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The map label for this gene is phbA [H]

Identifier: 15890018

GI number: 15890018

Start: 2773879

End: 2775060

Strand: Direct

Name: phbA [H]

Synonym: Atu2769

Alternate gene names: 15890018

Gene position: 2773879-2775060 (Clockwise)

Preceding gene: 15890016

Following gene: 159185371

Centisome position: 97.62

GC content: 63.28

Gene sequence:

>1182_bases
ATGACCCTGCCTTCAATCGTGATTGCCAGCGCCGCGCGCACCGCCGTCGGCTCTTTCAACGGCCACTTCGCCAACACGCC
CGCCCACGAACTTGGTGCCACCGTCATTAGTGCGGTGCTGGAACGTGCCGGCGTCGCGGCCAATGAAGTGGATGAGGTCA
TTCTCGGCCAGGTGCTCATGGCAGGCGAGGGGCAAAACCCGGCGCGGCAGGCAGCAATGAAGGCCGGCATTCCGCAGGAG
GCAACCGCCTTCGGCATCAATCAGCTCTGCGGCTCTGGCTTGCGCGCCGTGGCGCTGGGCATGCAGCAGATCGTGACGGG
GGATGCGGCCATCATCATTGCCGGCGGCCAGGAATCCATGTCCATGGCGCCGCATTGCGCCCATCTACGGGGCGGCGTGA
AGATGGGCGACTTCAAGATGATAGACACGATGATGAAGGACGGTCTGACCGACGCCTTTTACGGATACCCGATGGGCATC
ACTGCCGAAAACATCGCTCGCCAATGGCAGCTTTCCCGCGATGAGCAGGACCAGTTCGCAGTCGCATCGCAGAACAAGGC
CGAAGCCGCGCAGAACGCCGGTCGCTTCACTGACGAGATCGTGGCTTTCACGGTAAAGGGCCGCAAGGCCGATATCGTCA
TCGATGCGGACGAACATATCCGTCATGGCGCATCGCTCGAAACCATGGCCAAGCTGCGTCCCGCCTTCGACAAGGAAGGC
ACGGTCACGGCCGGTAACGCCTCCGGCCTGAATGACGGCGCAGCCGCCACGCTTCTCATGTCGGAACAGCAAGCGGCAAA
GCGCGGCATCAAACCGCTAGCGCGCATAGCCTCCTGGGCAACGGCCGGCGTTGATCCGCAGATCATGGGCACCGGTCCCA
TCCCCGCCTCCCGCAAGGCGCTGGCCAAGGCCGGCTGGTCGATCAACGATATTGGCCTTGTCGAGGCCAACGAGGCCTTT
GCCGCCCAATCCTGCGCGGTCGTGCGCGAGCTGGGCCTTAACCCTGACATCGTCAACGTTAATGGCGGAGCGATTGCCAT
CGGCCATCCGATCGGCGCTTCCGGCGCTCGCGTCCTGAACACGCTGATTTTCGAAATGCGTCGCCGCAACGTATCGAGGG
GTCTCGCAACGCTCTGCATCGGCGGCGGCATGGGTGTCGCCATGTGCATCGAGGCGCTCTAA

Upstream 100 bases:

>100_bases
GATTCCGACGTGATTTAGCAACATCTTTTAAAGCAACTTTCGGCATTTGACTTGTATTAAAAGCTTTGCCAGTCTCCGCC
CGCATGTGAGGAGATGAGAA

Downstream 100 bases:

>100_bases
AAACCCTCGCAAGGTTTGCCAAAAAGCAATTCCGGTTCGCCAGACAATAGGGTAGAAGCGGCCTCCCATTGGCCGTATTT
CTATGGCCGTTGGGCACAAC

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MTLPSIVIASAARTAVGSFNGHFANTPAHELGATVISAVLERAGVAANEVDEVILGQVLMAGEGQNPARQAAMKAGIPQE
ATAFGINQLCGSGLRAVALGMQQIVTGDAAIIIAGGQESMSMAPHCAHLRGGVKMGDFKMIDTMMKDGLTDAFYGYPMGI
TAENIARQWQLSRDEQDQFAVASQNKAEAAQNAGRFTDEIVAFTVKGRKADIVIDADEHIRHGASLETMAKLRPAFDKEG
TVTAGNASGLNDGAAATLLMSEQQAAKRGIKPLARIASWATAGVDPQIMGTGPIPASRKALAKAGWSINDIGLVEANEAF
AAQSCAVVRELGLNPDIVNVNGGAIAIGHPIGASGARVLNTLIFEMRRRNVSRGLATLCIGGGMGVAMCIEAL

Sequences:

>Translated_393_residues
MTLPSIVIASAARTAVGSFNGHFANTPAHELGATVISAVLERAGVAANEVDEVILGQVLMAGEGQNPARQAAMKAGIPQE
ATAFGINQLCGSGLRAVALGMQQIVTGDAAIIIAGGQESMSMAPHCAHLRGGVKMGDFKMIDTMMKDGLTDAFYGYPMGI
TAENIARQWQLSRDEQDQFAVASQNKAEAAQNAGRFTDEIVAFTVKGRKADIVIDADEHIRHGASLETMAKLRPAFDKEG
TVTAGNASGLNDGAAATLLMSEQQAAKRGIKPLARIASWATAGVDPQIMGTGPIPASRKALAKAGWSINDIGLVEANEAF
AAQSCAVVRELGLNPDIVNVNGGAIAIGHPIGASGARVLNTLIFEMRRRNVSRGLATLCIGGGMGVAMCIEAL
>Mature_392_residues
TLPSIVIASAARTAVGSFNGHFANTPAHELGATVISAVLERAGVAANEVDEVILGQVLMAGEGQNPARQAAMKAGIPQEA
TAFGINQLCGSGLRAVALGMQQIVTGDAAIIIAGGQESMSMAPHCAHLRGGVKMGDFKMIDTMMKDGLTDAFYGYPMGIT
AENIARQWQLSRDEQDQFAVASQNKAEAAQNAGRFTDEIVAFTVKGRKADIVIDADEHIRHGASLETMAKLRPAFDKEGT
VTAGNASGLNDGAAATLLMSEQQAAKRGIKPLARIASWATAGVDPQIMGTGPIPASRKALAKAGWSINDIGLVEANEAFA
AQSCAVVRELGLNPDIVNVNGGAIAIGHPIGASGARVLNTLIFEMRRRNVSRGLATLCIGGGMGVAMCIEAL

Specific function: SHORT-CHAIN FATTY ACIDS METABOLISM. [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=388, Percent_Identity=57.2164948453608, Blast_Score=459, Evalue=1e-129,
Organism=Homo sapiens, GI167614485, Length=393, Percent_Identity=43.5114503816794, Blast_Score=322, Evalue=3e-88,
Organism=Homo sapiens, GI4557237, Length=395, Percent_Identity=41.5189873417722, Blast_Score=298, Evalue=6e-81,
Organism=Homo sapiens, GI4501853, Length=393, Percent_Identity=40.7124681933842, Blast_Score=251, Evalue=8e-67,
Organism=Homo sapiens, GI4504327, Length=426, Percent_Identity=32.6291079812207, Blast_Score=185, Evalue=5e-47,
Organism=Homo sapiens, GI194353979, Length=394, Percent_Identity=29.6954314720812, Blast_Score=143, Evalue=3e-34,
Organism=Escherichia coli, GI1788554, Length=393, Percent_Identity=54.70737913486, Blast_Score=405, Evalue=1e-114,
Organism=Escherichia coli, GI87082165, Length=390, Percent_Identity=52.5641025641026, Blast_Score=405, Evalue=1e-114,
Organism=Escherichia coli, GI1787663, Length=394, Percent_Identity=43.4010152284264, Blast_Score=293, Evalue=2e-80,
Organism=Escherichia coli, GI48994986, Length=401, Percent_Identity=43.640897755611, Blast_Score=263, Evalue=1e-71,
Organism=Escherichia coli, GI1788683, Length=423, Percent_Identity=33.096926713948, Blast_Score=192, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI133906874, Length=390, Percent_Identity=43.8461538461538, Blast_Score=330, Evalue=1e-90,
Organism=Caenorhabditis elegans, GI25147385, Length=386, Percent_Identity=39.6373056994819, Blast_Score=283, Evalue=2e-76,
Organism=Caenorhabditis elegans, GI17535921, Length=395, Percent_Identity=39.2405063291139, Blast_Score=276, Evalue=1e-74,
Organism=Caenorhabditis elegans, GI17551802, Length=427, Percent_Identity=32.5526932084309, Blast_Score=183, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17535917, Length=393, Percent_Identity=31.5521628498728, Blast_Score=173, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6325229, Length=396, Percent_Identity=40.9090909090909, Blast_Score=280, Evalue=3e-76,
Organism=Saccharomyces cerevisiae, GI6322031, Length=388, Percent_Identity=36.0824742268041, Blast_Score=213, Evalue=3e-56,
Organism=Drosophila melanogaster, GI24655093, Length=391, Percent_Identity=55.7544757033248, Blast_Score=449, Evalue=1e-126,
Organism=Drosophila melanogaster, GI17648125, Length=393, Percent_Identity=41.4758269720102, Blast_Score=302, Evalue=3e-82,
Organism=Drosophila melanogaster, GI24640423, Length=393, Percent_Identity=42.2391857506361, Blast_Score=291, Evalue=4e-79,
Organism=Drosophila melanogaster, GI17137578, Length=424, Percent_Identity=33.7264150943396, Blast_Score=192, Evalue=3e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 40699; Mature: 40568

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLPSIVIASAARTAVGSFNGHFANTPAHELGATVISAVLERAGVAANEVDEVILGQVLM
CCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHC
AGEGQNPARQAAMKAGIPQEATAFGINQLCGSGLRAVALGMQQIVTGDAAIIIAGGQESM
CCCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEECCCCCC
SMAPHCAHLRGGVKMGDFKMIDTMMKDGLTDAFYGYPMGITAENIARQWQLSRDEQDQFA
CCCCHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHCCCCCCCHHHHHHHHHCCCCCCHHHH
VASQNKAEAAQNAGRFTDEIVAFTVKGRKADIVIDADEHIRHGASLETMAKLRPAFDKEG
HHCCCHHHHHHHCCCCCCEEEEEEECCCEEEEEEECHHHHHCCCCHHHHHHHCCCCCCCC
TVTAGNASGLNDGAAATLLMSEQQAAKRGIKPLARIASWATAGVDPQIMGTGPIPASRKA
CEEECCCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCEEEECCCCCHHHHH
LAKAGWSINDIGLVEANEAFAAQSCAVVRELGLNPDIVNVNGGAIAIGHPIGASGARVLN
HHHCCCCCCCEEEEECCHHHHHHHHHHHHHHCCCCCEEEECCCEEEECCCCCCCHHHHHH
TLIFEMRRRNVSRGLATLCIGGGMGVAMCIEAL
HHHHHHHHHHHHHCHHHHHCCCCCHHHHHHHCC
>Mature Secondary Structure 
TLPSIVIASAARTAVGSFNGHFANTPAHELGATVISAVLERAGVAANEVDEVILGQVLM
CCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHC
AGEGQNPARQAAMKAGIPQEATAFGINQLCGSGLRAVALGMQQIVTGDAAIIIAGGQESM
CCCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEECCCCCC
SMAPHCAHLRGGVKMGDFKMIDTMMKDGLTDAFYGYPMGITAENIARQWQLSRDEQDQFA
CCCCHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHCCCCCCCHHHHHHHHHCCCCCCHHHH
VASQNKAEAAQNAGRFTDEIVAFTVKGRKADIVIDADEHIRHGASLETMAKLRPAFDKEG
HHCCCHHHHHHHCCCCCCEEEEEEECCCEEEEEEECHHHHHCCCCHHHHHHHCCCCCCCC
TVTAGNASGLNDGAAATLLMSEQQAAKRGIKPLARIASWATAGVDPQIMGTGPIPASRKA
CEEECCCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCEEEECCCCCHHHHH
LAKAGWSINDIGLVEANEAFAAQSCAVVRELGLNPDIVNVNGGAIAIGHPIGASGARVLN
HHHCCCCCCCEEEEECCHHHHHHHHHHHHHHCCCCCEEEECCCEEEECCCCCCCHHHHHH
TLIFEMRRRNVSRGLATLCIGGGMGVAMCIEAL
HHHHHHHHHHHHHCHHHHHCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2878929; 2670935; 1673680; 10764581; 10545327; 12501183 [H]