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The map label for this gene is gda [H]

Identifier: 15889592

GI number: 15889592

Start: 2293053

End: 2294363

Strand: Direct

Name: gda [H]

Synonym: Atu2315

Alternate gene names: 15889592

Gene position: 2293053-2294363 (Clockwise)

Preceding gene: 159185155

Following gene: 159185156

Centisome position: 80.7

GC content: 59.88

Gene sequence:

>1311_bases
ATGAGCATGGTTCTGCTGCGTGGCCGCCTGCTGAGCTTCCGCCGCGCGCCGCTCTCGATCGACGATACGCAAAGCTATCT
TTATATCGAAGACGGCGGCCTGCTTCTCGAAAACGGCAGGATTGCCGCCATCGGCGAATACGCCGATATTCGCGAGACAG
CGCCGGAGGACGTCGAGGAAAAGGACCACCGCCCGCATCTCATCGTGCCCGGCCTCATCGACATGCACCTGCATTTCCCG
CAGATGCAGGTCATCGGCTCCTATGCCGCCAATCTCTTGGAATGGTTGAACACCTATACGTTTCCGGAAGAATGCCGCTT
CGTCGAAAGCGCCCATGCCCAGCGCATCGCCACGCATTTTTACGACGAGCTGCTGCGCCACGGCACCACCACGGCCGCTG
CCTATTGCTCCGTGCACAAAACCTCCGCCGACGCCTTTTTTACTGAGGCCATGAAGCGCAACATGCTGATGATCGGCGGC
AAGGTGATGATGGACCGCAACGCTCCGCAGGGCCTGCTGGACACGCCGGAAACCTCCTATGACGAGACGCGTCAGGTGAT
TGCCGACTGGCACGGCAGGGGCCGCAACCACGTCGCCATCACCCCCCGCTTCGCCATCACCTCCACGCCGAAGCAGATGG
AAGCCGCCCAGGCGCTGGCGCAGGAATTTCCCGATCTCTTCATCCAGACGCATCTTTCCGAAAATCTGGACGAGATCAAA
TATACCTGCGAACTCTATCCCGAAGCGACTGACTATACCGATATCTATGTGCGTTACGGCCTGATGGGCAACAAGACCCT
GCTCGGTCACGCCATCCACCTCTCCGATCGCGAAGCGGACGTACTGTCGGAAACCGGCGCGGTCGCCGTACATTGCCCCA
CTTCCAACCTCTTCATCGGCTCCGGCCTGTTCCCGATGAAAAAGCTGCAACGACGTGAAAAGCCTGTTCGTATCGCAGTC
GCGACCGATATTGGCGGCGGATCGAGCTATTCCATGCTGCGCACCATGGATGAGGCCTACAAGATCCAGCAATTGCTGGG
CGAACGCCTCAACCCGCTGGAAAGCTGGTATCTGATGACCCGCGGCAATGCCGAAGCGCTTTCGATGGTTGACCGCATCG
GCACGCTGGAGGCAGGCACGGACGCCGACATCACGGTGCTCAATGCCTCCTCGACGCCGGCCATGGCGCTGAAGATGGAA
GTCGTGAAAAGCCTGACGGAAGAACTGTTCCTGATGCTGACCATGGGCGACGACCGCACGGTGGTGGAGACCTATGTGGC
CGGCAGGGCGATGAAGAGCGTGCTGGCATAG

Upstream 100 bases:

>100_bases
CCGGCAACATCACCGCCATCACCCCGGATGAGCGCAAGGTGCTGACCGCCTGGTACGAAAGCGCGGTTTCCGGGGCCGGA
AAAGCCGAAGGAAAGACTGA

Downstream 100 bases:

>100_bases
TTCGGCTGGGGCCGAAACATAAGGTCACGATCTCGCTTAAACCAATATCCATGGAGTGAGCGGATGCCGCTTGTTTCTTC
TCCCCGCCGGGGAGAAGAAC

Product: guanine deaminase

Products: NA

Alternate protein names: Guanase; Guanine aminase; Guanine aminohydrolase; GAH [H]

Number of amino acids: Translated: 436; Mature: 435

Protein sequence:

>436_residues
MSMVLLRGRLLSFRRAPLSIDDTQSYLYIEDGGLLLENGRIAAIGEYADIRETAPEDVEEKDHRPHLIVPGLIDMHLHFP
QMQVIGSYAANLLEWLNTYTFPEECRFVESAHAQRIATHFYDELLRHGTTTAAAYCSVHKTSADAFFTEAMKRNMLMIGG
KVMMDRNAPQGLLDTPETSYDETRQVIADWHGRGRNHVAITPRFAITSTPKQMEAAQALAQEFPDLFIQTHLSENLDEIK
YTCELYPEATDYTDIYVRYGLMGNKTLLGHAIHLSDREADVLSETGAVAVHCPTSNLFIGSGLFPMKKLQRREKPVRIAV
ATDIGGGSSYSMLRTMDEAYKIQQLLGERLNPLESWYLMTRGNAEALSMVDRIGTLEAGTDADITVLNASSTPAMALKME
VVKSLTEELFLMLTMGDDRTVVETYVAGRAMKSVLA

Sequences:

>Translated_436_residues
MSMVLLRGRLLSFRRAPLSIDDTQSYLYIEDGGLLLENGRIAAIGEYADIRETAPEDVEEKDHRPHLIVPGLIDMHLHFP
QMQVIGSYAANLLEWLNTYTFPEECRFVESAHAQRIATHFYDELLRHGTTTAAAYCSVHKTSADAFFTEAMKRNMLMIGG
KVMMDRNAPQGLLDTPETSYDETRQVIADWHGRGRNHVAITPRFAITSTPKQMEAAQALAQEFPDLFIQTHLSENLDEIK
YTCELYPEATDYTDIYVRYGLMGNKTLLGHAIHLSDREADVLSETGAVAVHCPTSNLFIGSGLFPMKKLQRREKPVRIAV
ATDIGGGSSYSMLRTMDEAYKIQQLLGERLNPLESWYLMTRGNAEALSMVDRIGTLEAGTDADITVLNASSTPAMALKME
VVKSLTEELFLMLTMGDDRTVVETYVAGRAMKSVLA
>Mature_435_residues
SMVLLRGRLLSFRRAPLSIDDTQSYLYIEDGGLLLENGRIAAIGEYADIRETAPEDVEEKDHRPHLIVPGLIDMHLHFPQ
MQVIGSYAANLLEWLNTYTFPEECRFVESAHAQRIATHFYDELLRHGTTTAAAYCSVHKTSADAFFTEAMKRNMLMIGGK
VMMDRNAPQGLLDTPETSYDETRQVIADWHGRGRNHVAITPRFAITSTPKQMEAAQALAQEFPDLFIQTHLSENLDEIKY
TCELYPEATDYTDIYVRYGLMGNKTLLGHAIHLSDREADVLSETGAVAVHCPTSNLFIGSGLFPMKKLQRREKPVRIAVA
TDIGGGSSYSMLRTMDEAYKIQQLLGERLNPLESWYLMTRGNAEALSMVDRIGTLEAGTDADITVLNASSTPAMALKMEV
VKSLTEELFLMLTMGDDRTVVETYVAGRAMKSVLA

Specific function: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia [H]

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATZ/TRZ family [H]

Homologues:

Organism=Homo sapiens, GI4758426, Length=391, Percent_Identity=33.2480818414322, Blast_Score=198, Evalue=7e-51,
Organism=Escherichia coli, GI1789249, Length=425, Percent_Identity=45.1764705882353, Blast_Score=402, Evalue=1e-113,
Organism=Saccharomyces cerevisiae, GI6319963, Length=359, Percent_Identity=30.9192200557103, Blast_Score=179, Evalue=9e-46,
Organism=Drosophila melanogaster, GI24643849, Length=444, Percent_Identity=31.7567567567568, Blast_Score=195, Evalue=6e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR014311
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.4.3 [H]

Molecular weight: Translated: 48727; Mature: 48596

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS00146 BETA_LACTAMASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMVLLRGRLLSFRRAPLSIDDTQSYLYIEDGGLLLENGRIAAIGEYADIRETAPEDVEE
CCEEEEHHHHHHHHCCCCCCCCCCCEEEEECCCEEEECCEEEEECCHHHHHHCCCCCHHH
KDHRPHLIVPGLIDMHLHFPQMQVIGSYAANLLEWLNTYTFPEECRFVESAHAQRIATHF
HCCCCEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
YDELLRHGTTTAAAYCSVHKTSADAFFTEAMKRNMLMIGGKVMMDRNAPQGLLDTPETSY
HHHHHHCCCCHHHHHHEEECCCHHHHHHHHHHCCEEEECCEEEECCCCCCCCCCCCCCCH
DETRQVIADWHGRGRNHVAITPRFAITSTPKQMEAAQALAQEFPDLFIQTHLSENLDEIK
HHHHHHHHHHCCCCCCEEEEECCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHE
YTCELYPEATDYTDIYVRYGLMGNKTLLGHAIHLSDREADVLSETGAVAVHCPTSNLFIG
EEEEECCCCCCCEEEEEEECCCCCCEEEEEEEEECCCCHHHHHCCCCEEEECCCCCEEEC
SGLFPMKKLQRREKPVRIAVATDIGGGSSYSMLRTMDEAYKIQQLLGERLNPLESWYLMT
CCCCHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHEEEEE
RGNAEALSMVDRIGTLEAGTDADITVLNASSTPAMALKMEVVKSLTEELFLMLTMGDDRT
CCCHHHHHHHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHEEEEEECCCCH
VVETYVAGRAMKSVLA
HHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SMVLLRGRLLSFRRAPLSIDDTQSYLYIEDGGLLLENGRIAAIGEYADIRETAPEDVEE
CEEEEHHHHHHHHCCCCCCCCCCCEEEEECCCEEEECCEEEEECCHHHHHHCCCCCHHH
KDHRPHLIVPGLIDMHLHFPQMQVIGSYAANLLEWLNTYTFPEECRFVESAHAQRIATHF
HCCCCEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
YDELLRHGTTTAAAYCSVHKTSADAFFTEAMKRNMLMIGGKVMMDRNAPQGLLDTPETSY
HHHHHHCCCCHHHHHHEEECCCHHHHHHHHHHCCEEEECCEEEECCCCCCCCCCCCCCCH
DETRQVIADWHGRGRNHVAITPRFAITSTPKQMEAAQALAQEFPDLFIQTHLSENLDEIK
HHHHHHHHHHCCCCCCEEEEECCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHE
YTCELYPEATDYTDIYVRYGLMGNKTLLGHAIHLSDREADVLSETGAVAVHCPTSNLFIG
EEEEECCCCCCCEEEEEEECCCCCCEEEEEEEEECCCCHHHHHCCCCEEEECCCCCEEEC
SGLFPMKKLQRREKPVRIAVATDIGGGSSYSMLRTMDEAYKIQQLLGERLNPLESWYLMT
CCCCHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHEEEEE
RGNAEALSMVDRIGTLEAGTDADITVLNASSTPAMALKMEVVKSLTEELFLMLTMGDDRT
CCCHHHHHHHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHEEEEEECCCCH
VVETYVAGRAMKSVLA
HHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 10913105 [H]