Definition Agrobacterium tumefaciens str. C58 chromosome circular, complete sequence.
Accession NC_003062
Length 2,841,580

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The map label for this gene is yeaE [H]

Identifier: 15889320

GI number: 15889320

Start: 1991410

End: 1992255

Strand: Direct

Name: yeaE [H]

Synonym: Atu2032

Alternate gene names: 15889320

Gene position: 1991410-1992255 (Clockwise)

Preceding gene: 15889319

Following gene: 159185022

Centisome position: 70.08

GC content: 60.76

Gene sequence:

>846_bases
ATGCATGAGGATATTCCTGCCGTCACCCTGCCCTCTGGAAATGAGGTTCCAGCCCTCGGACTTGGCACCTGGAATATGGG
CGAGACGAGATCATCGGCAGACGACGAGATTGAAAGCATCCGCAAGGCGATCGATCTCGGCATGACGTTGGTCGACACCG
CGGAAATGTATGCCGACGGCCGGTCGGAAGAAGTGGTCGGCACGGCAATCGCCGGCCGCCGCGACGAGGTGTTTCTGGTC
AGCAAGGTCTATCCCTGGAATGCCAGCGCGAGAGGCACTGCGGAAGCGTGCGAGCGCAGCCTCGCAAGGCTCGGCACCGA
CCACATCGACCTCTATCTGCTGCACTGGCGCGGCGAGCACCCGCTTGGCGAAACCGTGGCCGCGTTCGAAAGGCTGAAGA
GCGACGGCAAGATCGGCAACTGGGGCGTCTCCAATTTCGATACCGACGATATGGAGGAGCTTTTCACCGTTCCAGAGGGC
AAAAACTGCGCCGCCAATCAGGTGCTCTATAACCTCTCCCGGCGCGGACCTGAATTTTCCCTTCTGCCCTGGTGCCAGGA
GCACGGCGTGCCGCTGATGGCCTATTCCCCCATCGAGCAGGGCCGTATCCTGAAGAACCACGAACTCATTCGCATCGCCA
AGGCTTATCAGGCAACCCCGGCGCAGCTGGCCTTGGCCTTTCTTTTGGATAGGGACGGCGTCATCGCCATTCCAAAATCC
GCCAGCGTGTCCCGTATCGTGGAAAATCGCGGCGCCACCGATCTTGAAATAACCGAGGAAGACTGGACCGCCCTCGACGC
CGCCTTCCCGCCGCCGACGCGCAAGACGTCCTTGGAAATGCTCTGA

Upstream 100 bases:

>100_bases
GACGAGGTCAAATTTTTTGATGGATCGATCGTCTCCGCCATGGGTTTGAGAAGTCGACACAAAAGACTATTGTCCAATCG
ACAACCGCTGGAGCAAAACC

Downstream 100 bases:

>100_bases
CATAACAGGGCGTTAGCGGACATTTCGGAATCAGCTGCTGAAGCGGTTGAATCGGAATGTGAGAACCGGGAACTGCCCGC
AATAAAGATTGCAATAACGG

Product: aldo/keto reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MHEDIPAVTLPSGNEVPALGLGTWNMGETRSSADDEIESIRKAIDLGMTLVDTAEMYADGRSEEVVGTAIAGRRDEVFLV
SKVYPWNASARGTAEACERSLARLGTDHIDLYLLHWRGEHPLGETVAAFERLKSDGKIGNWGVSNFDTDDMEELFTVPEG
KNCAANQVLYNLSRRGPEFSLLPWCQEHGVPLMAYSPIEQGRILKNHELIRIAKAYQATPAQLALAFLLDRDGVIAIPKS
ASVSRIVENRGATDLEITEEDWTALDAAFPPPTRKTSLEML

Sequences:

>Translated_281_residues
MHEDIPAVTLPSGNEVPALGLGTWNMGETRSSADDEIESIRKAIDLGMTLVDTAEMYADGRSEEVVGTAIAGRRDEVFLV
SKVYPWNASARGTAEACERSLARLGTDHIDLYLLHWRGEHPLGETVAAFERLKSDGKIGNWGVSNFDTDDMEELFTVPEG
KNCAANQVLYNLSRRGPEFSLLPWCQEHGVPLMAYSPIEQGRILKNHELIRIAKAYQATPAQLALAFLLDRDGVIAIPKS
ASVSRIVENRGATDLEITEEDWTALDAAFPPPTRKTSLEML
>Mature_281_residues
MHEDIPAVTLPSGNEVPALGLGTWNMGETRSSADDEIESIRKAIDLGMTLVDTAEMYADGRSEEVVGTAIAGRRDEVFLV
SKVYPWNASARGTAEACERSLARLGTDHIDLYLLHWRGEHPLGETVAAFERLKSDGKIGNWGVSNFDTDDMEELFTVPEG
KNCAANQVLYNLSRRGPEFSLLPWCQEHGVPLMAYSPIEQGRILKNHELIRIAKAYQATPAQLALAFLLDRDGVIAIPKS
ASVSRIVENRGATDLEITEEDWTALDAAFPPPTRKTSLEML

Specific function: Unknown

COG id: COG0656

COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI310109922, Length=290, Percent_Identity=31.7241379310345, Blast_Score=111, Evalue=8e-25,
Organism=Homo sapiens, GI5174695, Length=300, Percent_Identity=30.6666666666667, Blast_Score=109, Evalue=2e-24,
Organism=Homo sapiens, GI223468663, Length=294, Percent_Identity=28.5714285714286, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI45446745, Length=310, Percent_Identity=30, Blast_Score=104, Evalue=7e-23,
Organism=Homo sapiens, GI4503285, Length=310, Percent_Identity=30, Blast_Score=104, Evalue=7e-23,
Organism=Homo sapiens, GI5453543, Length=308, Percent_Identity=29.2207792207792, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI310109920, Length=310, Percent_Identity=30, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI24497577, Length=296, Percent_Identity=26.6891891891892, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI5174391, Length=296, Percent_Identity=26.6891891891892, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI24497585, Length=303, Percent_Identity=30.3630363036304, Blast_Score=101, Evalue=6e-22,
Organism=Homo sapiens, GI300116273, Length=282, Percent_Identity=30.8510638297872, Blast_Score=101, Evalue=9e-22,
Organism=Homo sapiens, GI24497583, Length=304, Percent_Identity=29.2763157894737, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI4502049, Length=294, Percent_Identity=30.2721088435374, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI291291012, Length=266, Percent_Identity=26.6917293233083, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI27436969, Length=298, Percent_Identity=27.5167785234899, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI4504825, Length=298, Percent_Identity=27.5167785234899, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI41327764, Length=197, Percent_Identity=31.4720812182741, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI27436962, Length=298, Percent_Identity=26.8456375838926, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI223718702, Length=208, Percent_Identity=28.3653846153846, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI27436964, Length=298, Percent_Identity=26.8456375838926, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI27436966, Length=298, Percent_Identity=26.8456375838926, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1788081, Length=271, Percent_Identity=50.9225092250922, Blast_Score=291, Evalue=4e-80,
Organism=Escherichia coli, GI1786400, Length=258, Percent_Identity=31.7829457364341, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI87082198, Length=264, Percent_Identity=32.5757575757576, Blast_Score=114, Evalue=5e-27,
Organism=Escherichia coli, GI1788070, Length=305, Percent_Identity=29.5081967213115, Blast_Score=107, Evalue=9e-25,
Organism=Escherichia coli, GI87081735, Length=274, Percent_Identity=27.007299270073, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1787674, Length=248, Percent_Identity=24.5967741935484, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1789199, Length=348, Percent_Identity=26.1494252873563, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1789375, Length=212, Percent_Identity=30.188679245283, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI48994888, Length=154, Percent_Identity=30.5194805194805, Blast_Score=65, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI71998625, Length=283, Percent_Identity=30.0353356890459, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17561298, Length=283, Percent_Identity=31.095406360424, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17564128, Length=309, Percent_Identity=29.4498381877023, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17550248, Length=302, Percent_Identity=26.8211920529801, Blast_Score=101, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17537075, Length=305, Percent_Identity=28.1967213114754, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17552492, Length=277, Percent_Identity=28.5198555956679, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17537077, Length=304, Percent_Identity=28.2894736842105, Blast_Score=98, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17566692, Length=305, Percent_Identity=25.2459016393443, Blast_Score=95, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17538386, Length=284, Percent_Identity=26.4084507042254, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17561300, Length=272, Percent_Identity=26.8382352941176, Blast_Score=85, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17562292, Length=283, Percent_Identity=27.208480565371, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17537079, Length=304, Percent_Identity=25.9868421052632, Blast_Score=74, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6320576, Length=276, Percent_Identity=30.4347826086957, Blast_Score=112, Evalue=7e-26,
Organism=Saccharomyces cerevisiae, GI6324694, Length=300, Percent_Identity=28.3333333333333, Blast_Score=111, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6320079, Length=279, Percent_Identity=29.0322580645161, Blast_Score=94, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6322556, Length=274, Percent_Identity=25.5474452554745, Blast_Score=89, Evalue=9e-19,
Organism=Drosophila melanogaster, GI45553081, Length=299, Percent_Identity=29.0969899665552, Blast_Score=121, Evalue=6e-28,
Organism=Drosophila melanogaster, GI24663317, Length=303, Percent_Identity=31.3531353135314, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24662789, Length=301, Percent_Identity=27.2425249169435, Blast_Score=104, Evalue=6e-23,
Organism=Drosophila melanogaster, GI20129731, Length=299, Percent_Identity=29.0969899665552, Blast_Score=104, Evalue=7e-23,
Organism=Drosophila melanogaster, GI24657054, Length=296, Percent_Identity=27.027027027027, Blast_Score=95, Evalue=4e-20,
Organism=Drosophila melanogaster, GI21356425, Length=306, Percent_Identity=25.4901960784314, Blast_Score=94, Evalue=7e-20,
Organism=Drosophila melanogaster, GI281366140, Length=259, Percent_Identity=27.7992277992278, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24662781, Length=298, Percent_Identity=27.5167785234899, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24662785, Length=297, Percent_Identity=27.6094276094276, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: NA

Molecular weight: Translated: 30922; Mature: 30922

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: PS00063 ALDOKETO_REDUCTASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MHEDIPAVTLPSGNEVPALGLGTWNMGETRSSADDEIESIRKAIDLGMTLVDTAEMYADG
CCCCCCEEECCCCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCC
RSEEVVGTAIAGRRDEVFLVSKVYPWNASARGTAEACERSLARLGTDHIDLYLLHWRGEH
CCCCEEEHHHCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEECCCC
PLGETVAAFERLKSDGKIGNWGVSNFDTDDMEELFTVPEGKNCAANQVLYNLSRRGPEFS
CCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCE
LLPWCQEHGVPLMAYSPIEQGRILKNHELIRIAKAYQATPAQLALAFLLDRDGVIAIPKS
ECCHHHHCCCCEEEECCCCCCCEECCCHHEEEHHHHCCCHHHHHHHHHCCCCCEEEECCC
ASVSRIVENRGATDLEITEEDWTALDAAFPPPTRKTSLEML
CHHHHHHHHCCCCCEEEECCCHHEECCCCCCCCCCCCCCCC
>Mature Secondary Structure
MHEDIPAVTLPSGNEVPALGLGTWNMGETRSSADDEIESIRKAIDLGMTLVDTAEMYADG
CCCCCCEEECCCCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCC
RSEEVVGTAIAGRRDEVFLVSKVYPWNASARGTAEACERSLARLGTDHIDLYLLHWRGEH
CCCCEEEHHHCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEECCCC
PLGETVAAFERLKSDGKIGNWGVSNFDTDDMEELFTVPEGKNCAANQVLYNLSRRGPEFS
CCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCE
LLPWCQEHGVPLMAYSPIEQGRILKNHELIRIAKAYQATPAQLALAFLLDRDGVIAIPKS
ECCHHHHCCCCEEEECCCCCCCEECCCHHEEEHHHHCCCHHHHHHHHHCCCCCEEEECCC
ASVSRIVENRGATDLEITEEDWTALDAAFPPPTRKTSLEML
CHHHHHHHHCCCCCEEEECCCHHEECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]