Click here to switch to the map view.

The map label for this gene is accC [H]

Identifier: 15888655

GI number: 15888655

Start: 1316847

End: 1318193

Strand: Reverse

Name: accC [H]

Synonym: Atu1330

Alternate gene names: 15888655

Gene position: 1318193-1316847 (Counterclockwise)

Preceding gene: 15888656

Following gene: 15888654

Centisome position: 46.39

GC content: 59.47

Gene sequence:

>1347_bases
ATGGTTTCGAAGATCCTTATAGCCAACCGCGGCGAAATCGCGCTGCGCGTCCTGCGCGCCGCGAAAGAGCTTGGCATTCC
GACCGTCGCCGTGCATTCCACGGCAGATGCGGATGCGATGCATGTGCGCCTTGCCGACGAAAGTGTGTGCATCGGCCCGC
CGCCCTCGCGTGACAGCTACCTCAACATCCACCAGATCGTTGCGGCCTGCGAAATCACAGGTGCGGATGCCGTTCACCCC
GGTTACGGCTTCCTGTCGGAAAACGCCAAGTTCGCCGATATTCTCGACGCCCACGGCATCACCTTCATCGGGCCGACCGC
CGAACATATCCGCATCATGGGCGACAAGATCACCGCCAAGCAGACGGCACAGGAACTCGGCATTCCCGTGGTTCCGGGTT
CGGATGGCGAAGTGAAGCCTGAAAATGCGCTGGAAATCGCCCGGACGATCGGCTTCCCGGTCCTCATCAAGGCGACGGCA
GGCGGTGGCGGCCGCGGCATGAAGGTGGCGAAGACCGAAGCCGATCTGGAAGATGCAGTTGCGACTGCCCGTTCCGAAGC
GGCAGCAGCCTTCGGCAACGATGCCGTCTATATGGAAAAATACCTCGGCAAGCCGCGCCATATCGAAGTGCAGGTTTTCG
GCGATGGCGAAGGCAATGCCGTTCACCTTGGCGAGCGCGATTGCTCGCTTCAGCGCCGCCACCAGAAGGTGCTGGAAGAA
GCCAATTCACCGGCTCTCACAGTCGAACAGCGCATGAAAATCGGCGAAATTTGCGCCGACGCGATGCGCAAGCTGAAATA
TCGCGGCGCCGGCACCATCGAGTTCCTGTATGAAAACGGCGAGTTCTATTTCATCGAAATGAACACCCGTCTGCAGGTGG
AGCATCCAGTGACGGAAGCGATCACTGGCATGGACCTCGTGCAGGAACAGATCAGGGTCGCTTCTGGTCAGGGCCTGTCG
GTCACACAGGCTGATATCGAATTTCATGGCCATGCCATCGAATGCCGTATCAATGCCGAAGACCCGCGCACCTTCGTTCC
GTCGCCGGGCACACTGACCTATTTCCACACGCCGGGCGGCCTTGGCGTTCGCGTCGATTCGGGTGCCTATCAGGGCTACA
AGATCCCGCCCTATTACGACAGCATGATCGGCAAGCTGATCGTTCACGGTCGCGACCGTGACGAGTGCATCCGTCGCCTG
CGTCGGGCGCTGGACGAATTCGTCGTCGATGGCATCAAGACCACGCTGCCGCTTTTCCAGGATCTCCTTCAGAACGAGGA
TATTCTGAACGGCGATTACGACATTCACTGGCTGGAGAAGTATCTGGCCGGTGACGCGTCTCACTAA

Upstream 100 bases:

>100_bases
GGCCCCCAAGTCCGGCAAGGTGGTGGAAATCATCGTCAACGACTCGCAGCCCGTGGAGTATGGCGAAGCCCTCGTGGTCA
TCGAATAAAGGCGGTTCAGC

Downstream 100 bases:

>100_bases
GACGATATGGCTGGGCGGCGCAGCAGAAACAACGACATAACGGTCGATATTCTGCTGCGCGCCTATTCCGCCGGCCTGTT
TCCCATGGCCGATTCGGCTG

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MVSKILIANRGEIALRVLRAAKELGIPTVAVHSTADADAMHVRLADESVCIGPPPSRDSYLNIHQIVAACEITGADAVHP
GYGFLSENAKFADILDAHGITFIGPTAEHIRIMGDKITAKQTAQELGIPVVPGSDGEVKPENALEIARTIGFPVLIKATA
GGGGRGMKVAKTEADLEDAVATARSEAAAAFGNDAVYMEKYLGKPRHIEVQVFGDGEGNAVHLGERDCSLQRRHQKVLEE
ANSPALTVEQRMKIGEICADAMRKLKYRGAGTIEFLYENGEFYFIEMNTRLQVEHPVTEAITGMDLVQEQIRVASGQGLS
VTQADIEFHGHAIECRINAEDPRTFVPSPGTLTYFHTPGGLGVRVDSGAYQGYKIPPYYDSMIGKLIVHGRDRDECIRRL
RRALDEFVVDGIKTTLPLFQDLLQNEDILNGDYDIHWLEKYLAGDASH

Sequences:

>Translated_448_residues
MVSKILIANRGEIALRVLRAAKELGIPTVAVHSTADADAMHVRLADESVCIGPPPSRDSYLNIHQIVAACEITGADAVHP
GYGFLSENAKFADILDAHGITFIGPTAEHIRIMGDKITAKQTAQELGIPVVPGSDGEVKPENALEIARTIGFPVLIKATA
GGGGRGMKVAKTEADLEDAVATARSEAAAAFGNDAVYMEKYLGKPRHIEVQVFGDGEGNAVHLGERDCSLQRRHQKVLEE
ANSPALTVEQRMKIGEICADAMRKLKYRGAGTIEFLYENGEFYFIEMNTRLQVEHPVTEAITGMDLVQEQIRVASGQGLS
VTQADIEFHGHAIECRINAEDPRTFVPSPGTLTYFHTPGGLGVRVDSGAYQGYKIPPYYDSMIGKLIVHGRDRDECIRRL
RRALDEFVVDGIKTTLPLFQDLLQNEDILNGDYDIHWLEKYLAGDASH
>Mature_448_residues
MVSKILIANRGEIALRVLRAAKELGIPTVAVHSTADADAMHVRLADESVCIGPPPSRDSYLNIHQIVAACEITGADAVHP
GYGFLSENAKFADILDAHGITFIGPTAEHIRIMGDKITAKQTAQELGIPVVPGSDGEVKPENALEIARTIGFPVLIKATA
GGGGRGMKVAKTEADLEDAVATARSEAAAAFGNDAVYMEKYLGKPRHIEVQVFGDGEGNAVHLGERDCSLQRRHQKVLEE
ANSPALTVEQRMKIGEICADAMRKLKYRGAGTIEFLYENGEFYFIEMNTRLQVEHPVTEAITGMDLVQEQIRVASGQGLS
VTQADIEFHGHAIECRINAEDPRTFVPSPGTLTYFHTPGGLGVRVDSGAYQGYKIPPYYDSMIGKLIVHGRDRDECIRRL
RRALDEFVVDGIKTTLPLFQDLLQNEDILNGDYDIHWLEKYLAGDASH

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI189095269, Length=440, Percent_Identity=51.8181818181818, Blast_Score=435, Evalue=1e-122,
Organism=Homo sapiens, GI65506442, Length=440, Percent_Identity=51.8181818181818, Blast_Score=435, Evalue=1e-122,
Organism=Homo sapiens, GI295821183, Length=440, Percent_Identity=51.8181818181818, Blast_Score=434, Evalue=1e-122,
Organism=Homo sapiens, GI116805327, Length=425, Percent_Identity=48.2352941176471, Blast_Score=418, Evalue=1e-117,
Organism=Homo sapiens, GI106049528, Length=448, Percent_Identity=46.4285714285714, Blast_Score=377, Evalue=1e-105,
Organism=Homo sapiens, GI106049295, Length=448, Percent_Identity=46.4285714285714, Blast_Score=377, Evalue=1e-105,
Organism=Homo sapiens, GI106049292, Length=448, Percent_Identity=46.4285714285714, Blast_Score=377, Evalue=1e-105,
Organism=Homo sapiens, GI134142062, Length=515, Percent_Identity=32.0388349514563, Blast_Score=228, Evalue=1e-59,
Organism=Homo sapiens, GI38679974, Length=515, Percent_Identity=30.4854368932039, Blast_Score=222, Evalue=7e-58,
Organism=Homo sapiens, GI38679977, Length=515, Percent_Identity=30.4854368932039, Blast_Score=221, Evalue=8e-58,
Organism=Homo sapiens, GI38679967, Length=515, Percent_Identity=30.4854368932039, Blast_Score=221, Evalue=8e-58,
Organism=Homo sapiens, GI38679960, Length=515, Percent_Identity=30.4854368932039, Blast_Score=221, Evalue=8e-58,
Organism=Homo sapiens, GI38679971, Length=515, Percent_Identity=30.4854368932039, Blast_Score=221, Evalue=9e-58,
Organism=Escherichia coli, GI1789654, Length=444, Percent_Identity=61.036036036036, Blast_Score=550, Evalue=1e-158,
Organism=Escherichia coli, GI1786216, Length=252, Percent_Identity=27.7777777777778, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17567343, Length=440, Percent_Identity=47.9545454545455, Blast_Score=411, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI71987519, Length=435, Percent_Identity=47.5862068965517, Blast_Score=400, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI17562816, Length=452, Percent_Identity=44.2477876106195, Blast_Score=356, Evalue=1e-98,
Organism=Caenorhabditis elegans, GI133931226, Length=493, Percent_Identity=29.4117647058824, Blast_Score=211, Evalue=6e-55,
Organism=Caenorhabditis elegans, GI71997168, Length=516, Percent_Identity=29.0697674418605, Blast_Score=201, Evalue=7e-52,
Organism=Caenorhabditis elegans, GI71997163, Length=516, Percent_Identity=29.0697674418605, Blast_Score=200, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6319685, Length=444, Percent_Identity=41.8918918918919, Blast_Score=362, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6319695, Length=444, Percent_Identity=45.4954954954955, Blast_Score=340, Evalue=2e-94,
Organism=Saccharomyces cerevisiae, GI6321376, Length=441, Percent_Identity=45.124716553288, Blast_Score=330, Evalue=2e-91,
Organism=Saccharomyces cerevisiae, GI6324343, Length=520, Percent_Identity=32.1153846153846, Blast_Score=229, Evalue=5e-61,
Organism=Saccharomyces cerevisiae, GI6323863, Length=491, Percent_Identity=32.7902240325866, Blast_Score=219, Evalue=9e-58,
Organism=Drosophila melanogaster, GI24652212, Length=448, Percent_Identity=49.3303571428571, Blast_Score=401, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652210, Length=448, Percent_Identity=49.3303571428571, Blast_Score=401, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652214, Length=448, Percent_Identity=49.3303571428571, Blast_Score=401, Evalue=1e-112,
Organism=Drosophila melanogaster, GI19921944, Length=448, Percent_Identity=49.3303571428571, Blast_Score=401, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652216, Length=448, Percent_Identity=49.3303571428571, Blast_Score=401, Evalue=1e-112,
Organism=Drosophila melanogaster, GI281363050, Length=448, Percent_Identity=49.3303571428571, Blast_Score=400, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652224, Length=448, Percent_Identity=49.3303571428571, Blast_Score=400, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652222, Length=448, Percent_Identity=49.3303571428571, Blast_Score=400, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652220, Length=448, Percent_Identity=49.3303571428571, Blast_Score=400, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652218, Length=448, Percent_Identity=49.3303571428571, Blast_Score=400, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24651757, Length=426, Percent_Identity=46.9483568075117, Blast_Score=390, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24651759, Length=388, Percent_Identity=45.6185567010309, Blast_Score=347, Evalue=1e-95,
Organism=Drosophila melanogaster, GI161076409, Length=510, Percent_Identity=30, Blast_Score=206, Evalue=3e-53,
Organism=Drosophila melanogaster, GI24586458, Length=510, Percent_Identity=30, Blast_Score=205, Evalue=4e-53,
Organism=Drosophila melanogaster, GI161076407, Length=510, Percent_Identity=30, Blast_Score=205, Evalue=4e-53,
Organism=Drosophila melanogaster, GI24586460, Length=510, Percent_Identity=30, Blast_Score=205, Evalue=4e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 48882; Mature: 48882

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSKILIANRGEIALRVLRAAKELGIPTVAVHSTADADAMHVRLADESVCIGPPPSRDSY
CCCEEEEECCCHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEECCCCEECCCCCCCCCC
LNIHQIVAACEITGADAVHPGYGFLSENAKFADILDAHGITFIGPTAEHIRIMGDKITAK
CHHHHHHHHHEECCCCCCCCCCCCCCCCCCHHHHHHCCCEEEECCCHHHEEEECCCHHHH
QTAQELGIPVVPGSDGEVKPENALEIARTIGFPVLIKATAGGGGRGMKVAKTEADLEDAV
HHHHHCCCEEECCCCCCCCCHHHHHHHHHCCCEEEEEEECCCCCCCCEEEECHHHHHHHH
ATARSEAAAAFGNDAVYMEKYLGKPRHIEVQVFGDGEGNAVHLGERDCSLQRRHQKVLEE
HHHHHHHHHHCCCCHHHHHHHCCCCCEEEEEEEECCCCCEEEECCCCHHHHHHHHHHHHH
ANSPALTVEQRMKIGEICADAMRKLKYRGAGTIEFLYENGEFYFIEMNTRLQVEHPVTEA
CCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEEEECCEEEECCCHHHH
ITGMDLVQEQIRVASGQGLSVTQADIEFHGHAIECRINAEDPRTFVPSPGTLTYFHTPGG
HHHHHHHHHHHHHHCCCCCEEEEECEEECCEEEEEEECCCCCCEECCCCCEEEEEECCCC
LGVRVDSGAYQGYKIPPYYDSMIGKLIVHGRDRDECIRRLRRALDEFVVDGIKTTLPLFQ
CEEEECCCCCCCCCCCCHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLLQNEDILNGDYDIHWLEKYLAGDASH
HHHCCCCCCCCCCCHHHHHHHHCCCCCC
>Mature Secondary Structure
MVSKILIANRGEIALRVLRAAKELGIPTVAVHSTADADAMHVRLADESVCIGPPPSRDSY
CCCEEEEECCCHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEECCCCEECCCCCCCCCC
LNIHQIVAACEITGADAVHPGYGFLSENAKFADILDAHGITFIGPTAEHIRIMGDKITAK
CHHHHHHHHHEECCCCCCCCCCCCCCCCCCHHHHHHCCCEEEECCCHHHEEEECCCHHHH
QTAQELGIPVVPGSDGEVKPENALEIARTIGFPVLIKATAGGGGRGMKVAKTEADLEDAV
HHHHHCCCEEECCCCCCCCCHHHHHHHHHCCCEEEEEEECCCCCCCCEEEECHHHHHHHH
ATARSEAAAAFGNDAVYMEKYLGKPRHIEVQVFGDGEGNAVHLGERDCSLQRRHQKVLEE
HHHHHHHHHHCCCCHHHHHHHCCCCCEEEEEEEECCCCCEEEECCCCHHHHHHHHHHHHH
ANSPALTVEQRMKIGEICADAMRKLKYRGAGTIEFLYENGEFYFIEMNTRLQVEHPVTEA
CCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEEEECCEEEECCCHHHH
ITGMDLVQEQIRVASGQGLSVTQADIEFHGHAIECRINAEDPRTFVPSPGTLTYFHTPGG
HHHHHHHHHHHHHHCCCCCEEEEECEEECCEEEEEEECCCCCCEECCCCCEEEEEECCCC
LGVRVDSGAYQGYKIPPYYDSMIGKLIVHGRDRDECIRRLRRALDEFVVDGIKTTLPLFQ
CEEEECCCCCCCCCCCCHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLLQNEDILNGDYDIHWLEKYLAGDASH
HHHCCCCCCCCCCCHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]