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The map label for this gene is coaE

Identifier: 159184121

GI number: 159184121

Start: 2508

End: 3089

Strand: Direct

Name: coaE

Synonym: Atu0004

Alternate gene names: 159184121

Gene position: 2508-3089 (Clockwise)

Preceding gene: 159184120

Following gene: 15887364

Centisome position: 0.09

GC content: 56.19

Gene sequence:

>582_bases
ATGATCGTCATCGGTCTCACCGGTTCGATTGGAATGGGAAAAACCACGACGGCGAAGCTCTTCGCCGAAGAGGGTGTTCC
GGTTCTCGATTCCGATGAGGTCGTGCACGGGCTTTATCGTGCGGAAGCCGTTCCACTGATCGACGCCGCCTTTCCCGGCA
CGACGATTTCCGGCATGGTCGACCGGCAGAAACTTGGAGACGTGCTGCGAAAGAATCCGGCTAATTTTAACAGGTTGGAA
GAGATCGTTCATCCGCTGGTGCGCAACAGACAGGAGGCCTTTCTGGCAAAGGCAAGGATAGACGATCGGGCTTTTGCTCT
GCTCGACATACCCTTGCTGTTTGAAACGGGGGCGGAAGGACGGGTCGATAAAGTCGTGGTGGTGAGTTGCGCGCCGGAAA
TCCAGCGCGAGCGCGTTTTATCCCGGCCCGGCATGACGGAGGAGAAATTCGAAATGATTCTTGCCCGGCAGATGCCGGAT
GCGGAAAAGCGCCAGCGCGCCGATTTTGTCGTCGATTCGGGAAATGGTGTCGAAGCGGCACGGGATCAGGTAAAAGAAAT
TCTGCAGAAACTAGGCGCTTGA

Upstream 100 bases:

>100_bases
TTCATCAGGCAAAACCTGGTTTCAGGCGATGGTTCGGCAGGATTCCGGAGGTGGATGAAACCCTTCGTTCCCTGATCATC
GCGGATATGGAGAAACATTG

Downstream 100 bases:

>100_bases
GTCGCGCCGCGGAGAGATGAATGCGTGAGATCATTTTCGATACGGAAACCACGGGCCTCGAATCGAAGCTGGACCGCGTG
ATTGAAATCGGCGGTATCGA

Product: dephospho-CoA kinase

Products: NA

Alternate protein names: Dephosphocoenzyme A kinase

Number of amino acids: Translated: 193; Mature: 193

Protein sequence:

>193_residues
MIVIGLTGSIGMGKTTTAKLFAEEGVPVLDSDEVVHGLYRAEAVPLIDAAFPGTTISGMVDRQKLGDVLRKNPANFNRLE
EIVHPLVRNRQEAFLAKARIDDRAFALLDIPLLFETGAEGRVDKVVVVSCAPEIQRERVLSRPGMTEEKFEMILARQMPD
AEKRQRADFVVDSGNGVEAARDQVKEILQKLGA

Sequences:

>Translated_193_residues
MIVIGLTGSIGMGKTTTAKLFAEEGVPVLDSDEVVHGLYRAEAVPLIDAAFPGTTISGMVDRQKLGDVLRKNPANFNRLE
EIVHPLVRNRQEAFLAKARIDDRAFALLDIPLLFETGAEGRVDKVVVVSCAPEIQRERVLSRPGMTEEKFEMILARQMPD
AEKRQRADFVVDSGNGVEAARDQVKEILQKLGA
>Mature_193_residues
MIVIGLTGSIGMGKTTTAKLFAEEGVPVLDSDEVVHGLYRAEAVPLIDAAFPGTTISGMVDRQKLGDVLRKNPANFNRLE
EIVHPLVRNRQEAFLAKARIDDRAFALLDIPLLFETGAEGRVDKVVVVSCAPEIQRERVLSRPGMTEEKFEMILARQMPD
AEKRQRADFVVDSGNGVEAARDQVKEILQKLGA

Specific function: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A

COG id: COG0237

COG function: function code H; Dephospho-CoA kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DPCK (dephospho-CoA kinase) domain

Homologues:

Organism=Homo sapiens, GI191252797, Length=192, Percent_Identity=30.7291666666667, Blast_Score=74, Evalue=6e-14,
Organism=Homo sapiens, GI191252795, Length=192, Percent_Identity=30.7291666666667, Blast_Score=74, Evalue=6e-14,
Organism=Escherichia coli, GI1786292, Length=181, Percent_Identity=30.939226519337, Blast_Score=82, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17554944, Length=198, Percent_Identity=29.2929292929293, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6320402, Length=200, Percent_Identity=25.5, Blast_Score=80, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24644728, Length=192, Percent_Identity=28.6458333333333, Blast_Score=92, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COAE_AGRT5 (Q8UJC4)

Other databases:

- EMBL:   AE007869
- PIR:   AE2577
- PIR:   D97359
- RefSeq:   NP_353044.2
- ProteinModelPortal:   Q8UJC4
- SMR:   Q8UJC4
- STRING:   Q8UJC4
- GeneID:   1132042
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu0004
- eggNOG:   COG0237
- HOGENOM:   HBG650290
- OMA:   RIIEEQY
- ProtClustDB:   PRK00081
- BioCyc:   ATUM176299-1:ATU0004-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00376
- InterPro:   IPR001977
- TIGRFAMs:   TIGR00152

Pfam domain/function: PF01121 CoaE

EC number: =2.7.1.24

Molecular weight: Translated: 21210; Mature: 21210

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS51219 DPCK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVIGLTGSIGMGKTTTAKLFAEEGVPVLDSDEVVHGLYRAEAVPLIDAAFPGTTISGMV
CEEEEECCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCEEECCCCCCHHHHHH
DRQKLGDVLRKNPANFNRLEEIVHPLVRNRQEAFLAKARIDDRAFALLDIPLLFETGAEG
HHHHHHHHHHCCCCCHHHHHHHHHHHHHCHHHHHHHHHHCCCCEEEEEEHHHHEECCCCC
RVDKVVVVSCAPEIQRERVLSRPGMTEEKFEMILARQMPDAEKRQRADFVVDSGNGVEAA
CCCEEEEEECCCHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHCCCEEEECCCCCHHH
RDQVKEILQKLGA
HHHHHHHHHHHCC
>Mature Secondary Structure
MIVIGLTGSIGMGKTTTAKLFAEEGVPVLDSDEVVHGLYRAEAVPLIDAAFPGTTISGMV
CEEEEECCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCEEECCCCCCHHHHHH
DRQKLGDVLRKNPANFNRLEEIVHPLVRNRQEAFLAKARIDDRAFALLDIPLLFETGAEG
HHHHHHHHHHCCCCCHHHHHHHHHHHHHCHHHHHHHHHHCCCCEEEEEEHHHHEECCCCC
RVDKVVVVSCAPEIQRERVLSRPGMTEEKFEMILARQMPDAEKRQRADFVVDSGNGVEAA
CCCEEEEEECCCHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHCCCEEEECCCCCHHH
RDQVKEILQKLGA
HHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194