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The map label for this gene is lhgO [H]

Identifier: 15889983

GI number: 15889983

Start: 2729525

End: 2730628

Strand: Direct

Name: lhgO [H]

Synonym: Atu2734

Alternate gene names: 15889983

Gene position: 2729525-2730628 (Clockwise)

Preceding gene: 159185354

Following gene: 159185356

Centisome position: 96.06

GC content: 61.05

Gene sequence:

>1104_bases
ATGACTGACATCGACGCTATCATCATCGGAGCGGGCGTGATCGGGCTTGCGACGGCCCGCGAATTGTCGATGCACGGCCT
TTCCGTTATCATTCTGGAAAGCGAAACGGAATTCGGTTCGGCCACTTCGTCCCGCAATAGCGAAGTCATCCATGCGGGGC
TTTATTATCCAGCCGGAAGCCTCAAGGCGAGGCTCTGTGTCGAGGGCAGGCAGCGGCTTTATGACTTTTGCGAGAGCCAC
GGCGTTGCGCACCGCCATTGCGGTAAACTCATCGTCGCCACGAGCGATGACGAAACGCCCTTGCTCGTTGCCCTCGGCGC
AAAAGGCAAAGCCAATGGCTGCGACGATCTGGAGCTGATCGACCAACGACACGCGCTTTCGCTCGAGCCTGCCCTTGCCT
GCAGCTCAGCCCTGCTCTCACCCTCGACGGGCATCATCGACAGCCACGGCTATATGCTGGCGCTGCTTGGTGAGGCACAA
GACCATGGCGCAGCCCTTGCGCTCAACGCACCGTTCGAACGGGCGGAAGCGATCGGCGACGGTTTCCGGGTTCATGTCGG
CGGAAAAGAACCTGTCAGCCTTACATGCCGGCTGCTCGTCAATTCCGCCGGGCTAGTCGCGCCGATGGTGGCAGCCATGA
TCGAGGGACTGCCGTCAGTGGCGATCCCGCAGGCACGTTTCGCCAAGGGCAGCTATTTCTCGCTGACAGGCAAATCGCCT
TTTTCGCGGTTAATCTATCCTGCACCGCACACCCACGGCCTTGGTGTGCACCTGACTTTGGATCTCGCCGGTCAGGCCCG
GTTCGGGCCCGATGTGGAATGGGTTGATACCATCGACTATGCCGTCGATCCCCGCCGCATGGAGGGTTTCGGCGACGCCA
TAAGGCGTTATTGGCCGGGCCTGCCGGAACACACGCTGGCCCCTGCCTATTCCGGTATCCGTCCGAAGATTTCCGGGCCG
GACGAACCAGCCATGGACTTTCGCATCGATGGGCCGGAAACCCATGGTTTTCCCGGCCTCGTCAATCTGTTCGGAATAGA
AAGTCCCGGCCTGACCGCGTCTCTGGCGATTGCCGGCGAGATCGCCGCACGGTTGGAGGCCTGA

Upstream 100 bases:

>100_bases
GTCGTCACTTGCCTCCCAACAAGCATCAATCTACCCATCGCGGACTATTAACGCGTCGGGAGGGAGTTGGTTCAAACGGC
CCTTCCGCGGACAGGAAGAC

Downstream 100 bases:

>100_bases
TATCAACCGAAGCGTGACAGAGCGTCGGCCATGATCCCGGGATCGACATTGCCGCCGGAGGCAACCGCAATCACGGTTTC
GCTTTCCAGTTCCTTGCCAT

Product: dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 367; Mature: 366

Protein sequence:

>367_residues
MTDIDAIIIGAGVIGLATARELSMHGLSVIILESETEFGSATSSRNSEVIHAGLYYPAGSLKARLCVEGRQRLYDFCESH
GVAHRHCGKLIVATSDDETPLLVALGAKGKANGCDDLELIDQRHALSLEPALACSSALLSPSTGIIDSHGYMLALLGEAQ
DHGAALALNAPFERAEAIGDGFRVHVGGKEPVSLTCRLLVNSAGLVAPMVAAMIEGLPSVAIPQARFAKGSYFSLTGKSP
FSRLIYPAPHTHGLGVHLTLDLAGQARFGPDVEWVDTIDYAVDPRRMEGFGDAIRRYWPGLPEHTLAPAYSGIRPKISGP
DEPAMDFRIDGPETHGFPGLVNLFGIESPGLTASLAIAGEIAARLEA

Sequences:

>Translated_367_residues
MTDIDAIIIGAGVIGLATARELSMHGLSVIILESETEFGSATSSRNSEVIHAGLYYPAGSLKARLCVEGRQRLYDFCESH
GVAHRHCGKLIVATSDDETPLLVALGAKGKANGCDDLELIDQRHALSLEPALACSSALLSPSTGIIDSHGYMLALLGEAQ
DHGAALALNAPFERAEAIGDGFRVHVGGKEPVSLTCRLLVNSAGLVAPMVAAMIEGLPSVAIPQARFAKGSYFSLTGKSP
FSRLIYPAPHTHGLGVHLTLDLAGQARFGPDVEWVDTIDYAVDPRRMEGFGDAIRRYWPGLPEHTLAPAYSGIRPKISGP
DEPAMDFRIDGPETHGFPGLVNLFGIESPGLTASLAIAGEIAARLEA
>Mature_366_residues
TDIDAIIIGAGVIGLATARELSMHGLSVIILESETEFGSATSSRNSEVIHAGLYYPAGSLKARLCVEGRQRLYDFCESHG
VAHRHCGKLIVATSDDETPLLVALGAKGKANGCDDLELIDQRHALSLEPALACSSALLSPSTGIIDSHGYMLALLGEAQD
HGAALALNAPFERAEAIGDGFRVHVGGKEPVSLTCRLLVNSAGLVAPMVAAMIEGLPSVAIPQARFAKGSYFSLTGKSPF
SRLIYPAPHTHGLGVHLTLDLAGQARFGPDVEWVDTIDYAVDPRRMEGFGDAIRRYWPGLPEHTLAPAYSGIRPKISGPD
EPAMDFRIDGPETHGFPGLVNLFGIESPGLTASLAIAGEIAARLEA

Specific function: Oxidizes L-2-hydroxyglutarate, probably to recover alpha-ketoglutarate mistakenly reduced by other enzymes or formed during growth on propionate [H]

COG id: COG0579

COG function: function code R; Predicted dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the L2HGDH family [H]

Homologues:

Organism=Homo sapiens, GI13376331, Length=271, Percent_Identity=31.7343173431734, Blast_Score=127, Evalue=2e-29,
Organism=Escherichia coli, GI87082148, Length=380, Percent_Identity=26.8421052631579, Blast_Score=111, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17565764, Length=276, Percent_Identity=36.9565217391304, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24585081, Length=399, Percent_Identity=29.3233082706767, Blast_Score=119, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015657
- InterPro:   IPR006076 [H]

Pfam domain/function: PF01266 DAO [H]

EC number: =1.1.3.15 [H]

Molecular weight: Translated: 38720; Mature: 38588

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDIDAIIIGAGVIGLATARELSMHGLSVIILESETEFGSATSSRNSEVIHAGLYYPAGS
CCCCEEEEEECCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCEEEEEEECCCCC
LKARLCVEGRQRLYDFCESHGVAHRHCGKLIVATSDDETPLLVALGAKGKANGCDDLELI
CEEEEHHHHHHHHHHHHHHCCCCHHCCCEEEEEECCCCCCEEEEECCCCCCCCCCHHHHH
DQRHALSLEPALACSSALLSPSTGIIDSHGYMLALLGEAQDHGAALALNAPFERAEAIGD
HCCCCCCCCHHHHHHHHHCCCCCCEEECCCEEEEEECCCCCCCEEEEECCCHHHHHHCCC
GFRVHVGGKEPVSLTCRLLVNSAGLVAPMVAAMIEGLPSVAIPQARFAKGSYFSLTGKSP
CEEEEECCCCCHHEEEEEEECCCCHHHHHHHHHHCCCCCCCCCHHHHCCCCEEEECCCCC
FSRLIYPAPHTHGLGVHLTLDLAGQARFGPDVEWVDTIDYAVDPRRMEGFGDAIRRYWPG
HHHEEECCCCCCCCEEEEEEEECCCCCCCCCCCCEEHHHHCCCCHHHHHHHHHHHHHCCC
LPEHTLAPAYSGIRPKISGPDEPAMDFRIDGPETHGFPGLVNLFGIESPGLTASLAIAGE
CCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCEEEEEECCCCCCEEEEEEHHH
IAARLEA
HHHHCCC
>Mature Secondary Structure 
TDIDAIIIGAGVIGLATARELSMHGLSVIILESETEFGSATSSRNSEVIHAGLYYPAGS
CCCEEEEEECCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCEEEEEEECCCCC
LKARLCVEGRQRLYDFCESHGVAHRHCGKLIVATSDDETPLLVALGAKGKANGCDDLELI
CEEEEHHHHHHHHHHHHHHCCCCHHCCCEEEEEECCCCCCEEEEECCCCCCCCCCHHHHH
DQRHALSLEPALACSSALLSPSTGIIDSHGYMLALLGEAQDHGAALALNAPFERAEAIGD
HCCCCCCCCHHHHHHHHHCCCCCCEEECCCEEEEEECCCCCCCEEEEECCCHHHHHHCCC
GFRVHVGGKEPVSLTCRLLVNSAGLVAPMVAAMIEGLPSVAIPQARFAKGSYFSLTGKSP
CEEEEECCCCCHHEEEEEEECCCCHHHHHHHHHHCCCCCCCCCHHHHCCCCEEEECCCCC
FSRLIYPAPHTHGLGVHLTLDLAGQARFGPDVEWVDTIDYAVDPRRMEGFGDAIRRYWPG
HHHEEECCCCCCCCEEEEEEEECCCCCCCCCCCCEEHHHHCCCCHHHHHHHHHHHHHCCC
LPEHTLAPAYSGIRPKISGPDEPAMDFRIDGPETHGFPGLVNLFGIESPGLTASLAIAGE
CCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCEEEEEECCCCCCEEEEEEHHH
IAARLEA
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 8297211; 7984428 [H]