BacMap

Definition	Agrobacterium tumefaciens str. C58 chromosome circular, complete sequence.
Accession	NC_003062
Length	2,841,580

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The map label for this gene is fabG2 [H]

Identifier: 15888741

GI number: 15888741

Start: 1410773

End: 1411546

Strand: Reverse

Name: fabG2 [H]

Synonym: Atu1415

Alternate gene names: 15888741

Gene position: 1411546-1410773 (Counterclockwise)

Preceding gene: 159184751

Following gene: 159184750

Centisome position: 49.67

GC content: 63.44

Gene sequence:

>774_bases
ATGAATATCGAAGGCGCAGGCGCACTCGTCACGGGTGCGGCATCCGGCCTCGGGGCGGCCGTGGCGCGAATGCTCGCGGC
TCGCGGCGCGGCGGTCACCATTTTTGACCGTAACGGCGAAGCCGGCAAAAAGCTGGCGGCGGAGATCGGCGGTAAGGCCG
TTCAAGGCGATGTGACAAGCGACGCCGATGCGCAGGCGGCAATAAAGGTAGCCGCTTCCGCCAAAGGCGGCCTTCGTATT
CTCGTCAATTGCGCGGGCATCGGCACCGCGGGTCGAATTCTCGGTCGCGAAGGGCCGCAACCGCTTGGCGATTTCGAACA
GGTCATCCGCGTCAACCTGATCGGCACCTTCAACATGATGCGGCTTGCGGCCGCTCACATGGCTGAGAGGGAACAGGATG
AAGGCCAAGACAGTCGCCAAGACAATGGTGTGATCGTCAACACGGCGTCGGTTGCCGCTTTCGAGGGCCAGATCGGGCAA
GCGGCCTATGCCGCGTCGAAAGGCGGCATCGTTTCACTCGCCCTGCCCGCAGCACGCGAACTTGCCCGCTTCCGCATTCG
GGTGAACACCGTGGCGCCCGGCATTTTCCTGACCCCCCTGCTTCAGGGATTGCCGCAGGAGGTTCAGGAGAGCCTTGCGG
GCCAGATACCCCACCCTTCCCGGCTCGGCGATCCAGCCGAATTCGCCGATACGGTGCGCTTTCTCATCGAGAACGATTAC
ATGAACGGTGAAGTCATCCGGCTGGATGGCGCGATCCGCATGCAGCCGCGGTGA

Upstream 100 bases:

>100_bases
CGATCAACCAGCGCGCCGTGCTTCTGCATCGCAAGGAGCTCGTAGAGTCACTTTACGGCGACACGCCGCAGGTCATCACC
GTTGGCAGAGAGGTAGCAGC

Downstream 100 bases:

>100_bases
TGTGATGAGTTTTTCAACCCAGGCGGCCCGCACGATGGAGCTTCTGAAGGCAACGTCCGGCTGGCGTCGCATCCAGTCTC
TCCGTGGCGATTGCGATGAT

Product: 3-hydroxyacyl-CoA dehydrogenase type II

Products: 3-oxoacyl-CoA; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 257; Mature: 257

Protein sequence:

>257_residues
MNIEGAGALVTGAASGLGAAVARMLAARGAAVTIFDRNGEAGKKLAAEIGGKAVQGDVTSDADAQAAIKVAASAKGGLRI
LVNCAGIGTAGRILGREGPQPLGDFEQVIRVNLIGTFNMMRLAAAHMAEREQDEGQDSRQDNGVIVNTASVAAFEGQIGQ
AAYAASKGGIVSLALPAARELARFRIRVNTVAPGIFLTPLLQGLPQEVQESLAGQIPHPSRLGDPAEFADTVRFLIENDY
MNGEVIRLDGAIRMQPR

Sequences:

>Translated_257_residues
MNIEGAGALVTGAASGLGAAVARMLAARGAAVTIFDRNGEAGKKLAAEIGGKAVQGDVTSDADAQAAIKVAASAKGGLRI
LVNCAGIGTAGRILGREGPQPLGDFEQVIRVNLIGTFNMMRLAAAHMAEREQDEGQDSRQDNGVIVNTASVAAFEGQIGQ
AAYAASKGGIVSLALPAARELARFRIRVNTVAPGIFLTPLLQGLPQEVQESLAGQIPHPSRLGDPAEFADTVRFLIENDY
MNGEVIRLDGAIRMQPR
>Mature_257_residues
MNIEGAGALVTGAASGLGAAVARMLAARGAAVTIFDRNGEAGKKLAAEIGGKAVQGDVTSDADAQAAIKVAASAKGGLRI
LVNCAGIGTAGRILGREGPQPLGDFEQVIRVNLIGTFNMMRLAAAHMAEREQDEGQDSRQDNGVIVNTASVAAFEGQIGQ
AAYAASKGGIVSLALPAARELARFRIRVNTVAPGIFLTPLLQGLPQEVQESLAGQIPHPSRLGDPAEFADTVRFLIENDY
MNGEVIRLDGAIRMQPR

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4758504, Length=259, Percent_Identity=51.7374517374517, Blast_Score=246, Evalue=2e-65,
Organism=Homo sapiens, GI83715985, Length=259, Percent_Identity=49.4208494208494, Blast_Score=228, Evalue=6e-60,
Organism=Homo sapiens, GI15277342, Length=267, Percent_Identity=35.2059925093633, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI40254992, Length=247, Percent_Identity=34.0080971659919, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI31542939, Length=266, Percent_Identity=28.1954887218045, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI4504505, Length=233, Percent_Identity=33.0472103004292, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI32483357, Length=252, Percent_Identity=28.968253968254, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI59889578, Length=228, Percent_Identity=26.7543859649123, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI224922801, Length=185, Percent_Identity=30.2702702702703, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI5031737, Length=254, Percent_Identity=29.5275590551181, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI10190704, Length=254, Percent_Identity=29.9212598425197, Blast_Score=68, Evalue=8e-12,
Organism=Homo sapiens, GI4503817, Length=207, Percent_Identity=28.0193236714976, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1787335, Length=258, Percent_Identity=33.7209302325581, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI87082100, Length=264, Percent_Identity=31.8181818181818, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1787905, Length=262, Percent_Identity=30.9160305343511, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI1790717, Length=262, Percent_Identity=30.9160305343511, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI87082160, Length=260, Percent_Identity=28.8461538461538, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI1789208, Length=260, Percent_Identity=29.6153846153846, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1786812, Length=265, Percent_Identity=32.0754716981132, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI2367175, Length=263, Percent_Identity=32.319391634981, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1789378, Length=249, Percent_Identity=29.718875502008, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788459, Length=255, Percent_Identity=27.0588235294118, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI2367365, Length=256, Percent_Identity=30.859375, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17538182, Length=257, Percent_Identity=49.0272373540856, Blast_Score=217, Evalue=4e-57,
Organism=Caenorhabditis elegans, GI25147288, Length=254, Percent_Identity=31.496062992126, Blast_Score=113, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI17555706, Length=253, Percent_Identity=32.8063241106719, Blast_Score=108, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17561402, Length=272, Percent_Identity=30.1470588235294, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17562910, Length=271, Percent_Identity=29.520295202952, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17560676, Length=257, Percent_Identity=29.1828793774319, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17560332, Length=270, Percent_Identity=28.1481481481481, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17568967, Length=232, Percent_Identity=29.3103448275862, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17562906, Length=270, Percent_Identity=27.037037037037, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17560150, Length=266, Percent_Identity=26.3157894736842, Blast_Score=71, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17563726, Length=272, Percent_Identity=27.5735294117647, Blast_Score=70, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17564282, Length=215, Percent_Identity=31.1627906976744, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17559104, Length=263, Percent_Identity=25.8555133079848, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI72000259, Length=276, Percent_Identity=27.8985507246377, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17538480, Length=274, Percent_Identity=28.4671532846715, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17560220, Length=269, Percent_Identity=27.5092936802974, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17562908, Length=270, Percent_Identity=27.4074074074074, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17531453, Length=272, Percent_Identity=29.4117647058824, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71994600, Length=267, Percent_Identity=25.0936329588015, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17562904, Length=268, Percent_Identity=26.1194029850746, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71994604, Length=266, Percent_Identity=26.6917293233083, Blast_Score=64, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=200, Percent_Identity=33, Blast_Score=84, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17737361, Length=258, Percent_Identity=49.2248062015504, Blast_Score=227, Evalue=6e-60,
Organism=Drosophila melanogaster, GI24639444, Length=255, Percent_Identity=36.078431372549, Blast_Score=137, Evalue=9e-33,
Organism=Drosophila melanogaster, GI24644339, Length=271, Percent_Identity=31.7343173431734, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI23397609, Length=271, Percent_Identity=30.6273062730627, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI21357041, Length=263, Percent_Identity=30.0380228136882, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI28571526, Length=263, Percent_Identity=30.0380228136882, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI18859837, Length=205, Percent_Identity=33.6585365853659, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21355319, Length=256, Percent_Identity=30.078125, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24665243, Length=215, Percent_Identity=29.7674418604651, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI221331218, Length=215, Percent_Identity=29.7674418604651, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24665247, Length=216, Percent_Identity=29.6296296296296, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI221331216, Length=216, Percent_Identity=29.6296296296296, Blast_Score=64, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.35

Molecular weight: Translated: 26623; Mature: 26623

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: PS00061 ADH_SHORT ; PS00687 ALDEHYDE_DEHYDR_GLU

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIEGAGALVTGAASGLGAAVARMLAARGAAVTIFDRNGEAGKKLAAEIGGKAVQGDVTS
CCCCCCCEEEECCCCHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHCCEEEECCCCC
DADAQAAIKVAASAKGGLRILVNCAGIGTAGRILGREGPQPLGDFEQVIRVNLIGTFNMM
CCCHHHHEEEEECCCCCEEEEEEECCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
RLAAAHMAEREQDEGQDSRQDNGVIVNTASVAAFEGQIGQAAYAASKGGIVSLALPAARE
HHHHHHHHHHHHHCCCCCCCCCCEEEEECCEEEECCCCCHHHHHCCCCCEEEEECHHHHH
LARFRIRVNTVAPGIFLTPLLQGLPQEVQESLAGQIPHPSRLGDPAEFADTVRFLIENDY
HHHHEEEEECCCCCHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCC
MNGEVIRLDGAIRMQPR
CCCEEEEECCEEEECCC
>Mature Secondary Structure
MNIEGAGALVTGAASGLGAAVARMLAARGAAVTIFDRNGEAGKKLAAEIGGKAVQGDVTS
CCCCCCCEEEECCCCHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHCCEEEECCCCC
DADAQAAIKVAASAKGGLRILVNCAGIGTAGRILGREGPQPLGDFEQVIRVNLIGTFNMM
CCCHHHHEEEEECCCCCEEEEEEECCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
RLAAAHMAEREQDEGQDSRQDNGVIVNTASVAAFEGQIGQAAYAASKGGIVSLALPAARE
HHHHHHHHHHHHHCCCCCCCCCCEEEEECCEEEECCCCCHHHHHCCCCCEEEEECHHHHH
LARFRIRVNTVAPGIFLTPLLQGLPQEVQESLAGQIPHPSRLGDPAEFADTVRFLIENDY
HHHHEEEEECCCCCHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCC
MNGEVIRLDGAIRMQPR
CCCEEEEECCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-3-hydroxyacyl-CoA; NAD+

Specific reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]