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The map label for this gene is aroE

Identifier: 159184120

GI number: 159184120

Start: 1648

End: 2508

Strand: Direct

Name: aroE

Synonym: Atu0003

Alternate gene names: 159184120

Gene position: 1648-2508 (Clockwise)

Preceding gene: 159184119

Following gene: 159184121

Centisome position: 0.06

GC content: 57.72

Gene sequence:

>861_bases
ATGGCTGATTCACGTGAAACATTAACTATAAATGCCTTCGTTGTCGGTTACCCGATCAAACATTCCCGGTCGCCGATCAT
CCATTCCTATTGGCTGAAAAAATTCGGTATCGCCGGTTCCTATACGGCAGTTGAGGTCTCCCCAGACGATTTCCCGAAGT
TCATTGCAACGCTGAAGGAAGGCAAGCCGGGTGCAGCGGTGGGCGGTAACGCCACCATTCCGCACAAGGAAGCGGCTTAC
CGGTTGGCCGATCATCCCGATGCCTTGGCGGAAGAACTCGGCGCCGCCAACACCATCTGGATGGAGGAGGGTAAACTCCA
CGCGACCAACACGGATGGTTACGGTTTCGTCTCGAACCTGGACGAGCGGCATCCGGGCTGGGATAAGACCCAGCGCGCGG
TGGTGTTCGGCGCCGGCGGTGCAAGCCGGGCCGTCATTCAGTCGCTGCGTGATCGGGATGTTGCGGAAATTCACGTCGTG
AACCGTACGGTCGAGCGCGCTCGCGAACTGGCCGACCGCTTTGGCCCACGGGTCTTTTCCCATCCCCAGGCAGCGCTTCA
GGAGGTCATGCACGGCGCGGGGTTGTTCGTGAATACGACATCGCTCGGAATGAATGGAACCGAAGCGCCGCATCTTGATT
TTTCGCATCTCGCGGCCAATGCGGTGGTGACCGATATCGTCTACGTGCCGTTGAAAACGCCGATCCTCAACATGGCGCAA
GAGCAGGGCATCGCAACCGTCGATGGGCTCGGCATGTTGCTTCATCAGGCAAAACCTGGTTTCAGGCGATGGTTCGGCAG
GATTCCGGAGGTGGATGAAACCCTTCGTTCCCTGATCATCGCGGATATGGAGAAACATTGA

Upstream 100 bases:

>100_bases
GGAATCCAGCTATTCACCTCCATAGAGGGGGATTATTTCACGATCCTCGGTTTGCCGCTTCTGCCTCTTTTATCGAAACT
ACGCGACATGGATGTCATCG

Downstream 100 bases:

>100_bases
TGATCGTCATCGGTCTCACCGGTTCGATTGGAATGGGAAAAACCACGACGGCGAAGCTCTTCGCCGAAGAGGGTGTTCCG
GTTCTCGATTCCGATGAGGT

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 286; Mature: 285

Protein sequence:

>286_residues
MADSRETLTINAFVVGYPIKHSRSPIIHSYWLKKFGIAGSYTAVEVSPDDFPKFIATLKEGKPGAAVGGNATIPHKEAAY
RLADHPDALAEELGAANTIWMEEGKLHATNTDGYGFVSNLDERHPGWDKTQRAVVFGAGGASRAVIQSLRDRDVAEIHVV
NRTVERARELADRFGPRVFSHPQAALQEVMHGAGLFVNTTSLGMNGTEAPHLDFSHLAANAVVTDIVYVPLKTPILNMAQ
EQGIATVDGLGMLLHQAKPGFRRWFGRIPEVDETLRSLIIADMEKH

Sequences:

>Translated_286_residues
MADSRETLTINAFVVGYPIKHSRSPIIHSYWLKKFGIAGSYTAVEVSPDDFPKFIATLKEGKPGAAVGGNATIPHKEAAY
RLADHPDALAEELGAANTIWMEEGKLHATNTDGYGFVSNLDERHPGWDKTQRAVVFGAGGASRAVIQSLRDRDVAEIHVV
NRTVERARELADRFGPRVFSHPQAALQEVMHGAGLFVNTTSLGMNGTEAPHLDFSHLAANAVVTDIVYVPLKTPILNMAQ
EQGIATVDGLGMLLHQAKPGFRRWFGRIPEVDETLRSLIIADMEKH
>Mature_285_residues
ADSRETLTINAFVVGYPIKHSRSPIIHSYWLKKFGIAGSYTAVEVSPDDFPKFIATLKEGKPGAAVGGNATIPHKEAAYR
LADHPDALAEELGAANTIWMEEGKLHATNTDGYGFVSNLDERHPGWDKTQRAVVFGAGGASRAVIQSLRDRDVAEIHVVN
RTVERARELADRFGPRVFSHPQAALQEVMHGAGLFVNTTSLGMNGTEAPHLDFSHLAANAVVTDIVYVPLKTPILNMAQE
QGIATVDGLGMLLHQAKPGFRRWFGRIPEVDETLRSLIIADMEKH

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1789675, Length=272, Percent_Identity=36.3970588235294, Blast_Score=134, Evalue=7e-33,
Organism=Escherichia coli, GI1787983, Length=267, Percent_Identity=34.8314606741573, Blast_Score=125, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6320332, Length=268, Percent_Identity=26.865671641791, Blast_Score=80, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROE_AGRT5 (Q8UJC5)

Other databases:

- EMBL:   AE007869
- PIR:   AD2577
- PIR:   C97359
- RefSeq:   NP_353043.2
- ProteinModelPortal:   Q8UJC5
- SMR:   Q8UJC5
- STRING:   Q8UJC5
- GeneID:   1132041
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu0003
- eggNOG:   COG0169
- HOGENOM:   HBG553408
- OMA:   ANTIWME
- PhylomeDB:   Q8UJC5
- ProtClustDB:   PRK00258
- BioCyc:   ATUM176299-1:ATU0003-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00222
- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR00507

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N

EC number: =1.1.1.25

Molecular weight: Translated: 31238; Mature: 31107

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: NA

Important sites: ACT_SITE 76-76

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADSRETLTINAFVVGYPIKHSRSPIIHSYWLKKFGIAGSYTAVEVSPDDFPKFIATLKE
CCCCCCEEEEEEEEEEECCCCCCCCHHHHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHC
GKPGAAVGGNATIPHKEAAYRLADHPDALAEELGAANTIWMEEGKLHATNTDGYGFVSNL
CCCCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHCCCCEEEEECCEEEECCCCCCCHHHCC
DERHPGWDKTQRAVVFGAGGASRAVIQSLRDRDVAEIHVVNRTVERARELADRFGPRVFS
HHCCCCCCCCCEEEEEECCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHC
HPQAALQEVMHGAGLFVNTTSLGMNGTEAPHLDFSHLAANAVVTDIVYVPLKTPILNMAQ
CHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHEEECCCCHHHHHHH
EQGIATVDGLGMLLHQAKPGFRRWFGRIPEVDETLRSLIIADMEKH
HCCCEEHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ADSRETLTINAFVVGYPIKHSRSPIIHSYWLKKFGIAGSYTAVEVSPDDFPKFIATLKE
CCCCCEEEEEEEEEEECCCCCCCCHHHHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHC
GKPGAAVGGNATIPHKEAAYRLADHPDALAEELGAANTIWMEEGKLHATNTDGYGFVSNL
CCCCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHCCCCEEEEECCEEEECCCCCCCHHHCC
DERHPGWDKTQRAVVFGAGGASRAVIQSLRDRDVAEIHVVNRTVERARELADRFGPRVFS
HHCCCCCCCCCEEEEEECCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHC
HPQAALQEVMHGAGLFVNTTSLGMNGTEAPHLDFSHLAANAVVTDIVYVPLKTPILNMAQ
CHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHEEECCCCHHHHHHH
EQGIATVDGLGMLLHQAKPGFRRWFGRIPEVDETLRSLIIADMEKH
HCCCEEHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194