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The map label for this gene is iunH [H]

Identifier: 159184830

GI number: 159184830

Start: 1573227

End: 1574186

Strand: Reverse

Name: iunH [H]

Synonym: Atu1590

Alternate gene names: 159184830

Gene position: 1574186-1573227 (Counterclockwise)

Preceding gene: 15888906

Following gene: 159184829

Centisome position: 55.4

GC content: 60.52

Gene sequence:

>960_bases
ATGCATAAAGTGATATTCGATACGGACCCCGGTGTGGATGATGCCATGGCGCTTCTTTTCCTGCACCGTCACCCCGATAT
CGATCTGATCGGTGTCACCACGGTTTTCGGTAATGCGCCCATCGACATCACCACCCGCAATGCGCTTTTCCTCAAGCGGG
AATGGCAGATGACCGCGCCTGTTGCGAAAGGCGCTGGCGTGACCTTTGATCCCGCCCGCAAGGAAGGCCACTGGCCGACC
TTCATTCATGGCGAAAATGGCCTCGGTGATATCGATATTCCCGAGACCATCGACCTGCCGCTCGATCCGCGTCCCGCGCA
TCGCTTCATTATCGAGACCGTGAAGGCCAATCCCGGCGAGGTGACGCTGATCGCCGTTGGCCGCATGACCAATCTGGCGC
TGGCATTGCGCGAGGAGCCGGATTTTGCAGCATTGGTGAAGCAGGTCATCGTCATGGGCGGCGCCTTCGATATCAACGGC
AATGTTTCGCCGGCGGCCGAGGCCAATATTCACGGTGATCCGGAAGCGGCCGATCTCGTCTTCACCGCCCCGTGGCGCGT
GGTGGTCGTCGGTCTCGATGTCACCACAAAAACGGTAATGACCAGCGCTTTCATGGCGGAGATGGCTGAAGCCGGCGGCA
AGCCCGTACAGCTGCTTTCTGACCTGTCGCAATTCTACATCGATTTTTACAAGACCCGCACCGGCGATGGCATGGTGGTG
CATGACAGCTGCGCCTGCGTCTATCTCGTGGCGCCTGAGCTGTTTACGACCCGCAGCGGCCCGGTGCGCGTCGTCTGCGG
TGGCCTTGCCGATGGCGAGACGATCCAGAAGCCGGATGGCCGCGCCTTTCCACCGGGTGACTGGGATGGGCATCCAAGCC
AGCTCATCTGCACGGATATCAAGCCGGAGCGCGTGCTTTCGGTCATCCGCGCGGCAATTGTGAAGGGCGAGCGCGGCTGA

Upstream 100 bases:

>100_bases
CTGCGGGCAGGGGGATTGCGGTGTGGCCGCTTATCGTTATGTTTCCGTGGCGCGTCGCCGGAAGAACGGATGGCGCTCGA
GACATATGGATGAGGGCATT

Downstream 100 bases:

>100_bases
ACGACAGGAATGGCCGTTCTTGAGCATGGCCTGCCTTGCATTTTCCCAGAATCTGGCGTTATGCAAGTTCCTTGATCCCA
TTACGTGATCCGCCTTGCCG

Product: inosine-uridine preferring nucleoside hydrolase

Products: NA

Alternate protein names: Cytidine/uridine-specific hydrolase [H]

Number of amino acids: Translated: 319; Mature: 319

Protein sequence:

>319_residues
MHKVIFDTDPGVDDAMALLFLHRHPDIDLIGVTTVFGNAPIDITTRNALFLKREWQMTAPVAKGAGVTFDPARKEGHWPT
FIHGENGLGDIDIPETIDLPLDPRPAHRFIIETVKANPGEVTLIAVGRMTNLALALREEPDFAALVKQVIVMGGAFDING
NVSPAAEANIHGDPEAADLVFTAPWRVVVVGLDVTTKTVMTSAFMAEMAEAGGKPVQLLSDLSQFYIDFYKTRTGDGMVV
HDSCACVYLVAPELFTTRSGPVRVVCGGLADGETIQKPDGRAFPPGDWDGHPSQLICTDIKPERVLSVIRAAIVKGERG

Sequences:

>Translated_319_residues
MHKVIFDTDPGVDDAMALLFLHRHPDIDLIGVTTVFGNAPIDITTRNALFLKREWQMTAPVAKGAGVTFDPARKEGHWPT
FIHGENGLGDIDIPETIDLPLDPRPAHRFIIETVKANPGEVTLIAVGRMTNLALALREEPDFAALVKQVIVMGGAFDING
NVSPAAEANIHGDPEAADLVFTAPWRVVVVGLDVTTKTVMTSAFMAEMAEAGGKPVQLLSDLSQFYIDFYKTRTGDGMVV
HDSCACVYLVAPELFTTRSGPVRVVCGGLADGETIQKPDGRAFPPGDWDGHPSQLICTDIKPERVLSVIRAAIVKGERG
>Mature_319_residues
MHKVIFDTDPGVDDAMALLFLHRHPDIDLIGVTTVFGNAPIDITTRNALFLKREWQMTAPVAKGAGVTFDPARKEGHWPT
FIHGENGLGDIDIPETIDLPLDPRPAHRFIIETVKANPGEVTLIAVGRMTNLALALREEPDFAALVKQVIVMGGAFDING
NVSPAAEANIHGDPEAADLVFTAPWRVVVVGLDVTTKTVMTSAFMAEMAEAGGKPVQLLSDLSQFYIDFYKTRTGDGMVV
HDSCACVYLVAPELFTTRSGPVRVVCGGLADGETIQKPDGRAFPPGDWDGHPSQLICTDIKPERVLSVIRAAIVKGERG

Specific function: Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively. Has a clear preference for cytidine over uridine. Strictly specific for ribonucleosides [H]

COG id: COG1957

COG function: function code F; Inosine-uridine nucleoside N-ribohydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IUNH family. RihB subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788486, Length=276, Percent_Identity=36.9565217391304, Blast_Score=162, Evalue=2e-41,
Organism=Escherichia coli, GI1786213, Length=288, Percent_Identity=35.4166666666667, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1786871, Length=258, Percent_Identity=34.4961240310078, Blast_Score=130, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI32565474, Length=197, Percent_Identity=31.4720812182741, Blast_Score=77, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17565698, Length=186, Percent_Identity=30.1075268817204, Blast_Score=76, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320608, Length=259, Percent_Identity=33.5907335907336, Blast_Score=113, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24641839, Length=190, Percent_Identity=31.5789473684211, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24641837, Length=236, Percent_Identity=28.8135593220339, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015910
- InterPro:   IPR023186
- InterPro:   IPR001910
- InterPro:   IPR022977 [H]

Pfam domain/function: PF01156 IU_nuc_hydro [H]

EC number: =3.2.2.8 [H]

Molecular weight: Translated: 34415; Mature: 34415

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHKVIFDTDPGVDDAMALLFLHRHPDIDLIGVTTVFGNAPIDITTRNALFLKREWQMTAP
CCEEEECCCCCHHHHHHHHHHHCCCCEEEEEEEEEECCCCEEEEECCEEEEEECCEEECC
VAKGAGVTFDPARKEGHWPTFIHGENGLGDIDIPETIDLPLDPRPAHRFIIETVKANPGE
CCCCCCCEECCCCCCCCCCEEEECCCCCCCCCCCCEECCCCCCCCHHEEEEEEECCCCCC
VTLIAVGRMTNLALALREEPDFAALVKQVIVMGGAFDINGNVSPAAEANIHGDPEAADLV
EEEEEECCCCEEEEEEECCCCHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCCCCEE
FTAPWRVVVVGLDVTTKTVMTSAFMAEMAEAGGKPVQLLSDLSQFYIDFYKTRTGDGMVV
EECCEEEEEEEECCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCEEE
HDSCACVYLVAPELFTTRSGPVRVVCGGLADGETIQKPDGRAFPPGDWDGHPSQLICTDI
ECCCEEEEEECCHHHCCCCCCEEEEECCCCCCCCEECCCCCCCCCCCCCCCCCCEEEECC
KPERVLSVIRAAIVKGERG
CHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MHKVIFDTDPGVDDAMALLFLHRHPDIDLIGVTTVFGNAPIDITTRNALFLKREWQMTAP
CCEEEECCCCCHHHHHHHHHHHCCCCEEEEEEEEEECCCCEEEEECCEEEEEECCEEECC
VAKGAGVTFDPARKEGHWPTFIHGENGLGDIDIPETIDLPLDPRPAHRFIIETVKANPGE
CCCCCCCEECCCCCCCCCCEEEECCCCCCCCCCCCEECCCCCCCCHHEEEEEEECCCCCC
VTLIAVGRMTNLALALREEPDFAALVKQVIVMGGAFDINGNVSPAAEANIHGDPEAADLV
EEEEEECCCCEEEEEEECCCCHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCCCCEE
FTAPWRVVVVGLDVTTKTVMTSAFMAEMAEAGGKPVQLLSDLSQFYIDFYKTRTGDGMVV
EECCEEEEEEEECCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCEEE
HDSCACVYLVAPELFTTRSGPVRVVCGGLADGETIQKPDGRAFPPGDWDGHPSQLICTDI
ECCCEEEEEECCHHHCCCCCCEEEEECCCCCCCCEECCCCCCCCCCCCCCCCCCEEEECC
KPERVLSVIRAAIVKGERG
CHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA