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The map label for this gene is ilvA [H]

Identifier: 15889984

GI number: 15889984

Start: 2730631

End: 2731605

Strand: Reverse

Name: ilvA [H]

Synonym: Atu2735

Alternate gene names: 15889984

Gene position: 2731605-2730631 (Counterclockwise)

Preceding gene: 15889985

Following gene: 159185355

Centisome position: 96.13

GC content: 61.74

Gene sequence:

>975_bases
ATGACAGATATTTCGATGATCGAGGCGGCGCGTGAGCGCATCGGCAACCATGCGGTGCGAACACCGCTGCTCACCTCGCC
TTTTCTGGACGAGATCGCCGGGCGAAAGCTGTTCGTTAAGGCGGAATGCCTGCAAAGGACGGGATCCTTCAAGTTTCGCG
GCGGCTGGTCGGCGGTATCCGGCCTGCCGGCGGATGTGCGCGCCAAGGGTGTGATCGCTTTTTCCTCCGGCAACCATGCG
CAGGGCGTGGCGCTCGCGGCCCGCCTGCATGGCATTCCCGCCGTCATCATCATGCCTTCGGATGCGCCGAAGATCAAAAT
CGACAATACCCGCGCCTATGGCGCCGAGGTGGTGCTTTACGACCGGGCGAATGAAGACCGTGACGCCATTGGCAACCGGT
TGTCGAGCGAGCGCGGTTTGACCCTGATCAGGCCTTACGATGAACCGCTGGTGATTGCGGGGCAGGGGACCGCTGGGCTG
GAAATCGCTGAGCAAGGCGCCGAACTCGGTATCGGTGCTGCCGAGGTTCTGGTGCCTTGCGGTGGCGGCGGCCTCACCTC
CGGCATCTCTCTTGCACTCGATGCGAAAGCGCGAAATTATAAGGTCAGGACGGCAGAACCGGAGCGTTTCGATGACGTGG
CGCGCTCCCTTGCGGCGGGCAAGATCGAGCGGAATGCGACGACATCGGGTTCGATCTGTGATGCAATCGTCACGCCGCAG
CCTGGCAATATCACCTTTCCCATCATGGCAGGGCTTTGCGGGAAAGGTATCGCCGTCAGCGAGGAGGAAGCGCTGCGGGC
CATGGTTCTCGCCTTCAACCGGCTGAAGGTCGTTATCGAGCCGGGTGGTGCTGTTGCGCTTGCCGCAGCGCTTTTTCATG
GCAAGGAACTGGAAAGCGAAACCGTGATTGCGGTTGCCTCCGGCGGCAATGTCGATCCCGGGATCATGGCCGACGCTCTG
TCACGCTTCGGTTGA

Upstream 100 bases:

>100_bases
AGGACCGGGGATTTTTCTTTTGGAGGCGGTTTCGCATTTGATCACGACCTCCTAATGTAGCCTGAGATTCCGCATTAGAT
CCGCTTACCGGGGGCAGGGC

Downstream 100 bases:

>100_bases
TATCAGGCCTCCAACCGTGCGGCGATCTCGCCGGCAATCGCCAGAGACGCGGTCAGGCCGGGACTTTCTATTCCGAACAG
ATTGACGAGGCCGGGAAAAC

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 324; Mature: 323

Protein sequence:

>324_residues
MTDISMIEAARERIGNHAVRTPLLTSPFLDEIAGRKLFVKAECLQRTGSFKFRGGWSAVSGLPADVRAKGVIAFSSGNHA
QGVALAARLHGIPAVIIMPSDAPKIKIDNTRAYGAEVVLYDRANEDRDAIGNRLSSERGLTLIRPYDEPLVIAGQGTAGL
EIAEQGAELGIGAAEVLVPCGGGGLTSGISLALDAKARNYKVRTAEPERFDDVARSLAAGKIERNATTSGSICDAIVTPQ
PGNITFPIMAGLCGKGIAVSEEEALRAMVLAFNRLKVVIEPGGAVALAAALFHGKELESETVIAVASGGNVDPGIMADAL
SRFG

Sequences:

>Translated_324_residues
MTDISMIEAARERIGNHAVRTPLLTSPFLDEIAGRKLFVKAECLQRTGSFKFRGGWSAVSGLPADVRAKGVIAFSSGNHA
QGVALAARLHGIPAVIIMPSDAPKIKIDNTRAYGAEVVLYDRANEDRDAIGNRLSSERGLTLIRPYDEPLVIAGQGTAGL
EIAEQGAELGIGAAEVLVPCGGGGLTSGISLALDAKARNYKVRTAEPERFDDVARSLAAGKIERNATTSGSICDAIVTPQ
PGNITFPIMAGLCGKGIAVSEEEALRAMVLAFNRLKVVIEPGGAVALAAALFHGKELESETVIAVASGGNVDPGIMADAL
SRFG
>Mature_323_residues
TDISMIEAARERIGNHAVRTPLLTSPFLDEIAGRKLFVKAECLQRTGSFKFRGGWSAVSGLPADVRAKGVIAFSSGNHAQ
GVALAARLHGIPAVIIMPSDAPKIKIDNTRAYGAEVVLYDRANEDRDAIGNRLSSERGLTLIRPYDEPLVIAGQGTAGLE
IAEQGAELGIGAAEVLVPCGGGGLTSGISLALDAKARNYKVRTAEPERFDDVARSLAAGKIERNATTSGSICDAIVTPQP
GNITFPIMAGLCGKGIAVSEEEALRAMVLAFNRLKVVIEPGGAVALAAALFHGKELESETVIAVASGGNVDPGIMADALS
RFG

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=312, Percent_Identity=38.4615384615385, Blast_Score=196, Evalue=2e-50,
Organism=Escherichia coli, GI1789505, Length=311, Percent_Identity=37.620578778135, Blast_Score=159, Evalue=2e-40,
Organism=Escherichia coli, GI1790207, Length=294, Percent_Identity=33.6734693877551, Blast_Score=127, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17508781, Length=316, Percent_Identity=32.2784810126582, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI71991565, Length=321, Percent_Identity=34.5794392523364, Blast_Score=134, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI17537387, Length=322, Percent_Identity=33.2298136645963, Blast_Score=110, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6322631, Length=303, Percent_Identity=42.9042904290429, Blast_Score=213, Evalue=3e-56,
Organism=Saccharomyces cerevisiae, GI6320930, Length=287, Percent_Identity=35.5400696864112, Blast_Score=125, Evalue=9e-30,
Organism=Saccharomyces cerevisiae, GI6319788, Length=311, Percent_Identity=24.4372990353698, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21355833, Length=305, Percent_Identity=31.4754098360656, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24645328, Length=227, Percent_Identity=29.0748898678414, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005789 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 33727; Mature: 33596

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDISMIEAARERIGNHAVRTPLLTSPFLDEIAGRKLFVKAECLQRTGSFKFRGGWSAVS
CCCHHHHHHHHHHHCCHHHCCCCCCCHHHHHHCCCEEEEEEHHHHHCCCEEECCCCHHHC
GLPADVRAKGVIAFSSGNHAQGVALAARLHGIPAVIIMPSDAPKIKIDNTRAYGAEVVLY
CCCCCCCCCEEEEECCCCCCCHHHHHHHHCCCCEEEEECCCCCEEEECCCCCCCEEEEEE
DRANEDRDAIGNRLSSERGLTLIRPYDEPLVIAGQGTAGLEIAEQGAELGIGAAEVLVPC
ECCCCCHHHHHHHCCCCCCEEEECCCCCCEEEEECCCCCHHHHHCCCCCCCCHHHEEEEC
GGGGLTSGISLALDAKARNYKVRTAEPERFDDVARSLAAGKIERNATTSGSICDAIVTPQ
CCCCCCCCEEEEEECCCCCEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCC
PGNITFPIMAGLCGKGIAVSEEEALRAMVLAFNRLKVVIEPGGAVALAAALFHGKELESE
CCCEEHHHHHCCCCCCCEECHHHHHHHHHHHHEEEEEEECCCCHHHHHHHHHCCCCCCCC
TVIAVASGGNVDPGIMADALSRFG
EEEEEECCCCCCCHHHHHHHHHCC
>Mature Secondary Structure 
TDISMIEAARERIGNHAVRTPLLTSPFLDEIAGRKLFVKAECLQRTGSFKFRGGWSAVS
CCHHHHHHHHHHHCCHHHCCCCCCCHHHHHHCCCEEEEEEHHHHHCCCEEECCCCHHHC
GLPADVRAKGVIAFSSGNHAQGVALAARLHGIPAVIIMPSDAPKIKIDNTRAYGAEVVLY
CCCCCCCCCEEEEECCCCCCCHHHHHHHHCCCCEEEEECCCCCEEEECCCCCCCEEEEEE
DRANEDRDAIGNRLSSERGLTLIRPYDEPLVIAGQGTAGLEIAEQGAELGIGAAEVLVPC
ECCCCCHHHHHHHCCCCCCEEEECCCCCCEEEEECCCCCHHHHHCCCCCCCCHHHEEEEC
GGGGLTSGISLALDAKARNYKVRTAEPERFDDVARSLAAGKIERNATTSGSICDAIVTPQ
CCCCCCCCEEEEEECCCCCEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCC
PGNITFPIMAGLCGKGIAVSEEEALRAMVLAFNRLKVVIEPGGAVALAAALFHGKELESE
CCCEEHHHHHCCCCCCCEECHHHHHHHHHHHHEEEEEEECCCCHHHHHHHHHCCCCCCCC
TVIAVASGGNVDPGIMADALSRFG
EEEEEECCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA