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The map label for this gene is pdhR [H]

Identifier: 15888004

GI number: 15888004

Start: 656688

End: 657461

Strand: Reverse

Name: pdhR [H]

Synonym: Atu0662

Alternate gene names: 15888004

Gene position: 657461-656688 (Counterclockwise)

Preceding gene: 159184411

Following gene: 159184410

Centisome position: 23.14

GC content: 61.37

Gene sequence:

>774_bases
ATGGACGAAACGCTTTTTGCGCGCATCGAACACAGCCGCACATCGCGGGAGGTGATCTTACGTTTCGAGGAACTGATCCT
CGACGGCATATTGCGCGATGGCGACCGGTTGCCTGGCGAGCGGGAACTGGCGCAGAAGCTGGATGTATCACGCCCGATCC
TTCGGGAAGCGCTGAAGGAACTCGAAAACCGCGGTCTTCTCACCAGCCGGCATGGCGGCGGCACCTATGTGGCCGATATT
GTCGGCCCGGTGTTTTCCGACCCATTAAGTGCACTGATCACCCGCCACAGCCGGGCGACGCGGGATTTTCTCGAATACCG
CCGCTACATTGAAGGCATGACCGCCGAACTCGCCGCCCAGCGGGCAACGGAACCGGACAGGCGCAACCTTGCGGCCATCG
TCGAGAGAATGCGCGAAGCGCATGAGGCGGGCCGCTTCGAAGAGGAGCTCTCGGGCGATGTGGAATTCCACAACGCCATC
GGCGAGGCGGCGCATAATATCGTGCTGATGCATACGCTACGATCCTGCTACCGGCTCCTGAGCGACGACATCTTCTATAA
TCGTCACCTCATTTTCACCATCGCCGGCGCCCATGATGAGGTGTTGCGGCAGCACATCGCCATCCATGACGCCATCGCCA
CCGGCGATCCGGCAGCGGCAAGGGCGGCGGCGGAAGCCCATATCGACTTCATCATGGAGACGACATCGAGAGCGCATCAG
GCGCGCGAATGGGACCGGATTTCCCGCCTGCGACAGCAGCAACGCAGCAGCTGA

Upstream 100 bases:

>100_bases
AGCGAGGGGGAACTGGATAGAATAATTGACCAGTACGATGCTTCGCTGATAATTTGCCGCTCATCACATACGGGGCGGCA
TTTCGCCGGAGAGTTCTGCG

Downstream 100 bases:

>100_bases
AAACGCCCTCCGGCGAAATCTGCAATCCATTTTATTCCGGTTTTTATGGAACCTTTTGTGCTCTTCGGTCTTTTTACCGG
GTTAATTGGAAAAATTTACC

Product: GntR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 257; Mature: 257

Protein sequence:

>257_residues
MDETLFARIEHSRTSREVILRFEELILDGILRDGDRLPGERELAQKLDVSRPILREALKELENRGLLTSRHGGGTYVADI
VGPVFSDPLSALITRHSRATRDFLEYRRYIEGMTAELAAQRATEPDRRNLAAIVERMREAHEAGRFEEELSGDVEFHNAI
GEAAHNIVLMHTLRSCYRLLSDDIFYNRHLIFTIAGAHDEVLRQHIAIHDAIATGDPAAARAAAEAHIDFIMETTSRAHQ
AREWDRISRLRQQQRSS

Sequences:

>Translated_257_residues
MDETLFARIEHSRTSREVILRFEELILDGILRDGDRLPGERELAQKLDVSRPILREALKELENRGLLTSRHGGGTYVADI
VGPVFSDPLSALITRHSRATRDFLEYRRYIEGMTAELAAQRATEPDRRNLAAIVERMREAHEAGRFEEELSGDVEFHNAI
GEAAHNIVLMHTLRSCYRLLSDDIFYNRHLIFTIAGAHDEVLRQHIAIHDAIATGDPAAARAAAEAHIDFIMETTSRAHQ
AREWDRISRLRQQQRSS
>Mature_257_residues
MDETLFARIEHSRTSREVILRFEELILDGILRDGDRLPGERELAQKLDVSRPILREALKELENRGLLTSRHGGGTYVADI
VGPVFSDPLSALITRHSRATRDFLEYRRYIEGMTAELAAQRATEPDRRNLAAIVERMREAHEAGRFEEELSGDVEFHNAI
GEAAHNIVLMHTLRSCYRLLSDDIFYNRHLIFTIAGAHDEVLRQHIAIHDAIATGDPAAARAAAEAHIDFIMETTSRAHQ
AREWDRISRLRQQQRSS

Specific function: Transcriptional repressor for the pyruvate dehydrogenase complex genes aceEF and lpd [H]

COG id: COG2186

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786303, Length=228, Percent_Identity=37.719298245614, Blast_Score=154, Evalue=5e-39,
Organism=Escherichia coli, GI1790032, Length=252, Percent_Identity=38.0952380952381, Blast_Score=127, Evalue=8e-31,
Organism=Escherichia coli, GI1789353, Length=210, Percent_Identity=33.8095238095238, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1790780, Length=225, Percent_Identity=32.4444444444444, Blast_Score=94, Evalue=7e-21,
Organism=Escherichia coli, GI87082208, Length=238, Percent_Identity=27.3109243697479, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011711
- InterPro:   IPR000524
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07729 FCD; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 29294; Mature: 29294

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDETLFARIEHSRTSREVILRFEELILDGILRDGDRLPGERELAQKLDVSRPILREALKE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHHHH
LENRGLLTSRHGGGTYVADIVGPVFSDPLSALITRHSRATRDFLEYRRYIEGMTAELAAQ
HHHCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RATEPDRRNLAAIVERMREAHEAGRFEEELSGDVEFHNAIGEAAHNIVLMHTLRSCYRLL
HCCCCHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
SDDIFYNRHLIFTIAGAHDEVLRQHIAIHDAIATGDPAAARAAAEAHIDFIMETTSRAHQ
HHHHHHCCEEEEEEECCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
AREWDRISRLRQQQRSS
HHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDETLFARIEHSRTSREVILRFEELILDGILRDGDRLPGERELAQKLDVSRPILREALKE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHHHH
LENRGLLTSRHGGGTYVADIVGPVFSDPLSALITRHSRATRDFLEYRRYIEGMTAELAAQ
HHHCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RATEPDRRNLAAIVERMREAHEAGRFEEELSGDVEFHNAIGEAAHNIVLMHTLRSCYRLL
HCCCCHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
SDDIFYNRHLIFTIAGAHDEVLRQHIAIHDAIATGDPAAARAAAEAHIDFIMETTSRAHQ
HHHHHHCCEEEEEEECCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
AREWDRISRLRQQQRSS
HHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]