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The map label for this gene is hsrA [H]

Identifier: 159184391

GI number: 159184391

Start: 609579

End: 610976

Strand: Reverse

Name: hsrA [H]

Synonym: Atu0621

Alternate gene names: 159184391

Gene position: 610976-609579 (Counterclockwise)

Preceding gene: 15887969

Following gene: 15887959

Centisome position: 21.5

GC content: 60.8

Gene sequence:

>1398_bases
ATGAATCGCATCATTCCCCTGATCCTTGCAGTCGCTCTTTTCATGGAGCAGATGGACTCCACCGTCATCGCCACCTCGCT
CCCGGCGATTGCAAAAGACCTCCATGTCGGCCCGATCACGCTCAAACTGGCGCTAACGGCCTATATGGTGGCGCTGGCGA
TCTTCATCCCCATCAGCGGCTGGATGGCCGATAAATACGGCGCGAAGAAAATCTTCCGCATCGCCATCGGCGTTTTCGTT
GTGGGGTCGATCTGCTGCGCGGTCTCGTCGTCGGTGTTCGAATTCGTGCTGTCGCGTTTCCTGCAGGGCATGGGCGGGGC
AATGATGACGCCAGTTGGCCGTCTGGTGCTGCTGCGCACGACCAAGCGCAGCGAACTGGTCTCCGCCATGGCGCTACTGA
CGATACCAGGGCTTGTCGGACCGCTCACCGGCCCGCCGATCGGCGGCTTCATCACCACCTATTTTTCATGGCACTGGATT
TTCCTGATCAACGTGCCCATCGGCATTATCGGCATCTGGCTCTCGACCATCTTCCTGCCGGAAATCGAAACCACTAACCC
ACCGCCGATGGACGGCAAGGGCTTCATTCTGTCAGGCATCGCCGCCTCCGGTGTGGTGTTCGGCGTGTCGGTGGTCAGCC
TTCCCGCCCTGCCGCCCGCCATCGGCATCGCCTCGACGGTCATCGGGTTTATCTGCGGTTTTCTTTACATGCGCCACGCC
GCGCGTCACCCTGCCCCCATTCTGGATTTCCGCATTTTCCAGAACGCGACCTTCCGGGCGGCCTCCGTCGGCGGCACCGT
TTTCCGCATTTCCACGGGCGCAATCCCCTTCCTGATGCCGCTGATGTTGCAGATCGGTTTCGGCCTCAACCCGTTCCAGT
CGGGCATGATCACCTTCGCCGGCGCGATCGGGGCGATCACCACGAAATTCATGGCCAAGCGCGTGTTTGCGGCAACGGGG
TTCCGCTCGACACTGATCGGGGCCGGTATCGTCGGTGCGTTCACGACGCTTGCCAACAGCTTTTTCACGCCTGAAACGCC
CTATCCGCTGATCATGATCTTTCTGGTCACGGCGGGATTTGCGCGGTCGTTCTTCTTCACCGGATCGAACGCGCTCAGCT
ACTCCGATATCGAGGACAGCCAGGCCAGTCAGGCGACCTCGATGGCCTCGGTGCTGCAACAGATCAGCCTGGCACTGGGC
GTGGCTTTCGCCGCCTCCATTCTGGAAGTCAGCAGCATGATGTCAGGCACACATTTACAACTTGCCGATTTCCACATCGC
CTTCACCATCGTCGCGCTGGTATCGTTGTTCGCGATCGTGCCGATCATCCGCATGGACGCGCAGGCCGGGGCGGCCGTTT
CCGGCCACCGCGGCAAGGTTTCGCAACCGGCGGAGTGA

Upstream 100 bases:

>100_bases
AAGTTGAGAAATTGATAATTAACGTGTTGGCAAGCCCGCCTATCAGGCGTAGGAGGAACGGCGATATCCCTTGTCGCAGC
GGAAAGCCGCAGGCAGTCCC

Downstream 100 bases:

>100_bases
TCAGTCCTCAGTCGACTCTTCGGCGTCGGCATCGATGGCCGGTTCGTGTCTGCGACCCTTGAAGTGCTTGGCAAGCAGGA
ACATTTCGACCGATTCCGAG

Product: MFS permease

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: High-copy suppressor of rspA [H]

Number of amino acids: Translated: 465; Mature: 465

Protein sequence:

>465_residues
MNRIIPLILAVALFMEQMDSTVIATSLPAIAKDLHVGPITLKLALTAYMVALAIFIPISGWMADKYGAKKIFRIAIGVFV
VGSICCAVSSSVFEFVLSRFLQGMGGAMMTPVGRLVLLRTTKRSELVSAMALLTIPGLVGPLTGPPIGGFITTYFSWHWI
FLINVPIGIIGIWLSTIFLPEIETTNPPPMDGKGFILSGIAASGVVFGVSVVSLPALPPAIGIASTVIGFICGFLYMRHA
ARHPAPILDFRIFQNATFRAASVGGTVFRISTGAIPFLMPLMLQIGFGLNPFQSGMITFAGAIGAITTKFMAKRVFAATG
FRSTLIGAGIVGAFTTLANSFFTPETPYPLIMIFLVTAGFARSFFFTGSNALSYSDIEDSQASQATSMASVLQQISLALG
VAFAASILEVSSMMSGTHLQLADFHIAFTIVALVSLFAIVPIIRMDAQAGAAVSGHRGKVSQPAE

Sequences:

>Translated_465_residues
MNRIIPLILAVALFMEQMDSTVIATSLPAIAKDLHVGPITLKLALTAYMVALAIFIPISGWMADKYGAKKIFRIAIGVFV
VGSICCAVSSSVFEFVLSRFLQGMGGAMMTPVGRLVLLRTTKRSELVSAMALLTIPGLVGPLTGPPIGGFITTYFSWHWI
FLINVPIGIIGIWLSTIFLPEIETTNPPPMDGKGFILSGIAASGVVFGVSVVSLPALPPAIGIASTVIGFICGFLYMRHA
ARHPAPILDFRIFQNATFRAASVGGTVFRISTGAIPFLMPLMLQIGFGLNPFQSGMITFAGAIGAITTKFMAKRVFAATG
FRSTLIGAGIVGAFTTLANSFFTPETPYPLIMIFLVTAGFARSFFFTGSNALSYSDIEDSQASQATSMASVLQQISLALG
VAFAASILEVSSMMSGTHLQLADFHIAFTIVALVSLFAIVPIIRMDAQAGAAVSGHRGKVSQPAE
>Mature_465_residues
MNRIIPLILAVALFMEQMDSTVIATSLPAIAKDLHVGPITLKLALTAYMVALAIFIPISGWMADKYGAKKIFRIAIGVFV
VGSICCAVSSSVFEFVLSRFLQGMGGAMMTPVGRLVLLRTTKRSELVSAMALLTIPGLVGPLTGPPIGGFITTYFSWHWI
FLINVPIGIIGIWLSTIFLPEIETTNPPPMDGKGFILSGIAASGVVFGVSVVSLPALPPAIGIASTVIGFICGFLYMRHA
ARHPAPILDFRIFQNATFRAASVGGTVFRISTGAIPFLMPLMLQIGFGLNPFQSGMITFAGAIGAITTKFMAKRVFAATG
FRSTLIGAGIVGAFTTLANSFFTPETPYPLIMIFLVTAGFARSFFFTGSNALSYSDIEDSQASQATSMASVLQQISLALG
VAFAASILEVSSMMSGTHLQLADFHIAFTIVALVSLFAIVPIIRMDAQAGAAVSGHRGKVSQPAE

Specific function: Unknown

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1790195, Length=466, Percent_Identity=37.1244635193133, Blast_Score=308, Evalue=7e-85,
Organism=Escherichia coli, GI1788392, Length=403, Percent_Identity=33.9950372208437, Blast_Score=224, Evalue=1e-59,
Organism=Escherichia coli, GI1788710, Length=403, Percent_Identity=27.2952853598015, Blast_Score=119, Evalue=6e-28,
Organism=Escherichia coli, GI1789042, Length=166, Percent_Identity=34.9397590361446, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI87081983, Length=430, Percent_Identity=25.1162790697674, Blast_Score=105, Evalue=5e-24,
Organism=Escherichia coli, GI1790146, Length=165, Percent_Identity=27.2727272727273, Blast_Score=68, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6325455, Length=127, Percent_Identity=31.496062992126, Blast_Score=68, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 49151; Mature: 49151

Theoretical pI: Translated: 10.01; Mature: 10.01

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRIIPLILAVALFMEQMDSTVIATSLPAIAKDLHVGPITLKLALTAYMVALAIFIPISG
CCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCC
WMADKYGAKKIFRIAIGVFVVGSICCAVSSSVFEFVLSRFLQGMGGAMMTPVGRLVLLRT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHEEEEEC
TKRSELVSAMALLTIPGLVGPLTGPPIGGFITTYFSWHWIFLINVPIGIIGIWLSTIFLP
CHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHEEEEEEECHHHHHHHHHHHHHCC
EIETTNPPPMDGKGFILSGIAASGVVFGVSVVSLPALPPAIGIASTVIGFICGFLYMRHA
CCCCCCCCCCCCCCEEEECHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
ARHPAPILDFRIFQNATFRAASVGGTVFRISTGAIPFLMPLMLQIGFGLNPFQSGMITFA
HCCCCCHHHHHHHCCCCEEEEECCCEEEEEECCCHHHHHHHHHHHCCCCCHHHCCHHHHH
GAIGAITTKFMAKRVFAATGFRSTLIGAGIVGAFTTLANSFFTPETPYPLIMIFLVTAGF
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
ARSFFFTGSNALSYSDIEDSQASQATSMASVLQQISLALGVAFAASILEVSSMMSGTHLQ
HHHHEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
LADFHIAFTIVALVSLFAIVPIIRMDAQAGAAVSGHRGKVSQPAE
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNRIIPLILAVALFMEQMDSTVIATSLPAIAKDLHVGPITLKLALTAYMVALAIFIPISG
CCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCC
WMADKYGAKKIFRIAIGVFVVGSICCAVSSSVFEFVLSRFLQGMGGAMMTPVGRLVLLRT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHEEEEEC
TKRSELVSAMALLTIPGLVGPLTGPPIGGFITTYFSWHWIFLINVPIGIIGIWLSTIFLP
CHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHEEEEEEECHHHHHHHHHHHHHCC
EIETTNPPPMDGKGFILSGIAASGVVFGVSVVSLPALPPAIGIASTVIGFICGFLYMRHA
CCCCCCCCCCCCCCEEEECHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
ARHPAPILDFRIFQNATFRAASVGGTVFRISTGAIPFLMPLMLQIGFGLNPFQSGMITFA
HCCCCCHHHHHHHCCCCEEEEECCCEEEEEECCCHHHHHHHHHHHCCCCCHHHCCHHHHH
GAIGAITTKFMAKRVFAATGFRSTLIGAGIVGAFTTLANSFFTPETPYPLIMIFLVTAGF
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
ARSFFFTGSNALSYSDIEDSQASQATSMASVLQQISLALGVAFAASILEVSSMMSGTHLQ
HHHHEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
LADFHIAFTIVALVSLFAIVPIIRMDAQAGAAVSGHRGKVSQPAE
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7686882; 9278503 [H]