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The map label for this gene is murC

Identifier: 15889377

GI number: 15889377

Start: 2056028

End: 2057443

Strand: Reverse

Name: murC

Synonym: Atu2093

Alternate gene names: 15889377

Gene position: 2057443-2056028 (Counterclockwise)

Preceding gene: 15889378

Following gene: 15889376

Centisome position: 72.4

GC content: 59.53

Gene sequence:

>1416_bases
ATGAAGATGCCGAAAGCCATAGGCCTTGTGCATTTCATCGGCATAGGCGGGATCGGCATGAGCGGCATTGCCGAAGTGCT
TCACAATCTCGGCCATCGCGTTCAGGGGTCGGATCAGGCCGACAGCGCCAATGTGCAGCGCCTGCGCGACAAGGGCATCG
AGGTTTTCGTTGGCCACACGGCGGATAATCTCGGTGATGCCGAGGTCGTTGTCGTTTCCACCGCAATCAAGAAGAACAAC
CCGGAACTGATCGCCGCGCGTGAAAAACACCTGCCGATCGTTCGCCGCGCCGAAATGCTGGCCGAGTTGATGCGTTTCCG
CAATGCCATCGCCATTGGCGGCACCCACGGCAAGACAACGACGACCTCCATGGTCGCAACGCTGCTCGAAGCCGGCAATC
TCGACCCGACCGTCATCAATGGCGGCATCATCAATGCCTATGGCACCAATGCGCGCATGGGCGAGGGCGAGTGGATGGTG
GTGGAGGCCGACGAATCCGACGGCACCTTCCTGAAGCTGCCGGCCGATGTGGCCGTCATCACCAATATCGATCCGGAGCA
TCTGGATCACTATGGCAATTTCGACGCCGTGCGCGCTGCTTTCCGACAGTTCGTCGAGAACGTGCCGTTCTACGGTTTCG
GCGTCATGTGCCTCGATCACCCTGAAGTGCAGGCGCTGGTCGGCCGGATCGAGGACCGCAAGGTCATCACATACGGTGAG
AACCCGCAGGCCGACGTGCGGTTCTCGAATGTCCGCATCGATGGTACGCGGTCGATCTTCGACGTGGAAATCCGTCGTCG
CCGCACCGGCAAGATATTCTCCTTCAAGGACCTCGTACTGCCGATGCCCGGACGCCACAATGTGTCCAATGCAACGGCGG
CGATTGCCGTTGCCAACCGTCTCGGCATCTCGGAAGCCGACATCAAGAAGGGACTTGCCTCCTTTGCCGGTGTCAAGCGT
CGCTTCACGCTGACGGGTGAGGCCAATGGCGTGCAGGTCTTCGACGATTACGGCCATCATCCGGTTGAGATCAAGGCCGT
GCTGGCGGCAGCGCGGGAGGCCTGCAAGGGTCGCATCATCGCCGTGCACCAACCGCACCGCTACAGCCGTCTTTCCAGCC
TGTTTGACGATTTCGCCCATTGTTTCAACGATGCCGATACGATTCTTCTTGCCCCGGTCTATGCTGCGGGCGAAGATCCA
ATCGAAGGTGCAAGCTCGGAAGCGCTGGTTTCGGCCATCAAGGCCGCCGGTCACCGCGATGCCCGTTTCCTCGAAAAACG
GGAGGACCTTGCGTCGCAGGTCGCAGCCATTGCGAATCCGGGTGATTTTGTGGTTCTCTTGGGGGCTGGAAATATCACAC
AATGGGCAGCCGCGCTGCCTTCGGAATTGAAGAGCATATCAGGAAAGTCTGAATGA

Upstream 100 bases:

>100_bases
GAAAACCGCATGCGGCGGATGTGCTGGCCGATCTGGTCGAGGCGATTGCCGAAGGCCGGTCCGTACAGGAATTCAAGAAG
AAGAATGAAGGAGTTGGGGC

Downstream 100 bases:

>100_bases
GACAGGTCGATGGGGTTAAATTGCTGGGGAGGCTCGGCGACGGGGTAAATGAATTGCGGGGACGTCTGACACCGGATGCG
CCCATGGACCGCGTGACGTG

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 471; Mature: 471

Protein sequence:

>471_residues
MKMPKAIGLVHFIGIGGIGMSGIAEVLHNLGHRVQGSDQADSANVQRLRDKGIEVFVGHTADNLGDAEVVVVSTAIKKNN
PELIAAREKHLPIVRRAEMLAELMRFRNAIAIGGTHGKTTTTSMVATLLEAGNLDPTVINGGIINAYGTNARMGEGEWMV
VEADESDGTFLKLPADVAVITNIDPEHLDHYGNFDAVRAAFRQFVENVPFYGFGVMCLDHPEVQALVGRIEDRKVITYGE
NPQADVRFSNVRIDGTRSIFDVEIRRRRTGKIFSFKDLVLPMPGRHNVSNATAAIAVANRLGISEADIKKGLASFAGVKR
RFTLTGEANGVQVFDDYGHHPVEIKAVLAAAREACKGRIIAVHQPHRYSRLSSLFDDFAHCFNDADTILLAPVYAAGEDP
IEGASSEALVSAIKAAGHRDARFLEKREDLASQVAAIANPGDFVVLLGAGNITQWAAALPSELKSISGKSE

Sequences:

>Translated_471_residues
MKMPKAIGLVHFIGIGGIGMSGIAEVLHNLGHRVQGSDQADSANVQRLRDKGIEVFVGHTADNLGDAEVVVVSTAIKKNN
PELIAAREKHLPIVRRAEMLAELMRFRNAIAIGGTHGKTTTTSMVATLLEAGNLDPTVINGGIINAYGTNARMGEGEWMV
VEADESDGTFLKLPADVAVITNIDPEHLDHYGNFDAVRAAFRQFVENVPFYGFGVMCLDHPEVQALVGRIEDRKVITYGE
NPQADVRFSNVRIDGTRSIFDVEIRRRRTGKIFSFKDLVLPMPGRHNVSNATAAIAVANRLGISEADIKKGLASFAGVKR
RFTLTGEANGVQVFDDYGHHPVEIKAVLAAAREACKGRIIAVHQPHRYSRLSSLFDDFAHCFNDADTILLAPVYAAGEDP
IEGASSEALVSAIKAAGHRDARFLEKREDLASQVAAIANPGDFVVLLGAGNITQWAAALPSELKSISGKSE
>Mature_471_residues
MKMPKAIGLVHFIGIGGIGMSGIAEVLHNLGHRVQGSDQADSANVQRLRDKGIEVFVGHTADNLGDAEVVVVSTAIKKNN
PELIAAREKHLPIVRRAEMLAELMRFRNAIAIGGTHGKTTTTSMVATLLEAGNLDPTVINGGIINAYGTNARMGEGEWMV
VEADESDGTFLKLPADVAVITNIDPEHLDHYGNFDAVRAAFRQFVENVPFYGFGVMCLDHPEVQALVGRIEDRKVITYGE
NPQADVRFSNVRIDGTRSIFDVEIRRRRTGKIFSFKDLVLPMPGRHNVSNATAAIAVANRLGISEADIKKGLASFAGVKR
RFTLTGEANGVQVFDDYGHHPVEIKAVLAAAREACKGRIIAVHQPHRYSRLSSLFDDFAHCFNDADTILLAPVYAAGEDP
IEGASSEALVSAIKAAGHRDARFLEKREDLASQVAAIANPGDFVVLLGAGNITQWAAALPSELKSISGKSE

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=466, Percent_Identity=43.3476394849785, Blast_Score=327, Evalue=8e-91,
Organism=Escherichia coli, GI1790680, Length=470, Percent_Identity=30, Blast_Score=184, Evalue=8e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_AGRT5 (Q8UDM9)

Other databases:

- EMBL:   AE007869
- PIR:   AF2833
- PIR:   B97611
- RefSeq:   NP_355058.1
- ProteinModelPortal:   Q8UDM9
- SMR:   Q8UDM9
- STRING:   Q8UDM9
- GeneID:   1134131
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu2093
- eggNOG:   COG0773
- HOGENOM:   HBG476594
- OMA:   YQPHRYS
- PhylomeDB:   Q8UDM9
- ProtClustDB:   PRK00421
- BioCyc:   ATUM176299-1:ATU2093-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 50800; Mature: 50800

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMPKAIGLVHFIGIGGIGMSGIAEVLHNLGHRVQGSDQADSANVQRLRDKGIEVFVGHT
CCCCHHHHHHHEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCEEEEECC
ADNLGDAEVVVVSTAIKKNNPELIAAREKHLPIVRRAEMLAELMRFRNAIAIGGTHGKTT
CCCCCCCEEEEEEEECCCCCCCEEEEHHHCCCHHHHHHHHHHHHHHHCEEEECCCCCCCH
TTSMVATLLEAGNLDPTVINGGIINAYGTNARMGEGEWMVVEADESDGTFLKLPADVAVI
HHHHHHHHHHHCCCCCEEEECCEEEECCCCCCCCCCCEEEEEECCCCCCEEEECCCEEEE
TNIDPEHLDHYGNFDAVRAAFRQFVENVPFYGFGVMCLDHPEVQALVGRIEDRKVITYGE
ECCCHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHCCCCCEEEEECC
NPQADVRFSNVRIDGTRSIFDVEIRRRRTGKIFSFKDLVLPMPGRHNVSNATAAIAVANR
CCCCCEEEEEEEECCCCCEEEEEHHHCCCCCEEEECCEEECCCCCCCCCCHHHHHHHHHH
LGISEADIKKGLASFAGVKRRFTLTGEANGVQVFDDYGHHPVEIKAVLAAAREACKGRII
CCCCHHHHHHHHHHHHCCCEEEEEECCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCEE
AVHQPHRYSRLSSLFDDFAHCFNDADTILLAPVYAAGEDPIEGASSEALVSAIKAAGHRD
EEECCHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCH
ARFLEKREDLASQVAAIANPGDFVVLLGAGNITQWAAALPSELKSISGKSE
HHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKMPKAIGLVHFIGIGGIGMSGIAEVLHNLGHRVQGSDQADSANVQRLRDKGIEVFVGHT
CCCCHHHHHHHEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCEEEEECC
ADNLGDAEVVVVSTAIKKNNPELIAAREKHLPIVRRAEMLAELMRFRNAIAIGGTHGKTT
CCCCCCCEEEEEEEECCCCCCCEEEEHHHCCCHHHHHHHHHHHHHHHCEEEECCCCCCCH
TTSMVATLLEAGNLDPTVINGGIINAYGTNARMGEGEWMVVEADESDGTFLKLPADVAVI
HHHHHHHHHHHCCCCCEEEECCEEEECCCCCCCCCCCEEEEEECCCCCCEEEECCCEEEE
TNIDPEHLDHYGNFDAVRAAFRQFVENVPFYGFGVMCLDHPEVQALVGRIEDRKVITYGE
ECCCHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHCCCCCEEEEECC
NPQADVRFSNVRIDGTRSIFDVEIRRRRTGKIFSFKDLVLPMPGRHNVSNATAAIAVANR
CCCCCEEEEEEEECCCCCEEEEEHHHCCCCCEEEECCEEECCCCCCCCCCHHHHHHHHHH
LGISEADIKKGLASFAGVKRRFTLTGEANGVQVFDDYGHHPVEIKAVLAAAREACKGRII
CCCCHHHHHHHHHHHHCCCEEEEEECCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCEE
AVHQPHRYSRLSSLFDDFAHCFNDADTILLAPVYAAGEDPIEGASSEALVSAIKAAGHRD
EEECCHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCH
ARFLEKREDLASQVAAIANPGDFVVLLGAGNITQWAAALPSELKSISGKSE
HHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194