASAPLLCAGI
TLYSPLQHWNAGPGKKVAIVGMGGLGHMGVKIGSAMGADITVLSQTLSKKEDGLKLGAKEYYATSDASTFEKLAGTFDLI
LCTVSAEIDWNAYLNLLKVNGTMVLLGVPEHAIPVHAFSVIPARRSLAGSMIGSIKETQEMLDFCGKHDIVSEIETIGIK
DVNEAYERVLKSDVRYRFVIDMASLDA

Specific function: Prefers aldehydes over alcohols [H]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI71743840, Length=365, Percent_Identity=25.4794520547945, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI262073058, Length=365, Percent_Identity=25.4794520547945, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI4501939, Length=350, Percent_Identity=23.1428571428571, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI156523966, Length=233, Percent_Identity=25.3218884120172, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI4501933, Length=362, Percent_Identity=26.5193370165746, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1786518, Length=346, Percent_Identity=51.1560693641619, Blast_Score=311, Evalue=4e-86,
Organism=Escherichia coli, GI87082401, Length=347, Percent_Identity=31.4121037463977, Blast_Score=180, Evalue=1e-46,
Organism=Escherichia coli, GI87081918, Length=341, Percent_Identity=24.3401759530792, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1788073, Length=202, Percent_Identity=28.7128712871287, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1788407, Length=210, Percent_Identity=27.6190476190476, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71988145, Length=339, Percent_Identity=26.8436578171091, Blast_Score=131, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI17562584, Length=338, Percent_Identity=28.1065088757396, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17562582, Length=327, Percent_Identity=27.82874617737, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI25146526, Length=365, Percent_Identity=24.9315068493151, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI71997431, Length=367, Percent_Identity=24.7956403269755, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323980, Length=323, Percent_Identity=42.7244582043344, Blast_Score=214, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6319949, Length=331, Percent_Identity=35.9516616314199, Blast_Score=174, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6319621, Length=330, Percent_Identity=31.5151515151515, Blast_Score=153, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6323961, Length=329, Percent_Identity=29.483282674772, Blast_Score=140, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6324486, Length=329, Percent_Identity=29.483282674772, Blast_Score=139, Evalue=6e-34,
Organism=Saccharomyces cerevisiae, GI6323729, Length=330, Percent_Identity=31.2121212121212, Blast_Score=131, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6320033, Length=373, Percent_Identity=28.4182305630027, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6319258, Length=333, Percent_Identity=26.1261261261261, Blast_Score=87, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6319257, Length=306, Percent_Identity=27.4509803921569, Blast_Score=80, Evalue=4e-16,
Organism=Drosophila melanogaster, GI17737895, Length=367, Percent_Identity=25.0681198910082, Blast_Score=71, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.2 [H]

Molecular weight: Translated: 37607; Mature: 37476

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIARGYAATDASKPLTPFTFERREPNDDDVVIDIKYAGICHSDIHTVRNEWHNAVYPIV
CCCCCCCCCCCCCCCCCCCEECCCCCCCCCEEEEEEECCCCHHHHHHHHHHHCCCEECCC
PGHEIAGVVRAVGSKVTRFKVGDHVGVGCFVDSCVGCATRDVDNEQYMPGLVQTYNSVER
CCHHHHHHHHHHCCHHEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
DGKSATQGGYSDHIVVREDYVLSIPDNLPLDASAPLLCAGITLYSPLQHWNAGPGKKVAI
CCCCCCCCCCCCEEEEECCEEEECCCCCCCCCCCCCEEECHHHHHHHHHCCCCCCCEEEE
VGMGGLGHMGVKIGSAMGADITVLSQTLSKKEDGLKLGAKEYYATSDASTFEKLAGTFDL
EEECCCCCCCEEECCCCCCCHHHHHHHHHCCCCCCCCCCHHHCCCCCHHHHHHHHCCEEE
ILCTVSAEIDWNAYLNLLKVNGTMVLLGVPEHAIPVHAFSVIPARRSLAGSMIGSIKETQ
EEEEEECCCCHHHEEEEEEECCEEEEEECCCCCCCEEHHHHCCHHHHHHHHHHHHHHHHH
EMLDFCGKHDIVSEIETIGIKDVNEAYERVLKSDVRYRFVIDMASLDA
HHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEEEEECCCCC
>Mature Secondary Structure 
AIARGYAATDASKPLTPFTFERREPNDDDVVIDIKYAGICHSDIHTVRNEWHNAVYPIV
CCCCCCCCCCCCCCCCCCEECCCCCCCCCEEEEEEECCCCHHHHHHHHHHHCCCEECCC
PGHEIAGVVRAVGSKVTRFKVGDHVGVGCFVDSCVGCATRDVDNEQYMPGLVQTYNSVER
CCHHHHHHHHHHCCHHEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
DGKSATQGGYSDHIVVREDYVLSIPDNLPLDASAPLLCAGITLYSPLQHWNAGPGKKVAI
CCCCCCCCCCCCEEEEECCEEEECCCCCCCCCCCCCEEECHHHHHHHHHCCCCCCCEEEE
VGMGGLGHMGVKIGSAMGADITVLSQTLSKKEDGLKLGAKEYYATSDASTFEKLAGTFDL
EEECCCCCCCEEECCCCCCCHHHHHHHHHCCCCCCCCCCHHHCCCCCHHHHHHHHCCEEE
ILCTVSAEIDWNAYLNLLKVNGTMVLLGVPEHAIPVHAFSVIPARRSLAGSMIGSIKETQ
EEEEEECCCCHHHEEEEEEECCEEEEEECCCCCCCEEHHHHCCHHHHHHHHHHHHHHHHH
EMLDFCGKHDIVSEIETIGIKDVNEAYERVLKSDVRYRFVIDMASLDA
HHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11257547 [H]