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The map label for this gene is fabF [H]

Identifier: 15888909

GI number: 15888909

Start: 1578309

End: 1579589

Strand: Reverse

Name: fabF [H]

Synonym: Atu1596

Alternate gene names: 15888909

Gene position: 1579589-1578309 (Counterclockwise)

Preceding gene: 15888910

Following gene: 15888908

Centisome position: 55.59

GC content: 62.14

Gene sequence:

>1281_bases
ATGACCAATTTTAAGGATCATCTCGGTCGCCCGATCGTTGCCGTGACCGGCATGGGCATCATCACCTCGCTCGGTCAGGG
ACTTGCCGACAACTGGGCAGCGCTGACATCAGGCAAGTCGGGTATTCACAAGATCACCCGCTTCCCGACTGAAGGGCTTT
CGACCCGCATCAGCGGCACGGTGGATTTCATCGATATCCCGGTTCCCAACTCCGTCGAGCGTTCTTATGCTTTCGCGCGT
GAAACCACCATCGAGGCGCTGGCGCAGGCCGGTATATCGGGTGATTTCGATGGGCCGCTGTTTCTCGCAGCGCCACCGAT
TGAGCCGGAATGGAGCGCCCGTTTCGAGCTTGCCGACCGGTCTCCGCCAGCCGCAAAGCCGGGTGACGCCTATGAGCGGT
TCATGACGGCGTTGCGCCAGCGTCCCGATCCGGCATTCCAGGAAGCCGCATTGTTCGGCGCGATTTCCGAACGTCTTTCC
GACCGTTTTGGCACGCGCGGCCTGCCGGTCACGCTGTCTACGGCCTGTGCTTCGGGTGCGACTGCGATCCAGCTCGGCGT
CGAGGCGATCCGCCAGGGCCGCACGGAGCGCGCTCTGACGGTTGCGACTGACGGTTCCGTCAGCGCCGAAGCCCTGATCC
GCTTCTCGCTTCTGTCTGCGCTTTCGACCCAGAACGATCCGCCCGAAAAGGCCTCCAAGCCGTTCAGCAAGGATCGCGAT
GGTTTCGTGATCGCTGAAGGTGCGGCGACGCTGGTGTTGGAATCGCTCGAAGCTGCCGTTGCCCGTGGCGCCAAGGTTCT
CGGCATCATCAAGGGCGCCGGCGAAAAGGCCGACAGCTTCCACCGCACGCGTTCTTCGCCCGATGGCGGCCCGGCGATCG
CGACGATCCGTGCGGCACTTGCCGATGCGGGCGTGGCCGAAAGCGATATCGGCTATATCAACGCTCACGGCACCTCGACG
CCTGAGAATGACAAGATGGAATATGGCTCGATGCTGGCCGTCTTCGGCGAAGGCCTGAAGAATATTCCGCTGTCGTCTAA
CAAGTCGATGATTGGCCATACGCTGACGGCCGCAGGCGCCGTGGAAGCGGTGTTCTCGCTGCAGACCATGCTGACCGGGA
CCCTGCCGCCGACGATCAACTACAACAATCCCGATCCGACCATCACCCTCGACGTGGTGCCGAATGTGAAGCGGGATGCG
CAGGTGGGTGCGGTTCTCTCCAACTCCTTCGGGTTTGGCGGGCAGAATGCAAGCCTTGTCATGACGCGGGAACCGGCTTA
A

Upstream 100 bases:

>100_bases
GATGGGCGAAGCGGCCACAGAGGCTGTCGTCACCACCGTCGGGCATGTGCGCGGCGAAGGTGTCGCCGTCCTGTCCCGTG
ACGTGTGAGGAGAAGAGACC

Downstream 100 bases:

>100_bases
CCGGTTCCGCCACAACAGGAGCGTTTCCAAAAGCACTGCGGAAACGCTCTCGTCTCTTTGATTACGCATTCCAGCCGCAA
AACCGTTACAGAGTTTTGCT

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 426; Mature: 425

Protein sequence:

>426_residues
MTNFKDHLGRPIVAVTGMGIITSLGQGLADNWAALTSGKSGIHKITRFPTEGLSTRISGTVDFIDIPVPNSVERSYAFAR
ETTIEALAQAGISGDFDGPLFLAAPPIEPEWSARFELADRSPPAAKPGDAYERFMTALRQRPDPAFQEAALFGAISERLS
DRFGTRGLPVTLSTACASGATAIQLGVEAIRQGRTERALTVATDGSVSAEALIRFSLLSALSTQNDPPEKASKPFSKDRD
GFVIAEGAATLVLESLEAAVARGAKVLGIIKGAGEKADSFHRTRSSPDGGPAIATIRAALADAGVAESDIGYINAHGTST
PENDKMEYGSMLAVFGEGLKNIPLSSNKSMIGHTLTAAGAVEAVFSLQTMLTGTLPPTINYNNPDPTITLDVVPNVKRDA
QVGAVLSNSFGFGGQNASLVMTREPA

Sequences:

>Translated_426_residues
MTNFKDHLGRPIVAVTGMGIITSLGQGLADNWAALTSGKSGIHKITRFPTEGLSTRISGTVDFIDIPVPNSVERSYAFAR
ETTIEALAQAGISGDFDGPLFLAAPPIEPEWSARFELADRSPPAAKPGDAYERFMTALRQRPDPAFQEAALFGAISERLS
DRFGTRGLPVTLSTACASGATAIQLGVEAIRQGRTERALTVATDGSVSAEALIRFSLLSALSTQNDPPEKASKPFSKDRD
GFVIAEGAATLVLESLEAAVARGAKVLGIIKGAGEKADSFHRTRSSPDGGPAIATIRAALADAGVAESDIGYINAHGTST
PENDKMEYGSMLAVFGEGLKNIPLSSNKSMIGHTLTAAGAVEAVFSLQTMLTGTLPPTINYNNPDPTITLDVVPNVKRDA
QVGAVLSNSFGFGGQNASLVMTREPA
>Mature_425_residues
TNFKDHLGRPIVAVTGMGIITSLGQGLADNWAALTSGKSGIHKITRFPTEGLSTRISGTVDFIDIPVPNSVERSYAFARE
TTIEALAQAGISGDFDGPLFLAAPPIEPEWSARFELADRSPPAAKPGDAYERFMTALRQRPDPAFQEAALFGAISERLSD
RFGTRGLPVTLSTACASGATAIQLGVEAIRQGRTERALTVATDGSVSAEALIRFSLLSALSTQNDPPEKASKPFSKDRDG
FVIAEGAATLVLESLEAAVARGAKVLGIIKGAGEKADSFHRTRSSPDGGPAIATIRAALADAGVAESDIGYINAHGTSTP
ENDKMEYGSMLAVFGEGLKNIPLSSNKSMIGHTLTAAGAVEAVFSLQTMLTGTLPPTINYNNPDPTITLDVVPNVKRDAQ
VGAVLSNSFGFGGQNASLVMTREPA

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=429, Percent_Identity=33.1002331002331, Blast_Score=181, Evalue=9e-46,
Organism=Homo sapiens, GI223972627, Length=149, Percent_Identity=40.9395973154362, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI41872631, Length=277, Percent_Identity=30.3249097472924, Blast_Score=95, Evalue=1e-19,
Organism=Escherichia coli, GI1787337, Length=414, Percent_Identity=34.7826086956522, Blast_Score=220, Evalue=2e-58,
Organism=Escherichia coli, GI1788663, Length=426, Percent_Identity=33.0985915492958, Blast_Score=176, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI71983541, Length=423, Percent_Identity=30.2600472813239, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI71983535, Length=263, Percent_Identity=36.8821292775665, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI212642053, Length=279, Percent_Identity=26.8817204301075, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17550940, Length=285, Percent_Identity=25.2631578947368, Blast_Score=76, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6320904, Length=451, Percent_Identity=31.0421286031042, Blast_Score=160, Evalue=3e-40,
Organism=Drosophila melanogaster, GI24644341, Length=425, Percent_Identity=33.8823529411765, Blast_Score=194, Evalue=1e-49,
Organism=Drosophila melanogaster, GI221330659, Length=283, Percent_Identity=27.9151943462898, Blast_Score=98, Evalue=9e-21,
Organism=Drosophila melanogaster, GI19920632, Length=283, Percent_Identity=27.9151943462898, Blast_Score=98, Evalue=9e-21,
Organism=Drosophila melanogaster, GI24581345, Length=277, Percent_Identity=26.7148014440433, Blast_Score=85, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 44545; Mature: 44413

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNFKDHLGRPIVAVTGMGIITSLGQGLADNWAALTSGKSGIHKITRFPTEGLSTRISGT
CCCCHHHHCCCEEEEECHHHHHHHCCCHHCCHHHHHCCCHHHHHHHHCCCCCCCEEECCC
VDFIDIPVPNSVERSYAFARETTIEALAQAGISGDFDGPLFLAAPPIEPEWSARFELADR
EEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCEEEECCC
SPPAAKPGDAYERFMTALRQRPDPAFQEAALFGAISERLSDRFGTRGLPVTLSTACASGA
CCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHCCCC
TAIQLGVEAIRQGRTERALTVATDGSVSAEALIRFSLLSALSTQNDPPEKASKPFSKDRD
HHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCC
GFVIAEGAATLVLESLEAAVARGAKVLGIIKGAGEKADSFHRTRSSPDGGPAIATIRAAL
CEEEECCHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHCCCCCCCHHHHHHHHHH
ADAGVAESDIGYINAHGTSTPENDKMEYGSMLAVFGEGLKNIPLSSNKSMIGHTLTAAGA
HHCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHCCHHCCCCCCCCCHHHHHHHHHHH
VEAVFSLQTMLTGTLPPTINYNNPDPTITLDVVPNVKRDAQVGAVLSNSFGFGGQNASLV
HHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHCCCCCCCCCCEEE
MTREPA
EEECCC
>Mature Secondary Structure 
TNFKDHLGRPIVAVTGMGIITSLGQGLADNWAALTSGKSGIHKITRFPTEGLSTRISGT
CCCHHHHCCCEEEEECHHHHHHHCCCHHCCHHHHHCCCHHHHHHHHCCCCCCCEEECCC
VDFIDIPVPNSVERSYAFARETTIEALAQAGISGDFDGPLFLAAPPIEPEWSARFELADR
EEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCEEEECCC
SPPAAKPGDAYERFMTALRQRPDPAFQEAALFGAISERLSDRFGTRGLPVTLSTACASGA
CCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHCCCC
TAIQLGVEAIRQGRTERALTVATDGSVSAEALIRFSLLSALSTQNDPPEKASKPFSKDRD
HHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCC
GFVIAEGAATLVLESLEAAVARGAKVLGIIKGAGEKADSFHRTRSSPDGGPAIATIRAAL
CEEEECCHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHCCCCCCCHHHHHHHHHH
ADAGVAESDIGYINAHGTSTPENDKMEYGSMLAVFGEGLKNIPLSSNKSMIGHTLTAAGA
HHCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHCCHHCCCCCCCCCHHHHHHHHHHH
VEAVFSLQTMLTGTLPPTINYNNPDPTITLDVVPNVKRDAQVGAVLSNSFGFGGQNASLV
HHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHCCCCCCCCCCEEE
MTREPA
EEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12704232 [H]