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The map label for this gene is folP [H]

Identifier: 159184725

GI number: 159184725

Start: 1346740

End: 1347525

Strand: Direct

Name: folP [H]

Synonym: Atu1352

Alternate gene names: 159184725

Gene position: 1346740-1347525 (Clockwise)

Preceding gene: 159184724

Following gene: 159184726

Centisome position: 47.39

GC content: 59.67

Gene sequence:

>786_bases
ATGGCCATCGTCAATGCAACGCCTGATTCCTTTTCCGATGGCGGCCGTTATCTTGCCGTCGATGCGGCTTTTTCCCATGC
GCTGACCTGCGTTGAGGAGGGAGCTGACATCATCGATATCGGCGGCGAATCCACACGGCCGGGTGCTGCCGCGGTCACGG
AGGCAGAGGAACAGGACCGAGTGCTGCCGGTTATCGAAAAATTGCGCTGCGAGACCGATGTGCTGATTTCCGTCGACACC
TATCGCGCCGCGACGGCAAGGCTGGCAATCGGCGCCGGCGCTCATATCGTCAATGACGTATTCGGCCTGCAGAAGGATCC
TGATATGGCGGGTGTGGTTGCCTCCACACGCGCCGGCATCTGCATCATGCATACCGGCCGTGACCGGCAGAAGCTTGCCG
ACGTCATCGACGATCAGTTTGAATTCCTCAATCGCTCGCTTGAAATCGCCGAGGCTGCGGGCATTGCCCTTGATGCCGTG
GTGCTCGATCCCGGCTTTGGATTTGCCAAGGATGAAAGCGAAAATGTCGCGCTGATGGCCCGTTTCGGTGAACTTGCCGC
TTTTGGTCTGCCGGTTCTTGCCGGCACGTCGCGCAAGCGTTTCATCGGGTCGCTGACGGGCAGGGATGTGGCAGAGGAAC
GCGATATCGGAACGGCTGCAACCACTGCGATCCTGAGGCTCGCGGGTGCTTCGATTTTTCGGGTGCATAATGTCGCCGCG
ACCCGCGATGCACTGGCTATTGCCGATGCGGTTCTTGCAAAAGCGTCGGCAAAGGCCGATGCGTAG

Upstream 100 bases:

>100_bases
GTTATTCCCGAAAGGCGCGTGTTACGTGATAACAGTCGGCAGCAACGCGTGGCAAGCGGCCCATGGCCGCTCCCTGAAAC
TTGATGGGCGTGGCCGTATT

Downstream 100 bases:

>100_bases
ATCAACGAGTGCCGGAATGCCGTGTCCCGAAGATGGCGCGGCTTTCAGGCGAAAACAATCCTGCCATGGAGGCGATGCGA
TGAGCCGCTATACCATCATC

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 261; Mature: 260

Protein sequence:

>261_residues
MAIVNATPDSFSDGGRYLAVDAAFSHALTCVEEGADIIDIGGESTRPGAAAVTEAEEQDRVLPVIEKLRCETDVLISVDT
YRAATARLAIGAGAHIVNDVFGLQKDPDMAGVVASTRAGICIMHTGRDRQKLADVIDDQFEFLNRSLEIAEAAGIALDAV
VLDPGFGFAKDESENVALMARFGELAAFGLPVLAGTSRKRFIGSLTGRDVAEERDIGTAATTAILRLAGASIFRVHNVAA
TRDALAIADAVLAKASAKADA

Sequences:

>Translated_261_residues
MAIVNATPDSFSDGGRYLAVDAAFSHALTCVEEGADIIDIGGESTRPGAAAVTEAEEQDRVLPVIEKLRCETDVLISVDT
YRAATARLAIGAGAHIVNDVFGLQKDPDMAGVVASTRAGICIMHTGRDRQKLADVIDDQFEFLNRSLEIAEAAGIALDAV
VLDPGFGFAKDESENVALMARFGELAAFGLPVLAGTSRKRFIGSLTGRDVAEERDIGTAATTAILRLAGASIFRVHNVAA
TRDALAIADAVLAKASAKADA
>Mature_260_residues
AIVNATPDSFSDGGRYLAVDAAFSHALTCVEEGADIIDIGGESTRPGAAAVTEAEEQDRVLPVIEKLRCETDVLISVDTY
RAATARLAIGAGAHIVNDVFGLQKDPDMAGVVASTRAGICIMHTGRDRQKLADVIDDQFEFLNRSLEIAEAAGIALDAVV
LDPGFGFAKDESENVALMARFGELAAFGLPVLAGTSRKRFIGSLTGRDVAEERDIGTAATTAILRLAGASIFRVHNVAAT
RDALAIADAVLAKASAKADA

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=264, Percent_Identity=42.8030303030303, Blast_Score=190, Evalue=8e-50,
Organism=Saccharomyces cerevisiae, GI6324073, Length=313, Percent_Identity=30.6709265175719, Blast_Score=137, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 27228; Mature: 27097

Theoretical pI: Translated: 4.46; Mature: 4.46

Prosite motif: PS50972 PTERIN_BINDING ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIVNATPDSFSDGGRYLAVDAAFSHALTCVEEGADIIDIGGESTRPGAAAVTEAEEQDR
CEEECCCCCCCCCCCCEEEEEHHHHHHHHHHHCCCCEEEECCCCCCCCCHHCCCCHHHCC
VLPVIEKLRCETDVLISVDTYRAATARLAIGAGAHIVNDVFGLQKDPDMAGVVASTRAGI
HHHHHHHHCCCCCEEEEEECHHHHHHHEEECCCHHHHHHHHCCCCCCCHHHEEECCCCCE
CIMHTGRDRQKLADVIDDQFEFLNRSLEIAEAAGIALDAVVLDPGFGFAKDESENVALMA
EEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCEEEEE
RFGELAAFGLPVLAGTSRKRFIGSLTGRDVAEERDIGTAATTAILRLAGASIFRVHNVAA
HHHHHHHHCCHHCCCCCHHHHHHCCCCCCHHHHHCCCHHHHHHHHHHHCCHHEEHHHHHH
TRDALAIADAVLAKASAKADA
HHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
AIVNATPDSFSDGGRYLAVDAAFSHALTCVEEGADIIDIGGESTRPGAAAVTEAEEQDR
EEECCCCCCCCCCCCEEEEEHHHHHHHHHHHCCCCEEEECCCCCCCCCHHCCCCHHHCC
VLPVIEKLRCETDVLISVDTYRAATARLAIGAGAHIVNDVFGLQKDPDMAGVVASTRAGI
HHHHHHHHCCCCCEEEEEECHHHHHHHEEECCCHHHHHHHHCCCCCCCHHHEEECCCCCE
CIMHTGRDRQKLADVIDDQFEFLNRSLEIAEAAGIALDAVVLDPGFGFAKDESENVALMA
EEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCEEEEE
RFGELAAFGLPVLAGTSRKRFIGSLTGRDVAEERDIGTAATTAILRLAGASIFRVHNVAA
HHHHHHHHCCHHCCCCCHHHHHHCCCCCCHHHHHCCCHHHHHHHHHHHCCHHEEHHHHHH
TRDALAIADAVLAKASAKADA
HHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2123867; 7584024; 9384377 [H]