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The map label for this gene is ilvD [H]

Identifier: 15889985

GI number: 15889985

Start: 2731730

End: 2733514

Strand: Reverse

Name: ilvD [H]

Synonym: Atu2736

Alternate gene names: 15889985

Gene position: 2733514-2731730 (Counterclockwise)

Preceding gene: 15889986

Following gene: 15889984

Centisome position: 96.2

GC content: 62.41

Gene sequence:

>1785_bases
ATGAGCGACGACAAGATACCCATGCGCCGCCTGCGATCCCAGGACTGGTTCGATAACCCCGATCATCTCGACATGACGGC
GCTCTATCTGGAGCGCTTCATGAATTACGGCGTGACGCCGGAAGAGCTGCGCTCCGGCAAGCCTGTCATCGGCATCGCGC
AGAGCGGCAGTGACCTCACGCCCTGCAACCGGGTCCATGTGGAACTGGTCAAGCGGGTACGCGATGGCATCCGTGATGCG
GGCGGCATACCGATCGAGTTTCCAACCCATCCGATGTTCGAAAACTGCAAGCGCCCAACGGCGGCGCTTGATCGCAATCT
CGCTTATCTCAGCCTCGTGGAAGTGCTTTACGGCTACCCGCTCGATGGTGTCGTTCTGACAACCGGCTGCGACAAGACCA
CGCCTTCGGCGCTGATGGCGGCGAGCACGGTGGATATTCCCGCCATCGTGCTTTCCGGCGGGCCGATGCTCGACGGGTAT
CATGACGGCGATCTGGTCGGTTCCGGCACCGTCATCTGGCGCATGCGCCGCAAATATGGCGCGGGCGAAATCACTCGCGA
GGAGTTTTTGCAGGCGGCGCTGGAATCGGCTCCGTCGGTCGGGCATTGCAACACCATGGGCACCGCATCCACCATGAATG
CCATTGCTGAAGCGCTCGGCATGTCACTTACCGGCTGCGGCGCGATCCCGGCCGCTTACCGCGAGCGTGGCCAGATGGCC
TATCGCACCGGTCGTCGTGCCGTCGAGCTTGTGATCGAGAATATCAAGCCCTCCGACATCATGACGCGCGAGGCGTTTTT
GAACGCGATCCGGGTCAACTCGGCGATCGGCGGTTCCACCAATGCCCAGCCGCATCTTGCGGCGATGGCCAAACATGCGG
GCGTCGAGCTTCGCGAAGAGGACTGGCAGGCTCACGGTTACGACATTCCGCTTCTCGCCAATGTCCAGCCTGCCGGCAAA
TGGCTGGGTGAGAAATACCACCGCGCCGGCGGCACGCCCGCCATCATGTGGGAGCTTCTGAAGGCAGGCAAGCTCGACGG
AAGTTGTCCGACCGTGACCGGCAAAACCATGGCGGAAAATCTCGACGGGCGGGAATCGACCGACCGCGACGTGATCCTGC
CCTATGACAAGCCGCTCAAGGAGCGCGCCGGTTTCCTCGTTCTCAAGGGCAATCTGTTCGATTTCGCCATCATGAAGACG
AGCGTGATCTCGGCGGAGTTCCGCCAGCGTTACCTCAGCGAGCCGGGCCGCGAGGGGATATTCGAAGGCAAGTGCGTCGT
ATTCGATGGTTCGGAGGATTATCACGCCCGCATCAACGAGCCGTCGCTGGATATTGACGAGCGCACCATTCTTGTCATTC
GTGGCGCGGGGCCGCTCGGCTGGCCGGGTTCGGCCGAGGTCGTCAACATGCAGCCACCGGATGCGCTTCTGAAAAAGGGC
ATTACCAGCCTGCCGACGATCGGCGACGGTCGGCAGTCGGGAACGGCGGACAGCCCGTCGATCCTCAATGCTTCCCCGGA
AAGTGCGGCGGGTGGCGGGCTGGCATGGCTGCGCACTGGCGATGTGATCCGCATCGACTTCAACAAGGGTGAGTGCAATG
CGCTGGTGCCGCAAGCGGAGCTTGATGCCCGCAAGGCCGACGGCATACCCGCCGTGCCCGCCGATGCAACGCCCTGGCAG
CGTATCTATCGTCAATCGGTGACCCAGCTTTCGGACGGTGCGGTGCTGGAAGGGGCGGCGGATTTCCGTCGGATCGCCGA
AAAAATGCCCCGGCACAATCACTGA

Upstream 100 bases:

