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The map label for this gene is gyaR [H]

Identifier: 15887430

GI number: 15887430

Start: 79181

End: 80185

Strand: Reverse

Name: gyaR [H]

Synonym: Atu0077

Alternate gene names: 15887430

Gene position: 80185-79181 (Counterclockwise)

Preceding gene: 15887433

Following gene: 15887429

Centisome position: 2.82

GC content: 61.49

Gene sequence:

>1005_bases
ATGACCCACAAGAAGAGACCGACAGTCTATATCACCCGCAAATTGCCTGACGTCGTCGAGACCAGAATGCGCGAACTCTT
CGATGCGGAACTGAATATCGACGACAGCCCACGCAGTGAGGAAGAGCTTGTCGCCGCCATGCAGCGCGTGGACGTGCTGG
TGCCGACCGTGACCGACCGCATCACCGCTGCGATGATCGAGAAAGCCGGACCGCAGCTGAAGCTGATCGCCAGCTTCTCC
AACGGCATCGACCATGTGGATGTCGACGCGGCCGCCCGCAAAGGTATCACCGTCACCAACACACCGAATGTGCTGACTGA
GGATAGCGCCGATATCACCATGGCGCTGGTGCTGGCGGTGCCGCGCCGCATGATCGAGGGAACGCGCGTGCTTGCCAATG
GCGCCGATGAATGGCTGGGCTGGTCTCCGACCTGGATGCTCGGACGCCGCATTTCCGGCAAGCGTATCGGCATTGTCGGC
ATGGGCCGCATCGGCACCGCAGTTGCGCGGCGCGCCAAGGCCTTCGGGCTTTCCATCCATTACCACAACCGCAAGCGCGT
CAATCCGGCAACGGAGGCGGAGCTTGAAGCCACCTACTGGGACAGTCTCGACCAGATGCTGGCCCGGGTGGATATCGTAT
CGGTCAATTGCCCTTCGACGCCGGCGACCTATCACCTGATCTCGGCACGGCGGCTGGCCTTGATGCAGCCGACCAGCTAC
ATCGTCAACACAGCGCGCGGCGATATCATCGACGAGGCGGCGATGATCCAGTGCCTGCGCGAGGGCAAGATCGCCGGCGC
CGGTCTCGATGTCTATGAGAATGAGCCGCAGGTGAATCCAAAGCTCATCAAACTCGCCAAGGAAGGCAAGGTCGTGCTGC
TGCCGCATATGGGCTCGGCAACGATCGAAGGCCGCATCGAAATGGGTGACAAGGTCATCATCAATATCCGCACATTGTTC
GACGGGCACCGCCCACCGAACCGGGTGCTGCCGGGGCGGAACTAA

Upstream 100 bases:

>100_bases
TTTTATTTGTCTTCGCCGGTGGGTCTGGTAGAAACGCCCTGATTGAAAGAAATTATCGCTCTTTCTGGTTAATGACTTCT
GAACAAGGCAGCGGCAAACG

Downstream 100 bases:

>100_bases
GCCGGCTTAGCCAAGCATCTTTCGAGCAACACAGGGAGTGAGAGTTCAATGGGAATACAGGCAAAGTTTTTGTTGCTGAT
CTCCGTTCTGCTCGTGCTGG

Product: D-isomer specific 2-hydroxyacid dehydrogenases family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 334; Mature: 333

Protein sequence:

>334_residues
MTHKKRPTVYITRKLPDVVETRMRELFDAELNIDDSPRSEEELVAAMQRVDVLVPTVTDRITAAMIEKAGPQLKLIASFS
NGIDHVDVDAAARKGITVTNTPNVLTEDSADITMALVLAVPRRMIEGTRVLANGADEWLGWSPTWMLGRRISGKRIGIVG
MGRIGTAVARRAKAFGLSIHYHNRKRVNPATEAELEATYWDSLDQMLARVDIVSVNCPSTPATYHLISARRLALMQPTSY
IVNTARGDIIDEAAMIQCLREGKIAGAGLDVYENEPQVNPKLIKLAKEGKVVLLPHMGSATIEGRIEMGDKVIINIRTLF
DGHRPPNRVLPGRN

Sequences:

>Translated_334_residues
MTHKKRPTVYITRKLPDVVETRMRELFDAELNIDDSPRSEEELVAAMQRVDVLVPTVTDRITAAMIEKAGPQLKLIASFS
NGIDHVDVDAAARKGITVTNTPNVLTEDSADITMALVLAVPRRMIEGTRVLANGADEWLGWSPTWMLGRRISGKRIGIVG
MGRIGTAVARRAKAFGLSIHYHNRKRVNPATEAELEATYWDSLDQMLARVDIVSVNCPSTPATYHLISARRLALMQPTSY
IVNTARGDIIDEAAMIQCLREGKIAGAGLDVYENEPQVNPKLIKLAKEGKVVLLPHMGSATIEGRIEMGDKVIINIRTLF
DGHRPPNRVLPGRN
>Mature_333_residues
THKKRPTVYITRKLPDVVETRMRELFDAELNIDDSPRSEEELVAAMQRVDVLVPTVTDRITAAMIEKAGPQLKLIASFSN
GIDHVDVDAAARKGITVTNTPNVLTEDSADITMALVLAVPRRMIEGTRVLANGADEWLGWSPTWMLGRRISGKRIGIVGM
GRIGTAVARRAKAFGLSIHYHNRKRVNPATEAELEATYWDSLDQMLARVDIVSVNCPSTPATYHLISARRLALMQPTSYI
VNTARGDIIDEAAMIQCLREGKIAGAGLDVYENEPQVNPKLIKLAKEGKVVLLPHMGSATIEGRIEMGDKVIINIRTLFD
GHRPPNRVLPGRN

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=303, Percent_Identity=34.6534653465347, Blast_Score=179, Evalue=4e-45,
Organism=Homo sapiens, GI23308577, Length=288, Percent_Identity=31.25, Blast_Score=154, Evalue=8e-38,
Organism=Homo sapiens, GI61743967, Length=268, Percent_Identity=32.4626865671642, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI4557497, Length=268, Percent_Identity=32.4626865671642, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI145580578, Length=268, Percent_Identity=32.8358208955224, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI4557499, Length=268, Percent_Identity=32.8358208955224, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI145580575, Length=268, Percent_Identity=32.8358208955224, Blast_Score=131, Evalue=7e-31,
Organism=Escherichia coli, GI87082289, Length=329, Percent_Identity=37.0820668693009, Blast_Score=186, Evalue=2e-48,
Organism=Escherichia coli, GI1789279, Length=246, Percent_Identity=30.8943089430894, Blast_Score=121, Evalue=6e-29,
Organism=Escherichia coli, GI1787645, Length=336, Percent_Identity=27.9761904761905, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1788660, Length=284, Percent_Identity=23.2394366197183, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI87081824, Length=239, Percent_Identity=24.6861924686192, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17532191, Length=281, Percent_Identity=28.1138790035587, Blast_Score=136, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI25147481, Length=207, Percent_Identity=32.3671497584541, Blast_Score=106, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6324055, Length=239, Percent_Identity=37.6569037656904, Blast_Score=154, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6320925, Length=283, Percent_Identity=29.3286219081272, Blast_Score=134, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6322116, Length=293, Percent_Identity=28.3276450511945, Blast_Score=130, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6324964, Length=219, Percent_Identity=30.1369863013699, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6321253, Length=274, Percent_Identity=29.1970802919708, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6325144, Length=173, Percent_Identity=32.3699421965318, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6324980, Length=148, Percent_Identity=29.7297297297297, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI28571528, Length=321, Percent_Identity=36.1370716510903, Blast_Score=185, Evalue=4e-47,
Organism=Drosophila melanogaster, GI28574284, Length=279, Percent_Identity=35.4838709677419, Blast_Score=161, Evalue=5e-40,
Organism=Drosophila melanogaster, GI24585514, Length=279, Percent_Identity=35.4838709677419, Blast_Score=161, Evalue=6e-40,
Organism=Drosophila melanogaster, GI28574282, Length=279, Percent_Identity=35.4838709677419, Blast_Score=161, Evalue=6e-40,
Organism=Drosophila melanogaster, GI45551003, Length=279, Percent_Identity=35.4838709677419, Blast_Score=161, Evalue=6e-40,
Organism=Drosophila melanogaster, GI45552429, Length=279, Percent_Identity=35.4838709677419, Blast_Score=161, Evalue=7e-40,
Organism=Drosophila melanogaster, GI28574286, Length=277, Percent_Identity=33.5740072202166, Blast_Score=149, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24585516, Length=287, Percent_Identity=30.6620209059233, Blast_Score=135, Evalue=4e-32,
Organism=Drosophila melanogaster, GI19921140, Length=274, Percent_Identity=31.7518248175182, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24646446, Length=259, Percent_Identity=33.2046332046332, Blast_Score=131, Evalue=8e-31,
Organism=Drosophila melanogaster, GI24646448, Length=259, Percent_Identity=33.2046332046332, Blast_Score=131, Evalue=8e-31,
Organism=Drosophila melanogaster, GI24646452, Length=259, Percent_Identity=33.2046332046332, Blast_Score=131, Evalue=8e-31,
Organism=Drosophila melanogaster, GI24646450, Length=259, Percent_Identity=33.2046332046332, Blast_Score=131, Evalue=8e-31,
Organism=Drosophila melanogaster, GI62472511, Length=259, Percent_Identity=33.2046332046332, Blast_Score=130, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 36855; Mature: 36724

Theoretical pI: Translated: 9.34; Mature: 9.34

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHKKRPTVYITRKLPDVVETRMRELFDAELNIDDSPRSEEELVAAMQRVDVLVPTVTDR
CCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHEECCHHHH
ITAAMIEKAGPQLKLIASFSNGIDHVDVDAAARKGITVTNTPNVLTEDSADITMALVLAV
HHHHHHHHCCCCEEEEEECCCCCCEEECCHHHHCCEEEECCCCCEECCCCHHHHHHHHHH
PRRMIEGTRVLANGADEWLGWSPTWMLGRRISGKRIGIVGMGRIGTAVARRAKAFGLSIH
HHHHHCCCEEEECCCHHHCCCCCHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHEEEEE
YHNRKRVNPATEAELEATYWDSLDQMLARVDIVSVNCPSTPATYHLISARRLALMQPTSY
ECCCCCCCCCCCCHHHHHHHHHHHHHHHHEEEEEECCCCCCCEEEHHHHHHHEEECCHHH
IVNTARGDIIDEAAMIQCLREGKIAGAGLDVYENEPQVNPKLIKLAKEGKVVLLPHMGSA
HHCCCCCCHHHHHHHHHHHHCCCCCCCCCCEECCCCCCCHHHEEEECCCCEEEEECCCCC
TIEGRIEMGDKVIINIRTLFDGHRPPNRVLPGRN
EEEEEEECCCEEEEEEEEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
THKKRPTVYITRKLPDVVETRMRELFDAELNIDDSPRSEEELVAAMQRVDVLVPTVTDR
CCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHEECCHHHH
ITAAMIEKAGPQLKLIASFSNGIDHVDVDAAARKGITVTNTPNVLTEDSADITMALVLAV
HHHHHHHHCCCCEEEEEECCCCCCEEECCHHHHCCEEEECCCCCEECCCCHHHHHHHHHH
PRRMIEGTRVLANGADEWLGWSPTWMLGRRISGKRIGIVGMGRIGTAVARRAKAFGLSIH
HHHHHCCCEEEECCCHHHCCCCCHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHEEEEE
YHNRKRVNPATEAELEATYWDSLDQMLARVDIVSVNCPSTPATYHLISARRLALMQPTSY
ECCCCCCCCCCCCHHHHHHHHHHHHHHHHEEEEEECCCCCCCEEEHHHHHHHEEECCHHH
IVNTARGDIIDEAAMIQCLREGKIAGAGLDVYENEPQVNPKLIKLAKEGKVVLLPHMGSA
HHCCCCCCHHHHHHHHHHHHCCCCCCCCCCEECCCCCCCHHHEEEECCCCEEEEECCCCC
TIEGRIEMGDKVIINIRTLFDGHRPPNRVLPGRN
EEEEEEECCCEEEEEEEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA