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The map label for this gene is atpA

Identifier: 15888058

GI number: 15888058

Start: 715883

End: 716632

Strand: Direct

Name: atpA

Synonym: Atu0714

Alternate gene names: 15888058

Gene position: 715883-716632 (Clockwise)

Preceding gene: 15888057

Following gene: 15888059

Centisome position: 25.19

GC content: 56.4

Gene sequence:

>750_bases
GTGGCAAACGATCCGACCCATCAGTTCTTGGTGCAGCCGATCATTCCGATCGAAATTGGCGGCGTCGATTTTTCCTTCAC
CAATGCGTCGCTGTTCATGGTTGCGACCGTGGCTGCTGCGTCCGGTTTTCTTTATTTCGCAACGTCGAACCGCGGTCTGA
TCCCGACCCGCATGCAGTCCGTTGCTGAAATGTCCTATGAGTTCATCGCCTCCATGCTGCGCGAAGGCGCCGGCAAGAAG
GGTATGGTGTTCTTCCCATTCGTTTTCTCGCTGTTCATGTTCGTGCTGACGGCAAACCTTCTCGGCATGTTCCCGTATTT
CTTCACGGTGACCAGCCAGATCATCGTCACATTCGCGCTTGCCTGCCTCGTCATCGGCACGGTCATCGTTTACGGTTTTT
ACAAGCATGGCCTGCATTTCTTCGGCATCTTCGCCCCGTCAGGCGTTCCGAAGGCGCTTTTGCCGCTTGTCGCGTCGATT
GAAATGATCTCGTTCCTGTCGCGCCCCATCAGCCTTTCGGTTCGTCTTTTCGCGAACATGCTGGCTGGCCACATCACGCT
CAAGGTTTTCGCAGGCTTCGTCGCCTCCATGGGTGCGCTCGGCGCACTCGGCGTCGGCGGCGCTGTCCTGCCTCTCATCA
TGACGGTCGCAATGACCGCTCTCGAATTTCTCGTTGCCTTCCTGCAGGCTTATGTGTTCGCGGTACTGACTTGCATGTAC
CTGAACGATGCCGTGCATGGTGGTCACTGA

Upstream 100 bases:

>100_bases
GGCGGACAGACAGGACGAGGGTGGAAAAGGCGGCGCTTAAGCTGTTTTTTCTTGCAGTTGAGATGCCGCGATGCGCGGCG
ACAGGTAAAGAGGGCAGCCG

Downstream 100 bases:

>100_bases
GAAGTAAAGTCGCTGGCCCCGGCAACGGGCGCCAAAAGATAGCCGCAACAACCTATATCTCAAGGAGTCTCACATGGAAG
CGGAAGCAGCAAAGTACATC

Product: F0F1 ATP synthase subunit A

Products: ADP; phosphate; H+

Alternate protein names: ATP synthase F0 sector subunit a; F-ATPase subunit 6

Number of amino acids: Translated: 249; Mature: 248

Protein sequence:

>249_residues
MANDPTHQFLVQPIIPIEIGGVDFSFTNASLFMVATVAAASGFLYFATSNRGLIPTRMQSVAEMSYEFIASMLREGAGKK
GMVFFPFVFSLFMFVLTANLLGMFPYFFTVTSQIIVTFALACLVIGTVIVYGFYKHGLHFFGIFAPSGVPKALLPLVASI
EMISFLSRPISLSVRLFANMLAGHITLKVFAGFVASMGALGALGVGGAVLPLIMTVAMTALEFLVAFLQAYVFAVLTCMY
LNDAVHGGH

Sequences:

>Translated_249_residues
MANDPTHQFLVQPIIPIEIGGVDFSFTNASLFMVATVAAASGFLYFATSNRGLIPTRMQSVAEMSYEFIASMLREGAGKK
GMVFFPFVFSLFMFVLTANLLGMFPYFFTVTSQIIVTFALACLVIGTVIVYGFYKHGLHFFGIFAPSGVPKALLPLVASI
EMISFLSRPISLSVRLFANMLAGHITLKVFAGFVASMGALGALGVGGAVLPLIMTVAMTALEFLVAFLQAYVFAVLTCMY
LNDAVHGGH
>Mature_248_residues
ANDPTHQFLVQPIIPIEIGGVDFSFTNASLFMVATVAAASGFLYFATSNRGLIPTRMQSVAEMSYEFIASMLREGAGKKG
MVFFPFVFSLFMFVLTANLLGMFPYFFTVTSQIIVTFALACLVIGTVIVYGFYKHGLHFFGIFAPSGVPKALLPLVASIE
MISFLSRPISLSVRLFANMLAGHITLKVFAGFVASMGALGALGVGGAVLPLIMTVAMTALEFLVAFLQAYVFAVLTCMYL
NDAVHGGH

Specific function: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane

COG id: COG0356

COG function: function code C; F0F1-type ATP synthase, subunit a

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase A chain family

Homologues:

Organism=Homo sapiens, GI251831112, Length=195, Percent_Identity=29.7435897435897, Blast_Score=97, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6226527, Length=247, Percent_Identity=32.3886639676113, Blast_Score=144, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ATP6_AGRT5 (A9CK03)

Other databases:

- EMBL:   AE007869
- PIR:   AD2664
- PIR:   C97446
- RefSeq:   NP_353739.1
- ProteinModelPortal:   A9CK03
- SMR:   A9CK03
- STRING:   A9CK03
- GeneID:   1132752
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu0714
- eggNOG:   COG0356
- HOGENOM:   HBG734175
- OMA:   MDQFIVK
- PhylomeDB:   A9CK03
- ProtClustDB:   PRK05815
- HAMAP:   MF_01393
- InterPro:   IPR000568
- InterPro:   IPR023011
- Gene3D:   G3DSA:1.20.120.220
- PANTHER:   PTHR11410
- PRINTS:   PR00123
- TIGRFAMs:   TIGR01131

Pfam domain/function: PF00119 ATP-synt_A; SSF81336 ATPase_F0_A

EC number: 3.6.3.14

Molecular weight: Translated: 26778; Mature: 26647

Theoretical pI: Translated: 8.23; Mature: 8.23

Prosite motif: PS00449 ATPASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xd518d2c)-; HASH(0xd34837c)-; HASH(0xd15fd14)-; HASH(0xc62557c)-; HASH(0xb42055c)-; HASH(0xc55af8c)-;

Cys/Met content:

0.8 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANDPTHQFLVQPIIPIEIGGVDFSFTNASLFMVATVAAASGFLYFATSNRGLIPTRMQS
CCCCCCHHHHHCCCCEEEECCEEEEECCHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHH
VAEMSYEFIASMLREGAGKKGMVFFPFVFSLFMFVLTANLLGMFPYFFTVTSQIIVTFAL
HHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ACLVIGTVIVYGFYKHGLHFFGIFAPSGVPKALLPLVASIEMISFLSRPISLSVRLFANM
HHHHHHHHHHHHHHHHCHHEEEEECCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
LAGHITLKVFAGFVASMGALGALGVGGAVLPLIMTVAMTALEFLVAFLQAYVFAVLTCMY
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LNDAVHGGH
HHHHCCCCH
>Mature Secondary Structure 
ANDPTHQFLVQPIIPIEIGGVDFSFTNASLFMVATVAAASGFLYFATSNRGLIPTRMQS
CCCCCHHHHHCCCCEEEECCEEEEECCHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHH
VAEMSYEFIASMLREGAGKKGMVFFPFVFSLFMFVLTANLLGMFPYFFTVTSQIIVTFAL
HHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ACLVIGTVIVYGFYKHGLHFFGIFAPSGVPKALLPLVASIEMISFLSRPISLSVRLFANM
HHHHHHHHHHHHHHHHCHHEEEEECCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
LAGHITLKVFAGFVASMGALGALGVGGAVLPLIMTVAMTALEFLVAFLQAYVFAVLTCMY
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LNDAVHGGH
HHHHCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Borate; diphosphate; HCO3- [C]

Metal ions: Co2+; Fe2+; Mn2+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: Ca2+; CN-; Efrapeptin; Ethidiumbromide; Guanidines analogs; Oligomycin; Quercetin; Trialkyl tin derivatives; Venturicidin [C]

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11743194; 11743193