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The map label for this gene is upp

Identifier: 15887490

GI number: 15887490

Start: 138594

End: 139223

Strand: Reverse

Name: upp

Synonym: Atu0135

Alternate gene names: 15887490

Gene position: 139223-138594 (Counterclockwise)

Preceding gene: 15887491

Following gene: 159184175

Centisome position: 4.9

GC content: 57.14

Gene sequence:

>630_bases
ATGGACGGCGTCACAGTCATCGAACATCCGCTGGTGCGGCACAAACTCACCATCATGCGCAAGAAGGAAACTTCCACGGC
CGGCTTCCGCCGTCTGCTCAGGGAAATTTCGACGCTGCTCTGCTATGAAGTGACGCGTGATCTTGAAATGACGATGGAAA
CCATCGATACGCCGCTCGAGACCATTCAGGCACCGGTTCTGGAAGGCAAGAAGCTGGTTTTCGCTTCCATCCTGCGCGCT
GGCAATGGTCTTCTGGAAGGCATGCTGGAGTTGGTTCCGTCCGCACGCGTGGCGCATGTCGGCGTCTATCGTGACCACGA
TACGCTTGAGGCCGTCGAATATTATTTCAAGGCTCCCGAAAGCCTCGATGCCCGCCTGGTCATCGTTGTCGATCCGATGC
TGGCGACCGGCAATTCCTCCATCGCCGCCGTTGAAAAGCTCAAAGAGCGCGGTGCGAAGAACATCCGTTTCCTGTGTCTG
CTGGCGGCACCAGAGGGCATCAAGAATTTCCGTGAAGCGCATCCCGATGTGCCGATTTACACGGCCGCAATCGACCGGCA
CCTGAACGAAAAAGGCTATATCGTTCCCGGCCTCGGCGATGCCGGTGACCGCATGTACGGCACCAAATAA

Upstream 100 bases:

>100_bases
CCTGAGACGGTTGTTGGCAGGGTAAAACCGCGAAGAAGGCTTGCGAAAAACGTGCTTTCGGTGAATTACAGGGCATAAGA
TAAAAAGGAAGGCCAGTTTC

Downstream 100 bases:

>100_bases
CGCCGTTCATCCTTGCTTAACCGTTTGAGCCATTCGCCGCCCGATAAGCGGCGAATGGCTTTTTCTTTTAAGATTTCAGC
ATGTTTTGCGCCTATGCTGC

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase

Number of amino acids: Translated: 209; Mature: 209

Protein sequence:

>209_residues
MDGVTVIEHPLVRHKLTIMRKKETSTAGFRRLLREISTLLCYEVTRDLEMTMETIDTPLETIQAPVLEGKKLVFASILRA
GNGLLEGMLELVPSARVAHVGVYRDHDTLEAVEYYFKAPESLDARLVIVVDPMLATGNSSIAAVEKLKERGAKNIRFLCL
LAAPEGIKNFREAHPDVPIYTAAIDRHLNEKGYIVPGLGDAGDRMYGTK

Sequences:

>Translated_209_residues
MDGVTVIEHPLVRHKLTIMRKKETSTAGFRRLLREISTLLCYEVTRDLEMTMETIDTPLETIQAPVLEGKKLVFASILRA
GNGLLEGMLELVPSARVAHVGVYRDHDTLEAVEYYFKAPESLDARLVIVVDPMLATGNSSIAAVEKLKERGAKNIRFLCL
LAAPEGIKNFREAHPDVPIYTAAIDRHLNEKGYIVPGLGDAGDRMYGTK
>Mature_209_residues
MDGVTVIEHPLVRHKLTIMRKKETSTAGFRRLLREISTLLCYEVTRDLEMTMETIDTPLETIQAPVLEGKKLVFASILRA
GNGLLEGMLELVPSARVAHVGVYRDHDTLEAVEYYFKAPESLDARLVIVVDPMLATGNSSIAAVEKLKERGAKNIRFLCL
LAAPEGIKNFREAHPDVPIYTAAIDRHLNEKGYIVPGLGDAGDRMYGTK

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family

Homologues:

Organism=Homo sapiens, GI301129207, Length=202, Percent_Identity=29.7029702970297, Blast_Score=81, Evalue=5e-16,
Organism=Homo sapiens, GI57863312, Length=202, Percent_Identity=29.7029702970297, Blast_Score=81, Evalue=7e-16,
Organism=Homo sapiens, GI21450816, Length=175, Percent_Identity=28.5714285714286, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI87082118, Length=206, Percent_Identity=51.9417475728155, Blast_Score=219, Evalue=9e-59,
Organism=Caenorhabditis elegans, GI17539892, Length=208, Percent_Identity=25.4807692307692, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17539894, Length=208, Percent_Identity=25.4807692307692, Blast_Score=68, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6321920, Length=193, Percent_Identity=38.860103626943, Blast_Score=120, Evalue=2e-28,
Organism=Drosophila melanogaster, GI45550449, Length=203, Percent_Identity=27.5862068965517, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI28573516, Length=203, Percent_Identity=27.5862068965517, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI28573514, Length=203, Percent_Identity=27.5862068965517, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI28573512, Length=203, Percent_Identity=27.5862068965517, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21358379, Length=184, Percent_Identity=26.0869565217391, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): UPP_AGRT5 (Q8UJ06)

Other databases:

- EMBL:   AE007869
- PIR:   AI2592
- PIR:   C97375
- RefSeq:   NP_353171.1
- ProteinModelPortal:   Q8UJ06
- SMR:   Q8UJ06
- STRING:   Q8UJ06
- GeneID:   1132173
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu0135
- eggNOG:   COG0035
- HOGENOM:   HBG326432
- OMA:   LRAGNGF
- PhylomeDB:   Q8UJ06
- ProtClustDB:   PRK00129
- BioCyc:   ATUM176299-1:ATU0135-MONOMER
- HAMAP:   MF_01218_B
- InterPro:   IPR000836
- InterPro:   IPR005765
- TIGRFAMs:   TIGR01091

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.9

Molecular weight: Translated: 23201; Mature: 23201

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: BINDING 79-79 BINDING 104-104 BINDING 194-194 BINDING 200-200

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDGVTVIEHPLVRHKLTIMRKKETSTAGFRRLLREISTLLCYEVTRDLEMTMETIDTPLE
CCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
TIQAPVLEGKKLVFASILRAGNGLLEGMLELVPSARVAHVGVYRDHDTLEAVEYYFKAPE
HHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHCCCCHHEEEEEECCCHHHHHHHHHHCCCC
SLDARLVIVVDPMLATGNSSIAAVEKLKERGAKNIRFLCLLAAPEGIKNFREAHPDVPIY
CCCCEEEEEECCEECCCCCHHHHHHHHHHCCCCCEEEEEEEECCHHHHHHHHHCCCCCEE
TAAIDRHLNEKGYIVPGLGDAGDRMYGTK
HHHHHHHCCCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MDGVTVIEHPLVRHKLTIMRKKETSTAGFRRLLREISTLLCYEVTRDLEMTMETIDTPLE
CCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
TIQAPVLEGKKLVFASILRAGNGLLEGMLELVPSARVAHVGVYRDHDTLEAVEYYFKAPE
HHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHCCCCHHEEEEEECCCHHHHHHHHHHCCCC
SLDARLVIVVDPMLATGNSSIAAVEKLKERGAKNIRFLCLLAAPEGIKNFREAHPDVPIY
CCCCEEEEEECCEECCCCCHHHHHHHHHHCCCCCEEEEEEEECCHHHHHHHHHCCCCCEE
TAAIDRHLNEKGYIVPGLGDAGDRMYGTK
HHHHHHHCCCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194