>100_bases
CGATGATTTCGTCGGTGATGGCGGGGCGGATATCGATCATAGCGGCATCCTGCTTTACCTCGAAAAACTCAACAATCGTG
AACAGGGCTGAGGCGATCTC

Downstream 100 bases:

>100_bases
CCGAACATGACAAAATCCCCGGCCAGGACCGGGGATTTTTCTTTTGGAGGCGGTTTCGCATTTGATCACGACCTCCTAAT
GTAGCCTGAGATTCCGCATT

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 594; Mature: 593

Protein sequence:

>594_residues
MSDDKIPMRRLRSQDWFDNPDHLDMTALYLERFMNYGVTPEELRSGKPVIGIAQSGSDLTPCNRVHVELVKRVRDGIRDA
GGIPIEFPTHPMFENCKRPTAALDRNLAYLSLVEVLYGYPLDGVVLTTGCDKTTPSALMAASTVDIPAIVLSGGPMLDGY
HDGDLVGSGTVIWRMRRKYGAGEITREEFLQAALESAPSVGHCNTMGTASTMNAIAEALGMSLTGCGAIPAAYRERGQMA
YRTGRRAVELVIENIKPSDIMTREAFLNAIRVNSAIGGSTNAQPHLAAMAKHAGVELREEDWQAHGYDIPLLANVQPAGK
WLGEKYHRAGGTPAIMWELLKAGKLDGSCPTVTGKTMAENLDGRESTDRDVILPYDKPLKERAGFLVLKGNLFDFAIMKT
SVISAEFRQRYLSEPGREGIFEGKCVVFDGSEDYHARINEPSLDIDERTILVIRGAGPLGWPGSAEVVNMQPPDALLKKG
ITSLPTIGDGRQSGTADSPSILNASPESAAGGGLAWLRTGDVIRIDFNKGECNALVPQAELDARKADGIPAVPADATPWQ
RIYRQSVTQLSDGAVLEGAADFRRIAEKMPRHNH

Sequences:

>Translated_594_residues
MSDDKIPMRRLRSQDWFDNPDHLDMTALYLERFMNYGVTPEELRSGKPVIGIAQSGSDLTPCNRVHVELVKRVRDGIRDA
GGIPIEFPTHPMFENCKRPTAALDRNLAYLSLVEVLYGYPLDGVVLTTGCDKTTPSALMAASTVDIPAIVLSGGPMLDGY
HDGDLVGSGTVIWRMRRKYGAGEITREEFLQAALESAPSVGHCNTMGTASTMNAIAEALGMSLTGCGAIPAAYRERGQMA
YRTGRRAVELVIENIKPSDIMTREAFLNAIRVNSAIGGSTNAQPHLAAMAKHAGVELREEDWQAHGYDIPLLANVQPAGK
WLGEKYHRAGGTPAIMWELLKAGKLDGSCPTVTGKTMAENLDGRESTDRDVILPYDKPLKERAGFLVLKGNLFDFAIMKT
SVISAEFRQRYLSEPGREGIFEGKCVVFDGSEDYHARINEPSLDIDERTILVIRGAGPLGWPGSAEVVNMQPPDALLKKG
ITSLPTIGDGRQSGTADSPSILNASPESAAGGGLAWLRTGDVIRIDFNKGECNALVPQAELDARKADGIPAVPADATPWQ
RIYRQSVTQLSDGAVLEGAADFRRIAEKMPRHNH
>Mature_593_residues
SDDKIPMRRLRSQDWFDNPDHLDMTALYLERFMNYGVTPEELRSGKPVIGIAQSGSDLTPCNRVHVELVKRVRDGIRDAG
GIPIEFPTHPMFENCKRPTAALDRNLAYLSLVEVLYGYPLDGVVLTTGCDKTTPSALMAASTVDIPAIVLSGGPMLDGYH
DGDLVGSGTVIWRMRRKYGAGEITREEFLQAALESAPSVGHCNTMGTASTMNAIAEALGMSLTGCGAIPAAYRERGQMAY
RTGRRAVELVIENIKPSDIMTREAFLNAIRVNSAIGGSTNAQPHLAAMAKHAGVELREEDWQAHGYDIPLLANVQPAGKW
LGEKYHRAGGTPAIMWELLKAGKLDGSCPTVTGKTMAENLDGRESTDRDVILPYDKPLKERAGFLVLKGNLFDFAIMKTS
VISAEFRQRYLSEPGREGIFEGKCVVFDGSEDYHARINEPSLDIDERTILVIRGAGPLGWPGSAEVVNMQPPDALLKKGI
TSLPTIGDGRQSGTADSPSILNASPESAAGGGLAWLRTGDVIRIDFNKGECNALVPQAELDARKADGIPAVPADATPWQR
IYRQSVTQLSDGAVLEGAADFRRIAEKMPRHNH

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=557, Percent_Identity=29.802513464991, Blast_Score=177, Evalue=1e-45,
Organism=Escherichia coli, GI1788157, Length=470, Percent_Identity=30.4255319148936, Blast_Score=177, Evalue=2e-45,
Organism=Escherichia coli, GI2367371, Length=464, Percent_Identity=28.448275862069, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1786464, Length=477, Percent_Identity=28.7211740041929, Blast_Score=121, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6322476, Length=560, Percent_Identity=28.5714285714286, Blast_Score=197, Evalue=4e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 64449; Mature: 64318

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDDKIPMRRLRSQDWFDNPDHLDMTALYLERFMNYGVTPEELRSGKPVIGIAQSGSDLT
CCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHCCCCEEEEECCCCCCC
PCNRVHVELVKRVRDGIRDAGGIPIEFPTHPMFENCKRPTAALDRNLAYLSLVEVLYGYP
CHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHCCCCHHHHHCCHHHHHHHHHHHCCC
LDGVVLTTGCDKTTPSALMAASTVDIPAIVLSGGPMLDGYHDGDLVGSGTVIWRMRRKYG
CCCEEEECCCCCCCCHHHHHHHCCCCCEEEEECCCCCCCCCCCCEECCCCEEEEEHHHCC
AGEITREEFLQAALESAPSVGHCNTMGTASTMNAIAEALGMSLTGCGAIPAAYRERGQMA
CCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHCCHHH
YRTGRRAVELVIENIKPSDIMTREAFLNAIRVNSAIGGSTNAQPHLAAMAKHAGVELREE
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCEEECC
DWQAHGYDIPLLANVQPAGKWLGEKYHRAGGTPAIMWELLKAGKLDGSCPTVTGKTMAEN
CCCCCCCCCCEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHC
LDGRESTDRDVILPYDKPLKERAGFLVLKGNLFDFAIMKTSVISAEFRQRYLSEPGREGI
CCCCCCCCCCEEECCCCCHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCC
FEGKCVVFDGSEDYHARINEPSLDIDERTILVIRGAGPLGWPGSAEVVNMQPPDALLKKG
CCCEEEEEECCCCCEEECCCCCCCCCCEEEEEEECCCCCCCCCCCCEEECCCCHHHHHCC
ITSLPTIGDGRQSGTADSPSILNASPESAAGGGLAWLRTGDVIRIDFNKGECNALVPQAE
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCEEEEECCCCCCCEECCCHH
LDARKADGIPAVPADATPWQRIYRQSVTQLSDGAVLEGAADFRRIAEKMPRHNH
HCCHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SDDKIPMRRLRSQDWFDNPDHLDMTALYLERFMNYGVTPEELRSGKPVIGIAQSGSDLT
CCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHCCCCEEEEECCCCCCC
PCNRVHVELVKRVRDGIRDAGGIPIEFPTHPMFENCKRPTAALDRNLAYLSLVEVLYGYP
CHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHCCCCHHHHHCCHHHHHHHHHHHCCC
LDGVVLTTGCDKTTPSALMAASTVDIPAIVLSGGPMLDGYHDGDLVGSGTVIWRMRRKYG
CCCEEEECCCCCCCCHHHHHHHCCCCCEEEEECCCCCCCCCCCCEECCCCEEEEEHHHCC
AGEITREEFLQAALESAPSVGHCNTMGTASTMNAIAEALGMSLTGCGAIPAAYRERGQMA
CCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHCCHHH
YRTGRRAVELVIENIKPSDIMTREAFLNAIRVNSAIGGSTNAQPHLAAMAKHAGVELREE
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCEEECC
DWQAHGYDIPLLANVQPAGKWLGEKYHRAGGTPAIMWELLKAGKLDGSCPTVTGKTMAEN
CCCCCCCCCCEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHC
LDGRESTDRDVILPYDKPLKERAGFLVLKGNLFDFAIMKTSVISAEFRQRYLSEPGREGI
CCCCCCCCCCEEECCCCCHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCC
FEGKCVVFDGSEDYHARINEPSLDIDERTILVIRGAGPLGWPGSAEVVNMQPPDALLKKG
CCCEEEEEECCCCCEEECCCCCCCCCCEEEEEEECCCCCCCCCCCCEEECCCCHHHHHCC
ITSLPTIGDGRQSGTADSPSILNASPESAAGGGLAWLRTGDVIRIDFNKGECNALVPQAE
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCEEEEECCCCCCCEECCCHH
LDARKADGIPAVPADATPWQRIYRQSVTQLSDGAVLEGAADFRRIAEKMPRHNH
HCCHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]