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The map label for this gene is cobW [H]

Identifier: 15890052

GI number: 15890052

Start: 2808391

End: 2809428

Strand: Reverse

Name: cobW [H]

Synonym: Atu2805

Alternate gene names: 15890052

Gene position: 2809428-2808391 (Counterclockwise)

Preceding gene: 159185390

Following gene: 15890051

Centisome position: 98.87

GC content: 60.69

Gene sequence:

>1038_bases
ATGAGCACCCTTCTGGACCGCGTTCCCTGCACCATCGTCACCGGCTTTCTGGGTGCCGGAAAAACCACACTGCTGCGCGG
TCTTCTCGAAAAGCTTGACGGCAAGCGGCTCGCCATCATCGTCAATGAATTCGGCGATATCGGCATTGATGGCGAAATTC
TGAAAGGCTGCGGCATTGAAAGCTGCCCGGAGGAAAACATCGTCGAGCTGGCCAATGGCTGCATCTGCTGCACGGTGGCG
GATGATTTCCAGCCCGCCATCGAACAAATCCTTAGCCGCCAGCCGAAGGTGGAGCATATTCTCATTGAGACCTCCGGCCT
TGCCCTGCCGAAGCCCCTGGTGCAGGCCTTCCAGTGGCCGGCCATCAAAAGCCGCGTGACTGTCGATGCCGTGGTCGCCG
TGGTGGATGGCGCGGCTCTGGCCGAGGGTCAGGTCGCCCACGACATGGAAGCGCTTGCTGCCCAGCGTGCCAACGACGAA
GCGCTCGACCATGACGATCCGGTCGAAGAGGTCTTCGAAGATCAGGTCGCCTGCGCCGATCTTATCGTGCTCACCAAGGC
CGATCTTCTCGACGATGCCGGCCTCGAGAAGGCCAAGGCCCATATCCTCGAACATCTGCCAAAGGCGGCGAAGATCGTTG
TTGCTTCGAATGGTGCCATCGATCCGACCGTGCTGATCGGTCTCGGCCTTGCGGTGGAAGAGGATATTGAAAACCGCCGC
ACCCATCATGATGGCGAACTCGATCATGAACACGATGATTTCGACAGCTTCGTCATCGACCTGCCGGCCGTTACCGATCC
GGAGGCGCTGGCGGCCCGTATCGCGCAGACGGCCGCTGCCGAGAATGTGCTGCGCATCAAGGGCTTCATCGAAGTCGCCA
CTAAGCCCATGCGTCTGCAGGTGCAGGCTGTCGGCAGCCGCGTCAACCACTACTACGACCGCCCCTGGGCGGCGGGTGAA
GAGCGCCGCAGCCGTCTCGTCGTCATCGGCGAAAAGGGCATTAACCGCGAAAAGATCGAACAGATGCTGGCCGCCTGA

Upstream 100 bases:

>100_bases
CCGCCCCCGACGGCCTGATGCCCTGGCGTGGCCGCCCGGAACCCCTAAAGCGCGGCATGCTGGCGCGCATTCCCCCATTC
GATTTTACCGAGGAGAGATC

Downstream 100 bases:

>100_bases
CATAAGCCGTTTGCGCATTGTCCGGACGCAAAACCGCTGCGCACTTTTACTGGAAATGCTTTAGATGCATATTCTCGCCA
CCACATCCTCGTCTCTGGAC

Product: cobalamin synthesis protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MSTLLDRVPCTIVTGFLGAGKTTLLRGLLEKLDGKRLAIIVNEFGDIGIDGEILKGCGIESCPEENIVELANGCICCTVA
DDFQPAIEQILSRQPKVEHILIETSGLALPKPLVQAFQWPAIKSRVTVDAVVAVVDGAALAEGQVAHDMEALAAQRANDE
ALDHDDPVEEVFEDQVACADLIVLTKADLLDDAGLEKAKAHILEHLPKAAKIVVASNGAIDPTVLIGLGLAVEEDIENRR
THHDGELDHEHDDFDSFVIDLPAVTDPEALAARIAQTAAAENVLRIKGFIEVATKPMRLQVQAVGSRVNHYYDRPWAAGE
ERRSRLVVIGEKGINREKIEQMLAA

Sequences:

>Translated_345_residues
MSTLLDRVPCTIVTGFLGAGKTTLLRGLLEKLDGKRLAIIVNEFGDIGIDGEILKGCGIESCPEENIVELANGCICCTVA
DDFQPAIEQILSRQPKVEHILIETSGLALPKPLVQAFQWPAIKSRVTVDAVVAVVDGAALAEGQVAHDMEALAAQRANDE
ALDHDDPVEEVFEDQVACADLIVLTKADLLDDAGLEKAKAHILEHLPKAAKIVVASNGAIDPTVLIGLGLAVEEDIENRR
THHDGELDHEHDDFDSFVIDLPAVTDPEALAARIAQTAAAENVLRIKGFIEVATKPMRLQVQAVGSRVNHYYDRPWAAGE
ERRSRLVVIGEKGINREKIEQMLAA
>Mature_344_residues
STLLDRVPCTIVTGFLGAGKTTLLRGLLEKLDGKRLAIIVNEFGDIGIDGEILKGCGIESCPEENIVELANGCICCTVAD
DFQPAIEQILSRQPKVEHILIETSGLALPKPLVQAFQWPAIKSRVTVDAVVAVVDGAALAEGQVAHDMEALAAQRANDEA
LDHDDPVEEVFEDQVACADLIVLTKADLLDDAGLEKAKAHILEHLPKAAKIVVASNGAIDPTVLIGLGLAVEEDIENRRT
HHDGELDHEHDDFDSFVIDLPAVTDPEALAARIAQTAAAENVLRIKGFIEVATKPMRLQVQAVGSRVNHYYDRPWAAGEE
RRSRLVVIGEKGINREKIEQMLAA

Specific function: Might be involved in cobalt reduction leading to cobalt(I) corrinoids [H]

COG id: COG0523

COG function: function code R; Putative GTPases (G3E family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cobW C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI33469141, Length=365, Percent_Identity=27.9452054794521, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI126722884, Length=365, Percent_Identity=27.3972602739726, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI148727351, Length=365, Percent_Identity=27.3972602739726, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI146231952, Length=362, Percent_Identity=27.6243093922652, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI223941779, Length=362, Percent_Identity=27.6243093922652, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI223941776, Length=354, Percent_Identity=26.5536723163842, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI119120938, Length=135, Percent_Identity=40, Blast_Score=95, Evalue=1e-19,
Organism=Escherichia coli, GI87082430, Length=335, Percent_Identity=29.2537313432836, Blast_Score=118, Evalue=6e-28,
Organism=Escherichia coli, GI1788499, Length=179, Percent_Identity=32.4022346368715, Blast_Score=89, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6324356, Length=191, Percent_Identity=33.5078534031414, Blast_Score=102, Evalue=7e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012824
- InterPro:   IPR003495
- InterPro:   IPR011629 [H]

Pfam domain/function: PF02492 cobW; PF07683 CobW_C [H]

EC number: NA

Molecular weight: Translated: 37266; Mature: 37135

Theoretical pI: Translated: 4.44; Mature: 4.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTLLDRVPCTIVTGFLGAGKTTLLRGLLEKLDGKRLAIIVNEFGDIGIDGEILKGCGIE
CCCHHHHCCHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHCCCCC
SCPEENIVELANGCICCTVADDFQPAIEQILSRQPKVEHILIETSGLALPKPLVQAFQWP
CCCHHHHHHHHCCEEEEEECHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHCCC
AIKSRVTVDAVVAVVDGAALAEGQVAHDMEALAAQRANDEALDHDDPVEEVFEDQVACAD
HHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
LIVLTKADLLDDAGLEKAKAHILEHLPKAAKIVVASNGAIDPTVLIGLGLAVEEDIENRR
HHHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHCCCHHHHHHHHCC
THHDGELDHEHDDFDSFVIDLPAVTDPEALAARIAQTAAAENVLRIKGFIEVATKPMRLQ
CCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEH
VQAVGSRVNHYYDRPWAAGEERRSRLVVIGEKGINREKIEQMLAA
HHHHHHHHHHHHCCCCCCCHHHCCEEEEECCCCCCHHHHHHHHCC
>Mature Secondary Structure 
STLLDRVPCTIVTGFLGAGKTTLLRGLLEKLDGKRLAIIVNEFGDIGIDGEILKGCGIE
CCHHHHCCHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHCCCCC
SCPEENIVELANGCICCTVADDFQPAIEQILSRQPKVEHILIETSGLALPKPLVQAFQWP
CCCHHHHHHHHCCEEEEEECHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHCCC
AIKSRVTVDAVVAVVDGAALAEGQVAHDMEALAAQRANDEALDHDDPVEEVFEDQVACAD
HHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
LIVLTKADLLDDAGLEKAKAHILEHLPKAAKIVVASNGAIDPTVLIGLGLAVEEDIENRR
HHHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHCCCHHHHHHHHCC
THHDGELDHEHDDFDSFVIDLPAVTDPEALAARIAQTAAAENVLRIKGFIEVATKPMRLQ
CCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEH
VQAVGSRVNHYYDRPWAAGEERRSRLVVIGEKGINREKIEQMLAA
HHHHHHHHHHHHCCCCCCCHHHCCEEEEECCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1655697 [H]