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The map label for this gene is zwf [H]

Identifier: 159184383

GI number: 159184383

Start: 585849

End: 587324

Strand: Reverse

Name: zwf [H]

Synonym: Atu0600

Alternate gene names: 159184383

Gene position: 587324-585849 (Counterclockwise)

Preceding gene: 15887946

Following gene: 159184382

Centisome position: 20.67

GC content: 60.3

Gene sequence:

>1476_bases
ATGAGCAGTCAGATCATTCCTGTTGAACCTTTTGATTGTGTCGTTTTCGGCGGCACGGGCGATCTTGCCGAGCGCAAGCT
TCTGCCGGCCCTTTATCACCGGCAGGTCGAAGGCCAGTTCACGGAGCCGACCCGCATCATCGGCGCGTCGCGTTCGGTCA
TGACCCATGAGGAATATCGCAAATTCGCGCAGGACGCCCTGAAGGAACACCTGAAGGCCGGCGAATATGACGATGCGCAG
GTGACCCTGTTCCTCAACCGGCTTTTCTACGTGCCCGTCGATGCCAAGTCCGGCAATGGCTGGGACGTGCTGAAGAAACT
GCTCGATGAGGGCAAGGAACGCATCCGCGCGTTTTATCTGGCCGTCGCACCCGGCATTTTCGGCGACATCGCCGACAAGA
TCCGTGAGCACAAGCTGATCACCCGCTCGACCCGCATCGTCGTTGAAAAGCCGATCGGCCGGGATCTCGCATCCGCGCAG
GAACTGAACGACACCATCGGTCACGTCTTCAAGGAAGAGCAGATCTTCCGCATCGACCACTATCTCGGCAAGGAGACGGT
GCAGAACCTGATGGCGCTGCGTTTCGCCAATGCGCTTTACGAGCCGCTGTGGAATTCCGCCCATATCGACCACGTTCAGA
TCACCGTTGCCGAAGCGGTGGGTCTTGAAGGTCGCGCCGGTTATTACGACAAGGCCGGTGCGCTGCGCGACATGGTGCAG
AACCACATTCTCCAGCTGCTTTGCCTCGTTGCCATGGAGCCGCCCGCTTCCATGAAATCGGAGGCAGTGCGCGACGAAAA
GCTCAAGGTACTGCGCTCGCTGAAGCCAATCGATACCAGCAATGTCGAAAAGCTGACGGTACGCGGCCAGTACCGCGCCG
GCGCTTCCGCAGGCGGCCCCGTCAAGGGTTATCTGGAAGAGCTGGAAGGCGGCGTTTCCAACACCGAAACCTTCGTCGCC
ATCAAGGCTGAAATCGCCAACTGGCGCTGGGCCGGCGTTCCCTTCTACATCCGCACCGGCAAACGCCTCGCGACCCGTGT
TTCGGAAATCGTCGTCACCTTCAAGCAGATCCCGCACTCGATCTTCGACGATGCGGCTGGCAAGATCGAAGCCAACAAGC
TGGTCATTCGCCTGCAGCCGGATGAAGGCGTCAAGCAGTCGCTCCTCATCAAGGATCCCGGTCCAGGCGGCATGCGCCTG
CGTCAGGTCTCGCTGGACATGAGCTTTGCCGAAGCCTTCAACGTGCGCAGCCCCGATGCCTATGAGCGGCTGTTGATGGA
CACCATTCGTTCCAACCAGACATTGTTCATGCGCCGCGACGAGGTCGAGGCCGCGTGGGACTGGATCGACCCCATCTTGA
AGAGCTGGGAAGAGCTGGGACAGAGCGTACAGGGTTACACTGCCGGCACCTGGGGCCCGAGCGGTTCGATCGCACTGATC
GAGCGCGACGGCCGCACCTGGCACGATGCCGACTGA

Upstream 100 bases:

>100_bases
TTGGCGGAAGCAAAACTCATAATTTCACATAACTGAGTCTGGCATTTTTAAATCGATTAGATTATTGATGCCCCAACCTT
TGAAGATCGAGAGAATCGAT

Downstream 100 bases:

>100_bases
GGGCCGGGCGATGAGCGAAACGATCCACGTCTTCGACACCGCCGCCGCGCTGGCCACCGCACTTGCGGCGGAGGTTGCCA
AACGCCTTGATGCGGCGACC

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 491; Mature: 490

Protein sequence:

>491_residues
MSSQIIPVEPFDCVVFGGTGDLAERKLLPALYHRQVEGQFTEPTRIIGASRSVMTHEEYRKFAQDALKEHLKAGEYDDAQ
VTLFLNRLFYVPVDAKSGNGWDVLKKLLDEGKERIRAFYLAVAPGIFGDIADKIREHKLITRSTRIVVEKPIGRDLASAQ
ELNDTIGHVFKEEQIFRIDHYLGKETVQNLMALRFANALYEPLWNSAHIDHVQITVAEAVGLEGRAGYYDKAGALRDMVQ
NHILQLLCLVAMEPPASMKSEAVRDEKLKVLRSLKPIDTSNVEKLTVRGQYRAGASAGGPVKGYLEELEGGVSNTETFVA
IKAEIANWRWAGVPFYIRTGKRLATRVSEIVVTFKQIPHSIFDDAAGKIEANKLVIRLQPDEGVKQSLLIKDPGPGGMRL
RQVSLDMSFAEAFNVRSPDAYERLLMDTIRSNQTLFMRRDEVEAAWDWIDPILKSWEELGQSVQGYTAGTWGPSGSIALI
ERDGRTWHDAD

Sequences:

>Translated_491_residues
MSSQIIPVEPFDCVVFGGTGDLAERKLLPALYHRQVEGQFTEPTRIIGASRSVMTHEEYRKFAQDALKEHLKAGEYDDAQ
VTLFLNRLFYVPVDAKSGNGWDVLKKLLDEGKERIRAFYLAVAPGIFGDIADKIREHKLITRSTRIVVEKPIGRDLASAQ
ELNDTIGHVFKEEQIFRIDHYLGKETVQNLMALRFANALYEPLWNSAHIDHVQITVAEAVGLEGRAGYYDKAGALRDMVQ
NHILQLLCLVAMEPPASMKSEAVRDEKLKVLRSLKPIDTSNVEKLTVRGQYRAGASAGGPVKGYLEELEGGVSNTETFVA
IKAEIANWRWAGVPFYIRTGKRLATRVSEIVVTFKQIPHSIFDDAAGKIEANKLVIRLQPDEGVKQSLLIKDPGPGGMRL
RQVSLDMSFAEAFNVRSPDAYERLLMDTIRSNQTLFMRRDEVEAAWDWIDPILKSWEELGQSVQGYTAGTWGPSGSIALI
ERDGRTWHDAD
>Mature_490_residues
SSQIIPVEPFDCVVFGGTGDLAERKLLPALYHRQVEGQFTEPTRIIGASRSVMTHEEYRKFAQDALKEHLKAGEYDDAQV
TLFLNRLFYVPVDAKSGNGWDVLKKLLDEGKERIRAFYLAVAPGIFGDIADKIREHKLITRSTRIVVEKPIGRDLASAQE
LNDTIGHVFKEEQIFRIDHYLGKETVQNLMALRFANALYEPLWNSAHIDHVQITVAEAVGLEGRAGYYDKAGALRDMVQN
HILQLLCLVAMEPPASMKSEAVRDEKLKVLRSLKPIDTSNVEKLTVRGQYRAGASAGGPVKGYLEELEGGVSNTETFVAI
KAEIANWRWAGVPFYIRTGKRLATRVSEIVVTFKQIPHSIFDDAAGKIEANKLVIRLQPDEGVKQSLLIKDPGPGGMRLR
QVSLDMSFAEAFNVRSPDAYERLLMDTIRSNQTLFMRRDEVEAAWDWIDPILKSWEELGQSVQGYTAGTWGPSGSIALIE
RDGRTWHDAD

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI108773793, Length=479, Percent_Identity=39.0396659707724, Blast_Score=313, Evalue=2e-85,
Organism=Homo sapiens, GI109389365, Length=479, Percent_Identity=39.0396659707724, Blast_Score=313, Evalue=2e-85,
Organism=Homo sapiens, GI52145310, Length=479, Percent_Identity=29.6450939457203, Blast_Score=176, Evalue=4e-44,
Organism=Escherichia coli, GI1788158, Length=482, Percent_Identity=50.8298755186722, Blast_Score=480, Evalue=1e-137,
Organism=Caenorhabditis elegans, GI17538218, Length=487, Percent_Identity=35.7289527720739, Blast_Score=310, Evalue=1e-84,
Organism=Saccharomyces cerevisiae, GI6324088, Length=473, Percent_Identity=38.2663847780127, Blast_Score=303, Evalue=5e-83,
Organism=Drosophila melanogaster, GI24643350, Length=476, Percent_Identity=35.9243697478992, Blast_Score=291, Evalue=8e-79,
Organism=Drosophila melanogaster, GI24643352, Length=476, Percent_Identity=35.9243697478992, Blast_Score=291, Evalue=9e-79,
Organism=Drosophila melanogaster, GI221513548, Length=498, Percent_Identity=29.718875502008, Blast_Score=203, Evalue=2e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 55052; Mature: 54920

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSQIIPVEPFDCVVFGGTGDLAERKLLPALYHRQVEGQFTEPTRIIGASRSVMTHEEYR
CCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCHHHHHHHHH
KFAQDALKEHLKAGEYDDAQVTLFLNRLFYVPVDAKSGNGWDVLKKLLDEGKERIRAFYL
HHHHHHHHHHHHCCCCCCCEEEEEEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
AVAPGIFGDIADKIREHKLITRSTRIVVEKPIGRDLASAQELNDTIGHVFKEEQIFRIDH
HHCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
YLGKETVQNLMALRFANALYEPLWNSAHIDHVQITVAEAVGLEGRAGYYDKAGALRDMVQ
HHCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHHCCCCCCCCCHHHHHHHHHHH
NHILQLLCLVAMEPPASMKSEAVRDEKLKVLRSLKPIDTSNVEKLTVRGQYRAGASAGGP
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCC
VKGYLEELEGGVSNTETFVAIKAEIANWRWAGVPFYIRTGKRLATRVSEIVVTFKQIPHS
HHHHHHHHCCCCCCCCEEEEEEEEECCEEECCCCEEEECCHHHHHHHHHHHHHHHHHCHH
IFDDAAGKIEANKLVIRLQPDEGVKQSLLIKDPGPGGMRLRQVSLDMSFAEAFNVRSPDA
HHHHCCCCEEECEEEEEECCCCCCCCEEEEECCCCCCCEEEEEECCHHHHHHHCCCCCHH
YERLLMDTIRSNQTLFMRRDEVEAAWDWIDPILKSWEELGQSVQGYTAGTWGPSGSIALI
HHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEE
ERDGRTWHDAD
ECCCCCCCCCC
>Mature Secondary Structure 
SSQIIPVEPFDCVVFGGTGDLAERKLLPALYHRQVEGQFTEPTRIIGASRSVMTHEEYR
CCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCHHHHHHHHH
KFAQDALKEHLKAGEYDDAQVTLFLNRLFYVPVDAKSGNGWDVLKKLLDEGKERIRAFYL
HHHHHHHHHHHHCCCCCCCEEEEEEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
AVAPGIFGDIADKIREHKLITRSTRIVVEKPIGRDLASAQELNDTIGHVFKEEQIFRIDH
HHCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
YLGKETVQNLMALRFANALYEPLWNSAHIDHVQITVAEAVGLEGRAGYYDKAGALRDMVQ
HHCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHHCCCCCCCCCHHHHHHHHHHH
NHILQLLCLVAMEPPASMKSEAVRDEKLKVLRSLKPIDTSNVEKLTVRGQYRAGASAGGP
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCC
VKGYLEELEGGVSNTETFVAIKAEIANWRWAGVPFYIRTGKRLATRVSEIVVTFKQIPHS
HHHHHHHHCCCCCCCCEEEEEEEEECCEEECCCCEEEECCHHHHHHHHHHHHHHHHHCHH
IFDDAAGKIEANKLVIRLQPDEGVKQSLLIKDPGPGGMRLRQVSLDMSFAEAFNVRSPDA
HHHHCCCCEEECEEEEEECCCCCCCCEEEEECCCCCCCEEEEEECCHHHHHHHCCCCCHH
YERLLMDTIRSNQTLFMRRDEVEAAWDWIDPILKSWEELGQSVQGYTAGTWGPSGSIALI
HHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEE
ERDGRTWHDAD
ECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10400573; 11481430 [H]