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The map label for this gene is ahcY

Identifier: 15887387

GI number: 15887387

Start: 31882

End: 33282

Strand: Reverse

Name: ahcY

Synonym: Atu0029

Alternate gene names: 15887387

Gene position: 33282-31882 (Counterclockwise)

Preceding gene: 15887388

Following gene: 159184130

Centisome position: 1.17

GC content: 57.96

Gene sequence:

>1401_bases
ATGAGCCTTGAGAAGGACTACATCGTCGCCGACATCAACCTTGCCGCATTCGGCCGCAAGGAACTGGACATCGCCGAAAC
CGAAATGCCGGGCCTGATGTCCTGCCGCAAGGAGTTCGGTGAAAGCAAGCCGCTGAAGGGCGCACGTATCACCGGCTCTC
TTCACATGACGATCCAGACCGGTGTTCTCATCGAAACGCTCAAAGAACTGGGCGCGGAAATCCGCTGGGCCTCCTGCAAC
ATCTTTTCGACCCAGGACCATGCGGCAGCGGCCATTGCAGCAGCCGGCATTCCGGTCTTCGCCGTCAAGGGTGAAAGCCT
GACAGAATATTGGGAATATACCGACAAGATCTTCCAGTGGACCGATGGCGGCCTCTCCAACATGATCCTCGATGATGGCG
GCGATGCCACCATGTATATCCTGCTTGGCGCACGCGCCGAAGCCGGTGAGGATGTGCTTTCCAATCCGGGGTCGGAAGAA
GAGGAAATCCTCTTCGCGCAGATCAACAAGCGCCTCAAGGCTTCCCCCGGCTGGTTCACCAAGCAGCGTGATGCGTTGAA
GGGCGTGACGGAAGAAACGACGACCGGCGTTCATCGTTTGTACGATCTCGCCAAGAAGGGCCTGCTGCCCTTCCCGGCCA
TCAACGTCAACGACAGCGTTACCAAGTCGAAGTTCGACAACAAATACGGCTGCAAGGAATCGCTCGTCGACGGCATTCGC
CGTGCAACCGACGTGATGATGGCCGGCAAGGTTGCCGTGGTCTGCGGTTACGGCGATGTGGGCAAGGGTTCCGCGGCCTC
GCTGCAGGGTGCCGGCGCCCGCGTGAAGGTCACAGAAATCGACCCTATCTGCGCACTTCAGGCCGCGATGGACGGTTTCG
AGGTGGTTCGCCTGGAGGACGTGGTTTCCTCCGCCGATATCTTCATCACCACCACCGGCAACAAGGACGTGATCCGCATC
GAGCATATGCGCGAGATGAAGGACATGGCCATCGTCGGTAACATCGGCCACTTCGACAATGAAATTCAGGTCGCCTCGCT
GCGTAACCTGAAGTGGACGAACATCAAGCCGCAGGTCGACATGATCGAGTTCCCGAAGGGCAACCGCATCATCCTGCTTT
CCGAAGGCCGCCTGCTGAACCTTGGCAACGCTACCGGTCACCCGTCCTTCGTCATGTCGGCATCCTTCACCAACCAGGTG
CTTGGCCAGATCGAGCTTTTCACCAAGCCGGGTGAATACAAGAACGAAGTTTACGTGCTGCCGAAGCACCTCGATGAGAA
GGTCGCGCGCCTCCACCTCGAGAAGCTCGGTGTGCGGCTAACCGAACTTTCCGACCTTCAGGCAGATTATATCGGCATCT
CCAAGCAGGGTCCGTTCAAGGCTGAACACTACAGATATTAA

Upstream 100 bases:

>100_bases
TCTTTATATCATTATTGCCAGATCGGTTGTGGCCTGCTAAACCGCTGCTACGTTTAAGAGCCGGGCCGTCAGGCGCGGCG
TTTCTGATCTGGAGAACCTT

Downstream 100 bases:

>100_bases
TATCATAGTTAATATCCACTGAAATTACACAATATCTAGATGCCGTGCGCTTGACAAAGCGCGCGGCATCTTTTTTGCGC
GCTCCCTTCCCGCAGATTTA

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase

Number of amino acids: Translated: 466; Mature: 465

Protein sequence:

>466_residues
MSLEKDYIVADINLAAFGRKELDIAETEMPGLMSCRKEFGESKPLKGARITGSLHMTIQTGVLIETLKELGAEIRWASCN
IFSTQDHAAAAIAAAGIPVFAVKGESLTEYWEYTDKIFQWTDGGLSNMILDDGGDATMYILLGARAEAGEDVLSNPGSEE
EEILFAQINKRLKASPGWFTKQRDALKGVTEETTTGVHRLYDLAKKGLLPFPAINVNDSVTKSKFDNKYGCKESLVDGIR
RATDVMMAGKVAVVCGYGDVGKGSAASLQGAGARVKVTEIDPICALQAAMDGFEVVRLEDVVSSADIFITTTGNKDVIRI
EHMREMKDMAIVGNIGHFDNEIQVASLRNLKWTNIKPQVDMIEFPKGNRIILLSEGRLLNLGNATGHPSFVMSASFTNQV
LGQIELFTKPGEYKNEVYVLPKHLDEKVARLHLEKLGVRLTELSDLQADYIGISKQGPFKAEHYRY

Sequences:

>Translated_466_residues
MSLEKDYIVADINLAAFGRKELDIAETEMPGLMSCRKEFGESKPLKGARITGSLHMTIQTGVLIETLKELGAEIRWASCN
IFSTQDHAAAAIAAAGIPVFAVKGESLTEYWEYTDKIFQWTDGGLSNMILDDGGDATMYILLGARAEAGEDVLSNPGSEE
EEILFAQINKRLKASPGWFTKQRDALKGVTEETTTGVHRLYDLAKKGLLPFPAINVNDSVTKSKFDNKYGCKESLVDGIR
RATDVMMAGKVAVVCGYGDVGKGSAASLQGAGARVKVTEIDPICALQAAMDGFEVVRLEDVVSSADIFITTTGNKDVIRI
EHMREMKDMAIVGNIGHFDNEIQVASLRNLKWTNIKPQVDMIEFPKGNRIILLSEGRLLNLGNATGHPSFVMSASFTNQV
LGQIELFTKPGEYKNEVYVLPKHLDEKVARLHLEKLGVRLTELSDLQADYIGISKQGPFKAEHYRY
>Mature_465_residues
SLEKDYIVADINLAAFGRKELDIAETEMPGLMSCRKEFGESKPLKGARITGSLHMTIQTGVLIETLKELGAEIRWASCNI
FSTQDHAAAAIAAAGIPVFAVKGESLTEYWEYTDKIFQWTDGGLSNMILDDGGDATMYILLGARAEAGEDVLSNPGSEEE
EILFAQINKRLKASPGWFTKQRDALKGVTEETTTGVHRLYDLAKKGLLPFPAINVNDSVTKSKFDNKYGCKESLVDGIRR
ATDVMMAGKVAVVCGYGDVGKGSAASLQGAGARVKVTEIDPICALQAAMDGFEVVRLEDVVSSADIFITTTGNKDVIRIE
HMREMKDMAIVGNIGHFDNEIQVASLRNLKWTNIKPQVDMIEFPKGNRIILLSEGRLLNLGNATGHPSFVMSASFTNQVL
GQIELFTKPGEYKNEVYVLPKHLDEKVARLHLEKLGVRLTELSDLQADYIGISKQGPFKAEHYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family

Homologues:

Organism=Homo sapiens, GI9951915, Length=468, Percent_Identity=58.3333333333333, Blast_Score=501, Evalue=1e-142,
Organism=Homo sapiens, GI239937451, Length=440, Percent_Identity=57.7272727272727, Blast_Score=470, Evalue=1e-132,
Organism=Homo sapiens, GI24308043, Length=464, Percent_Identity=51.0775862068966, Blast_Score=462, Evalue=1e-130,
Organism=Homo sapiens, GI195539337, Length=464, Percent_Identity=51.0775862068966, Blast_Score=462, Evalue=1e-130,
Organism=Homo sapiens, GI298286489, Length=464, Percent_Identity=51.0775862068966, Blast_Score=462, Evalue=1e-130,
Organism=Homo sapiens, GI195539349, Length=464, Percent_Identity=51.0775862068966, Blast_Score=462, Evalue=1e-130,
Organism=Homo sapiens, GI21361647, Length=464, Percent_Identity=50.2155172413793, Blast_Score=441, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI17506425, Length=465, Percent_Identity=57.8494623655914, Blast_Score=505, Evalue=1e-143,
Organism=Saccharomyces cerevisiae, GI6320882, Length=479, Percent_Identity=57.2025052192067, Blast_Score=501, Evalue=1e-142,
Organism=Drosophila melanogaster, GI24642172, Length=462, Percent_Identity=59.3073593073593, Blast_Score=510, Evalue=1e-145,
Organism=Drosophila melanogaster, GI24656245, Length=465, Percent_Identity=50.752688172043, Blast_Score=455, Evalue=1e-128,
Organism=Drosophila melanogaster, GI45553387, Length=463, Percent_Identity=50.5399568034557, Blast_Score=446, Evalue=1e-125,
Organism=Drosophila melanogaster, GI45553385, Length=462, Percent_Identity=50.4329004329004, Blast_Score=443, Evalue=1e-124,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SAHH_AGRT5 (Q8UJ99)

Other databases:

- EMBL:   AE007869
- PIR:   AF2580
- PIR:   D97362
- RefSeq:   NP_353068.1
- ProteinModelPortal:   Q8UJ99
- SMR:   Q8UJ99
- STRING:   Q8UJ99
- GeneID:   1132067
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu0029
- eggNOG:   COG0499
- HOGENOM:   HBG352029
- OMA:   VITHDHM
- PhylomeDB:   Q8UJ99
- ProtClustDB:   PRK05476
- BioCyc:   ATUM176299-1:ATU0029-MONOMER
- GO:   GO:0005737
- GO:   GO:0005488
- HAMAP:   MF_00563
- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082
- PANTHER:   PTHR23420
- PIRSF:   PIRSF001109
- TIGRFAMs:   TIGR00936

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD

EC number: =3.3.1.1

Molecular weight: Translated: 51160; Mature: 51029

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS00738 ADOHCYASE_1; PS00739 ADOHCYASE_2

Important sites: BINDING 57-57 BINDING 132-132 BINDING 192-192 BINDING 222-222 BINDING 226-226 BINDING 227-227 BINDING 279-279 BINDING 314-314 BINDING 380-380

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLEKDYIVADINLAAFGRKELDIAETEMPGLMSCRKEFGESKPLKGARITGSLHMTIQT
CCCCCCEEEEEEEEEECCCCCCCCHHCCCCHHHHHHHHHCCCCCCCCEEEEEEEEEEEEC
GVLIETLKELGAEIRWASCNIFSTQDHAAAAIAAAGIPVFAVKGESLTEYWEYTDKIFQW
CHHHHHHHHHCCCEEEEEEEEECCCCHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHEE
TDGGLSNMILDDGGDATMYILLGARAEAGEDVLSNPGSEEEEILFAQINKRLKASPGWFT
CCCCCCEEEEECCCCEEEEEEEECCCCCCCHHHCCCCCCHHHHHHHHHHHHHCCCCCCCC
KQRDALKGVTEETTTGVHRLYDLAKKGLLPFPAINVNDSVTKSKFDNKYGCKESLVDGIR
CHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCCCCCHHHHHHHHH
RATDVMMAGKVAVVCGYGDVGKGSAASLQGAGARVKVTEIDPICALQAAMDGFEVVRLED
HHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHCCCCEEEEHHH
VVSSADIFITTTGNKDVIRIEHMREMKDMAIVGNIGHFDNEIQVASLRNLKWTNIKPQVD
HHCCCCEEEEECCCCCEEEHHHHHHHHHEEEEECCCCCCCCEEEEEECCCEECCCCCCCC
MIEFPKGNRIILLSEGRLLNLGNATGHPSFVMSASFTNQVLGQIELFTKPGEYKNEVYVL
EEECCCCCEEEEEECCCEEECCCCCCCCCEEEECCHHHHHHCEEEEEECCCCCCCEEEEE
PKHLDEKVARLHLEKLGVRLTELSDLQADYIGISKQGPFKAEHYRY
CHHHHHHHHHHHHHHHCCEEEHHHHCCHHHEECCCCCCCCCCCCCC
>Mature Secondary Structure 
SLEKDYIVADINLAAFGRKELDIAETEMPGLMSCRKEFGESKPLKGARITGSLHMTIQT
CCCCCEEEEEEEEEECCCCCCCCHHCCCCHHHHHHHHHCCCCCCCCEEEEEEEEEEEEC
GVLIETLKELGAEIRWASCNIFSTQDHAAAAIAAAGIPVFAVKGESLTEYWEYTDKIFQW
CHHHHHHHHHCCCEEEEEEEEECCCCHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHEE
TDGGLSNMILDDGGDATMYILLGARAEAGEDVLSNPGSEEEEILFAQINKRLKASPGWFT
CCCCCCEEEEECCCCEEEEEEEECCCCCCCHHHCCCCCCHHHHHHHHHHHHHCCCCCCCC
KQRDALKGVTEETTTGVHRLYDLAKKGLLPFPAINVNDSVTKSKFDNKYGCKESLVDGIR
CHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCCCCCHHHHHHHHH
RATDVMMAGKVAVVCGYGDVGKGSAASLQGAGARVKVTEIDPICALQAAMDGFEVVRLED
HHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHCCCCEEEEHHH
VVSSADIFITTTGNKDVIRIEHMREMKDMAIVGNIGHFDNEIQVASLRNLKWTNIKPQVD
HHCCCCEEEEECCCCCEEEHHHHHHHHHEEEEECCCCCCCCEEEEEECCCEECCCCCCCC
MIEFPKGNRIILLSEGRLLNLGNATGHPSFVMSASFTNQVLGQIELFTKPGEYKNEVYVL
EEECCCCCEEEEEECCCEEECCCCCCCCCEEEECCHHHHHHCEEEEEECCCCCCCEEEEE
PKHLDEKVARLHLEKLGVRLTELSDLQADYIGISKQGPFKAEHYRY
CHHHHHHHHHHHHHHHCCEEEHHHHCCHHHEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194