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The map label for this gene is serA [H]

Identifier: 15888726

GI number: 15888726

Start: 1394282

End: 1395268

Strand: Reverse

Name: serA [H]

Synonym: Atu1400

Alternate gene names: 15888726

Gene position: 1395268-1394282 (Counterclockwise)

Preceding gene: 15888727

Following gene: 159184745

Centisome position: 49.1

GC content: 58.46

Gene sequence:

>987_bases
ATGTCAAAACGGATCGTTTTTCACGGCGAAAATGCCGCCTGTTTCAGCGATGACTTCAAAAACCTGGTGGAGGGCGGCGC
GGAAATCGCTCTGCTGCCGGATCAACTCGTCACCGAGGAAGACCGCAACGCCTATCGCAAAGCCGATATCATCGTTGGCG
TCAAATTTGATGCATCGTTGCCGACGCCTGAAAGACTGACGCTGTTTCATGTGCCCGGCGCCGGTTATGACGCCGTCAAT
CTCGACCTGCTGCCGAAAAGCGCGGTCGTGTGCAACTGCTTTGGCCATGATCCCGCAATTGCCGAATATGTGTTTTCAGC
CATTCTCAACCGTCATGTTCCGTTGCGCGATGCCGACAACAAATTGCGCGCCGGCCAGTGGGCCTACTGGTCCGGTTCGA
CCGAGCGCCTGCACGACGAAATGTCCGGAAAAACCATCGGTCTTCTCGGCTTCGGCCATATCGGGAAGGCCATTGCGGTC
CGCGCGAAGGCGTTCGGAATGCAGGTCAGCGTCGCCAATCGCAGCCGCGTGGAAACGTCGGATCTGGTAGACCGCTCCTT
CACACTGGATCAGCTCAACGAATTCTGGCCGACCGCAGATTTCATCGTCGTCTCCGTACCACTAACGGACACGACACGCG
GGATCGTCGATGCGGAGGCTTTCGCAGCGATGAAATCCGGTGCCGTCATCATCAATGTCGGGCGCGGCCCGACCATAGAC
GAGCAGGCGCTTTATGACGCGCTGAAAAGCGGAACCATCGGCGGTGCGGTCATCGATACCTGGTACGCCTATCCGTCACC
CGACGCGCCGACGAGACAACCGTCCGCACTGCCATTCAATCAACTCGAGAACATCATCATGACGCCGCACATGTCCGGCT
GGACCAGTGGAACGGTGCGGCGGCGGCAGCAGACGATCGCGGAAAACATCAATCGGCGGCTGAAGGGGCAAGACTGCATC
AACATCGTCCGCACCGCGTCTGAATAG

Upstream 100 bases:

>100_bases
ACGGGCGAGCGGATCCGATCGTGACCATGAACGTGACCGGACCTGCATCAGCGCAACCTTTTTTCAATCTCCAGAAATAT
CCGCAGCGGGGAGAATAGAC

Downstream 100 bases:

>100_bases
CAGATCACCGCATGGCCGGGAGGAGCCGGCCATAAACCACAGCTCAATCAACCAGGGAGAGAGTGATGAGCATCTTTCAG
TCTTTTAAATCCGTTGCTGC

Product: phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 328; Mature: 327

Protein sequence:

>328_residues
MSKRIVFHGENAACFSDDFKNLVEGGAEIALLPDQLVTEEDRNAYRKADIIVGVKFDASLPTPERLTLFHVPGAGYDAVN
LDLLPKSAVVCNCFGHDPAIAEYVFSAILNRHVPLRDADNKLRAGQWAYWSGSTERLHDEMSGKTIGLLGFGHIGKAIAV
RAKAFGMQVSVANRSRVETSDLVDRSFTLDQLNEFWPTADFIVVSVPLTDTTRGIVDAEAFAAMKSGAVIINVGRGPTID
EQALYDALKSGTIGGAVIDTWYAYPSPDAPTRQPSALPFNQLENIIMTPHMSGWTSGTVRRRQQTIAENINRRLKGQDCI
NIVRTASE

Sequences:

>Translated_328_residues
MSKRIVFHGENAACFSDDFKNLVEGGAEIALLPDQLVTEEDRNAYRKADIIVGVKFDASLPTPERLTLFHVPGAGYDAVN
LDLLPKSAVVCNCFGHDPAIAEYVFSAILNRHVPLRDADNKLRAGQWAYWSGSTERLHDEMSGKTIGLLGFGHIGKAIAV
RAKAFGMQVSVANRSRVETSDLVDRSFTLDQLNEFWPTADFIVVSVPLTDTTRGIVDAEAFAAMKSGAVIINVGRGPTID
EQALYDALKSGTIGGAVIDTWYAYPSPDAPTRQPSALPFNQLENIIMTPHMSGWTSGTVRRRQQTIAENINRRLKGQDCI
NIVRTASE
>Mature_327_residues
SKRIVFHGENAACFSDDFKNLVEGGAEIALLPDQLVTEEDRNAYRKADIIVGVKFDASLPTPERLTLFHVPGAGYDAVNL
DLLPKSAVVCNCFGHDPAIAEYVFSAILNRHVPLRDADNKLRAGQWAYWSGSTERLHDEMSGKTIGLLGFGHIGKAIAVR
AKAFGMQVSVANRSRVETSDLVDRSFTLDQLNEFWPTADFIVVSVPLTDTTRGIVDAEAFAAMKSGAVIINVGRGPTIDE
QALYDALKSGTIGGAVIDTWYAYPSPDAPTRQPSALPFNQLENIIMTPHMSGWTSGTVRRRQQTIAENINRRLKGQDCIN
IVRTASE

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=266, Percent_Identity=30.4511278195489, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI6912396, Length=259, Percent_Identity=28.957528957529, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI145580578, Length=272, Percent_Identity=28.6764705882353, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI4557499, Length=272, Percent_Identity=28.6764705882353, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI145580575, Length=272, Percent_Identity=29.0441176470588, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI61743967, Length=190, Percent_Identity=28.9473684210526, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI4557497, Length=190, Percent_Identity=28.9473684210526, Blast_Score=86, Evalue=4e-17,
Organism=Escherichia coli, GI87082289, Length=264, Percent_Identity=28.7878787878788, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1789279, Length=245, Percent_Identity=28.1632653061224, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1787645, Length=317, Percent_Identity=27.1293375394322, Blast_Score=79, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17532191, Length=325, Percent_Identity=31.3846153846154, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI25147481, Length=192, Percent_Identity=32.2916666666667, Blast_Score=89, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6320925, Length=233, Percent_Identity=31.3304721030043, Blast_Score=103, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6322116, Length=218, Percent_Identity=31.651376146789, Blast_Score=102, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6324055, Length=337, Percent_Identity=26.4094955489614, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6325144, Length=172, Percent_Identity=30.2325581395349, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6324964, Length=270, Percent_Identity=24.4444444444444, Blast_Score=63, Evalue=6e-11,
Organism=Drosophila melanogaster, GI19921140, Length=248, Percent_Identity=31.4516129032258, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24585514, Length=188, Percent_Identity=30.8510638297872, Blast_Score=91, Evalue=8e-19,
Organism=Drosophila melanogaster, GI28574282, Length=188, Percent_Identity=30.8510638297872, Blast_Score=91, Evalue=8e-19,
Organism=Drosophila melanogaster, GI45552429, Length=184, Percent_Identity=31.5217391304348, Blast_Score=91, Evalue=9e-19,
Organism=Drosophila melanogaster, GI45551003, Length=188, Percent_Identity=30.8510638297872, Blast_Score=91, Evalue=9e-19,
Organism=Drosophila melanogaster, GI28574284, Length=188, Percent_Identity=30.8510638297872, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI28571528, Length=204, Percent_Identity=30.8823529411765, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI28574286, Length=189, Percent_Identity=32.8042328042328, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24585516, Length=254, Percent_Identity=27.1653543307087, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24646446, Length=307, Percent_Identity=24.7557003257329, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24646448, Length=307, Percent_Identity=24.7557003257329, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24646452, Length=307, Percent_Identity=24.7557003257329, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24646450, Length=307, Percent_Identity=24.7557003257329, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI62472511, Length=307, Percent_Identity=24.7557003257329, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 35864; Mature: 35733

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKRIVFHGENAACFSDDFKNLVEGGAEIALLPDQLVTEEDRNAYRKADIIVGVKFDASL
CCCEEEEECCCCCCHHHHHHHHHHCCCEEEECCHHHHCCHHHHHHEEEEEEEEEEECCCC
PTPERLTLFHVPGAGYDAVNLDLLPKSAVVCNCFGHDPAIAEYVFSAILNRHVPLRDADN
CCCCCEEEEECCCCCCCEEEEEECCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCC
KLRAGQWAYWSGSTERLHDEMSGKTIGLLGFGHIGKAIAVRAKAFGMQVSVANRSRVETS
CCCCCEEEEECCCHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHCEEEEECCCCCCCHH
DLVDRSFTLDQLNEFWPTADFIVVSVPLTDTTRGIVDAEAFAAMKSGAVIINVGRGPTID
HHHHCCCCHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHCCCEEEEECCCCCCCC
EQALYDALKSGTIGGAVIDTWYAYPSPDAPTRQPSALPFNQLENIIMTPHMSGWTSGTVR
HHHHHHHHHCCCCCCHHHHHEECCCCCCCCCCCCCCCCHHHHHHEEECCCCCCCCCHHHH
RRQQTIAENINRRLKGQDCINIVRTASE
HHHHHHHHHHHHHCCCHHHHHHHHHCCC
>Mature Secondary Structure 
SKRIVFHGENAACFSDDFKNLVEGGAEIALLPDQLVTEEDRNAYRKADIIVGVKFDASL
CCEEEEECCCCCCHHHHHHHHHHCCCEEEECCHHHHCCHHHHHHEEEEEEEEEEECCCC
PTPERLTLFHVPGAGYDAVNLDLLPKSAVVCNCFGHDPAIAEYVFSAILNRHVPLRDADN
CCCCCEEEEECCCCCCCEEEEEECCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCC
KLRAGQWAYWSGSTERLHDEMSGKTIGLLGFGHIGKAIAVRAKAFGMQVSVANRSRVETS
CCCCCEEEEECCCHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHCEEEEECCCCCCCHH
DLVDRSFTLDQLNEFWPTADFIVVSVPLTDTTRGIVDAEAFAAMKSGAVIINVGRGPTID
HHHHCCCCHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHCCCEEEEECCCCCCCC
EQALYDALKSGTIGGAVIDTWYAYPSPDAPTRQPSALPFNQLENIIMTPHMSGWTSGTVR
HHHHHHHHHCCCCCCHHHHHEECCCCCCCCCCCCCCCCHHHHHHEEECCCCCCCCCHHHH
RRQQTIAENINRRLKGQDCINIVRTASE
HHHHHHHHHHHHHCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]