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The map label for this gene is glxR [H]

Identifier: 15889986

GI number: 15889986

Start: 2733524

End: 2734426

Strand: Reverse

Name: glxR [H]

Synonym: Atu2737

Alternate gene names: 15889986

Gene position: 2734426-2733524 (Counterclockwise)

Preceding gene: 15889987

Following gene: 15889985

Centisome position: 96.23

GC content: 62.24

Gene sequence:

>903_bases
ATGAGTGTCGGCGGGGAGGAGAAGAAGCGGTCTGTCGCCTTTATCGGCACGGGCCTGATGGGCGGGCCGATGGCCCGGCG
TTTGCTGGGTACCGGCTTTTCGGTAAAGGTCTGGAACCGCAGCGTCGATAAGGCGCAGGCGCTCGTTGCCGATGGTGCCG
TTCTGGCGGCCTCTCCGGCGGAGGCCGCAAGGGGTGCCGATATCGTCATCACCATGCTGAGCGATGGCAATGCCGTGGGC
GAAGTGCTGTTCGAGGCGGGCGTGGCCGAAGCGCTGGCAAAAGGTGCCGTCGTGATCGACAGCAGTTCGATTGCGCCGCC
TATTGCGCGCGAACACTCTTCCCGTCTACAGGCAATGGGTATTCATCACGTCGATGCACCGGTTTCCGGTGGTGTGCCCG
GTGCAACGGCCGGCACGCTCGCCATCATGGCGGGCGGTGACGAGGCATTGATATCTGGACTTGTGGATGTCTTCGCGCCG
ATGGGCCGGCTCACCTATGTCGGCCCCTCGGGTGCGGGCCAGCTCTGCAAGCTCGCCAACCAGCAGATCGTCGCCATCAC
CATCGGCGCTGTTGCCGAAGCGATGATGCTGGTGGAGGCGGGCGGAGCGTCCCGCGAAGGGTTCCGCAATGCCATACGCG
GCGGTTTTGCCGAAAGTCGGATTCTGGAACTGCATGGCGAACGCATGGTGAAGCGCAATTTCGTGCCGGGCGGTCCGTCC
AAGTTCCAGCTCAAGGATCTGAACGGCGTGCTTGCAACGGCCAAGGATCTCGCTCTTACCCTGCCACTCACCCAGCAGGT
GACGCGGGAATTCGATGATTTCGTCGGTGATGGCGGGGCGGATATCGATCATAGCGGCATCCTGCTTTACCTCGAAAAAC
TCAACAATCGTGAACAGGGCTGA

Upstream 100 bases:

>100_bases
TCGAAGCAAAGCGCGCCCGCGAGCTCGGCTTTACGGCCGAGAGCTCGTTTGAAGAGATCATTCAGGTTCATATTGAGGAC
GAACTGGGAGGTTCACTGAA

Downstream 100 bases:

>100_bases
GGCGATCTCATGAGCGACGACAAGATACCCATGCGCCGCCTGCGATCCCAGGACTGGTTCGATAACCCCGATCATCTCGA
CATGACGGCGCTCTATCTGG

Product: oxidoredutase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 300; Mature: 299

Protein sequence:

>300_residues
MSVGGEEKKRSVAFIGTGLMGGPMARRLLGTGFSVKVWNRSVDKAQALVADGAVLAASPAEAARGADIVITMLSDGNAVG
EVLFEAGVAEALAKGAVVIDSSSIAPPIAREHSSRLQAMGIHHVDAPVSGGVPGATAGTLAIMAGGDEALISGLVDVFAP
MGRLTYVGPSGAGQLCKLANQQIVAITIGAVAEAMMLVEAGGASREGFRNAIRGGFAESRILELHGERMVKRNFVPGGPS
KFQLKDLNGVLATAKDLALTLPLTQQVTREFDDFVGDGGADIDHSGILLYLEKLNNREQG

Sequences:

