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The map label for this gene is proW [H]

Identifier: 15888234

GI number: 15888234

Start: 884715

End: 885623

Strand: Reverse

Name: proW [H]

Synonym: Atu0894

Alternate gene names: 15888234

Gene position: 885623-884715 (Counterclockwise)

Preceding gene: 15888235

Following gene: 159184520

Centisome position: 31.17

GC content: 60.62

Gene sequence:

>909_bases
ATGGCCCTCTGCAATTACCTGCCGGACCTGCTCTGCAAGTTCCCGGCCATCGACAACTCCACGATGCGTGTGGCACGCAA
GACCATCGATGACGGTTTTCGCGACATCGTGCGCAATTACGGCGATGCGATCGATGTGATCGTGCATCCGCTGCAACTCT
TCCTCAACGCCTCGGAGCGGCTGTTCATCGAGACGCCGTGGATCATCACGATGCTCGTCATTCTGGCCATCGTGCATCTG
GCCGGGCGCAGCTTCAAGATCACCGGTGGCACCGCAATCTCCCTCTTCATGATCGGCGCCGTTGGCCTGTGGCGCGACGC
CATGACGACGCTGTCCATCGTCACCATCGCCACGCTGATCGCCATCGTCATCGGCCTGCCGCTTGGCATCCTGATGGGTC
GTTCCGAACGCCTGCAACGCCTCATCAATCCCGTGCTCGACGTGATGCAGACCCTGCCAAGCTTCGTTTATCTCATCCCC
GTGGTGGTGATTTTCGGCATCGGCAAGGTACCGGGCCTGATCGCAGTGGTGATCTACGCCATTCCGCCCGTCATTCGCCT
GACGAGCCTCGGCATCCGCCTGGTGGACCGGGAAGTGCTGGAAGCGGCGGATGCCTTCGGTTCCTCCAACGGCCAGAAGC
TGTTCAACGTGCAGCTGCCGCTGGCGCTGCCCACCATCATGACCGGCATCAACCAGACCATCATGATGGCGCTCGCCATG
GTCGTCGTCGCCTCGATGGTCGGCGTCGGTGGTCTCGGCAAGAATGTGCTGCAGGCCATCAACAACCAGTTTTTCACGGT
GGGCTTCCTGAACGGTTTCGCTCTGGTCGCCATCGCCATCATGTTTGATCGGGCAAGCCAGGCTTTCGGCAAGCGCCTGC
AGAAATACCGCGAGGTCTCCCATGGCTAA

Upstream 100 bases:

>100_bases
ATCTCCCCCCTTGTGGGGGAGATGTCCGGCGGGACAGAGGGGGGTGCCCGCGCACTCGAACCTCGCGCCCATCCCATAAC
CCAAAGGGAAAACAACAATA

Downstream 100 bases:

>100_bases
AAGCATCGAAATCAAGAATCTTTACAAGATCTTCGGCAAGCATCCCGAGAAATACCTCGAGGCGGTGCGGTCGGGCATGG
ACAAGGTCGAACTGAACGAC

Product: ABC transporter, membrane spanning protein

Products: ADP; phosphate; L-proline [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 302; Mature: 301

Protein sequence:

>302_residues
MALCNYLPDLLCKFPAIDNSTMRVARKTIDDGFRDIVRNYGDAIDVIVHPLQLFLNASERLFIETPWIITMLVILAIVHL
AGRSFKITGGTAISLFMIGAVGLWRDAMTTLSIVTIATLIAIVIGLPLGILMGRSERLQRLINPVLDVMQTLPSFVYLIP
VVVIFGIGKVPGLIAVVIYAIPPVIRLTSLGIRLVDREVLEAADAFGSSNGQKLFNVQLPLALPTIMTGINQTIMMALAM
VVVASMVGVGGLGKNVLQAINNQFFTVGFLNGFALVAIAIMFDRASQAFGKRLQKYREVSHG

Sequences:

>Translated_302_residues
MALCNYLPDLLCKFPAIDNSTMRVARKTIDDGFRDIVRNYGDAIDVIVHPLQLFLNASERLFIETPWIITMLVILAIVHL
AGRSFKITGGTAISLFMIGAVGLWRDAMTTLSIVTIATLIAIVIGLPLGILMGRSERLQRLINPVLDVMQTLPSFVYLIP
VVVIFGIGKVPGLIAVVIYAIPPVIRLTSLGIRLVDREVLEAADAFGSSNGQKLFNVQLPLALPTIMTGINQTIMMALAM
VVVASMVGVGGLGKNVLQAINNQFFTVGFLNGFALVAIAIMFDRASQAFGKRLQKYREVSHG
>Mature_301_residues
ALCNYLPDLLCKFPAIDNSTMRVARKTIDDGFRDIVRNYGDAIDVIVHPLQLFLNASERLFIETPWIITMLVILAIVHLA
GRSFKITGGTAISLFMIGAVGLWRDAMTTLSIVTIATLIAIVIGLPLGILMGRSERLQRLINPVLDVMQTLPSFVYLIPV
VVIFGIGKVPGLIAVVIYAIPPVIRLTSLGIRLVDREVLEAADAFGSSNGQKLFNVQLPLALPTIMTGINQTIMMALAMV
VVASMVGVGGLGKNVLQAINNQFFTVGFLNGFALVAIAIMFDRASQAFGKRLQKYREVSHG

Specific function: Involved in a multicomponent binding-protein-dependent transport system for glycine betaine/L-proline [H]

COG id: COG4176

COG function: function code E; ABC-type proline/glycine betaine transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1789033, Length=268, Percent_Identity=44.7761194029851, Blast_Score=210, Evalue=1e-55,
Organism=Escherichia coli, GI1788451, Length=195, Percent_Identity=34.8717948717949, Blast_Score=95, Evalue=7e-21,
Organism=Escherichia coli, GI1788449, Length=195, Percent_Identity=30.7692307692308, Blast_Score=88, Evalue=9e-19,
Organism=Escherichia coli, GI1786564, Length=158, Percent_Identity=29.746835443038, Blast_Score=75, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 32794; Mature: 32663

Theoretical pI: Translated: 9.95; Mature: 9.95

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALCNYLPDLLCKFPAIDNSTMRVARKTIDDGFRDIVRNYGDAIDVIVHPLQLFLNASER
CCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCC
LFIETPWIITMLVILAIVHLAGRSFKITGGTAISLFMIGAVGLWRDAMTTLSIVTIATLI
EEEECCHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIVIGLPLGILMGRSERLQRLINPVLDVMQTLPSFVYLIPVVVIFGIGKVPGLIAVVIYA
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
IPPVIRLTSLGIRLVDREVLEAADAFGSSNGQKLFNVQLPLALPTIMTGINQTIMMALAM
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHH
VVVASMVGVGGLGKNVLQAINNQFFTVGFLNGFALVAIAIMFDRASQAFGKRLQKYREVS
HHHHHHHCCCCCCHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
HG
CC
>Mature Secondary Structure 
ALCNYLPDLLCKFPAIDNSTMRVARKTIDDGFRDIVRNYGDAIDVIVHPLQLFLNASER
CHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCC
LFIETPWIITMLVILAIVHLAGRSFKITGGTAISLFMIGAVGLWRDAMTTLSIVTIATLI
EEEECCHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIVIGLPLGILMGRSERLQRLINPVLDVMQTLPSFVYLIPVVVIFGIGKVPGLIAVVIYA
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
IPPVIRLTSLGIRLVDREVLEAADAFGSSNGQKLFNVQLPLALPTIMTGINQTIMMALAM
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHH
VVVASMVGVGGLGKNVLQAINNQFFTVGFLNGFALVAIAIMFDRASQAFGKRLQKYREVS
HHHHHHHCCCCCCHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
HG
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-proline [Periplasm]; H2O [C]

Specific reaction: ATP + L-proline [Periplasm] + H2O = ADP + phosphate + L-proline [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2649479; 9205837; 9278503 [H]