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The map label for this gene is trpF

Identifier: 15887376

GI number: 15887376

Start: 14475

End: 15137

Strand: Direct

Name: trpF

Synonym: Atu0017

Alternate gene names: 15887376

Gene position: 14475-15137 (Clockwise)

Preceding gene: 15887375

Following gene: 159184125

Centisome position: 0.51

GC content: 55.96

Gene sequence:

>663_bases
ATGAAACCGGATATCAAGATTTGCGGATTGAAGACACCGGAAACGCTGGAGCGCGTCGTCCGGCGCGGTGCGTCCCATGT
CGGTTTTATTTTCTTTGAAAAAAGCCCCCGCTATATCGAGCCGGACCTTGCCGGCCGGTTGGCCGAAGCCGCCCGTGGCG
CCGCCAAAGTGGTTGCCGTCACTGTCGATGCTGATAATGATTATCTCGATGAAATCGTCGATCTTGTCAGGCCGGATATT
CTGCAATTGCATGGCAGCGAAAGCCCGGAGCGGCTGCTGCATATCAAGGCGCTTTACGGCCTGCCGGTGATGAAGGCGAT
TTCCATTCGCGATGCCGCGGATCTTGCCAAAATAGAGCCTTATATTGGCATAGCCGACCGTTTCCTGCTGGATGCCAAGG
CGCCTGCCGGTTCTGATCTGCCTGGCGGCAACGGCGTCTCGTTCGACTGGACGATCCTGCGCTCACTTGACGAAAGTGTG
GATTACATGCTTTCCGGGGGGCTGAATAAGGACAATGTCGCCGAGGCTCTGGCGGAAACCCGGGCGAGCGGATTAGATTT
GTCGTCTGGCGTCGAAAGCGCGCCGGGCGTCAAGGATTTGTCCAAGATTGATGCTTTTTTCGATGTGGTGAATGATTGGT
CGAAAGGCCCAAAGGGAGCTTGA

Upstream 100 bases:

>100_bases
CTGGCGGCGTGCATCGCCATCTGGATTCACGTGAAACATTCCATCGAAAAGGGATGCGATTTGGCTCGACTCTTGTCGCA
TTTCATGTCAGGTCGCGGGT

Downstream 100 bases:

>100_bases
AGTGAACGACGCGCCAACACCCAATTCTTTTCGTGCTGGTCCCGATGAGGACGGACGCTTCGGCATTTACGGAGGACGCT
TCGTTGCCGAAACGCTGATG

Product: N-(5'-phosphoribosyl)anthranilate isomerase

Products: NA

Alternate protein names: PRAI

Number of amino acids: Translated: 220; Mature: 220

Protein sequence:

>220_residues
MKPDIKICGLKTPETLERVVRRGASHVGFIFFEKSPRYIEPDLAGRLAEAARGAAKVVAVTVDADNDYLDEIVDLVRPDI
LQLHGSESPERLLHIKALYGLPVMKAISIRDAADLAKIEPYIGIADRFLLDAKAPAGSDLPGGNGVSFDWTILRSLDESV
DYMLSGGLNKDNVAEALAETRASGLDLSSGVESAPGVKDLSKIDAFFDVVNDWSKGPKGA

Sequences:

>Translated_220_residues
MKPDIKICGLKTPETLERVVRRGASHVGFIFFEKSPRYIEPDLAGRLAEAARGAAKVVAVTVDADNDYLDEIVDLVRPDI
LQLHGSESPERLLHIKALYGLPVMKAISIRDAADLAKIEPYIGIADRFLLDAKAPAGSDLPGGNGVSFDWTILRSLDESV
DYMLSGGLNKDNVAEALAETRASGLDLSSGVESAPGVKDLSKIDAFFDVVNDWSKGPKGA
>Mature_220_residues
MKPDIKICGLKTPETLERVVRRGASHVGFIFFEKSPRYIEPDLAGRLAEAARGAAKVVAVTVDADNDYLDEIVDLVRPDI
LQLHGSESPERLLHIKALYGLPVMKAISIRDAADLAKIEPYIGIADRFLLDAKAPAGSDLPGGNGVSFDWTILRSLDESV
DYMLSGGLNKDNVAEALAETRASGLDLSSGVESAPGVKDLSKIDAFFDVVNDWSKGPKGA

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0135

COG function: function code E; Phosphoribosylanthranilate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpF family

Homologues:

Organism=Escherichia coli, GI87081863, Length=217, Percent_Identity=30.8755760368664, Blast_Score=75, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6320210, Length=215, Percent_Identity=31.1627906976744, Blast_Score=78, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPF_AGRT5 (Q8UJB1)

Other databases:

- EMBL:   AE007869
- PIR:   A97361
- PIR:   AB2579
- RefSeq:   NP_353057.1
- ProteinModelPortal:   Q8UJB1
- SMR:   Q8UJB1
- STRING:   Q8UJB1
- GeneID:   1132055
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu0017
- eggNOG:   COG0135
- HOGENOM:   HBG554803
- OMA:   SKICGIT
- PhylomeDB:   Q8UJB1
- ProtClustDB:   PRK01222
- BioCyc:   ATUM176299-1:ATU0017-MONOMER
- HAMAP:   MF_00135_B
- InterPro:   IPR013785
- InterPro:   IPR001240
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00697 PRAI; SSF51366 RibP_bind_barrel

EC number: =5.3.1.24

Molecular weight: Translated: 23633; Mature: 23633

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPDIKICGLKTPETLERVVRRGASHVGFIFFEKSPRYIEPDLAGRLAEAARGAAKVVAV
CCCCCEEECCCCHHHHHHHHHCCCCCEEEEEECCCCCEECHHHHHHHHHHHCCCEEEEEE
TVDADNDYLDEIVDLVRPDILQLHGSESPERLLHIKALYGLPVMKAISIRDAADLAKIEP
EEECCCHHHHHHHHHHCHHHEECCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCC
YIGIADRFLLDAKAPAGSDLPGGNGVSFDWTILRSLDESVDYMLSGGLNKDNVAEALAET
CHHHHHHHHEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
RASGLDLSSGVESAPGVKDLSKIDAFFDVVNDWSKGPKGA
HHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKPDIKICGLKTPETLERVVRRGASHVGFIFFEKSPRYIEPDLAGRLAEAARGAAKVVAV
CCCCCEEECCCCHHHHHHHHHCCCCCEEEEEECCCCCEECHHHHHHHHHHHCCCEEEEEE
TVDADNDYLDEIVDLVRPDILQLHGSESPERLLHIKALYGLPVMKAISIRDAADLAKIEP
EEECCCHHHHHHHHHHCHHHEECCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCC
YIGIADRFLLDAKAPAGSDLPGGNGVSFDWTILRSLDESVDYMLSGGLNKDNVAEALAET
CHHHHHHHHEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
RASGLDLSSGVESAPGVKDLSKIDAFFDVVNDWSKGPKGA
HHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194