>Translated_300_residues
MSVGGEEKKRSVAFIGTGLMGGPMARRLLGTGFSVKVWNRSVDKAQALVADGAVLAASPAEAARGADIVITMLSDGNAVG
EVLFEAGVAEALAKGAVVIDSSSIAPPIAREHSSRLQAMGIHHVDAPVSGGVPGATAGTLAIMAGGDEALISGLVDVFAP
MGRLTYVGPSGAGQLCKLANQQIVAITIGAVAEAMMLVEAGGASREGFRNAIRGGFAESRILELHGERMVKRNFVPGGPS
KFQLKDLNGVLATAKDLALTLPLTQQVTREFDDFVGDGGADIDHSGILLYLEKLNNREQG
>Mature_299_residues
SVGGEEKKRSVAFIGTGLMGGPMARRLLGTGFSVKVWNRSVDKAQALVADGAVLAASPAEAARGADIVITMLSDGNAVGE
VLFEAGVAEALAKGAVVIDSSSIAPPIAREHSSRLQAMGIHHVDAPVSGGVPGATAGTLAIMAGGDEALISGLVDVFAPM
GRLTYVGPSGAGQLCKLANQQIVAITIGAVAEAMMLVEAGGASREGFRNAIRGGFAESRILELHGERMVKRNFVPGGPSK
FQLKDLNGVLATAKDLALTLPLTQQVTREFDDFVGDGGADIDHSGILLYLEKLNNREQG

Specific function: Glyoxylate catabolism. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=191, Percent_Identity=36.6492146596859, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI40556376, Length=245, Percent_Identity=28.1632653061224, Blast_Score=102, Evalue=4e-22,
Organism=Escherichia coli, GI1786719, Length=287, Percent_Identity=42.5087108013937, Blast_Score=204, Evalue=5e-54,
Organism=Escherichia coli, GI145693186, Length=289, Percent_Identity=41.1764705882353, Blast_Score=193, Evalue=1e-50,
Organism=Escherichia coli, GI1790315, Length=193, Percent_Identity=39.3782383419689, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1789092, Length=281, Percent_Identity=28.4697508896797, Blast_Score=71, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17557316, Length=187, Percent_Identity=34.7593582887701, Blast_Score=80, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24655230, Length=299, Percent_Identity=31.7725752508361, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI19922568, Length=299, Percent_Identity=31.7725752508361, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI28574115, Length=284, Percent_Identity=25, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 30841; Mature: 30710

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVGGEEKKRSVAFIGTGLMGGPMARRLLGTGFSVKVWNRSVDKAQALVADGAVLAASPA
CCCCCCCHHCEEEEEECCCCCCHHHHHHHCCCCEEEEECCCHHHHHHHHHCCCEEEECCH
EAARGADIVITMLSDGNAVGEVLFEAGVAEALAKGAVVIDSSSIAPPIAREHSSRLQAMG
HHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHHC
IHHVDAPVSGGVPGATAGTLAIMAGGDEALISGLVDVFAPMGRLTYVGPSGAGQLCKLAN
CEECCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHCC
QQIVAITIGAVAEAMMLVEAGGASREGFRNAIRGGFAESRILELHGERMVKRNFVPGGPS
CEEEEEEHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCC
KFQLKDLNGVLATAKDLALTLPLTQQVTREFDDFVGDGGADIDHSGILLYLEKLNNREQG
CEEEECCCCHHHHHHHHEEECCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEHHCCCCCC
>Mature Secondary Structure 
SVGGEEKKRSVAFIGTGLMGGPMARRLLGTGFSVKVWNRSVDKAQALVADGAVLAASPA
CCCCCCHHCEEEEEECCCCCCHHHHHHHCCCCEEEEECCCHHHHHHHHHCCCEEEECCH
EAARGADIVITMLSDGNAVGEVLFEAGVAEALAKGAVVIDSSSIAPPIAREHSSRLQAMG
HHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHHC
IHHVDAPVSGGVPGATAGTLAIMAGGDEALISGLVDVFAPMGRLTYVGPSGAGQLCKLAN
CEECCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHCC
QQIVAITIGAVAEAMMLVEAGGASREGFRNAIRGGFAESRILELHGERMVKRNFVPGGPS
CEEEEEEHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCC
KFQLKDLNGVLATAKDLALTLPLTQQVTREFDDFVGDGGADIDHSGILLYLEKLNNREQG
CEEEECCCCHHHHHHHHEEECCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10601204; 9278503 [H]