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The map label for this gene is gor [H]

Identifier: 159184837

GI number: 159184837

Start: 1593624

End: 1595012

Strand: Reverse

Name: gor [H]

Synonym: Atu1611

Alternate gene names: 159184837

Gene position: 1595012-1593624 (Counterclockwise)

Preceding gene: 15888925

Following gene: 15888923

Centisome position: 56.13

GC content: 59.4

Gene sequence:

>1389_bases
ATGACAGCTTATGACTACGATCTCTTCGTCATCGGTGGTGGTTCCGGCGGCGTGCGCAGCGGCCGCGTGGCGGCCTCGCT
GGGCAAGCGCGTGGGAATAGCTGAAGAATACCGTTATGGCGGTACCTGCGTCATTCGCGGCTGCGTGCCGAAGAAGCTGT
TCGTTTATGCCTCGCAATTCCCTGAATATTTCGAGGATGCCGAAGGTTTCGGCTGGAGCGTCGGCGAGCGCCGTTTCGAC
TGGAAGAAGCTGATCGCGGCGAAGGACAAGGAAATCACCCGGCTCGAAGGCCTCTATCGCAAGGGGCTGGAGAACGCCAA
GGCCGACATCTTCGACAGCCGTGCGGAACTGGTCGATGCCCATACCGTGAAGCTCACAAAAACCGGTGAGACCTACACGG
CAGAGCGTATCGTGATTGCCGTTGGCGGTACGCCGAACGAGCACAAGGCGCTGCCCGGTCATGAACTGACGATCTCCTCC
AACGAAGCCTTCGATCTAGAAGAACCGCCGAAATCGATCCTGATTGCCGGCGGCGGTTATATCGCTGTCGAATTCGCCAA
TATCTTCCACGGGCTCGGCGTGGAAACGACGCTGATCTATCGCGGCAAGGAAATCCTGTCGCGTTTCGATCACGACATGC
GCAAGGGCCTGCATGAGGCGATGGAGGCCAAGGGCATCCGCATCATTCTCGAAGATATTATCGAGGAAGTCAGCAAGGAT
GGCGCCGGCGGCTTCGTGGCACGCACCAAACAGGGCAGCTCGCTGCATGTCGGCCTGGTGATGCTGGCGCTCGGTCGCGA
CCCGAACACCAAGGGACTCGGTCTCGAAAATGCCGGTGTGAAGGTGGATGCGCGCGGCGCGATCATCGTCGACGACTATT
CGCGCACGAACGTGCCCAGCATCTTCGCGCTGGGTGACGTCACCGACCGGGTACAGCTGACGCCGGTAGCGATCCACGAG
GCTATGTGCTTCATCGAGACCGAATACAAGAACAATCCGACCAAGCCGGATCACGAGCTGATTGCGACGGCGGTGTTCTC
GCAGCCGGAAATCGGAACCGTTGGTCTTTCGGAAGAGGAAGCCGGCAAGAAATATCGGGAACTGGAAGTCTATCGCGCCC
AGTTCCGGCCGATGAAGGCGACGCTTTCCGGCCGACAGGAAAAGACGATCATGAAGCTGATCGTCAATGCGAGCGACCGC
AGGGTTGTCGGTGTGCATATTCTTGGCCACGAGGCGGGTGAAATGGCGCAGCTTCTCGGCATCACGCTGAAGGCGGGCTG
CACCAAGGATGATTTCGACCGCACCATGGCGGTTCATCCCACAGCCGCCGAAGAACTGGTGACGATGTATGCGCCGAGCT
ACCGCGTGGTGAATGGCGAGCGCGTGTAA

Upstream 100 bases:

>100_bases
GACCGGGCTTTTCATTTGTGCGTCGCAGCACCTATATGTGGCGTGAACAGACCGCTGGCCCATATCGGGGTCATGGCGGT
TTTGAGCAGGGGTTTTGACT

Downstream 100 bases:

>100_bases
CGCCAATACAGGCGTGATGTGATCGCTGTCCAAATTCGCCCGCCGCCCTTCGAAAACGGATGTTTTTTGGATGGCGGCGG
GTGCGTTAAATCGTTTGAAT

Product: glutathione reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 462; Mature: 461

Protein sequence:

>462_residues
MTAYDYDLFVIGGGSGGVRSGRVAASLGKRVGIAEEYRYGGTCVIRGCVPKKLFVYASQFPEYFEDAEGFGWSVGERRFD
WKKLIAAKDKEITRLEGLYRKGLENAKADIFDSRAELVDAHTVKLTKTGETYTAERIVIAVGGTPNEHKALPGHELTISS
NEAFDLEEPPKSILIAGGGYIAVEFANIFHGLGVETTLIYRGKEILSRFDHDMRKGLHEAMEAKGIRIILEDIIEEVSKD
GAGGFVARTKQGSSLHVGLVMLALGRDPNTKGLGLENAGVKVDARGAIIVDDYSRTNVPSIFALGDVTDRVQLTPVAIHE
AMCFIETEYKNNPTKPDHELIATAVFSQPEIGTVGLSEEEAGKKYRELEVYRAQFRPMKATLSGRQEKTIMKLIVNASDR
RVVGVHILGHEAGEMAQLLGITLKAGCTKDDFDRTMAVHPTAAEELVTMYAPSYRVVNGERV

Sequences:

>Translated_462_residues
MTAYDYDLFVIGGGSGGVRSGRVAASLGKRVGIAEEYRYGGTCVIRGCVPKKLFVYASQFPEYFEDAEGFGWSVGERRFD
WKKLIAAKDKEITRLEGLYRKGLENAKADIFDSRAELVDAHTVKLTKTGETYTAERIVIAVGGTPNEHKALPGHELTISS
NEAFDLEEPPKSILIAGGGYIAVEFANIFHGLGVETTLIYRGKEILSRFDHDMRKGLHEAMEAKGIRIILEDIIEEVSKD
GAGGFVARTKQGSSLHVGLVMLALGRDPNTKGLGLENAGVKVDARGAIIVDDYSRTNVPSIFALGDVTDRVQLTPVAIHE
AMCFIETEYKNNPTKPDHELIATAVFSQPEIGTVGLSEEEAGKKYRELEVYRAQFRPMKATLSGRQEKTIMKLIVNASDR
RVVGVHILGHEAGEMAQLLGITLKAGCTKDDFDRTMAVHPTAAEELVTMYAPSYRVVNGERV
>Mature_461_residues
TAYDYDLFVIGGGSGGVRSGRVAASLGKRVGIAEEYRYGGTCVIRGCVPKKLFVYASQFPEYFEDAEGFGWSVGERRFDW
KKLIAAKDKEITRLEGLYRKGLENAKADIFDSRAELVDAHTVKLTKTGETYTAERIVIAVGGTPNEHKALPGHELTISSN
EAFDLEEPPKSILIAGGGYIAVEFANIFHGLGVETTLIYRGKEILSRFDHDMRKGLHEAMEAKGIRIILEDIIEEVSKDG
AGGFVARTKQGSSLHVGLVMLALGRDPNTKGLGLENAGVKVDARGAIIVDDYSRTNVPSIFALGDVTDRVQLTPVAIHEA
MCFIETEYKNNPTKPDHELIATAVFSQPEIGTVGLSEEEAGKKYRELEVYRAQFRPMKATLSGRQEKTIMKLIVNASDRR
VVGVHILGHEAGEMAQLLGITLKAGCTKDDFDRTMAVHPTAAEELVTMYAPSYRVVNGERV

Specific function: Maintains High Levels Of Reduced Glutathione In The Cytosol. [C]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=459, Percent_Identity=38.3442265795207, Blast_Score=293, Evalue=2e-79,
Organism=Homo sapiens, GI33519430, Length=475, Percent_Identity=37.2631578947368, Blast_Score=258, Evalue=1e-68,
Organism=Homo sapiens, GI33519428, Length=475, Percent_Identity=37.2631578947368, Blast_Score=258, Evalue=1e-68,
Organism=Homo sapiens, GI33519426, Length=475, Percent_Identity=37.2631578947368, Blast_Score=258, Evalue=1e-68,
Organism=Homo sapiens, GI148277065, Length=475, Percent_Identity=37.2631578947368, Blast_Score=258, Evalue=1e-68,
Organism=Homo sapiens, GI148277071, Length=475, Percent_Identity=37.2631578947368, Blast_Score=257, Evalue=1e-68,
Organism=Homo sapiens, GI291045266, Length=474, Percent_Identity=35.6540084388186, Blast_Score=243, Evalue=3e-64,
Organism=Homo sapiens, GI22035672, Length=470, Percent_Identity=33.6170212765957, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI291045268, Length=472, Percent_Identity=33.6864406779661, Blast_Score=210, Evalue=3e-54,
Organism=Homo sapiens, GI91199540, Length=456, Percent_Identity=26.7543859649123, Blast_Score=157, Evalue=2e-38,
Organism=Escherichia coli, GI1789915, Length=430, Percent_Identity=38.3720930232558, Blast_Score=285, Evalue=6e-78,
Organism=Escherichia coli, GI1786307, Length=452, Percent_Identity=27.8761061946903, Blast_Score=170, Evalue=2e-43,
Organism=Escherichia coli, GI87082354, Length=458, Percent_Identity=27.9475982532751, Blast_Score=162, Evalue=4e-41,
Organism=Escherichia coli, GI87081717, Length=455, Percent_Identity=26.1538461538462, Blast_Score=139, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI71983419, Length=450, Percent_Identity=40.4444444444444, Blast_Score=269, Evalue=2e-72,
Organism=Caenorhabditis elegans, GI71983429, Length=450, Percent_Identity=40.4444444444444, Blast_Score=268, Evalue=3e-72,
Organism=Caenorhabditis elegans, GI17557007, Length=474, Percent_Identity=30.379746835443, Blast_Score=227, Evalue=9e-60,
Organism=Caenorhabditis elegans, GI71982272, Length=482, Percent_Identity=32.3651452282158, Blast_Score=199, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI32565766, Length=456, Percent_Identity=27.8508771929825, Blast_Score=175, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI17559934, Length=189, Percent_Identity=30.1587301587302, Blast_Score=72, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6325166, Length=462, Percent_Identity=37.2294372294372, Blast_Score=279, Evalue=9e-76,
Organism=Saccharomyces cerevisiae, GI6321091, Length=461, Percent_Identity=25.8134490238612, Blast_Score=149, Evalue=8e-37,
Organism=Saccharomyces cerevisiae, GI6325240, Length=470, Percent_Identity=25.7446808510638, Blast_Score=139, Evalue=9e-34,
Organism=Drosophila melanogaster, GI24640553, Length=474, Percent_Identity=33.7552742616034, Blast_Score=232, Evalue=4e-61,
Organism=Drosophila melanogaster, GI24640549, Length=474, Percent_Identity=33.7552742616034, Blast_Score=232, Evalue=4e-61,
Organism=Drosophila melanogaster, GI24640551, Length=474, Percent_Identity=33.7552742616034, Blast_Score=231, Evalue=6e-61,
Organism=Drosophila melanogaster, GI17737741, Length=472, Percent_Identity=32.6271186440678, Blast_Score=220, Evalue=1e-57,
Organism=Drosophila melanogaster, GI21358499, Length=460, Percent_Identity=27.1739130434783, Blast_Score=163, Evalue=2e-40,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006324
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 50588; Mature: 50457

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAYDYDLFVIGGGSGGVRSGRVAASLGKRVGIAEEYRYGGTCVIRGCVPKKLFVYASQF
CCEEEEEEEEEECCCCCCCCCHHHHHHHHHCCCHHHHCCCCEEEEECCCCCHHHHHHHHC
PEYFEDAEGFGWSVGERRFDWKKLIAAKDKEITRLEGLYRKGLENAKADIFDSRAELVDA
HHHHHHCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHCHHHHEEC
HTVKLTKTGETYTAERIVIAVGGTPNEHKALPGHELTISSNEAFDLEEPPKSILIAGGGY
EEEEEEECCCCEEEEEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCEEEEECCCE
IAVEFANIFHGLGVETTLIYRGKEILSRFDHDMRKGLHEAMEAKGIRIILEDIIEEVSKD
EEEEEHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHCC
GAGGFVARTKQGSSLHVGLVMLALGRDPNTKGLGLENAGVKVDARGAIIVDDYSRTNVPS
CCCCEEEECCCCCCEEEEEEEEEECCCCCCCCCCCCCCCEEEECCCEEEEECCCCCCCCE
IFALGDVTDRVQLTPVAIHEAMCFIETEYKNNPTKPDHELIATAVFSQPEIGTVGLSEEE
EEEECCCCCCEEEEHHHHHHEEEEEEEECCCCCCCCHHHHHHHHHCCCCCCCEECCCHHH
AGKKYRELEVYRAQFRPMKATLSGRQEKTIMKLIVNASDRRVVGVHILGHEAGEMAQLLG
HHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHCCCCCCEEEEEEEECCCHHHHHHHHC
ITLKAGCTKDDFDRTMAVHPTAAEELVTMYAPSYRVVNGERV
EEEECCCCCCCCCCEEEECCCHHHHHHHHHCCCEEEECCCCC
>Mature Secondary Structure 
TAYDYDLFVIGGGSGGVRSGRVAASLGKRVGIAEEYRYGGTCVIRGCVPKKLFVYASQF
CEEEEEEEEEECCCCCCCCCHHHHHHHHHCCCHHHHCCCCEEEEECCCCCHHHHHHHHC
PEYFEDAEGFGWSVGERRFDWKKLIAAKDKEITRLEGLYRKGLENAKADIFDSRAELVDA
HHHHHHCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHCHHHHEEC
HTVKLTKTGETYTAERIVIAVGGTPNEHKALPGHELTISSNEAFDLEEPPKSILIAGGGY
EEEEEEECCCCEEEEEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCEEEEECCCE
IAVEFANIFHGLGVETTLIYRGKEILSRFDHDMRKGLHEAMEAKGIRIILEDIIEEVSKD
EEEEEHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHCC
GAGGFVARTKQGSSLHVGLVMLALGRDPNTKGLGLENAGVKVDARGAIIVDDYSRTNVPS
CCCCEEEECCCCCCEEEEEEEEEECCCCCCCCCCCCCCCEEEECCCEEEEECCCCCCCCE
IFALGDVTDRVQLTPVAIHEAMCFIETEYKNNPTKPDHELIATAVFSQPEIGTVGLSEEE
EEEECCCCCCEEEEHHHHHHEEEEEEEECCCCCCCCHHHHHHHHHCCCCCCCEECCCHHH
AGKKYRELEVYRAQFRPMKATLSGRQEKTIMKLIVNASDRRVVGVHILGHEAGEMAQLLG
HHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHCCCCCCEEEEEEEECCCHHHHHHHHC
ITLKAGCTKDDFDRTMAVHPTAAEELVTMYAPSYRVVNGERV
EEEECCCCCCCCCCEEEECCCHHHHHHHHHCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7538273 [H]