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The map label for this gene is fcbB1 [H]

Identifier: 159184444

GI number: 159184444

Start: 732951

End: 733709

Strand: Direct

Name: fcbB1 [H]

Synonym: Atu0733

Alternate gene names: 159184444

Gene position: 732951-733709 (Clockwise)

Preceding gene: 15888075

Following gene: 15888077

Centisome position: 25.79

GC content: 61.13

Gene sequence:

>759_bases
ATGTCGGACGATCATATTCTTGTTGAGCCGGTTGGTCATGCGCCTGAGGTTGTGACCATCCGCTTCAACCGGCCGGAGAA
GAAAAATGCCATCACCGATGCCATGTATCTGCGCATGGCCGAAGCCCTGCATGCCGCCAATGCGAACACCGAAATTCGGG
TGGTCGCATTTCTCGGCACGGAAGGCTGCTTTTCCGCCGGTAATGACATGGCCGATTTCCTCGCCTTCGCCATGTCGGGC
GGCAAGGGCAAGCTTGCGGCACTCGAATTTCTGAAAGCGCTCGTCGCCTTCGAAAAGCCGCTGGTTTCGGGCGTGGACGG
GCTCGCCATCGGCATCGGCACGACGCTGAACCTGCATTGTGACCTGACGGTCGCCTCCAGCCGCAGCCTGTTCAAGACGC
CCTTCGTGGATCTGGCACTGGTGCCGGAAGCGGCCTCCAGCCTGCTTGTGCCAAAACTCATTGGCCATCAGCGCGCCTTT
GCGCTGCTTGCCATGGGCGAGGGTTTTTCCGCTGAACAGGCGATGCAGGCCGGGCTGATCTGGAAGGTTGTCGCTCCGGA
ACACGTAGAAACCGAAACGCTGGCGCTCGCCACCCGCCTTGCCGCCAAACCGCAGCAGGCGCTGAAGATCGCGCGTGATC
TGGTTCGCGGTAACCCGCAGGACATACTTGCCCGCATCGAAGAGGAAGGCCGCCACTTCATCGCGCAGCTGCAGAGTGCG
GAAGCCCGCGCTGCCTTCGAAGCCTTCATGCGCCGTTAA

Upstream 100 bases:

>100_bases
GAAAACCTGCTGGCGGAAACGGCGGCGCTGAAGGATCGCGTTATATCAGGGGCGGCAAGCCTTGCCGCCGCCCGCACCCT
GTTGGCTTGAGGAGTTTCAG

Downstream 100 bases:

>100_bases
GCGTTCCAGCAGGAAATAGTTGCGGTTAAGTGCCGGGCAATACGCGCTGTGTTAAATCATGCACCGTCCACCCTTTGGAA
GGCCACCCGCATGCGTCAAT

Product: enoyl-CoA hydratase

Products: NA

Alternate protein names: 4-CBA-CoA dehalogenase-1; 4-CBCoA dehalogenase-1; 4-chlorobenzoyl-CoA dehalogenase-1 [H]

Number of amino acids: Translated: 252; Mature: 251

Protein sequence:

>252_residues
MSDDHILVEPVGHAPEVVTIRFNRPEKKNAITDAMYLRMAEALHAANANTEIRVVAFLGTEGCFSAGNDMADFLAFAMSG
GKGKLAALEFLKALVAFEKPLVSGVDGLAIGIGTTLNLHCDLTVASSRSLFKTPFVDLALVPEAASSLLVPKLIGHQRAF
ALLAMGEGFSAEQAMQAGLIWKVVAPEHVETETLALATRLAAKPQQALKIARDLVRGNPQDILARIEEEGRHFIAQLQSA
EARAAFEAFMRR

Sequences:

>Translated_252_residues
MSDDHILVEPVGHAPEVVTIRFNRPEKKNAITDAMYLRMAEALHAANANTEIRVVAFLGTEGCFSAGNDMADFLAFAMSG
GKGKLAALEFLKALVAFEKPLVSGVDGLAIGIGTTLNLHCDLTVASSRSLFKTPFVDLALVPEAASSLLVPKLIGHQRAF
ALLAMGEGFSAEQAMQAGLIWKVVAPEHVETETLALATRLAAKPQQALKIARDLVRGNPQDILARIEEEGRHFIAQLQSA
EARAAFEAFMRR
>Mature_251_residues
SDDHILVEPVGHAPEVVTIRFNRPEKKNAITDAMYLRMAEALHAANANTEIRVVAFLGTEGCFSAGNDMADFLAFAMSGG
KGKLAALEFLKALVAFEKPLVSGVDGLAIGIGTTLNLHCDLTVASSRSLFKTPFVDLALVPEAASSLLVPKLIGHQRAFA
LLAMGEGFSAEQAMQAGLIWKVVAPEHVETETLALATRLAAKPQQALKIARDLVRGNPQDILARIEEEGRHFIAQLQSAE
ARAAFEAFMRR

Specific function: Dehalogenates 4-chlorobenzoyl-CoA, 4-iodobenzoyl-CoA, 4- bromobenzoyl-CoA and, at a slower rate, 4-fluorobenzoyl-CoA. Does not dehalogenate 2-chlorobenzoyl-CoA or 3-chlorobenzoyl-CoA [H]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI45643119, Length=242, Percent_Identity=32.2314049586777, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI260275230, Length=242, Percent_Identity=32.2314049586777, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI260274832, Length=242, Percent_Identity=32.2314049586777, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI194097323, Length=215, Percent_Identity=25.1162790697674, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI116235487, Length=219, Percent_Identity=26.9406392694064, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI4757968, Length=202, Percent_Identity=28.7128712871287, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI49355787, Length=202, Percent_Identity=28.7128712871287, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI68989263, Length=201, Percent_Identity=29.8507462686567, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI25453481, Length=202, Percent_Identity=28.2178217821782, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI51538573, Length=202, Percent_Identity=28.2178217821782, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI4757966, Length=202, Percent_Identity=28.2178217821782, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI51538581, Length=202, Percent_Identity=28.2178217821782, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI221136756, Length=129, Percent_Identity=29.4573643410853, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI221136753, Length=129, Percent_Identity=29.4573643410853, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI221307494, Length=133, Percent_Identity=29.3233082706767, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI31542718, Length=248, Percent_Identity=25, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI70995211, Length=186, Percent_Identity=24.7311827956989, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI20127408, Length=177, Percent_Identity=25.4237288135593, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1787659, Length=247, Percent_Identity=29.1497975708502, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1787660, Length=242, Percent_Identity=29.3388429752066, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788597, Length=200, Percent_Identity=25, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI221142681, Length=242, Percent_Identity=26.0330578512397, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17535521, Length=247, Percent_Identity=28.7449392712551, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17549921, Length=202, Percent_Identity=31.1881188118812, Blast_Score=107, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI17554946, Length=234, Percent_Identity=24.7863247863248, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI25145438, Length=259, Percent_Identity=24.7104247104247, Blast_Score=87, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17560910, Length=203, Percent_Identity=24.1379310344828, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17536985, Length=214, Percent_Identity=26.6355140186916, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17534483, Length=228, Percent_Identity=22.8070175438596, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17540714, Length=248, Percent_Identity=24.1935483870968, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24654903, Length=256, Percent_Identity=29.296875, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI20129971, Length=251, Percent_Identity=23.5059760956175, Blast_Score=91, Evalue=9e-19,
Organism=Drosophila melanogaster, GI24653477, Length=251, Percent_Identity=23.5059760956175, Blast_Score=91, Evalue=9e-19,
Organism=Drosophila melanogaster, GI21357171, Length=226, Percent_Identity=26.9911504424779, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24653139, Length=224, Percent_Identity=28.125, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI19920382, Length=214, Percent_Identity=24.2990654205607, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =3.8.1.7 [H]

Molecular weight: Translated: 27103; Mature: 26972

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDDHILVEPVGHAPEVVTIRFNRPEKKNAITDAMYLRMAEALHAANANTEIRVVAFLGT
CCCCCEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECC
EGCFSAGNDMADFLAFAMSGGKGKLAALEFLKALVAFEKPLVSGVDGLAIGIGTTLNLHC
CCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCEEEEEE
DLTVASSRSLFKTPFVDLALVPEAASSLLVPKLIGHQRAFALLAMGEGFSAEQAMQAGLI
EEEECCCCCHHCCCCCCEEECCHHHHHHHHHHHHCCHHHEEEEEECCCCCHHHHHHCCCE
WKVVAPEHVETETLALATRLAAKPQQALKIARDLVRGNPQDILARIEEEGRHFIAQLQSA
EEEECCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
EARAAFEAFMRR
HHHHHHHHHHCC
>Mature Secondary Structure 
SDDHILVEPVGHAPEVVTIRFNRPEKKNAITDAMYLRMAEALHAANANTEIRVVAFLGT
CCCCEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECC
EGCFSAGNDMADFLAFAMSGGKGKLAALEFLKALVAFEKPLVSGVDGLAIGIGTTLNLHC
CCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCEEEEEE
DLTVASSRSLFKTPFVDLALVPEAASSLLVPKLIGHQRAFALLAMGEGFSAEQAMQAGLI
EEEECCCCCHHCCCCCCEEECCHHHHHHHHHHHHCCHHHEEEEEECCCCCHHHHHHCCCE
WKVVAPEHVETETLALATRLAAKPQQALKIARDLVRGNPQDILARIEEEGRHFIAQLQSA
EEEECCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
EARAAFEAFMRR
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA