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The map label for this gene is ribA [H]

Identifier: 15888096

GI number: 15888096

Start: 750516

End: 751616

Strand: Reverse

Name: ribA [H]

Synonym: Atu0753

Alternate gene names: 15888096

Gene position: 751616-750516 (Counterclockwise)

Preceding gene: 159184451

Following gene: 159184450

Centisome position: 26.45

GC content: 61.04

Gene sequence:

>1101_bases
ATGGCCTATGACCAGAAACGCGTTGTCGACGCCATCCGCGCATTCGAAGCCGGCGAAATCGTTGTCGTGACCGATGATGA
CGACCGCGAGAACGAAGGCGATCTGATCATTTCGGCGGTTCACTGCACGCCGGAAAAAATGGCGCTGATCGTGCGCCATA
CATCCGGCATCGTCTGCGCGCCGATGCCGCGCGAAGAAGCGAAGCGTCTGAACCTCAACGCCATGGTGGCGGAAAACGAC
AGCGCCCACACGACGGCCTTCACCGTCAGCGTCGATTTCAAGCACGGCACAACGACCGGCATTTCCGCCGATGACCGCAC
CCTAACGGTGCGCAATCTTGCCAATCCCAATGTCGGCGCTTCCGACTTCACCCGGCCGGGCCATATTTTCCCGCTGATTT
CCCGCGAAGGCGGCGTGTTGATGCGTTCCGGCCACACCGAAGCGGCCGTCGATCTCTGCCGGCTCGCCGGCCTGCCGCCC
ATCGGTGTCATCAGCGAGCTTGTGAATGATGATGGCAGCGTGATGCGCGGCCCGCAGGTTCTGGATTTCGCCGACAAACA
CGGCATGAAACATGTGTCGGTTGCCGACCTCATCGCCTATCGCCAGCGCAAGGAAACACTGGTGGAGATGGAATCCTCCT
TCACCATCGAGACGCCCTTCGGGCCGGCCATGGCGCAGACCTATTCCCTGCCCTGGGACCCGATGCAGCATATGGCGGTG
ATTTTCGGCGACATCAGGGACGGCGTCGACATTCCCGTTCGCCTGCATACGGAAAATGTCGCCGACGACGTATTCGGCGA
CCGTCAGCCAGTGCGGCATTACATGCAGAAGATCGCTGAAGAAGGCCGCGGCGTCATCGTCTATCTGCGCGAGGGCTCCG
TCGGCGTCGGCCAGGTCGCCGGACGCCGCAAGGCGCGTGATCCCGATGAAGCGCATGCGCAGGCCCGCTCTCGCGAGAAT
GAATGGCTGGAAATCGGCCTTGGCGCACAAATTCTCAAAGACCTCGGCATCAGCTCCATCAAGCTGCTGACAACCCGCGA
ACGCCATTATGTCGGGCTTGAAGGGTTCGGCATCCAGATTTCGGCGACGGATATCTGCTGA

Upstream 100 bases:

>100_bases
CGCCGTTCCGATCGGTGAAGCGATGATCGCCTGCACCGTTGCCGACCATTACCTGAGAGACCGCGGCCAGACCGGCCGAC
TGAAATAAGGGGATATCGCC

Downstream 100 bases:

>100_bases
TTTTAAGCTTCACTGACGCTGAGCATCAATTCGCCCATCGGTGAATATGGAGCGGGCGGATATCGCTTGTTTCTTCTCCC
CGGCGGGAGAAGAAATATGC

Product: 3,4-dihydroxy-2-butanone-4-phoshate synthase/GTP cyclohydrolase II

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 366; Mature: 365

Protein sequence:

>366_residues
MAYDQKRVVDAIRAFEAGEIVVVTDDDDRENEGDLIISAVHCTPEKMALIVRHTSGIVCAPMPREEAKRLNLNAMVAEND
SAHTTAFTVSVDFKHGTTTGISADDRTLTVRNLANPNVGASDFTRPGHIFPLISREGGVLMRSGHTEAAVDLCRLAGLPP
IGVISELVNDDGSVMRGPQVLDFADKHGMKHVSVADLIAYRQRKETLVEMESSFTIETPFGPAMAQTYSLPWDPMQHMAV
IFGDIRDGVDIPVRLHTENVADDVFGDRQPVRHYMQKIAEEGRGVIVYLREGSVGVGQVAGRRKARDPDEAHAQARSREN
EWLEIGLGAQILKDLGISSIKLLTTRERHYVGLEGFGIQISATDIC

Sequences:

>Translated_366_residues
MAYDQKRVVDAIRAFEAGEIVVVTDDDDRENEGDLIISAVHCTPEKMALIVRHTSGIVCAPMPREEAKRLNLNAMVAEND
SAHTTAFTVSVDFKHGTTTGISADDRTLTVRNLANPNVGASDFTRPGHIFPLISREGGVLMRSGHTEAAVDLCRLAGLPP
IGVISELVNDDGSVMRGPQVLDFADKHGMKHVSVADLIAYRQRKETLVEMESSFTIETPFGPAMAQTYSLPWDPMQHMAV
IFGDIRDGVDIPVRLHTENVADDVFGDRQPVRHYMQKIAEEGRGVIVYLREGSVGVGQVAGRRKARDPDEAHAQARSREN
EWLEIGLGAQILKDLGISSIKLLTTRERHYVGLEGFGIQISATDIC
>Mature_365_residues
AYDQKRVVDAIRAFEAGEIVVVTDDDDRENEGDLIISAVHCTPEKMALIVRHTSGIVCAPMPREEAKRLNLNAMVAENDS
AHTTAFTVSVDFKHGTTTGISADDRTLTVRNLANPNVGASDFTRPGHIFPLISREGGVLMRSGHTEAAVDLCRLAGLPPI
GVISELVNDDGSVMRGPQVLDFADKHGMKHVSVADLIAYRQRKETLVEMESSFTIETPFGPAMAQTYSLPWDPMQHMAVI
FGDIRDGVDIPVRLHTENVADDVFGDRQPVRHYMQKIAEEGRGVIVYLREGSVGVGQVAGRRKARDPDEAHAQARSRENE
WLEIGLGAQILKDLGISSIKLLTTRERHYVGLEGFGIQISATDIC

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1789420, Length=200, Percent_Identity=50.5, Blast_Score=202, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6320695, Length=201, Percent_Identity=47.7611940298507, Blast_Score=186, Evalue=6e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 40132; Mature: 40001

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYDQKRVVDAIRAFEAGEIVVVTDDDDRENEGDLIISAVHCTPEKMALIVRHTSGIVCA
CCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCCEEEEEEECCCCCEEEEEEECCCEEEC
PMPREEAKRLNLNAMVAENDSAHTTAFTVSVDFKHGTTTGISADDRTLTVRNLANPNVGA
CCCHHHHHHCCCEEEEECCCCCCEEEEEEEEEECCCCCCCCCCCCCEEEEEECCCCCCCC
SDFTRPGHIFPLISREGGVLMRSGHTEAAVDLCRLAGLPPIGVISELVNDDGSVMRGPQV
CCCCCCCCEEEEEECCCCEEEECCCCHHHHHHHHHCCCCCHHHHHHHHCCCCCEECCCCC
LDFADKHGMKHVSVADLIAYRQRKETLVEMESSFTIETPFGPAMAQTYSLPWDPMQHMAV
EEHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHCCCCCCHHHHHHH
IFGDIRDGVDIPVRLHTENVADDVFGDRQPVRHYMQKIAEEGRGVIVYLREGSVGVGQVA
HHHHHCCCCCCEEEEECCCHHHHHCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHC
GRRKARDPDEAHAQARSRENEWLEIGLGAQILKDLGISSIKLLTTRERHYVGLEGFGIQI
CCCCCCCCHHHHHHHHCCCCCEEEECCCHHHHHHCCCCEEEEEEECCCEEEEEECCCEEE
SATDIC
EECCCC
>Mature Secondary Structure 
AYDQKRVVDAIRAFEAGEIVVVTDDDDRENEGDLIISAVHCTPEKMALIVRHTSGIVCA
CCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCCEEEEEEECCCCCEEEEEEECCCEEEC
PMPREEAKRLNLNAMVAENDSAHTTAFTVSVDFKHGTTTGISADDRTLTVRNLANPNVGA
CCCHHHHHHCCCEEEEECCCCCCEEEEEEEEEECCCCCCCCCCCCCEEEEEECCCCCCCC
SDFTRPGHIFPLISREGGVLMRSGHTEAAVDLCRLAGLPPIGVISELVNDDGSVMRGPQV
CCCCCCCCEEEEEECCCCEEEECCCCHHHHHHHHHCCCCCHHHHHHHHCCCCCEECCCCC
LDFADKHGMKHVSVADLIAYRQRKETLVEMESSFTIETPFGPAMAQTYSLPWDPMQHMAV
EEHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHCCCCCCHHHHHHH
IFGDIRDGVDIPVRLHTENVADDVFGDRQPVRHYMQKIAEEGRGVIVYLREGSVGVGQVA
HHHHHCCCCCCEEEEECCCHHHHHCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHC
GRRKARDPDEAHAQARSRENEWLEIGLGAQILKDLGISSIKLLTTRERHYVGLEGFGIQI
CCCCCCCCHHHHHHHHCCCCCEEEECCCHHHHHHCCCCEEEEEEECCCEEEEEECCCEEE
SATDIC
EECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA