Click here to switch to the map view.

The map label for this gene is norM

Identifier: 15889451

GI number: 15889451

Start: 2143463

End: 2144860

Strand: Reverse

Name: norM

Synonym: Atu2172

Alternate gene names: 15889451

Gene position: 2144860-2143463 (Counterclockwise)

Preceding gene: 15889454

Following gene: 15889448

Centisome position: 75.48

GC content: 59.44

Gene sequence:

>1398_bases
ATGTCTTCGTCGGTTGTTGCAGAAACCGTTCCTTCCGGATCGGGGTCGTGGTTTTCGCATTTCAAGGCTACGCTCGTTCT
CGGGATTCCGCTTATCGGCGCCCAGCTTGCTCAGCTTGGTATCCACACCACTGATATGGTGATCGTCGGTCAGCTGGGAG
CAGAGAAGCTTGCGGCCATGGTGCTGGCCGGACAGTTCTTCTTCGTCGTCTTTATTTTCGGCTCGGGCTTTTCTGTTGCC
GTCGTGCCGATGGTGGCGCAGGCTTACGGGCAGGGCGATGCGACATCGGCCCGCCGCTCGCTGCGCATGGGCATGTGGGT
GGCGATCGCCTATTGGCTGCTCGCCTTGCCGATCTTCTTCAATGCCGAACGCATTCTGGTCTATCTCGGGCAGAACCCCA
ATGTTGCGGCACTGACCGGCCATTATCTCGCCATTGCCAAGTTCGGCCTCCTGCCGGCGCTGCTTTTTTATGTGCTGCGC
GGGCTTGTCAGCGCCATCGGCCGTGCAGGCATCATTCTTTATGTCACCATCATCATGCTGGTGATGAACGGTCTGATGGC
CTATGTGCTGGTCTTCGGCCATTTCGGATTGCCGGCGATGGGCATGAATGGTGCTGCCGTTGTTGCCGTCATCGTTAATG
CCTTCAGCTTCATCTTCATCGTCGCTTATGTGCAGACGCGGGAGGAAACGAAGAAATACGAGCTGTTCGTGCGCTTCTGG
CGGCCGGACTGGCATGCGCTTTTCGAAGTCCTGCGGCTTGGCCTGCCGATCAGCATCACCATTCTAGCCGAAGTGACGCT
GTTTGCGGCCGCTTCGATCCTGATGGGGCAGATCGGCACGGTGCAACTTGCCGCCCACGGTATTGCCCTCCAGCTCGCCT
CCATCGCCTTCATGATTCCGCTTGGTCTTTCCCAAGCGGCGACGGTGCGTGTGGGCGTGGCGCGCGGGCAGGGGGATTTC
AAAAACCTCATCCGCGCCTCGATCATGATCTATGCCATCGCCTGTGGCATCGCCCTTTGCGGTGGCATCCTGTTTGCGGC
CGTGCCGGAATTCCTGGCGAAATGGTTCCTCGATCCGAAATTGCCGGAAGCTGCTGAAGTGCTTGCCTATGCCAGCAGCC
TCGTGGTGATTGCCGGCATCTTCCAGCTGGTGGACGGCATTCAGGCCGTGACGGCAGGTTTGCTGCGTGGCCTTAAGGAT
GCACGCATACCGGCGATGCTGGCGCTGATTTCCTATTGGCCGATCGGGCTGGCGCTCGCCTGGACCATGGCCTTTCCGCT
CGGCTTTGGCGGGCGCGGCGTATGGTTCGGTTTCGTGATCGGTCTTTCGACGGCCGCCGTTCTGTTGACGGTGCGCTTCG
TGCTCTTGGTGAAGCGCGAAATGAAAACGGCCCGCTAA

Upstream 100 bases:

>100_bases
CGCACTGCTGCCGGTTGCGTGCAGGATGGGAATATTTTATTCATCCTCGTGCTGCCGTTGCGCAATTCGCGGGCAACGGC
CAAGGTTCAGGTGAATTACA

Downstream 100 bases:

>100_bases
AAGCGGGCCGTCGGGTGGTCATCCGGCCATGGCGCGTCTGCGCCTCGAAAAGAGTTCCTCACGGGATGCCTCAATCGCAA
GCCTTGTCTTGTCTGGGTTC

Product: multidrug efflux protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter

Number of amino acids: Translated: 465; Mature: 464

Protein sequence:

>465_residues
MSSSVVAETVPSGSGSWFSHFKATLVLGIPLIGAQLAQLGIHTTDMVIVGQLGAEKLAAMVLAGQFFFVVFIFGSGFSVA
VVPMVAQAYGQGDATSARRSLRMGMWVAIAYWLLALPIFFNAERILVYLGQNPNVAALTGHYLAIAKFGLLPALLFYVLR
GLVSAIGRAGIILYVTIIMLVMNGLMAYVLVFGHFGLPAMGMNGAAVVAVIVNAFSFIFIVAYVQTREETKKYELFVRFW
RPDWHALFEVLRLGLPISITILAEVTLFAAASILMGQIGTVQLAAHGIALQLASIAFMIPLGLSQAATVRVGVARGQGDF
KNLIRASIMIYAIACGIALCGGILFAAVPEFLAKWFLDPKLPEAAEVLAYASSLVVIAGIFQLVDGIQAVTAGLLRGLKD
ARIPAMLALISYWPIGLALAWTMAFPLGFGGRGVWFGFVIGLSTAAVLLTVRFVLLVKREMKTAR

Sequences:

>Translated_465_residues
MSSSVVAETVPSGSGSWFSHFKATLVLGIPLIGAQLAQLGIHTTDMVIVGQLGAEKLAAMVLAGQFFFVVFIFGSGFSVA
VVPMVAQAYGQGDATSARRSLRMGMWVAIAYWLLALPIFFNAERILVYLGQNPNVAALTGHYLAIAKFGLLPALLFYVLR
GLVSAIGRAGIILYVTIIMLVMNGLMAYVLVFGHFGLPAMGMNGAAVVAVIVNAFSFIFIVAYVQTREETKKYELFVRFW
RPDWHALFEVLRLGLPISITILAEVTLFAAASILMGQIGTVQLAAHGIALQLASIAFMIPLGLSQAATVRVGVARGQGDF
KNLIRASIMIYAIACGIALCGGILFAAVPEFLAKWFLDPKLPEAAEVLAYASSLVVIAGIFQLVDGIQAVTAGLLRGLKD
ARIPAMLALISYWPIGLALAWTMAFPLGFGGRGVWFGFVIGLSTAAVLLTVRFVLLVKREMKTAR
>Mature_464_residues
SSSVVAETVPSGSGSWFSHFKATLVLGIPLIGAQLAQLGIHTTDMVIVGQLGAEKLAAMVLAGQFFFVVFIFGSGFSVAV
VPMVAQAYGQGDATSARRSLRMGMWVAIAYWLLALPIFFNAERILVYLGQNPNVAALTGHYLAIAKFGLLPALLFYVLRG
LVSAIGRAGIILYVTIIMLVMNGLMAYVLVFGHFGLPAMGMNGAAVVAVIVNAFSFIFIVAYVQTREETKKYELFVRFWR
PDWHALFEVLRLGLPISITILAEVTLFAAASILMGQIGTVQLAAHGIALQLASIAFMIPLGLSQAATVRVGVARGQGDFK
NLIRASIMIYAIACGIALCGGILFAAVPEFLAKWFLDPKLPEAAEVLAYASSLVVIAGIFQLVDGIQAVTAGLLRGLKDA
RIPAMLALISYWPIGLALAWTMAFPLGFGGRGVWFGFVIGLSTAAVLLTVRFVLLVKREMKTAR

Specific function: Multidrug efflux pump

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family

Homologues:

Organism=Homo sapiens, GI153792564, Length=425, Percent_Identity=26.8235294117647, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI38261960, Length=464, Percent_Identity=25.8620689655172, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI22907060, Length=434, Percent_Identity=25.8064516129032, Blast_Score=103, Evalue=5e-22,
Organism=Escherichia coli, GI48994890, Length=453, Percent_Identity=29.3598233995585, Blast_Score=182, Evalue=6e-47,
Organism=Escherichia coli, GI226510954, Length=450, Percent_Identity=22.4444444444444, Blast_Score=66, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6320545, Length=394, Percent_Identity=23.0964467005076, Blast_Score=67, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6321821, Length=397, Percent_Identity=25.6926952141058, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NORM_AGRT5 (Q8UDF5)

Other databases:

- EMBL:   AE007869
- PIR:   AC2843
- PIR:   D97620
- RefSeq:   NP_355132.1
- STRING:   Q8UDF5
- GeneID:   1134210
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu2172
- eggNOG:   COG0534
- HOGENOM:   HBG479615
- OMA:   IRASIMI
- PhylomeDB:   Q8UDF5
- ProtClustDB:   CLSK800498
- BioCyc:   ATUM176299-1:ATU2172-MONOMER
- InterPro:   IPR002528
- PANTHER:   PTHR11206
- TIGRFAMs:   TIGR00797

Pfam domain/function: PF01554 MatE

EC number: NA

Molecular weight: Translated: 49726; Mature: 49595

Theoretical pI: Translated: 10.12; Mature: 10.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xfe491a4)-; HASH(0xd529134)-; HASH(0xff8d9e8)-; HASH(0xba7b774)-; HASH(0xff5c244)-; HASH(0x1009aa08)-; HASH(0xf89e35c)-; HASH(0xff5fd68)-; HASH(0x104d3a3c)-; HASH(0xfd7ee2c)-; HASH(0xf921c10)-;

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSSVVAETVPSGSGSWFSHFKATLVLGIPLIGAQLAQLGIHTTDMVIVGQLGAEKLAAM
CCCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHH
VLAGQFFFVVFIFGSGFSVAVVPMVAQAYGQGDATSARRSLRMGMWVAIAYWLLALPIFF
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
NAERILVYLGQNPNVAALTGHYLAIAKFGLLPALLFYVLRGLVSAIGRAGIILYVTIIML
CCCEEEEEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
VMNGLMAYVLVFGHFGLPAMGMNGAAVVAVIVNAFSFIFIVAYVQTREETKKYELFVRFW
HHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEE
RPDWHALFEVLRLGLPISITILAEVTLFAAASILMGQIGTVQLAAHGIALQLASIAFMIP
CCCHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
LGLSQAATVRVGVARGQGDFKNLIRASIMIYAIACGIALCGGILFAAVPEFLAKWFLDPK
CCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
LPEAAEVLAYASSLVVIAGIFQLVDGIQAVTAGLLRGLKDARIPAMLALISYWPIGLALA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
WTMAFPLGFGGRGVWFGFVIGLSTAAVLLTVRFVLLVKREMKTAR
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
>Mature Secondary Structure 
SSSVVAETVPSGSGSWFSHFKATLVLGIPLIGAQLAQLGIHTTDMVIVGQLGAEKLAAM
CCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHH
VLAGQFFFVVFIFGSGFSVAVVPMVAQAYGQGDATSARRSLRMGMWVAIAYWLLALPIFF
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
NAERILVYLGQNPNVAALTGHYLAIAKFGLLPALLFYVLRGLVSAIGRAGIILYVTIIML
CCCEEEEEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
VMNGLMAYVLVFGHFGLPAMGMNGAAVVAVIVNAFSFIFIVAYVQTREETKKYELFVRFW
HHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEE
RPDWHALFEVLRLGLPISITILAEVTLFAAASILMGQIGTVQLAAHGIALQLASIAFMIP
CCCHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
LGLSQAATVRVGVARGQGDFKNLIRASIMIYAIACGIALCGGILFAAVPEFLAKWFLDPK
CCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
LPEAAEVLAYASSLVVIAGIFQLVDGIQAVTAGLLRGLKDARIPAMLALISYWPIGLALA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
WTMAFPLGFGGRGVWFGFVIGLSTAAVLLTVRFVLLVKREMKTAR
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194