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The map label for this gene is fabB [H]

Identifier: 159184184

GI number: 159184184

Start: 158274

End: 159497

Strand: Reverse

Name: fabB [H]

Synonym: Atu0150

Alternate gene names: 159184184

Gene position: 159497-158274 (Counterclockwise)

Preceding gene: 159184185

Following gene: 159184183

Centisome position: 5.61

GC content: 60.54

Gene sequence:

>1224_bases
ATGAGACGAGTTGTTGTCACCGGCCTCGGTATTGTTTCCTCCATCGGCGGTGATGCCGCTGAGGTCACCGCGTCGCTGCG
CCAAGCCAAGTCCGGCATTTCATTTTCGCCGGATTTTGCCGAGCACGGTTTCAAATGCCAGGTCTGGGGCAAGCCCTCTC
TCGACCCGACCGATCTGGTCGACCGCCGCGCCATGCGCTTCCTGTCGCAGGGTGGCGCGTGGAACCATGTGGCCATGAAG
CAGGCGATCGCCGATTCCGGTCTCGAAGAGAGCGATATCAGCGGCAATGAGCGCACTGGCATCATCATGGGTTCGGGCGG
CCCTTCCACCCGCACCATCGTCGAAGCCGCCGATATTACGCTCAAGAACAACAGCCCGAAGCGCATCGGCCCCTTCGCCG
TGCCGAAGGCCATGTCATCGACCGCCTCGGCCACGCTCGCGACCTGGTTCAAGATCCACGGCGTCAACTATTCGATCTCG
TCGGCCTGCTCCACCTCGGCGCATTGCATCGGCAACGCCGCCGAGATGATCCAGTGGGGCAAACAGGACGTGATGTTTGC
GGGCGGCCATGAGGATCTCGACTGGTCGATGTCCAACCTCTTCGACGCCATGGGCGCAATGTCGTCCAAATACAATGAAA
CACCCGGCGTCGCCTCGCGCGCCTATGACGTCAACCGCGACGGTTTCGTGATCGCCGGCGGTGCAGGCGTGCTGGTTCTC
GAAGAACTGGAACATGCCAAGGCGCGCGGCGCCAAGATTTACGCCGAGATCGTCGGTTATGGCGCAACCTCTGATGGTTA
CGACATGGTGGCTCCTTCAGGCGAAGGCGCGATCCGCTGCATGCGTCAGGCGCTTGCCACCGTCAAGGGTGACATTGACT
ACATCAACACCCACGGCACCTCCACGCCGGTTGGCGACAGCAAGGAAATCGGCGCGATCCGCGAAGTCTTCGGCGACAAG
ATTCCGCATATCCAGTCGACCAAGTCGCTCACCGGCCATTCGCTTGGTGCTGCTGGCGTGCAGGAATCGATCTACGGCCT
GTTGATGATGCAGGAACGTTTCATCGGCGAAAGCGCGCATATTTCCGAACTCGATCCGGAATTTGCGGGCGTTCCGATTG
TTCGCAGCCGCATCGACGACGCCAAGATCGACACCATCCTTTCCAATTCCTTCGGCTTCGGCGGCACCAACGCCACGCTC
GTCTTCCAGCGTCATAACGGATAA

Upstream 100 bases:

>100_bases
CCTGTCCAAGGAAAAGGCTGCCTGAGGCAGACGGAATAGTTCAGACAAACGCCGGGCGGCTTCGGTCGTCCGGCCGAAAT
CTTAAGAAAAGGTCCCTTTC

Downstream 100 bases:

>100_bases
TTGCCCATGAACGGCATCATGCAAGGTAAGCGCGGCCTCATCATGGGCGTCGCTAACAATCACTCGATCGCCTGGGGTAT
TTCCAAGGCACTTGCGGCAC

Product: 3-oxoacyl-(acyl carrier protein) synthase I

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase I; Beta-ketoacyl-ACP synthase I; KAS I [H]

Number of amino acids: Translated: 407; Mature: 407

Protein sequence:

>407_residues
MRRVVVTGLGIVSSIGGDAAEVTASLRQAKSGISFSPDFAEHGFKCQVWGKPSLDPTDLVDRRAMRFLSQGGAWNHVAMK
QAIADSGLEESDISGNERTGIIMGSGGPSTRTIVEAADITLKNNSPKRIGPFAVPKAMSSTASATLATWFKIHGVNYSIS
SACSTSAHCIGNAAEMIQWGKQDVMFAGGHEDLDWSMSNLFDAMGAMSSKYNETPGVASRAYDVNRDGFVIAGGAGVLVL
EELEHAKARGAKIYAEIVGYGATSDGYDMVAPSGEGAIRCMRQALATVKGDIDYINTHGTSTPVGDSKEIGAIREVFGDK
IPHIQSTKSLTGHSLGAAGVQESIYGLLMMQERFIGESAHISELDPEFAGVPIVRSRIDDAKIDTILSNSFGFGGTNATL
VFQRHNG

Sequences:

>Translated_407_residues
MRRVVVTGLGIVSSIGGDAAEVTASLRQAKSGISFSPDFAEHGFKCQVWGKPSLDPTDLVDRRAMRFLSQGGAWNHVAMK
QAIADSGLEESDISGNERTGIIMGSGGPSTRTIVEAADITLKNNSPKRIGPFAVPKAMSSTASATLATWFKIHGVNYSIS
SACSTSAHCIGNAAEMIQWGKQDVMFAGGHEDLDWSMSNLFDAMGAMSSKYNETPGVASRAYDVNRDGFVIAGGAGVLVL
EELEHAKARGAKIYAEIVGYGATSDGYDMVAPSGEGAIRCMRQALATVKGDIDYINTHGTSTPVGDSKEIGAIREVFGDK
IPHIQSTKSLTGHSLGAAGVQESIYGLLMMQERFIGESAHISELDPEFAGVPIVRSRIDDAKIDTILSNSFGFGGTNATL
VFQRHNG
>Mature_407_residues
MRRVVVTGLGIVSSIGGDAAEVTASLRQAKSGISFSPDFAEHGFKCQVWGKPSLDPTDLVDRRAMRFLSQGGAWNHVAMK
QAIADSGLEESDISGNERTGIIMGSGGPSTRTIVEAADITLKNNSPKRIGPFAVPKAMSSTASATLATWFKIHGVNYSIS
SACSTSAHCIGNAAEMIQWGKQDVMFAGGHEDLDWSMSNLFDAMGAMSSKYNETPGVASRAYDVNRDGFVIAGGAGVLVL
EELEHAKARGAKIYAEIVGYGATSDGYDMVAPSGEGAIRCMRQALATVKGDIDYINTHGTSTPVGDSKEIGAIREVFGDK
IPHIQSTKSLTGHSLGAAGVQESIYGLLMMQERFIGESAHISELDPEFAGVPIVRSRIDDAKIDTILSNSFGFGGTNATL
VFQRHNG

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=417, Percent_Identity=35.0119904076739, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI223972627, Length=137, Percent_Identity=42.3357664233577, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI41872631, Length=337, Percent_Identity=24.9258160237389, Blast_Score=91, Evalue=1e-18,
Organism=Escherichia coli, GI1788663, Length=404, Percent_Identity=61.3861386138614, Blast_Score=497, Evalue=1e-142,
Organism=Escherichia coli, GI1787337, Length=414, Percent_Identity=37.43961352657, Blast_Score=238, Evalue=5e-64,
Organism=Caenorhabditis elegans, GI71983541, Length=415, Percent_Identity=33.0120481927711, Blast_Score=187, Evalue=8e-48,
Organism=Caenorhabditis elegans, GI71983535, Length=258, Percent_Identity=38.7596899224806, Blast_Score=155, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI212642053, Length=339, Percent_Identity=25.3687315634218, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17550940, Length=280, Percent_Identity=27.8571428571429, Blast_Score=88, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6320904, Length=450, Percent_Identity=31.3333333333333, Blast_Score=186, Evalue=4e-48,
Organism=Drosophila melanogaster, GI24644341, Length=419, Percent_Identity=35.799522673031, Blast_Score=221, Evalue=5e-58,
Organism=Drosophila melanogaster, GI19920632, Length=338, Percent_Identity=28.698224852071, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI221330659, Length=338, Percent_Identity=28.698224852071, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24581345, Length=340, Percent_Identity=23.5294117647059, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: 24024 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 30,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.41 [H]

Molecular weight: Translated: 43031; Mature: 43031

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRVVVTGLGIVSSIGGDAAEVTASLRQAKSGISFSPDFAEHGFKCQVWGKPSLDPTDLV
CCEEEEECCHHHHHCCCCHHHHHHHHHHHHCCCCCCCCHHHCCCEEEECCCCCCCHHHHH
DRRAMRFLSQGGAWNHVAMKQAIADSGLEESDISGNERTGIIMGSGGPSTRTIVEAADIT
HHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCEEEEEEEEE
LKNNSPKRIGPFAVPKAMSSTASATLATWFKIHGVNYSISSACSTSAHCIGNAAEMIQWG
EECCCCCCCCCCCCCHHHHHHHHHHHHHEEEEECCCEEHHHHCCCCHHHHCCHHHHHHCC
KQDVMFAGGHEDLDWSMSNLFDAMGAMSSKYNETPGVASRAYDVNRDGFVIAGGAGVLVL
CCCEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHCEECCCCCEEEECCCCEEEH
EELEHAKARGAKIYAEIVGYGATSDGYDMVAPSGEGAIRCMRQALATVKGDIDYINTHGT
HHHHHHHHCCCEEEEEHEECCCCCCCCEEECCCCCHHHHHHHHHHHHHCCCCEEEECCCC
STPVGDSKEIGAIREVFGDKIPHIQSTKSLTGHSLGAAGVQESIYGLLMMQERFIGESAH
CCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
ISELDPEFAGVPIVRSRIDDAKIDTILSNSFGFGGTNATLVFQRHNG
CCCCCCCCCCCCHHHHCCCCHHHHHHHHCCCCCCCCCEEEEEEECCC
>Mature Secondary Structure
MRRVVVTGLGIVSSIGGDAAEVTASLRQAKSGISFSPDFAEHGFKCQVWGKPSLDPTDLV
CCEEEEECCHHHHHCCCCHHHHHHHHHHHHCCCCCCCCHHHCCCEEEECCCCCCCHHHHH
DRRAMRFLSQGGAWNHVAMKQAIADSGLEESDISGNERTGIIMGSGGPSTRTIVEAADIT
HHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCEEEEEEEEE
LKNNSPKRIGPFAVPKAMSSTASATLATWFKIHGVNYSISSACSTSAHCIGNAAEMIQWG
EECCCCCCCCCCCCCHHHHHHHHHHHHHEEEEECCCEEHHHHCCCCHHHHCCHHHHHHCC
KQDVMFAGGHEDLDWSMSNLFDAMGAMSSKYNETPGVASRAYDVNRDGFVIAGGAGVLVL
CCCEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHCEECCCCCEEEECCCCEEEH
EELEHAKARGAKIYAEIVGYGATSDGYDMVAPSGEGAIRCMRQALATVKGDIDYINTHGT
HHHHHHHHCCCEEEEEHEECCCCCCCCEEECCCCCHHHHHHHHHHHHHCCCCEEEECCCC
STPVGDSKEIGAIREVFGDKIPHIQSTKSLTGHSLGAAGVQESIYGLLMMQERFIGESAH
CCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
ISELDPEFAGVPIVRSRIDDAKIDTILSNSFGFGGTNATLVFQRHNG
CCCCCCCCCCCCHHHHCCCCHHHHHHHHCCCCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]