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The map label for this gene is galU [C]

Identifier: 159184129

GI number: 159184129

Start: 26768

End: 27505

Strand: Reverse

Name: galU [C]

Synonym: Atu0025

Alternate gene names: 159184129

Gene position: 27505-26768 (Counterclockwise)

Preceding gene: 15887385

Following gene: 15887383

Centisome position: 0.97

GC content: 58.4

Gene sequence:

>738_bases
ATGACGATCAAAAACGCGATGGTGCTGGCCGCCGGGCTTGGCACGCGCATGCGCCCGATCACGGATACGATCCCGAAGCC
GCTTGTGAAGATCGCCGGCAAGCCGATGATCGATTACGCGCTCGACGCCCTTGTCGAAGCCGGGGCTGAAACCATCGTCG
TCAATGTGCATCACCATGCCGAACAGATGATCTCCCACCTTGGACATCGCACCGATGCGGAAATTCTGATCTCGGATGAA
CGCACGCAGCTGATGAATTCCGGCGGTGGGCTCGCAAAAGGCCTGAAGCTTCTGAAACCCGGCCCGGTCTTCGTCATGAA
CGCGGATCTTTTCTGGATTGGTGAGCGGCTGAACGCCGTCAGCAACCTGCGCAAGCTAGCTCAATTCCTTGACCCGGCGC
GTATGGACATGGCGCTGCTTTGCGTCGACATGGATCGCACCACCGGCCACAACGGCAAGAGGGATTTCAACCTTGCCGGC
GAGGGAAAGCTGACGCGCTATCGCGATGGTGACGCTAACCCGGTGGTTTATGCCGGCGCCATCGCCATGGATTCGCGGCT
GCTTGACGATGCGCCGGCGGACGCTTTCAACCTTAACATCTATTTCGACCGCGCCATTGAAAAAGACCGGCTTTTCGGCC
TGTCGCTGGATGGCCACTGGATCACCGTGGGAACGCCTGACGCGATTGACGATGCGGAAAGCATCATCCGGCAATTCAGA
GAAAAACGTTTCGCATGA

Upstream 100 bases:

>100_bases
GTTATCTCGCTGACGCGCTTTCGCATCCCGAACTCGCGCCACTCCGGGAATGGTGTGTCCGTATGGGCATGGACTTTAAC
GACTAACACGGTTGACCACG

Downstream 100 bases:

>100_bases
CGCTCACCCACCACGCAAAGCGCGTCCTGACGATCGCTGCGGGAACACCGTTTCTCAAAACGCTCGCGGAAACGCTGTGT
GACGGGCGGCTGACAGCCGG

Product: hypothetical protein

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 245; Mature: 244

Protein sequence:

>245_residues
MTIKNAMVLAAGLGTRMRPITDTIPKPLVKIAGKPMIDYALDALVEAGAETIVVNVHHHAEQMISHLGHRTDAEILISDE
RTQLMNSGGGLAKGLKLLKPGPVFVMNADLFWIGERLNAVSNLRKLAQFLDPARMDMALLCVDMDRTTGHNGKRDFNLAG
EGKLTRYRDGDANPVVYAGAIAMDSRLLDDAPADAFNLNIYFDRAIEKDRLFGLSLDGHWITVGTPDAIDDAESIIRQFR
EKRFA

Sequences:

>Translated_245_residues
MTIKNAMVLAAGLGTRMRPITDTIPKPLVKIAGKPMIDYALDALVEAGAETIVVNVHHHAEQMISHLGHRTDAEILISDE
RTQLMNSGGGLAKGLKLLKPGPVFVMNADLFWIGERLNAVSNLRKLAQFLDPARMDMALLCVDMDRTTGHNGKRDFNLAG
EGKLTRYRDGDANPVVYAGAIAMDSRLLDDAPADAFNLNIYFDRAIEKDRLFGLSLDGHWITVGTPDAIDDAESIIRQFR
EKRFA
>Mature_244_residues
TIKNAMVLAAGLGTRMRPITDTIPKPLVKIAGKPMIDYALDALVEAGAETIVVNVHHHAEQMISHLGHRTDAEILISDER
TQLMNSGGGLAKGLKLLKPGPVFVMNADLFWIGERLNAVSNLRKLAQFLDPARMDMALLCVDMDRTTGHNGKRDFNLAGE
GKLTRYRDGDANPVVYAGAIAMDSRLLDDAPADAFNLNIYFDRAIEKDRLFGLSLDGHWITVGTPDAIDDAESIIRQFRE
KRFA

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetyl-glucosamine (UDP- GlcNAc). Responsible for the acetylation of GlcN-1-P to GlcNAc-1- P, and for the uridyl transfer from UTP to GlcNAc-1-P, to produce UDP-GlcN

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Caenorhabditis elegans, GI133931050, Length=236, Percent_Identity=29.6610169491525, Blast_Score=79, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6320148, Length=230, Percent_Identity=26.0869565217391, Blast_Score=73, Evalue=3e-14,
Organism=Drosophila melanogaster, GI21355443, Length=227, Percent_Identity=25.9911894273128, Blast_Score=80, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24644084, Length=227, Percent_Identity=25.9911894273128, Blast_Score=80, Evalue=9e-16,

Paralogues:

None

Copy number: 120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 260 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 26966; Mature: 26835

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIKNAMVLAAGLGTRMRPITDTIPKPLVKIAGKPMIDYALDALVEAGAETIVVNVHHHA
CCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEEEHHHH
EQMISHLGHRTDAEILISDERTQLMNSGGGLAKGLKLLKPGPVFVMNADLFWIGERLNAV
HHHHHHHCCCCCCEEEEECHHHHHHHCCCCHHHHHHHCCCCCEEEEECCEEEHHHHHHHH
SNLRKLAQFLDPARMDMALLCVDMDRTTGHNGKRDFNLAGEGKLTRYRDGDANPVVYAGA
HHHHHHHHHHCHHHCCEEEEEEECCCCCCCCCCCCCCCCCCCCEEEECCCCCCCEEEEEH
IAMDSRLLDDAPADAFNLNIYFDRAIEKDRLFGLSLDGHWITVGTPDAIDDAESIIRQFR
HHHCCHHHCCCCCCEEEEEEEEECCCCCCCEEEEEECCCEEEECCCCCHHHHHHHHHHHH
EKRFA
HHCCC
>Mature Secondary Structure 
TIKNAMVLAAGLGTRMRPITDTIPKPLVKIAGKPMIDYALDALVEAGAETIVVNVHHHA
CCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEEEHHHH
EQMISHLGHRTDAEILISDERTQLMNSGGGLAKGLKLLKPGPVFVMNADLFWIGERLNAV
HHHHHHHCCCCCCEEEEECHHHHHHHCCCCHHHHHHHCCCCCEEEEECCEEEHHHHHHHH
SNLRKLAQFLDPARMDMALLCVDMDRTTGHNGKRDFNLAGEGKLTRYRDGDANPVVYAGA
HHHHHHHHHHCHHHCCEEEEEEECCCCCCCCCCCCCCCCCCCCEEEECCCCCCCEEEEEH
IAMDSRLLDDAPADAFNLNIYFDRAIEKDRLFGLSLDGHWITVGTPDAIDDAESIIRQFR
HHHCCHHHCCCCCCEEEEEEEEECCCCCCCEEEEEECCCEEEECCCCCHHHHHHHHHHHH
EKRFA
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA