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The map label for this gene is folK [H]

Identifier: 159184727

GI number: 159184727

Start: 1347990

End: 1348490

Strand: Direct

Name: folK [H]

Synonym: Atu1354

Alternate gene names: 159184727

Gene position: 1347990-1348490 (Clockwise)

Preceding gene: 159184726

Following gene: 159184729

Centisome position: 47.44

GC content: 62.67

Gene sequence:

>501_bases
CTGGGTCTCGGCGGCAATATCGGCGATCCCGCCGCTGCCATGGCGCGGGCGCTGCGTGAACTCGACGCGCATGATGATTG
CCGGGTGCAGGCCGTTTCCGGCCTCTATCGCACGCCGCCCTGGGGAAAGACCGATCAGGCGGATTTCTTCAATTGCTGTG
CGCTGGTCGAGACATCGCTGACCGCGCTGGCGCTGCTGCAACTCTGCCTCGATATCGAAAGGGGCATGAAGCGGGTGCGG
ACGGAACGCTGGGGACCGCGCACCATCGATATAGACGTGCTGACTTATGGCAATGAGGCTATCGTTACGGAAAGCATCGA
GGTGCCGCATCCGCGTATGACGGAGCGCGCTTTTGTGCTGATGCCGCTTGCCGACATCGCGCCCGATCTTGAGGTCAAGG
GAAAGCCGGTGCGGCAATGGCTCCAGCAGGCGGACAGGAGTGGCATTGTCCGCGCAAACGAAAAGCGGGAGTGGTGGACA
CTCCCGCTCGGCGATGACTGA

Upstream 100 bases:

>100_bases
AAGATCACGGTGCGTAAACCCTCGGCACCGGTTCCCGGCATTCTCGATTATGCACAGGTGAGCGTTGAACATCGCGCCTG
AAAAGCCGACTGTCGCCGCA

Downstream 100 bases:

>100_bases
GAAGATTATGGCTTTTACGGCTTGATCGAGCCGACGGCGATCTGGTCGATATCGCGCGCCAGCGTGACGCCGATGACAGG
GATCATCTGGTCTGCGACCT

Product: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 166; Mature: 165

Protein sequence:

>166_residues
MGLGGNIGDPAAAMARALRELDAHDDCRVQAVSGLYRTPPWGKTDQADFFNCCALVETSLTALALLQLCLDIERGMKRVR
TERWGPRTIDIDVLTYGNEAIVTESIEVPHPRMTERAFVLMPLADIAPDLEVKGKPVRQWLQQADRSGIVRANEKREWWT
LPLGDD

Sequences:

>Translated_166_residues
MGLGGNIGDPAAAMARALRELDAHDDCRVQAVSGLYRTPPWGKTDQADFFNCCALVETSLTALALLQLCLDIERGMKRVR
TERWGPRTIDIDVLTYGNEAIVTESIEVPHPRMTERAFVLMPLADIAPDLEVKGKPVRQWLQQADRSGIVRANEKREWWT
LPLGDD
>Mature_165_residues
GLGGNIGDPAAAMARALRELDAHDDCRVQAVSGLYRTPPWGKTDQADFFNCCALVETSLTALALLQLCLDIERGMKRVRT
ERWGPRTIDIDVLTYGNEAIVTESIEVPHPRMTERAFVLMPLADIAPDLEVKGKPVRQWLQQADRSGIVRANEKREWWTL
PLGDD

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=144, Percent_Identity=42.3611111111111, Blast_Score=113, Evalue=6e-27,
Organism=Saccharomyces cerevisiae, GI6324073, Length=173, Percent_Identity=35.2601156069364, Blast_Score=94, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 18556; Mature: 18425

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLGGNIGDPAAAMARALRELDAHDDCRVQAVSGLYRTPPWGKTDQADFFNCCALVETSL
CCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHH
TALALLQLCLDIERGMKRVRTERWGPRTIDIDVLTYGNEAIVTESIEVPHPRMTERAFVL
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCEEEECCCCCCCCCCCCCEEEE
MPLADIAPDLEVKGKPVRQWLQQADRSGIVRANEKREWWTLPLGDD
EEHHHCCCCCCCCCHHHHHHHHHHCCCCCEEECCCCCEEECCCCCC
>Mature Secondary Structure 
GLGGNIGDPAAAMARALRELDAHDDCRVQAVSGLYRTPPWGKTDQADFFNCCALVETSL
CCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHH
TALALLQLCLDIERGMKRVRTERWGPRTIDIDVLTYGNEAIVTESIEVPHPRMTERAFVL
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCEEEECCCCCCCCCCCCCEEEE
MPLADIAPDLEVKGKPVRQWLQQADRSGIVRANEKREWWTLPLGDD
EEHHHCCCCCCCCCHHHHHHHHHHCCCCCEEECCCCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9168622 [H]