Click here to switch to the map view.

The map label for this gene is ispA [H]

Identifier: 15889973

GI number: 15889973

Start: 2706550

End: 2707464

Strand: Direct

Name: ispA [H]

Synonym: Atu2721

Alternate gene names: 15889973

Gene position: 2706550-2707464 (Clockwise)

Preceding gene: 15889971

Following gene: 159185351

Centisome position: 95.25

GC content: 62.84

Gene sequence:

>915_bases
ATGGACGCTCAGATGACGAATTTCGAAACGCGGCTGCGCGAAAACGCGGCGAAAACCGAAGCGCTGCTTGGCCACCTGCT
TTCCGGCGAGGCGCGCGCGGACGAGATCACACGCCCGCAAAACCTGCTAGAGGCCATGCGCCATGGCGTGCTGAACGGCG
GCAAACGCCTGCGGCCTTTTCTTGTCATCGAGAGTGTCGCCCTTCTGGGCGGAGATGCCGAAGCCGGCCTCCACGTCGGC
GCAGCACTCGAATGCCTCCATTGTTATTCGCTTGTCCATGACGATCTGCCAGCCATGGACGACGACGACCTGCGCCGTGG
CCAGCCGACCGTGCACCGCAAATTCGACGAGGCAACCGCCATCCTCGCCGGTGACAGCCTGCTGACGCTTGCTTTCGACA
TAATCGCCTCGGATGACAATCCGCTGGCGGCCGAGCGCAAGGCCGCCCTCGTTATCTCGCTCGCGCGTGCCGCCGGTATT
GGTGGCATGGCTGGCGGGCAGGCCCTTGATCTCGCTGCCGAAAAGAAAGCGCCCGACGAGGATGGCATTATTACATTGCA
GGCTATGAAAACCGGTGCCTTGCTGCGTTTCGCCTGTGAGGCCGGCGCGATCATTGCCGGCAGCAATCAAGCCGAAAGGC
AGCGACTGCGCCTCTTCGGCGAAAAGATTGGCCTTTCCTTCCAGCTTGCCGACGATCTTCTGGATCTGACCGCCGATGCC
GCCACCATGGGCAAGGCGACCGGCAAGGATGCCGCACGCGGCAAGGGCACGCTGGTGGCCTTACGCGGCGAAGCATGGGC
ACGCGAAAAGCTTCAGGAGCAGGTGGCGGAAGCCAGCGAACTCCTCGCCCCCTACGGCGAAAAGGCCGCGATTCTCATCG
CGGCCGCAAGATTCATCGCCGAACGGAAAAGCTGA

Upstream 100 bases:

>100_bases
TAGTCCATTGCCGTCTTCAAGGCGAGTCCGGTCACGCTGTTGCGCCTTCGGAATCACGAAAAGGTTTGCCTGCATTCGTC
CGGCATGCCAAAGAGCGCGC

Downstream 100 bases:

>100_bases
CCTCTCAGCTTTTCATCATCCAATCAGCCCTTGAGCGGCGAAATCAGCACTTCGACGCGGCGGTTCTGCGCACGACCATC
CGACGTGGCATTCGAAGCAA

Product: geranyltranstransferase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MDAQMTNFETRLRENAAKTEALLGHLLSGEARADEITRPQNLLEAMRHGVLNGGKRLRPFLVIESVALLGGDAEAGLHVG
AALECLHCYSLVHDDLPAMDDDDLRRGQPTVHRKFDEATAILAGDSLLTLAFDIIASDDNPLAAERKAALVISLARAAGI
GGMAGGQALDLAAEKKAPDEDGIITLQAMKTGALLRFACEAGAIIAGSNQAERQRLRLFGEKIGLSFQLADDLLDLTADA
ATMGKATGKDAARGKGTLVALRGEAWAREKLQEQVAEASELLAPYGEKAAILIAAARFIAERKS

Sequences:

>Translated_304_residues
MDAQMTNFETRLRENAAKTEALLGHLLSGEARADEITRPQNLLEAMRHGVLNGGKRLRPFLVIESVALLGGDAEAGLHVG
AALECLHCYSLVHDDLPAMDDDDLRRGQPTVHRKFDEATAILAGDSLLTLAFDIIASDDNPLAAERKAALVISLARAAGI
GGMAGGQALDLAAEKKAPDEDGIITLQAMKTGALLRFACEAGAIIAGSNQAERQRLRLFGEKIGLSFQLADDLLDLTADA
ATMGKATGKDAARGKGTLVALRGEAWAREKLQEQVAEASELLAPYGEKAAILIAAARFIAERKS
>Mature_304_residues
MDAQMTNFETRLRENAAKTEALLGHLLSGEARADEITRPQNLLEAMRHGVLNGGKRLRPFLVIESVALLGGDAEAGLHVG
AALECLHCYSLVHDDLPAMDDDDLRRGQPTVHRKFDEATAILAGDSLLTLAFDIIASDDNPLAAERKAALVISLARAAGI
GGMAGGQALDLAAEKKAPDEDGIITLQAMKTGALLRFACEAGAIIAGSNQAERQRLRLFGEKIGLSFQLADDLLDLTADA
ATMGKATGKDAARGKGTLVALRGEAWAREKLQEQVAEASELLAPYGEKAAILIAAARFIAERKS

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=225, Percent_Identity=30.2222222222222, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1786623, Length=268, Percent_Identity=46.6417910447761, Blast_Score=181, Evalue=7e-47,
Organism=Escherichia coli, GI1789578, Length=215, Percent_Identity=32.093023255814, Blast_Score=107, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17505681, Length=186, Percent_Identity=29.5698924731183, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24651612, Length=232, Percent_Identity=28.448275862069, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 32199; Mature: 32199

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDAQMTNFETRLRENAAKTEALLGHLLSGEARADEITRPQNLLEAMRHGVLNGGKRLRPF
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHHHCCCCCCCHH
LVIESVALLGGDAEAGLHVGAALECLHCYSLVHDDLPAMDDDDLRRGQPTVHRKFDEATA
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCHHHHHHHHHHE
ILAGDSLLTLAFDIIASDDNPLAAERKAALVISLARAAGIGGMAGGQALDLAAEKKAPDE
EEECCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEHHHHCCCCCC
DGIITLQAMKTGALLRFACEAGAIIAGSNQAERQRLRLFGEKIGLSFQLADDLLDLTADA
CCEEEEEEHHCCHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHCCEEEHHHHHHHHHHHH
ATMGKATGKDAARGKGTLVALRGEAWAREKLQEQVAEASELLAPYGEKAAILIAAARFIA
HHHCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
ERKS
HCCC
>Mature Secondary Structure
MDAQMTNFETRLRENAAKTEALLGHLLSGEARADEITRPQNLLEAMRHGVLNGGKRLRPF
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHHHCCCCCCCHH
LVIESVALLGGDAEAGLHVGAALECLHCYSLVHDDLPAMDDDDLRRGQPTVHRKFDEATA
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCHHHHHHHHHHE
ILAGDSLLTLAFDIIASDDNPLAAERKAALVISLARAAGIGGMAGGQALDLAAEKKAPDE
EEECCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEHHHHCCCCCC
DGIITLQAMKTGALLRFACEAGAIIAGSNQAERQRLRLFGEKIGLSFQLADDLLDLTADA
CCEEEEEEHHCCHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHCCEEEHHHHHHHHHHHH
ATMGKATGKDAARGKGTLVALRGEAWAREKLQEQVAEASELLAPYGEKAAILIAAARFIA
HHHCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
ERKS
HCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9515931 [H]