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The map label for this gene is hslU [H]

Identifier: 15887403

GI number: 15887403

Start: 45214

End: 46521

Strand: Direct

Name: hslU [H]

Synonym: Atu0045

Alternate gene names: 15887403

Gene position: 45214-46521 (Clockwise)

Preceding gene: 229007174

Following gene: 15887404

Centisome position: 1.59

GC content: 59.25

Gene sequence:

>1308_bases
ATGACCACTTTTTCTCCCCGGGAGATCGTCTCGGAACTCGACCGCCACATCATCGGCCAGCATGATGCAAAACGCGCGGT
CGCGATTGCACTGCGCAACCGCTGGCGCCGCCAGCAGCTCGATGAGAGCCTGCGCGACGAAGTCATGCCAAAAAACATTC
TGATGATCGGGCCGACCGGTGTCGGCAAGACGGAGATTTCCCGCCGCCTCGCCAAGCTGGCCGGCGCGCCTTTCATCAAG
GTCGAAGCCACCAAATTCACCGAAGTCGGTTATGTCGGCCGCGATGTCGAGCAGATCATCCGCGATCTGGTGGAGATCGG
TATCGGTCTCGTGCGCGAAAAGAAGCGCGCCGAAGTCCAGGCTAAGGCGCATCAAAGCGCCGAGGAACGGGTGCTTGATG
CACTTGTTGGCTCGACCGCATCGCCGGGCACGCGTGAGAGCTTCCGCAAAAAGCTGCGCGACGGTGAGCTGGACGACAAG
GAAATCGATATCGAGGTGGCGGATAGCGGCTCGGGCATGCCCGGTTTCGAAATTCCCGGCATGCCGGGCGCCAATATCGG
CGTGCTGAACCTGTCGGAAATGTTCGGCAAGGCTATGGGCGGACGTACCAAGAAGGTGCGCACCACGGTCTCGAAGTCCT
ATACCGATCTTGTCCGCGACGAATCCGACAAGCTGCTGGATAATGAAATGATCCAGCGCGAGGCGGTGAAGTCGGTGGAA
AATGACGGCATCGTCTTCCTCGACGAGATCGACAAGATCGCCGCCCGCGATGGCGGCATGGGCGCCGGCGTCTCCCGCGA
GGGTGTGCAGCGCGATCTCCTGCCGCTTGTAGAAGGCACGACGGTTTCGACGAAATATGGCCCTGTCAAAACCGACCATG
TCCTCTTCATCGCCTCTGGAGCCTTCCATGTGGCGAAGCCGTCGGATCTTCTGCCGGAGCTTCAGGGTCGCCTGCCGATC
CGCGTCGAGTTGAAGCCGCTGACCAAGGAAGATTTCCGCCGTATCCTCACCGAGACGGAAGCAAGCCTTATCCGCCAGTA
CAAGGCGCTGATGGCAACGGAAGAACTTGATCTCGATTTCACAGATGACGCCATCGATGCACTGGCCGATGTCGCCGTTC
ATCTCAACTCATCGGTCGAAAACATCGGTGCGCGCCGCCTGCAGACCGTGATGGAGCGCGTTCTCGACGAGATCTCCTTC
AACGCACCGGATCGTGGTGGGTCTGCCGTCAAGATCGATCAGGAATACGTCAAAAAACATGTCGGCGATCTTGCCGCCGA
TACGGATTTGTCGCGTTACATTCTCTGA

Upstream 100 bases:

>100_bases
CGACGCAGAATAAGCGAATTTCTCAACCCCATTTCTCACCCAAGGGTCCTGTGGGCCGGGCCGGAATGGCCGGCCGGAGC
AGGAAAGCCGAGAGGATAGA

Downstream 100 bases:

>100_bases
AGACTTCAGGGACAACGAAAGAAGAGTGCGGCCATATTTGCCGCACTCTTTTATTTTATCTGCCTCATCTCGCATTCAGC
CCGCATTTTGTTTATGGGAA

Product: ATP-dependent protease ATP-binding subunit HslU

Products: NA

Alternate protein names: Unfoldase HslU [H]

Number of amino acids: Translated: 435; Mature: 434

Protein sequence:

>435_residues
MTTFSPREIVSELDRHIIGQHDAKRAVAIALRNRWRRQQLDESLRDEVMPKNILMIGPTGVGKTEISRRLAKLAGAPFIK
VEATKFTEVGYVGRDVEQIIRDLVEIGIGLVREKKRAEVQAKAHQSAEERVLDALVGSTASPGTRESFRKKLRDGELDDK
EIDIEVADSGSGMPGFEIPGMPGANIGVLNLSEMFGKAMGGRTKKVRTTVSKSYTDLVRDESDKLLDNEMIQREAVKSVE
NDGIVFLDEIDKIAARDGGMGAGVSREGVQRDLLPLVEGTTVSTKYGPVKTDHVLFIASGAFHVAKPSDLLPELQGRLPI
RVELKPLTKEDFRRILTETEASLIRQYKALMATEELDLDFTDDAIDALADVAVHLNSSVENIGARRLQTVMERVLDEISF
NAPDRGGSAVKIDQEYVKKHVGDLAADTDLSRYIL

Sequences:

>Translated_435_residues
MTTFSPREIVSELDRHIIGQHDAKRAVAIALRNRWRRQQLDESLRDEVMPKNILMIGPTGVGKTEISRRLAKLAGAPFIK
VEATKFTEVGYVGRDVEQIIRDLVEIGIGLVREKKRAEVQAKAHQSAEERVLDALVGSTASPGTRESFRKKLRDGELDDK
EIDIEVADSGSGMPGFEIPGMPGANIGVLNLSEMFGKAMGGRTKKVRTTVSKSYTDLVRDESDKLLDNEMIQREAVKSVE
NDGIVFLDEIDKIAARDGGMGAGVSREGVQRDLLPLVEGTTVSTKYGPVKTDHVLFIASGAFHVAKPSDLLPELQGRLPI
RVELKPLTKEDFRRILTETEASLIRQYKALMATEELDLDFTDDAIDALADVAVHLNSSVENIGARRLQTVMERVLDEISF
NAPDRGGSAVKIDQEYVKKHVGDLAADTDLSRYIL
>Mature_434_residues
TTFSPREIVSELDRHIIGQHDAKRAVAIALRNRWRRQQLDESLRDEVMPKNILMIGPTGVGKTEISRRLAKLAGAPFIKV
EATKFTEVGYVGRDVEQIIRDLVEIGIGLVREKKRAEVQAKAHQSAEERVLDALVGSTASPGTRESFRKKLRDGELDDKE
IDIEVADSGSGMPGFEIPGMPGANIGVLNLSEMFGKAMGGRTKKVRTTVSKSYTDLVRDESDKLLDNEMIQREAVKSVEN
DGIVFLDEIDKIAARDGGMGAGVSREGVQRDLLPLVEGTTVSTKYGPVKTDHVLFIASGAFHVAKPSDLLPELQGRLPIR
VELKPLTKEDFRRILTETEASLIRQYKALMATEELDLDFTDDAIDALADVAVHLNSSVENIGARRLQTVMERVLDEISFN
APDRGGSAVKIDQEYVKKHVGDLAADTDLSRYIL

Specific function: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N

COG id: COG1220

COG function: function code O; ATP-dependent protease HslVU (ClpYQ), ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family. HslU subfamily [H]

Homologues:

Organism=Homo sapiens, GI7242140, Length=121, Percent_Identity=36.3636363636364, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI1790366, Length=447, Percent_Identity=57.9418344519016, Blast_Score=497, Evalue=1e-142,
Organism=Escherichia coli, GI1786642, Length=102, Percent_Identity=46.078431372549, Blast_Score=92, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24648289, Length=242, Percent_Identity=30.9917355371901, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24648291, Length=242, Percent_Identity=30.9917355371901, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR019489
- InterPro:   IPR004491 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 47997; Mature: 47866

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTFSPREIVSELDRHIIGQHDAKRAVAIALRNRWRRQQLDESLRDEVMPKNILMIGPTG
CCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCC
VGKTEISRRLAKLAGAPFIKVEATKFTEVGYVGRDVEQIIRDLVEIGIGLVREKKRAEVQ
CCHHHHHHHHHHHHCCCEEEEECCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKAHQSAEERVLDALVGSTASPGTRESFRKKLRDGELDDKEIDIEVADSGSGMPGFEIPG
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCC
MPGANIGVLNLSEMFGKAMGGRTKKVRTTVSKSYTDLVRDESDKLLDNEMIQREAVKSVE
CCCCCEEEEEHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHC
NDGIVFLDEIDKIAARDGGMGAGVSREGVQRDLLPLVEGTTVSTKYGPVKTDHVLFIASG
CCCEEEEEHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCEEECCCCCCCCCCEEEEECC
AFHVAKPSDLLPELQGRLPIRVELKPLTKEDFRRILTETEASLIRQYKALMATEELDLDF
CEECCCCHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
TDDAIDALADVAVHLNSSVENIGARRLQTVMERVLDEISFNAPDRGGSAVKIDQEYVKKH
CHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECHHHHHHH
VGDLAADTDLSRYIL
HHHHHHCCCHHHHCC
>Mature Secondary Structure 
TTFSPREIVSELDRHIIGQHDAKRAVAIALRNRWRRQQLDESLRDEVMPKNILMIGPTG
CCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCC
VGKTEISRRLAKLAGAPFIKVEATKFTEVGYVGRDVEQIIRDLVEIGIGLVREKKRAEVQ
CCHHHHHHHHHHHHCCCEEEEECCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKAHQSAEERVLDALVGSTASPGTRESFRKKLRDGELDDKEIDIEVADSGSGMPGFEIPG
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCC
MPGANIGVLNLSEMFGKAMGGRTKKVRTTVSKSYTDLVRDESDKLLDNEMIQREAVKSVE
CCCCCEEEEEHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHC
NDGIVFLDEIDKIAARDGGMGAGVSREGVQRDLLPLVEGTTVSTKYGPVKTDHVLFIASG
CCCEEEEEHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCEEECCCCCCCCCCEEEEECC
AFHVAKPSDLLPELQGRLPIRVELKPLTKEDFRRILTETEASLIRQYKALMATEELDLDF
CEECCCCHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
TDDAIDALADVAVHLNSSVENIGARRLQTVMERVLDEISFNAPDRGGSAVKIDQEYVKKH
CHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECHHHHHHH
VGDLAADTDLSRYIL
HHHHHHCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA