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The map label for this gene is pleC [H]

Identifier: 15888325

GI number: 15888325

Start: 974550

End: 976886

Strand: Reverse

Name: pleC [H]

Synonym: Atu0982

Alternate gene names: 15888325

Gene position: 976886-974550 (Counterclockwise)

Preceding gene: 159184561

Following gene: 15888323

Centisome position: 34.38

GC content: 61.79

Gene sequence:

>2337_bases
ATGACGAACGTGCGGCGGGCGACTGCGGGCGATGAGCGGCCGTATGCCAAATTTTCTGATCTTGCGGCCTGGGGCGAAAG
GCTTTCCAACGACCTGATGGGTTTGATGAATGGCTCCGACCGCCCGATGCCGCAGGTCGAGACCCTGCTGAAACGCCTGA
TCCCCATTCTCATCCTCGCCTTTCTTGTCGTTGTCGCGGCCTCGCGCATGCTGGGCATCGCCGCCGAATATGGCCGCATG
GAAGAAGCCGCCCGCCACTCCACCGCGCTGACGGCGCTCACCGCCAAGGCAGCACTTCTCAACAATGATACGATCTTCAC
CGCGCAGGATCGCACCCGCGCCGAGGCGAGCCTTGTCGCCGCTTTGCCGTCGGGCAGCCTGGCCGATGGCACTATGGTGC
TGCTATCCGGCAGCAACGGCCGCATCTTCGCGGGCGCCGGCAAGGAAGCTTCGCTTTATGTCGGCACCTCGCTGCCGGCC
CTGCTTCCCGAGATCGCCATCGTGCAGCGTTTCCCCGGCACGCCCGGCACCATCGAGACCAATATAGACGGCCAGCAGCA
TTATGCGACGATGATCCCCTTCGGCGACGATGGCGCGATGGTGATCGCGGCACGCTCGCTGCAACCTATTCGCTCCTTCT
GGCGCAGCGAAATCGCCATGAACGTCACGCTGTTTGCCGGCATCTCCTCCATCCTGCTCGTCGTGCTCTATGCCTATTAC
ATGCAGGTGAAGCGCGCCCGCGATGCCGACGACATCTTCGCCGAATCGAACCTGCGGGTCGAGACGGCGCTCTCGCGCGG
CCGCTGCGGCCTGTGGGATTTCGATCTCTCCAGCCGACGCATGTTCTGGTCCGGTTCGCTCTACGAAATTCTTGGGCTGC
CGCCGAAGGCCGCACCGCTTTCCTTTTCCGACGCGGCCCGGATGATGCATTCCGAAGACGGCAATCTCTATGAACTGGCA
CGCGCTGTCGGCTGCGGTAACCTGCGCCAGATCGACCAGATTTTTCGCATGCGTCATTCCAAAGGGCACTATGTCTGGCT
GCGGGCCCGCGCCCAGGTCATCCGCACCAATAACGGTCCACGCGTCATCGGCATCGCCATGGATGTCACCGAGCAGCATC
GTCTTGCCCAGCGCTACGCAGAGGCCGATCAGCGCCTTGCTGACGCCATCGAATCCACCTCGGAAGCCTTCGTGCTATGG
GACAAGAACGACCGCCTCGTAATGTGCAATATCCACTACCAGAAGGCCTATGGCCTACCGGACAGCGTGCTGGTGGCCGG
TACGGAAAAGAGCACGGTCTACGCTGCCGCCGCACGCCCGGTCGTGGAACGGCGCGTCGCCGATCCGGATCAGTCCGGCC
TGTCGCGCACAACGGAAGTGCAGCTTGCCGATGACCGTTGGCTGCAGATCAACGAACGCCGCACCCGCGATGGCGGCCTC
GTCTCCGTCGGCACAGACATCACGCTTCTGAAGCGCCATCAGGAACGGCTGCGCGATTCCGAGCGACGGCTGATGGCTAC
CATCGGCGACCTCTCCGCCTCACAGCACAAGCTGGAGCGGCAGAAGACCGAGCTTTCGGACGCCAATGCCAATTACCTCG
CCGAAAAAGAGCGCGCCCAGGCCGCCAACCGGGCGAAATCGGAATTCCTCGCCAATATGAGCCATGAGCTGCGCACGCCG
CTCAACGCCATTCTCGGCTTCTCAGAAATCCTGCAAAACGAGATGTTCGGGCCGGTCGGCTCACCGAAATATTCCGAATA
TGCCCGCGACATCCATGACAGCGGCAAACACCTCTTGAACGTCATCAACGACATTCTCGACATGTCGAAGATCGAGGCGG
GCCATATGCGCATCAACCGCGAGACCATCGATCTCGCACCGCTGATCGAGGAAACCCTGCGTCTGACTGCCATTCAGGCC
GAACAGAAGAACATCACCGTGCAGCAGAAGGTGTGCGCCGGGTTGACGATGCAGGGCGACCGCCGGGCCATGAAGCAGAT
CATGCTCAACATTCTTTCAAATGCCGTGAAATTCACCGGCGATGGTGGCCGCATCGCGCTGCGCACCCATGTGCATGAGG
CGGCGATGATCCTCACCATCGCCGATACCGGCATCGGCATTCCGGCGCAGGCCTTGCAAAAGATCGGTCAGCCCTTTGAA
CAGGTGCAGAGCCAATATGCCAAGAGCCAGGGCGGCTCCGGCCTCGGACTTGCGATTTCCCGCTCGCTGGTGAAGCTGCA
TGGCGGCACGATGAAAATCCGCTCGTGTGAGGGCCGCGGTACGGTGGTGACGATCATTATTCCGCATGCGGCAGGGGTGT
GTGGGACGGTGCATTGA

Upstream 100 bases:

>100_bases
TTTAACTTTTGCCTCTGGACACGGCGAATCGCATTTGATTCATTAGGGATATTCGAGCGGCGGCGCTTCGAATCAGTGGG
GATATCTAAAAGGCGGGACA

Downstream 100 bases:

>100_bases
AGCTTGGTGGGCGTGGTTTGCGCCCCTTTGCGTTGGCGAGTGCGGTTTACCCCCTCTGCCCTGCCGGGCATCTCCCCCTC
AAGGGGGGAGATCAGCTAGA

Product: two component sensor kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 778; Mature: 777

Protein sequence:

>778_residues
MTNVRRATAGDERPYAKFSDLAAWGERLSNDLMGLMNGSDRPMPQVETLLKRLIPILILAFLVVVAASRMLGIAAEYGRM
EEAARHSTALTALTAKAALLNNDTIFTAQDRTRAEASLVAALPSGSLADGTMVLLSGSNGRIFAGAGKEASLYVGTSLPA
LLPEIAIVQRFPGTPGTIETNIDGQQHYATMIPFGDDGAMVIAARSLQPIRSFWRSEIAMNVTLFAGISSILLVVLYAYY
MQVKRARDADDIFAESNLRVETALSRGRCGLWDFDLSSRRMFWSGSLYEILGLPPKAAPLSFSDAARMMHSEDGNLYELA
RAVGCGNLRQIDQIFRMRHSKGHYVWLRARAQVIRTNNGPRVIGIAMDVTEQHRLAQRYAEADQRLADAIESTSEAFVLW
DKNDRLVMCNIHYQKAYGLPDSVLVAGTEKSTVYAAAARPVVERRVADPDQSGLSRTTEVQLADDRWLQINERRTRDGGL
VSVGTDITLLKRHQERLRDSERRLMATIGDLSASQHKLERQKTELSDANANYLAEKERAQAANRAKSEFLANMSHELRTP
LNAILGFSEILQNEMFGPVGSPKYSEYARDIHDSGKHLLNVINDILDMSKIEAGHMRINRETIDLAPLIEETLRLTAIQA
EQKNITVQQKVCAGLTMQGDRRAMKQIMLNILSNAVKFTGDGGRIALRTHVHEAAMILTIADTGIGIPAQALQKIGQPFE
QVQSQYAKSQGGSGLGLAISRSLVKLHGGTMKIRSCEGRGTVVTIIIPHAAGVCGTVH

Sequences:

>Translated_778_residues
MTNVRRATAGDERPYAKFSDLAAWGERLSNDLMGLMNGSDRPMPQVETLLKRLIPILILAFLVVVAASRMLGIAAEYGRM
EEAARHSTALTALTAKAALLNNDTIFTAQDRTRAEASLVAALPSGSLADGTMVLLSGSNGRIFAGAGKEASLYVGTSLPA
LLPEIAIVQRFPGTPGTIETNIDGQQHYATMIPFGDDGAMVIAARSLQPIRSFWRSEIAMNVTLFAGISSILLVVLYAYY
MQVKRARDADDIFAESNLRVETALSRGRCGLWDFDLSSRRMFWSGSLYEILGLPPKAAPLSFSDAARMMHSEDGNLYELA
RAVGCGNLRQIDQIFRMRHSKGHYVWLRARAQVIRTNNGPRVIGIAMDVTEQHRLAQRYAEADQRLADAIESTSEAFVLW
DKNDRLVMCNIHYQKAYGLPDSVLVAGTEKSTVYAAAARPVVERRVADPDQSGLSRTTEVQLADDRWLQINERRTRDGGL
VSVGTDITLLKRHQERLRDSERRLMATIGDLSASQHKLERQKTELSDANANYLAEKERAQAANRAKSEFLANMSHELRTP
LNAILGFSEILQNEMFGPVGSPKYSEYARDIHDSGKHLLNVINDILDMSKIEAGHMRINRETIDLAPLIEETLRLTAIQA
EQKNITVQQKVCAGLTMQGDRRAMKQIMLNILSNAVKFTGDGGRIALRTHVHEAAMILTIADTGIGIPAQALQKIGQPFE
QVQSQYAKSQGGSGLGLAISRSLVKLHGGTMKIRSCEGRGTVVTIIIPHAAGVCGTVH
>Mature_777_residues
TNVRRATAGDERPYAKFSDLAAWGERLSNDLMGLMNGSDRPMPQVETLLKRLIPILILAFLVVVAASRMLGIAAEYGRME
EAARHSTALTALTAKAALLNNDTIFTAQDRTRAEASLVAALPSGSLADGTMVLLSGSNGRIFAGAGKEASLYVGTSLPAL
LPEIAIVQRFPGTPGTIETNIDGQQHYATMIPFGDDGAMVIAARSLQPIRSFWRSEIAMNVTLFAGISSILLVVLYAYYM
QVKRARDADDIFAESNLRVETALSRGRCGLWDFDLSSRRMFWSGSLYEILGLPPKAAPLSFSDAARMMHSEDGNLYELAR
AVGCGNLRQIDQIFRMRHSKGHYVWLRARAQVIRTNNGPRVIGIAMDVTEQHRLAQRYAEADQRLADAIESTSEAFVLWD
KNDRLVMCNIHYQKAYGLPDSVLVAGTEKSTVYAAAARPVVERRVADPDQSGLSRTTEVQLADDRWLQINERRTRDGGLV
SVGTDITLLKRHQERLRDSERRLMATIGDLSASQHKLERQKTELSDANANYLAEKERAQAANRAKSEFLANMSHELRTPL
NAILGFSEILQNEMFGPVGSPKYSEYARDIHDSGKHLLNVINDILDMSKIEAGHMRINRETIDLAPLIEETLRLTAIQAE
QKNITVQQKVCAGLTMQGDRRAMKQIMLNILSNAVKFTGDGGRIALRTHVHEAAMILTIADTGIGIPAQALQKIGQPFEQ
VQSQYAKSQGGSGLGLAISRSLVKLHGGTMKIRSCEGRGTVVTIIIPHAAGVCGTVH

Specific function: Member of the two-component regulatory system involved in the regulation of polar organelle development. PleC functions as a membrane-associated protein kinase that transfers phosphate to the response regulator pleD, leading to its activation [H]

COG id: COG2202

COG function: function code T; FOG: PAS/PAC domain

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI48994928, Length=253, Percent_Identity=35.5731225296443, Blast_Score=145, Evalue=9e-36,
Organism=Escherichia coli, GI1789149, Length=259, Percent_Identity=35.5212355212355, Blast_Score=142, Evalue=9e-35,
Organism=Escherichia coli, GI87081816, Length=249, Percent_Identity=35.7429718875502, Blast_Score=136, Evalue=6e-33,
Organism=Escherichia coli, GI1788713, Length=245, Percent_Identity=33.8775510204082, Blast_Score=127, Evalue=3e-30,
Organism=Escherichia coli, GI145693157, Length=244, Percent_Identity=35.2459016393443, Blast_Score=122, Evalue=7e-29,
Organism=Escherichia coli, GI1786912, Length=273, Percent_Identity=29.3040293040293, Blast_Score=106, Evalue=6e-24,
Organism=Escherichia coli, GI87082128, Length=250, Percent_Identity=27.2, Blast_Score=105, Evalue=8e-24,
Organism=Escherichia coli, GI1786600, Length=224, Percent_Identity=28.125, Blast_Score=105, Evalue=1e-23,
Organism=Escherichia coli, GI1788549, Length=247, Percent_Identity=29.9595141700405, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1788393, Length=278, Percent_Identity=26.6187050359712, Blast_Score=99, Evalue=1e-21,
Organism=Escherichia coli, GI1790436, Length=221, Percent_Identity=28.0542986425339, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1790861, Length=219, Percent_Identity=26.4840182648402, Blast_Score=81, Evalue=3e-16,
Organism=Escherichia coli, GI1790346, Length=225, Percent_Identity=27.1111111111111, Blast_Score=79, Evalue=2e-15,
Organism=Escherichia coli, GI1786783, Length=235, Percent_Identity=23.8297872340426, Blast_Score=73, Evalue=6e-14,
Organism=Escherichia coli, GI1790300, Length=251, Percent_Identity=22.7091633466135, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1787894, Length=261, Percent_Identity=27.2030651340996, Blast_Score=67, Evalue=5e-12,
Organism=Escherichia coli, GI1788279, Length=208, Percent_Identity=21.1538461538462, Blast_Score=63, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 85415; Mature: 85284

Theoretical pI: Translated: 8.85; Mature: 8.85

Prosite motif: PS50113 PAC ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNVRRATAGDERPYAKFSDLAAWGERLSNDLMGLMNGSDRPMPQVETLLKRLIPILILA
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
FLVVVAASRMLGIAAEYGRMEEAARHSTALTALTAKAALLNNDTIFTAQDRTRAEASLVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHEEE
ALPSGSLADGTMVLLSGSNGRIFAGAGKEASLYVGTSLPALLPEIAIVQRFPGTPGTIET
ECCCCCCCCCEEEEEECCCCEEEEECCCCCEEEECCCCHHHHHHHHHHHHCCCCCCEEEE
NIDGQQHYATMIPFGDDGAMVIAARSLQPIRSFWRSEIAMNVTLFAGISSILLVVLYAYY
CCCCCCEEEEEEEECCCCCEEEEECCHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHHHH
MQVKRARDADDIFAESNLRVETALSRGRCGLWDFDLSSRRMFWSGSLYEILGLPPKAAPL
HHHHHCCCHHHHHHCCCCEEEEHHCCCCCCEEECCCCCCEEEECCCHHHHHCCCCCCCCC
SFSDAARMMHSEDGNLYELARAVGCGNLRQIDQIFRMRHSKGHYVWLRARAQVIRTNNGP
CHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEEEEEEEEEECCCC
RVIGIAMDVTEQHRLAQRYAEADQRLADAIESTSEAFVLWDKNDRLVMCNIHYQKAYGLP
EEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEEEEHHHCCCC
DSVLVAGTEKSTVYAAAARPVVERRVADPDQSGLSRTTEVQLADDRWLQINERRTRDGGL
CCEEEECCCCCEEEEHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCEEEECCCCCCCCCE
VSVGTDITLLKRHQERLRDSERRLMATIGDLSASQHKLERQKTELSDANANYLAEKERAQ
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHH
AANRAKSEFLANMSHELRTPLNAILGFSEILQNEMFGPVGSPKYSEYARDIHDSGKHLLN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
VINDILDMSKIEAGHMRINRETIDLAPLIEETLRLTAIQAEQKNITVQQKVCAGLTMQGD
HHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHCCCCCCCH
RRAMKQIMLNILSNAVKFTGDGGRIALRTHVHEAAMILTIADTGIGIPAQALQKIGQPFE
HHHHHHHHHHHHHHHHEEECCCCEEEEEEECCCEEEEEEEECCCCCCCHHHHHHHCCHHH
QVQSQYAKSQGGSGLGLAISRSLVKLHGGTMKIRSCEGRGTVVTIIIPHAAGVCGTVH
HHHHHHHHHCCCCCEEHHHHHHHHHHCCCEEEEEEECCCCCEEEEEECCCCCCCCCCC
>Mature Secondary Structure 
TNVRRATAGDERPYAKFSDLAAWGERLSNDLMGLMNGSDRPMPQVETLLKRLIPILILA
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
FLVVVAASRMLGIAAEYGRMEEAARHSTALTALTAKAALLNNDTIFTAQDRTRAEASLVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHEEE
ALPSGSLADGTMVLLSGSNGRIFAGAGKEASLYVGTSLPALLPEIAIVQRFPGTPGTIET
ECCCCCCCCCEEEEEECCCCEEEEECCCCCEEEECCCCHHHHHHHHHHHHCCCCCCEEEE
NIDGQQHYATMIPFGDDGAMVIAARSLQPIRSFWRSEIAMNVTLFAGISSILLVVLYAYY
CCCCCCEEEEEEEECCCCCEEEEECCHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHHHH
MQVKRARDADDIFAESNLRVETALSRGRCGLWDFDLSSRRMFWSGSLYEILGLPPKAAPL
HHHHHCCCHHHHHHCCCCEEEEHHCCCCCCEEECCCCCCEEEECCCHHHHHCCCCCCCCC
SFSDAARMMHSEDGNLYELARAVGCGNLRQIDQIFRMRHSKGHYVWLRARAQVIRTNNGP
CHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEEEEEEEEEECCCC
RVIGIAMDVTEQHRLAQRYAEADQRLADAIESTSEAFVLWDKNDRLVMCNIHYQKAYGLP
EEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEEEEHHHCCCC
DSVLVAGTEKSTVYAAAARPVVERRVADPDQSGLSRTTEVQLADDRWLQINERRTRDGGL
CCEEEECCCCCEEEEHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCEEEECCCCCCCCCE
VSVGTDITLLKRHQERLRDSERRLMATIGDLSASQHKLERQKTELSDANANYLAEKERAQ
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHH
AANRAKSEFLANMSHELRTPLNAILGFSEILQNEMFGPVGSPKYSEYARDIHDSGKHLLN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
VINDILDMSKIEAGHMRINRETIDLAPLIEETLRLTAIQAEQKNITVQQKVCAGLTMQGD
HHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHCCCCCCCH
RRAMKQIMLNILSNAVKFTGDGGRIALRTHVHEAAMILTIADTGIGIPAQALQKIGQPFE
HHHHHHHHHHHHHHHHEEECCCCEEEEEEECCCEEEEEEEECCCCCCCHHHHHHHCCHHH
QVQSQYAKSQGGSGLGLAISRSLVKLHGGTMKIRSCEGRGTVVTIIIPHAAGVCGTVH
HHHHHHHHHCCCCCEEHHHHHHHHHHCCCEEEEEEECCCCCEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8421698; 11259647 [H]