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The map label for this gene is trxA [C]

Identifier: 159184127

GI number: 159184127

Start: 19641

End: 19961

Strand: Reverse

Name: trxA [C]

Synonym: Atu0022

Alternate gene names: 159184127

Gene position: 19961-19641 (Counterclockwise)

Preceding gene: 159184128

Following gene: 15887372

Centisome position: 0.7

GC content: 57.94

Gene sequence:

>321_bases
ATGGCTACCGTAAAAGTCGATGCCGCCAACTTCCAGTCCGAAGTCCTCGAATCCGCCGAACCCGTCGTGGTGGATTTCTG
GGCCGAGTGGTGCGGTCCGTGCAAGATGATCGCGCCGAGCCTTGAGGAAATTTCCTCCGAGCTGGCTGGCAAGGTCAAAG
TTGCGAAGCTCAACATCGACGAAAACCCGGAGCTGGCCGCTCAGTTCGGCGTTCGCTCGATCCCGACGCTTGCCATATTC
AAGGGTGGCGAAGTGGCTGATATCAAGGTAGGTGCTGCACCCAAGACAGCGCTTTCCGCCTGGATTTCCAGCGCTGCTTA
A

Upstream 100 bases:

>100_bases
TTGCCGCAATAAAGACAAAGTGAGATACCGGGGCATTGAAATTTCGACGCGCCCGCATCACATCGATAGCGGAAAAGATT
TACTGAAAGGAGAGCCAGAT

Downstream 100 bases:

>100_bases
GCCGTTTTTATGGAATGAAAAAAGCCCGGCATGATCGCCGGGCTTTTTTATTGGGGAACGGTACCGTTGAAAGCAAGGGC
GTTTCCGGCAAGATAAAGCG

Product: thioredoxin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 106; Mature: 105

Protein sequence:

>106_residues
MATVKVDAANFQSEVLESAEPVVVDFWAEWCGPCKMIAPSLEEISSELAGKVKVAKLNIDENPELAAQFGVRSIPTLAIF
KGGEVADIKVGAAPKTALSAWISSAA

Sequences:

>Translated_106_residues
MATVKVDAANFQSEVLESAEPVVVDFWAEWCGPCKMIAPSLEEISSELAGKVKVAKLNIDENPELAAQFGVRSIPTLAIF
KGGEVADIKVGAAPKTALSAWISSAA
>Mature_105_residues
ATVKVDAANFQSEVLESAEPVVVDFWAEWCGPCKMIAPSLEEISSELAGKVKVAKLNIDENPELAAQFGVRSIPTLAIFK
GGEVADIKVGAAPKTALSAWISSAA

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=96, Percent_Identity=42.7083333333333, Blast_Score=93, Evalue=6e-20,
Organism=Homo sapiens, GI21361657, Length=90, Percent_Identity=40, Blast_Score=65, Evalue=9e-12,
Organism=Homo sapiens, GI20070125, Length=92, Percent_Identity=34.7826086956522, Blast_Score=64, Evalue=2e-11,
Organism=Homo sapiens, GI5031973, Length=79, Percent_Identity=37.9746835443038, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI87082331, Length=95, Percent_Identity=55.7894736842105, Blast_Score=118, Evalue=8e-29,
Organism=Escherichia coli, GI1788936, Length=93, Percent_Identity=45.1612903225806, Blast_Score=104, Evalue=1e-24,
Organism=Escherichia coli, GI87081747, Length=102, Percent_Identity=35.2941176470588, Blast_Score=71, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI212646193, Length=75, Percent_Identity=46.6666666666667, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI115532378, Length=73, Percent_Identity=43.8356164383562, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI115532380, Length=73, Percent_Identity=43.8356164383562, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17544108, Length=73, Percent_Identity=43.8356164383562, Blast_Score=73, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17556044, Length=75, Percent_Identity=37.3333333333333, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17549970, Length=106, Percent_Identity=34.9056603773585, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17510299, Length=101, Percent_Identity=35.6435643564356, Blast_Score=64, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6321648, Length=94, Percent_Identity=40.4255319148936, Blast_Score=72, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323072, Length=95, Percent_Identity=44.2105263157895, Blast_Score=70, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6319925, Length=92, Percent_Identity=33.695652173913, Blast_Score=66, Evalue=1e-12,
Organism=Drosophila melanogaster, GI28573567, Length=96, Percent_Identity=42.7083333333333, Blast_Score=94, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24639826, Length=80, Percent_Identity=43.75, Blast_Score=89, Evalue=6e-19,
Organism=Drosophila melanogaster, GI21358065, Length=98, Percent_Identity=39.7959183673469, Blast_Score=81, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24664269, Length=80, Percent_Identity=41.25, Blast_Score=78, Evalue=1e-15,
Organism=Drosophila melanogaster, GI17648013, Length=78, Percent_Identity=41.025641025641, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24583090, Length=78, Percent_Identity=41.025641025641, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI19921434, Length=79, Percent_Identity=40.5063291139241, Blast_Score=71, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24639068, Length=103, Percent_Identity=31.0679611650485, Blast_Score=68, Evalue=1e-12,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11132; Mature: 11001

Theoretical pI: Translated: 4.32; Mature: 4.32

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATVKVDAANFQSEVLESAEPVVVDFWAEWCGPCKMIAPSLEEISSELAGKVKVAKLNID
CCEEEECHHHHHHHHHHCCCCEEEEEHHHHCCCHHHHCCCHHHHHHHHCCCEEEEEECCC
ENPELAAQFGVRSIPTLAIFKGGEVADIKVGAAPKTALSAWISSAA
CCCHHHHHCCCCCCCEEEEECCCCEEEEEECCCCHHHHHHHHHCCC
>Mature Secondary Structure 
ATVKVDAANFQSEVLESAEPVVVDFWAEWCGPCKMIAPSLEEISSELAGKVKVAKLNID
CEEEECHHHHHHHHHHCCCCEEEEEHHHHCCCHHHHCCCHHHHHHHHCCCEEEEEECCC
ENPELAAQFGVRSIPTLAIFKGGEVADIKVGAAPKTALSAWISSAA
CCCHHHHHCCCCCCCEEEEECCCCEEEEEECCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7021558 [H]