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The map label for this gene is clpP [H]

Identifier: 239618479

GI number: 239618479

Start: 2253707

End: 2254327

Strand: Reverse

Name: clpP [H]

Synonym: Kole_2120

Alternate gene names: 239618479

Gene position: 2254327-2253707 (Counterclockwise)

Preceding gene: 239618480

Following gene: 239618478

Centisome position: 97.92

GC content: 42.03

Gene sequence:

>621_bases
GTGGACTTTAAAATGATGCCTGTTGTACCTTATGTTGTTGAAAACAAAGGCAGAGGTGAAAGGATATACGACATATTCAC
AAAGCTTTTGAGCGAAAGGATAATATTTCTTGGCTGGCCACTTGACGATGAAATATCAAATATCGTTGTGGCCCAATTGT
TGTTCTTAGAATCTCAAGACCCGGATAAGGATATAAGTATCTATATCAATAGCCCGGGTGGTTCTGTAACTTCAGGACTG
GCGATCTATGACACAATGCAGTATATAAAACCAGATGTCAGCACGATATGTATTGGTATGGCTGCTTCAATGGCTGCGGT
GATACTCGCTGGCGGAAGCAAAGGAAAGCGATTTGCGTTACCACATTCCAGAATAATGATTCATCAGCCATGGGGCGGAG
CCGAAGGAACAGCAAAAGATATTGAGATAAGAACTCGTGAACTGCTCTTTATAAGGGATCAGATAAACGAGATTCTCAGT
CATCACACCAATCAACCGAAGGAAAAGATAGAAGAGGACACAGATAGAGATTTCTATATGAGCCCCGCAGAGGCCGTGAA
ATATGGACTGGTAGATAAGGTTATAGAGCCGAGAAAATTGAAGGTTGCTAAGAAGGCTTGA

Upstream 100 bases:

>100_bases
ACGGACAGTGGCCATTTGATATTCTCATTTGTTCCGGTTGAGAAACTTATCGAAAAACTTTTTGATGGCGAAGAAAGATA
AGACAGGAGGGCAAATAACC

Downstream 100 bases:

>100_bases
CGATCCATTTTTTGAAAAATCGCCGGCGCTAAGCGCCGGTTTTTAGGCTTATATGGAGTGATAGCAATGAAGAACAAAAG
TCTGACACCAATGATGAGAC

Product: ATP-dependent Clp protease, proteolytic subunit ClpP

Products: NA

Alternate protein names: Endopeptidase Clp [H]

Number of amino acids: Translated: 206; Mature: 206

Protein sequence:

>206_residues
MDFKMMPVVPYVVENKGRGERIYDIFTKLLSERIIFLGWPLDDEISNIVVAQLLFLESQDPDKDISIYINSPGGSVTSGL
AIYDTMQYIKPDVSTICIGMAASMAAVILAGGSKGKRFALPHSRIMIHQPWGGAEGTAKDIEIRTRELLFIRDQINEILS
HHTNQPKEKIEEDTDRDFYMSPAEAVKYGLVDKVIEPRKLKVAKKA

Sequences:

>Translated_206_residues
MDFKMMPVVPYVVENKGRGERIYDIFTKLLSERIIFLGWPLDDEISNIVVAQLLFLESQDPDKDISIYINSPGGSVTSGL
AIYDTMQYIKPDVSTICIGMAASMAAVILAGGSKGKRFALPHSRIMIHQPWGGAEGTAKDIEIRTRELLFIRDQINEILS
HHTNQPKEKIEEDTDRDFYMSPAEAVKYGLVDKVIEPRKLKVAKKA
>Mature_206_residues
MDFKMMPVVPYVVENKGRGERIYDIFTKLLSERIIFLGWPLDDEISNIVVAQLLFLESQDPDKDISIYINSPGGSVTSGL
AIYDTMQYIKPDVSTICIGMAASMAAVILAGGSKGKRFALPHSRIMIHQPWGGAEGTAKDIEIRTRELLFIRDQINEILS
HHTNQPKEKIEEDTDRDFYMSPAEAVKYGLVDKVIEPRKLKVAKKA

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=192, Percent_Identity=52.6041666666667, Blast_Score=219, Evalue=9e-58,
Organism=Escherichia coli, GI1786641, Length=194, Percent_Identity=56.701030927835, Blast_Score=252, Evalue=1e-68,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=53.763440860215, Blast_Score=215, Evalue=1e-56,
Organism=Drosophila melanogaster, GI20129427, Length=189, Percent_Identity=52.3809523809524, Blast_Score=212, Evalue=1e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 23142; Mature: 23142

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS00381 CLP_PROTEASE_SER ; PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFKMMPVVPYVVENKGRGERIYDIFTKLLSERIIFLGWPLDDEISNIVVAQLLFLESQD
CCCCCCCCCCEEECCCCCCCHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHCCCC
PDKDISIYINSPGGSVTSGLAIYDTMQYIKPDVSTICIGMAASMAAVILAGGSKGKRFAL
CCCCEEEEEECCCCCHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHEEEEECCCCCCEEEC
PHSRIMIHQPWGGAEGTAKDIEIRTRELLFIRDQINEILSHHTNQPKEKIEEDTDRDFYM
CCCEEEEECCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCEEE
SPAEAVKYGLVDKVIEPRKLKVAKKA
CHHHHHHHHHHHHHCCCCHHCCCCCC
>Mature Secondary Structure
MDFKMMPVVPYVVENKGRGERIYDIFTKLLSERIIFLGWPLDDEISNIVVAQLLFLESQD
CCCCCCCCCCEEECCCCCCCHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHCCCC
PDKDISIYINSPGGSVTSGLAIYDTMQYIKPDVSTICIGMAASMAAVILAGGSKGKRFAL
CCCCEEEEEECCCCCHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHEEEEECCCCCCEEEC
PHSRIMIHQPWGGAEGTAKDIEIRTRELLFIRDQINEILSHHTNQPKEKIEEDTDRDFYM
CCCEEEEECCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCEEE
SPAEAVKYGLVDKVIEPRKLKVAKKA
CHHHHHHHHHHHHHCCCCHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]