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The map label for this gene is lpxD

Identifier: 15888708

GI number: 15888708

Start: 1376888

End: 1377955

Strand: Direct

Name: lpxD

Synonym: Atu1382

Alternate gene names: 15888708

Gene position: 1376888-1377955 (Clockwise)

Preceding gene: 15888707

Following gene: 159184740

Centisome position: 48.46

GC content: 58.99

Gene sequence:

>1068_bases
ATGGAATACAACGCATTTTTTCCGCCCCACGAGGGACTGCGATTGAAAGATATCGCAGACCTTTTTGGGGCGGAACTGTC
TGATGACGCGGCGGGCGAGCGGATTATCAGGTCCGTTGCACCGGTCTACCGGGCAAAACCGGATCAGCTCTGTTACATTC
TTTCCCGCAAGAGCGGCGAAGAGCTGCTGACCTGCGAGGCCGGTGCTGTCATTTGTGACGCGGCCCTGAAGAGCCTGATT
CCTTCCCATATTCCCGCATTGATATCGAAGACCCCGCACACGCTGTTTGCGCAGGTCGGTGCTTTGCTGCATCCATCCGC
CATGCGGCCCTCGCTTGTTGCTCGGATGGAAGCGGAAATTTCCCCGGCTGCCTATGTCGATCCATCGGCAAAGCTCGAGC
CGGGCGTCATCGTGGAACCCATGGCCGTGATCGGCGCGGGCGTTCATATCGGCGCTGGCACGCGCATTGGCCCGGGTGTC
GTTATCGGCTCCGATGTCCAGATCGGTCGCGATTGTACGATTGCCGGTGGAGCGAGCATTTTGGCGGCGCTGCTCGGCAA
TAATGTCATCATCCATAACGGTGCACGCATCGGCCAGGATGGTTTCGGTTATGCGCCGGGTCCGCGTGGCATGCTGAAGA
TCGTGCAGATCGGCCGGGTCATCATTCAGGACCATGTCGAGGTCGGCGCCAATACGACGATCGATCGCGGCACGATGGAT
GACACCGTCATCGGCGAAGGCACCAAGATCGACAATCAGGTGCAGATCGGTCACAACGTTCGCATCGGTCGCCATTGCGG
CATTGTCAGCGGGGTCGGTATTGCCGGCAGCACCCGCATCGGTGACGGTGTGATGATTGGCGGCGCAACGGGCGTTAATG
GCCATATCACCATTGGCGATGGTGTGCAGATTGCCGCGATGAGCGGCGTGGTTTCCGATGTTCCGGCCGGCACCCGTTAC
GGCGGCATTCCGGCGCGTCCGATGAAACATTTCCTGCGCGATATGGCCGATATTCTGGCGCGCGCCGAAGAGCGTGATAA
AAAAACAGGAGAAAAAAACAATGGCTGA

Upstream 100 bases:

>100_bases
GACTACGACGAGGAACAGCGTTTCCGGTTTGGCATGTCCAACACTTTCTGATATCGGCAGTCCAGAACTGCAACTTTGAA
CGTTCTGGAGTTTCCGGCTG

Downstream 100 bases:

>100_bases
CGAAACGAAGGCGACGCTTGGCACGGCCGACATCTTGGAAGTCATGAAACTTCTGCCGCATCGTTACCCGTTTTTGCTCA
TCGACAAGATCATCGAGATC

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 355; Mature: 355

Protein sequence:

>355_residues
MEYNAFFPPHEGLRLKDIADLFGAELSDDAAGERIIRSVAPVYRAKPDQLCYILSRKSGEELLTCEAGAVICDAALKSLI
PSHIPALISKTPHTLFAQVGALLHPSAMRPSLVARMEAEISPAAYVDPSAKLEPGVIVEPMAVIGAGVHIGAGTRIGPGV
VIGSDVQIGRDCTIAGGASILAALLGNNVIIHNGARIGQDGFGYAPGPRGMLKIVQIGRVIIQDHVEVGANTTIDRGTMD
DTVIGEGTKIDNQVQIGHNVRIGRHCGIVSGVGIAGSTRIGDGVMIGGATGVNGHITIGDGVQIAAMSGVVSDVPAGTRY
GGIPARPMKHFLRDMADILARAEERDKKTGEKNNG

Sequences:

>Translated_355_residues
MEYNAFFPPHEGLRLKDIADLFGAELSDDAAGERIIRSVAPVYRAKPDQLCYILSRKSGEELLTCEAGAVICDAALKSLI
PSHIPALISKTPHTLFAQVGALLHPSAMRPSLVARMEAEISPAAYVDPSAKLEPGVIVEPMAVIGAGVHIGAGTRIGPGV
VIGSDVQIGRDCTIAGGASILAALLGNNVIIHNGARIGQDGFGYAPGPRGMLKIVQIGRVIIQDHVEVGANTTIDRGTMD
DTVIGEGTKIDNQVQIGHNVRIGRHCGIVSGVGIAGSTRIGDGVMIGGATGVNGHITIGDGVQIAAMSGVVSDVPAGTRY
GGIPARPMKHFLRDMADILARAEERDKKTGEKNNG
>Mature_355_residues
MEYNAFFPPHEGLRLKDIADLFGAELSDDAAGERIIRSVAPVYRAKPDQLCYILSRKSGEELLTCEAGAVICDAALKSLI
PSHIPALISKTPHTLFAQVGALLHPSAMRPSLVARMEAEISPAAYVDPSAKLEPGVIVEPMAVIGAGVHIGAGTRIGPGV
VIGSDVQIGRDCTIAGGASILAALLGNNVIIHNGARIGQDGFGYAPGPRGMLKIVQIGRVIIQDHVEVGANTTIDRGTMD
DTVIGEGTKIDNQVQIGHNVRIGRHCGIVSGVGIAGSTRIGDGVMIGGATGVNGHITIGDGVQIAAMSGVVSDVPAGTRY
GGIPARPMKHFLRDMADILARAEERDKKTGEKNNG

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily

Homologues:

Organism=Escherichia coli, GI1786376, Length=349, Percent_Identity=36.3896848137536, Blast_Score=191, Evalue=7e-50,
Organism=Escherichia coli, GI1786378, Length=195, Percent_Identity=31.2820512820513, Blast_Score=69, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXD_AGRT5 (Q8UFL5)

Other databases:

- EMBL:   AE007869
- PIR:   AF2746
- PIR:   E97527
- RefSeq:   NP_354389.1
- ProteinModelPortal:   Q8UFL5
- SMR:   Q8UFL5
- STRING:   Q8UFL5
- GeneID:   1133420
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu1382
- eggNOG:   COG1044
- HOGENOM:   HBG469615
- OMA:   VQIGRVI
- PhylomeDB:   Q8UFL5
- ProtClustDB:   PRK00892
- BioCyc:   ATUM176299-1:ATU1382-MONOMER
- HAMAP:   MF_00523
- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573
- TIGRFAMs:   TIGR01853

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD; SSF51161 Trimer_LpxA_like

EC number: 2.3.1.-

Molecular weight: Translated: 36886; Mature: 36886

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEYNAFFPPHEGLRLKDIADLFGAELSDDAAGERIIRSVAPVYRAKPDQLCYILSRKSGE
CCCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCC
ELLTCEAGAVICDAALKSLIPSHIPALISKTPHTLFAQVGALLHPSAMRPSLVARMEAEI
EEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCC
SPAAYVDPSAKLEPGVIVEPMAVIGAGVHIGAGTRIGPGVVIGSDVQIGRDCTIAGGASI
CCCEEECCCCCCCCCEEECCHHHHCCCEEECCCCCCCCCEEECCCCEECCCEEECCHHHH
LAALLGNNVIIHNGARIGQDGFGYAPGPRGMLKIVQIGRVIIQDHVEVGANTTIDRGTMD
HHHHHCCCEEEECCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
DTVIGEGTKIDNQVQIGHNVRIGRHCGIVSGVGIAGSTRIGDGVMIGGATGVNGHITIGD
CCEECCCCCCCCEEEECCCEEECCCCCCEECCCCCCCCCCCCEEEECCCCCCCCEEEECC
GVQIAAMSGVVSDVPAGTRYGGIPARPMKHFLRDMADILARAEERDKKTGEKNNG
CEEEEEHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MEYNAFFPPHEGLRLKDIADLFGAELSDDAAGERIIRSVAPVYRAKPDQLCYILSRKSGE
CCCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCC
ELLTCEAGAVICDAALKSLIPSHIPALISKTPHTLFAQVGALLHPSAMRPSLVARMEAEI
EEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCC
SPAAYVDPSAKLEPGVIVEPMAVIGAGVHIGAGTRIGPGVVIGSDVQIGRDCTIAGGASI
CCCEEECCCCCCCCCEEECCHHHHCCCEEECCCCCCCCCEEECCCCEECCCEEECCHHHH
LAALLGNNVIIHNGARIGQDGFGYAPGPRGMLKIVQIGRVIIQDHVEVGANTTIDRGTMD
HHHHHCCCEEEECCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
DTVIGEGTKIDNQVQIGHNVRIGRHCGIVSGVGIAGSTRIGDGVMIGGATGVNGHITIGD
CCEECCCCCCCCEEEECCCEEECCCCCCEECCCCCCCCCCCCEEEECCCCCCCCEEEECC
GVQIAAMSGVVSDVPAGTRYGGIPARPMKHFLRDMADILARAEERDKKTGEKNNG
CEEEEEHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194