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The map label for this gene is hpcE [C]

Identifier: 15887373

GI number: 15887373

Start: 11335

End: 12177

Strand: Direct

Name: hpcE [C]

Synonym: Atu0014

Alternate gene names: 15887373

Gene position: 11335-12177 (Clockwise)

Preceding gene: 159184123

Following gene: 159184124

Centisome position: 0.4

GC content: 59.79

Gene sequence:

>843_bases
ATGAAATTGATGCGTGTTGGCCAGCCCGGCCAGGAAAAACCAGCCATTCTCGATGCGGAAGGAAAAGTCCGCGATCTGTC
CGCCCATGTGAAAGATATCGGCGGCGACGCGATTTCTCCCGAGGGTCTCAAGAAGATCGCCGCGATCGACCTCGCCACCC
TGCCGGTGTTGAGCGAAGAGCGCATTGGCGCCTGCGTTGCGGGTACCGGAAAATTCATCTGCATCGGCCTCAACTTCTCC
GACCATGCGGCTGAAACGGGTGCTACCGTACCGCCGGAACCGGTCATTTTCATGAAGGCGACCTCGGCCATCGTCGGTCC
GAACGATAACGTCACCATTCCGCGCGGCTCGGAAAAGACCGACTGGGAAGTCGAGCTTGGCGTCGTCATCGGCAAGACCG
CGAAATACGTCTCGGAAGCGGACGCCCTCGATTATGTCGCCGGTTATTGCGTATCGCACGACGTTTCCGAGCGCGCCTTC
CAGACAGAACGTGCCGGTCAGTGGACAAAGGGCAAGTCCTGCGACACTTTCGGCCCCATCGGCCCCTGGCTGGTGACGAA
GGACGAAATCACCGATCCGCAGAACCTCGGCATGTGGCTGAAGGTCAATGGCCAGACCATGCAGGACGGTTCCAGCAAGA
CAATGGTTTACGGCGTCGCCCACGTTGTCTCCTATCTCAGCCAGTTCATGTCGCTGCATCCCGGCGATGTCATTTCCACC
GGCACCCCTCCCGGCGTCGGCATGGGCCAAAAGCCGCCGCGTTACCTGAAGACTGGTGACGTCGTGGAACTCGGCATCGA
GGGCCTCGGTTCCCAGAAGCAGACTTTCGTCGCTGACATCTGA

Upstream 100 bases:

>100_bases
GAAAAGGTATTTTTCGAAACTTGGCGCAGTCAAGGGGTGACAAGTATGAATGCATCGTTCATATATGCATCACCTTGTCT
GACAACCGGGAGAGAGTTCC

Downstream 100 bases:

>100_bases
TCGCCGGCAGGCATTCAACGAAAAGTGAGGCGCCGGCGGGAAACCGCTGGCGCCTTAAATTTTGTGCACCTGCGAAAAGC
TGCTATGGTCAGAAAAAGAG

Product: 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase

Products: NA

Alternate protein names: UGL; Ureidoglycolase; Ureidoglycolatase; Ureidoglycolate hydrolase [H]

Number of amino acids: Translated: 280; Mature: 280

Protein sequence:

>280_residues
MKLMRVGQPGQEKPAILDAEGKVRDLSAHVKDIGGDAISPEGLKKIAAIDLATLPVLSEERIGACVAGTGKFICIGLNFS
DHAAETGATVPPEPVIFMKATSAIVGPNDNVTIPRGSEKTDWEVELGVVIGKTAKYVSEADALDYVAGYCVSHDVSERAF
QTERAGQWTKGKSCDTFGPIGPWLVTKDEITDPQNLGMWLKVNGQTMQDGSSKTMVYGVAHVVSYLSQFMSLHPGDVIST
GTPPGVGMGQKPPRYLKTGDVVELGIEGLGSQKQTFVADI

Sequences:

>Translated_280_residues
MKLMRVGQPGQEKPAILDAEGKVRDLSAHVKDIGGDAISPEGLKKIAAIDLATLPVLSEERIGACVAGTGKFICIGLNFS
DHAAETGATVPPEPVIFMKATSAIVGPNDNVTIPRGSEKTDWEVELGVVIGKTAKYVSEADALDYVAGYCVSHDVSERAF
QTERAGQWTKGKSCDTFGPIGPWLVTKDEITDPQNLGMWLKVNGQTMQDGSSKTMVYGVAHVVSYLSQFMSLHPGDVIST
GTPPGVGMGQKPPRYLKTGDVVELGIEGLGSQKQTFVADI
>Mature_280_residues
MKLMRVGQPGQEKPAILDAEGKVRDLSAHVKDIGGDAISPEGLKKIAAIDLATLPVLSEERIGACVAGTGKFICIGLNFS
DHAAETGATVPPEPVIFMKATSAIVGPNDNVTIPRGSEKTDWEVELGVVIGKTAKYVSEADALDYVAGYCVSHDVSERAF
QTERAGQWTKGKSCDTFGPIGPWLVTKDEITDPQNLGMWLKVNGQTMQDGSSKTMVYGVAHVVSYLSQFMSLHPGDVIST
GTPPGVGMGQKPPRYLKTGDVVELGIEGLGSQKQTFVADI

Specific function: Unknown

COG id: COG0179

COG function: function code Q; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAH family [H]

Homologues:

Organism=Homo sapiens, GI156231349, Length=222, Percent_Identity=50.4504504504504, Blast_Score=227, Evalue=7e-60,
Organism=Homo sapiens, GI40786394, Length=222, Percent_Identity=50, Blast_Score=224, Evalue=8e-59,
Organism=Homo sapiens, GI13654274, Length=203, Percent_Identity=37.9310344827586, Blast_Score=147, Evalue=8e-36,
Organism=Homo sapiens, GI66348062, Length=202, Percent_Identity=37.6237623762376, Blast_Score=147, Evalue=9e-36,
Organism=Homo sapiens, GI215422413, Length=201, Percent_Identity=37.8109452736318, Blast_Score=147, Evalue=9e-36,
Organism=Escherichia coli, GI1787428, Length=201, Percent_Identity=34.8258706467662, Blast_Score=127, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI17557057, Length=199, Percent_Identity=37.1859296482412, Blast_Score=144, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6324161, Length=228, Percent_Identity=31.140350877193, Blast_Score=100, Evalue=2e-22,
Organism=Drosophila melanogaster, GI28572127, Length=210, Percent_Identity=48.0952380952381, Blast_Score=197, Evalue=8e-51,
Organism=Drosophila melanogaster, GI28571789, Length=209, Percent_Identity=38.2775119617225, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24663695, Length=237, Percent_Identity=32.4894514767932, Blast_Score=139, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002529
- InterPro:   IPR011234 [H]

Pfam domain/function: PF01557 FAA_hydrolase [H]

EC number: =4.3.2.3 [H]

Molecular weight: Translated: 29702; Mature: 29702

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLMRVGQPGQEKPAILDAEGKVRDLSAHVKDIGGDAISPEGLKKIAAIDLATLPVLSEE
CCCCCCCCCCCCCCEEECCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCC
RIGACVAGTGKFICIGLNFSDHAAETGATVPPEPVIFMKATSAIVGPNDNVTIPRGSEKT
CCCEEEECCCCEEEEEECCCHHHHCCCCCCCCCCEEEEEECCEEECCCCCEEECCCCCCC
DWEVELGVVIGKTAKYVSEADALDYVAGYCVSHDVSERAFQTERAGQWTKGKSCDTFGPI
CEEEEEEEEECCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCC
GPWLVTKDEITDPQNLGMWLKVNGQTMQDGSSKTMVYGVAHVVSYLSQFMSLHPGDVIST
CCEEEECCCCCCHHHCCEEEEECCCEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEC
GTPPGVGMGQKPPRYLKTGDVVELGIEGLGSQKQTFVADI
CCCCCCCCCCCCCCCCCCCCEEEECHHCCCCCCCEEEECC
>Mature Secondary Structure
MKLMRVGQPGQEKPAILDAEGKVRDLSAHVKDIGGDAISPEGLKKIAAIDLATLPVLSEE
CCCCCCCCCCCCCCEEECCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCC
RIGACVAGTGKFICIGLNFSDHAAETGATVPPEPVIFMKATSAIVGPNDNVTIPRGSEKT
CCCEEEECCCCEEEEEECCCHHHHCCCCCCCCCCEEEEEECCEEECCCCCEEECCCCCCC
DWEVELGVVIGKTAKYVSEADALDYVAGYCVSHDVSERAFQTERAGQWTKGKSCDTFGPI
CEEEEEEEEECCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCC
GPWLVTKDEITDPQNLGMWLKVNGQTMQDGSSKTMVYGVAHVVSYLSQFMSLHPGDVIST
CCEEEECCCCCCHHHCCEEEEECCCEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEC
GTPPGVGMGQKPPRYLKTGDVVELGIEGLGSQKQTFVADI
CCCCCCCCCCCCCCCCCCCCEEEECHHCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA