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The map label for this gene is mntH

Identifier: 159184892

GI number: 159184892

Start: 1721995

End: 1723365

Strand: Reverse

Name: mntH

Synonym: Atu1736

Alternate gene names: 159184892

Gene position: 1723365-1721995 (Counterclockwise)

Preceding gene: 159184893

Following gene: 159184888

Centisome position: 60.65

GC content: 59.81

Gene sequence:

>1371_bases
ATGATTTGCAATTGCATTAATTCGATTTCCATGAAAGCACAGAAGATGGACAAGCCAGTCTTTGGATGGCGACGGAACGG
CGATGATCTCTCGCTGTCTGACGTTCACAGTTCGATCCGCATCAAACCGGATGCCAGCACGTTTCGCCGGGCAATGGCCT
TTTTTGGCCCCGGCTATCTCGTCGCTGTCGGTTACATGGATCCCGGGAACTGGGCGACGTCGCTCGCCGGCGGCTCCAAA
TTCGGCTACACGCTGCTGGCAGTCGCGCTGGTTTCCAACATCATGGCGATTGTGCTGCAGTCGCTCTGTGCCCGTCTTGC
GATCGCCTCCGGCCGCGATCTCGCCCAGGCCTGCCGTGATGCCTATCCGAAACCCGTTGCCATGGTGCTGTGGCTGCTCG
CGGAAATCGCCATCATCGCCACCGACATTGCCGAGGTGATCGGCACCGCCATCGGCCTCAACCTGATCTTCGGCATTCCG
CTGGAACTTGGCGTCCTCATCACCGCGCTCGATGTGTTCCTGATCCTCTATCTGCAAAAGCTCGGTTTTCGCTGGGTGGA
GGCACTGGTCATCACGCTGCTCGGCGTCATCGCCGTGTGTTTCGCCATTCAGCTGGCGCTGGCCGATCCTGACTGGGGGC
AGGTGATCCTCGGTTTTGCGCCGACGACGGAGATTGTCACCAATCCGGACATGCTTTATCTGGCGCTCGGCATTCTGGGT
GCGACTGTCATGCCGCATAATCTCTATCTGCATTCGGGCATCGTGCAGACCCGCGAAATCGGCCCCACCATTGCCGAAAA
ACGCGAGGCGCTGAAATTCGCCACGCTCGATTCCACCATCGCGCTGATGTTCGCTTTGCTCATCAACGCCTCGATCCTCA
TTCTCGCGGCGGCGACCTTCAACAAAACGGGGCAGACTAATGTCGCCGAACTCGGCGAAGCGCATAGTCTGCTTGCGCCG
CTGCTCGGCCTTGCCATAGCGCCGACGCTGTTCGGCGTGGCGCTTCTGTGCTGCGGCATCAATTCCACCGTCACGGCAAC
GCTCGCCGGCCAGATCGTGATGGAAGGTTTCCTCAAGATGCGGCTCGCCCCATGGCTGCGCCGCCTCATCACCCGCGCCA
TCGCCATCGTTCCCGCCGCCGGCGTCACCATCTTTTATGGCGACAGCGGCACGGGCCAGCTGCTGATCCTGACGCAGGTG
GTGCTCAGCCTGCAACTTTCCTTCGCCGTCTTCCCGCTTGTGATGTTTACCTCCGACAAGGCCAAGATGGGTGAGTTGCG
CTCGCCACTCTGGCTCTCGGCCATTGCGTGGTTGATCGCGGTGGTGATTGCGGCGCTGAATGTGAAGTTGCTGATGGATT
TTATGGGGTGA

Upstream 100 bases:

>100_bases
TCGGCCGGCTGGCCTCCGGCTTGGAGTGAGGACGACGGGGAGGGGGAGAACCGGCAGTCCTCCGTGAAACTCCGCTTGCC
AGTTCATGTTCTTTATGAGA

Downstream 100 bases:

>100_bases
GGCGGGTCAGGTTGCGCCTTTACGGAGCGCGGCCGCCGTTCCCTCGGGGTCAACGGCGATGATCTTCAGATAAGCGCGGG
CCGGTTGATCCGGCTCGCTG

Product: manganese transport protein MntH

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 456; Mature: 456

Protein sequence:

>456_residues
MICNCINSISMKAQKMDKPVFGWRRNGDDLSLSDVHSSIRIKPDASTFRRAMAFFGPGYLVAVGYMDPGNWATSLAGGSK
FGYTLLAVALVSNIMAIVLQSLCARLAIASGRDLAQACRDAYPKPVAMVLWLLAEIAIIATDIAEVIGTAIGLNLIFGIP
LELGVLITALDVFLILYLQKLGFRWVEALVITLLGVIAVCFAIQLALADPDWGQVILGFAPTTEIVTNPDMLYLALGILG
ATVMPHNLYLHSGIVQTREIGPTIAEKREALKFATLDSTIALMFALLINASILILAAATFNKTGQTNVAELGEAHSLLAP
LLGLAIAPTLFGVALLCCGINSTVTATLAGQIVMEGFLKMRLAPWLRRLITRAIAIVPAAGVTIFYGDSGTGQLLILTQV
VLSLQLSFAVFPLVMFTSDKAKMGELRSPLWLSAIAWLIAVVIAALNVKLLMDFMG

Sequences:

>Translated_456_residues
MICNCINSISMKAQKMDKPVFGWRRNGDDLSLSDVHSSIRIKPDASTFRRAMAFFGPGYLVAVGYMDPGNWATSLAGGSK
FGYTLLAVALVSNIMAIVLQSLCARLAIASGRDLAQACRDAYPKPVAMVLWLLAEIAIIATDIAEVIGTAIGLNLIFGIP
LELGVLITALDVFLILYLQKLGFRWVEALVITLLGVIAVCFAIQLALADPDWGQVILGFAPTTEIVTNPDMLYLALGILG
ATVMPHNLYLHSGIVQTREIGPTIAEKREALKFATLDSTIALMFALLINASILILAAATFNKTGQTNVAELGEAHSLLAP
LLGLAIAPTLFGVALLCCGINSTVTATLAGQIVMEGFLKMRLAPWLRRLITRAIAIVPAAGVTIFYGDSGTGQLLILTQV
VLSLQLSFAVFPLVMFTSDKAKMGELRSPLWLSAIAWLIAVVIAALNVKLLMDFMG
>Mature_456_residues
MICNCINSISMKAQKMDKPVFGWRRNGDDLSLSDVHSSIRIKPDASTFRRAMAFFGPGYLVAVGYMDPGNWATSLAGGSK
FGYTLLAVALVSNIMAIVLQSLCARLAIASGRDLAQACRDAYPKPVAMVLWLLAEIAIIATDIAEVIGTAIGLNLIFGIP
LELGVLITALDVFLILYLQKLGFRWVEALVITLLGVIAVCFAIQLALADPDWGQVILGFAPTTEIVTNPDMLYLALGILG
ATVMPHNLYLHSGIVQTREIGPTIAEKREALKFATLDSTIALMFALLINASILILAAATFNKTGQTNVAELGEAHSLLAP
LLGLAIAPTLFGVALLCCGINSTVTATLAGQIVMEGFLKMRLAPWLRRLITRAIAIVPAAGVTIFYGDSGTGQLLILTQV
VLSLQLSFAVFPLVMFTSDKAKMGELRSPLWLSAIAWLIAVVIAALNVKLLMDFMG

Specific function: H(+)-stimulated, highly selective, manganese uptake system

COG id: COG1914

COG function: function code P; Mn2+ and Fe2+ transporters of the NRAMP family

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NRAMP family

Homologues:

Organism=Homo sapiens, GI109255241, Length=441, Percent_Identity=36.0544217687075, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI295293167, Length=435, Percent_Identity=34.7126436781609, Blast_Score=226, Evalue=2e-59,
Organism=Homo sapiens, GI295293171, Length=432, Percent_Identity=34.9537037037037, Blast_Score=226, Evalue=3e-59,
Organism=Homo sapiens, GI295293169, Length=432, Percent_Identity=34.9537037037037, Blast_Score=226, Evalue=3e-59,
Organism=Homo sapiens, GI295293178, Length=435, Percent_Identity=34.7126436781609, Blast_Score=226, Evalue=3e-59,
Organism=Homo sapiens, GI295293175, Length=435, Percent_Identity=34.7126436781609, Blast_Score=226, Evalue=4e-59,
Organism=Homo sapiens, GI295293173, Length=435, Percent_Identity=34.7126436781609, Blast_Score=226, Evalue=4e-59,
Organism=Homo sapiens, GI10835169, Length=435, Percent_Identity=34.7126436781609, Blast_Score=226, Evalue=4e-59,
Organism=Escherichia coli, GI1788736, Length=422, Percent_Identity=39.5734597156398, Blast_Score=279, Evalue=2e-76,
Organism=Caenorhabditis elegans, GI71999499, Length=460, Percent_Identity=34.3478260869565, Blast_Score=230, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI193210616, Length=465, Percent_Identity=33.1182795698925, Blast_Score=230, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI17569473, Length=407, Percent_Identity=33.4152334152334, Blast_Score=213, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI71993856, Length=242, Percent_Identity=35.9504132231405, Blast_Score=155, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6323062, Length=414, Percent_Identity=41.304347826087, Blast_Score=268, Evalue=1e-72,
Organism=Saccharomyces cerevisiae, GI6324450, Length=451, Percent_Identity=37.0288248337029, Blast_Score=263, Evalue=3e-71,
Organism=Saccharomyces cerevisiae, GI6321841, Length=460, Percent_Identity=39.5652173913043, Blast_Score=259, Evalue=6e-70,
Organism=Drosophila melanogaster, GI24648607, Length=438, Percent_Identity=34.4748858447489, Blast_Score=241, Evalue=5e-64,
Organism=Drosophila melanogaster, GI281362176, Length=438, Percent_Identity=34.4748858447489, Blast_Score=241, Evalue=5e-64,
Organism=Drosophila melanogaster, GI24648609, Length=438, Percent_Identity=34.4748858447489, Blast_Score=241, Evalue=5e-64,
Organism=Drosophila melanogaster, GI45553443, Length=416, Percent_Identity=35.5769230769231, Blast_Score=238, Evalue=7e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MNTH_AGRT5 (Q8UEM1)

Other databases:

- EMBL:   AE007869
- PIR:   AI2789
- PIR:   H97568
- RefSeq:   NP_354720.2
- STRING:   Q8UEM1
- GeneID:   1133774
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu1736
- eggNOG:   COG1914
- HOGENOM:   HBG312498
- OMA:   KFGYALL
- PhylomeDB:   Q8UEM1
- ProtClustDB:   PRK00701
- BioCyc:   ATUM176299-1:ATU1736-MONOMER
- HAMAP:   MF_00221
- InterPro:   IPR023056
- InterPro:   IPR001046
- PANTHER:   PTHR11706
- PRINTS:   PR00447
- TIGRFAMs:   TIGR01197

Pfam domain/function: PF01566 Nramp

EC number: NA

Molecular weight: Translated: 48748; Mature: 48748

Theoretical pI: Translated: 7.75; Mature: 7.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xe16d594)-; HASH(0xf087b80)-; HASH(0xc733824)-; HASH(0xbbb6e88)-; HASH(0xf481fd0)-; HASH(0xf17bbec)-; HASH(0xeb60664)-; HASH(0xed81708)-; HASH(0xf1978b4)-; HASH(0xee68e58)-; HASH(0xeb30e84)-;

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MICNCINSISMKAQKMDKPVFGWRRNGDDLSLSDVHSSIRIKPDASTFRRAMAFFGPGYL
CCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHCCCEEECCCHHHHHHHHHHHCCCEE
VAVGYMDPGNWATSLAGGSKFGYTLLAVALVSNIMAIVLQSLCARLAIASGRDLAQACRD
EEEEECCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
AYPKPVAMVLWLLAEIAIIATDIAEVIGTAIGLNLIFGIPLELGVLITALDVFLILYLQK
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
LGFRWVEALVITLLGVIAVCFAIQLALADPDWGQVILGFAPTTEIVTNPDMLYLALGILG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHCCCHHHHHHHHHHH
ATVMPHNLYLHSGIVQTREIGPTIAEKREALKFATLDSTIALMFALLINASILILAAATF
HHHCCCCEEECCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHEEHHC
NKTGQTNVAELGEAHSLLAPLLGLAIAPTLFGVALLCCGINSTVTATLAGQIVMEGFLKM
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
RLAPWLRRLITRAIAIVPAAGVTIFYGDSGTGQLLILTQVVLSLQLSFAVFPLVMFTSDK
HHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
AKMGELRSPLWLSAIAWLIAVVIAALNVKLLMDFMG
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCH
>Mature Secondary Structure
MICNCINSISMKAQKMDKPVFGWRRNGDDLSLSDVHSSIRIKPDASTFRRAMAFFGPGYL
CCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHCCCEEECCCHHHHHHHHHHHCCCEE
VAVGYMDPGNWATSLAGGSKFGYTLLAVALVSNIMAIVLQSLCARLAIASGRDLAQACRD
EEEEECCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
AYPKPVAMVLWLLAEIAIIATDIAEVIGTAIGLNLIFGIPLELGVLITALDVFLILYLQK
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
LGFRWVEALVITLLGVIAVCFAIQLALADPDWGQVILGFAPTTEIVTNPDMLYLALGILG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHCCCHHHHHHHHHHH
ATVMPHNLYLHSGIVQTREIGPTIAEKREALKFATLDSTIALMFALLINASILILAAATF
HHHCCCCEEECCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHEEHHC
NKTGQTNVAELGEAHSLLAPLLGLAIAPTLFGVALLCCGINSTVTATLAGQIVMEGFLKM
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
RLAPWLRRLITRAIAIVPAAGVTIFYGDSGTGQLLILTQVVLSLQLSFAVFPLVMFTSDK
HHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
AKMGELRSPLWLSAIAWLIAVVIAALNVKLLMDFMG
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194