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The map label for this gene is dxs [H]

Identifier: 239618471

GI number: 239618471

Start: 2244112

End: 2246007

Strand: Reverse

Name: dxs [H]

Synonym: Kole_2112

Alternate gene names: 239618471

Gene position: 2246007-2244112 (Counterclockwise)

Preceding gene: 239618472

Following gene: 239618470

Centisome position: 97.56

GC content: 42.09

Gene sequence:

>1896_bases
ATGATTGAGTTTGATGAGGTTCCTCTTTACAAGAAAATAAAAGGGTATAGCTATCCTGAACTTGAGATACTGGCGGAAGA
ATTCAGGAACTACATCGCTAATGTTGTGTCGAAAAATACAGGGCACCTTGCCTCAAATCTTGGTACCATTGAGTTAACAT
TTGCCCTTTATCGTGTCTTCGATCCGGAAAAAGATATTATCATCTGGGACACAGGACATCAGGCCTATTCTCATAAACTC
CTGACAGGGCGCTTTAAGGCTTTCAAAACCTTAAGGCAAAGGCATGGGATAAGCGGATTCACCAAACGGGACGAGAGTAA
GTACGATGTATTTGGCGCTGGACATGTTGGAACTGCTATTCCAGCGGCTCTTGGAATTGAACAGGCTTTAAAGTTAAGAA
ACGAGAAGAGAAACATTGTTGTTGTCGTAGGAGATGGTGCGTTGACATCCGGGATAAGCCTGGAAGCCTTAAATCAGATA
CGGGAACTTTCATCGAAGATAAAGATAGTGGTAAATGACAATGGAATGAGTATCAGCAGAAACGTCGGATCTCTTTCAAC
AAAACTCAATGAATTTCGATTGAATCCTATTTACCGTGAATTAAAAGAGGACCTGAAAAGTGCACTTGAGACAATGAGGC
TCAGTAAAATTGAGAATATACTTTCCAAACTCAAATCGGGGGTAAAGCATTCCCTTCTTGGCGGAAATATATTTGAAGAT
CTTGGGTTGAACTACATTGGCCCAATTAACGGCCACAATATCCGTGAAATGGAAGGCTTGTTCAAGATGGTTAAAAACTT
TGATGAGCCATTCTTGATACATGTAGTGACCAAAAAGGGTGCAGGTCTTGACTACGCTGAGAAGGATCCAACGACATTTC
ACAGTGTTTCCAGGATCGATCCGGAAACAGGGCAGAAAATAACTCAAACGAATATGGTTTCTTACAGCAGGGTCTTTGGC
TCGGTTCTAGCAAAGCTTGGTGAATTGGATCCAAGAATCGTCGCGGTCACCGCAGCGATGCCTGATGGAACAGGATTAGC
AGAGTTTGCCAGAAAGTTCCCTGAAAGATTTTTTGATCTGGGGATTACCGAGCAACTCTGCACAACTTTCGCTGCCGGTA
TCGCCACCAAAAATTTGAAACCTGTTTTCGCTGTATATTCTACTTTCTTACAGCGTTCTTTTGATCAGTTGATTCACGAT
GTTGCTTTACAACGATTGCCGGTTGTTTTTGCTATAGATAGAGCAGGAATTGTGGGAAGGGATGGTCCTACACACAACGG
AATATTTGATATCGCTTATCTCAGCATGATACCAAACATGAGGGTTTTAGCGCCATCGAATCTACAGGAACTGGCAAATA
TTGTGTGCACTATTCTGTCAGATGAAGAAATTTCGGGCCCCATTGCAATAAGATATCCGAGACAATCTGAGATAGCCAAC
CTTGAAGAGATTCTCAATTCTATGATGAAGATCAACGTGTGGAAATGGGAAAAACTTTTTGATGGCAAAGAAGTGGCAAT
ACTCGCTGTTGGCAGTATGGTTTCACCAGCGAAACAGGTAGCTGAAAAACATGGTTATACACTATACAACTGTAGATCAG
TAAAACCCTTAGATGAGGTGACTTTAGCCGAGGTGTTGAAGAAGCATGACCTTGTTGTTTGCATAGAGGAAGGAGTCAAA
ATAGGTGGTTTTGGTTCCAGCGTAATGCTTTATGCAAGCGATCACGGTTTTTCCACCAGAGTCGTAGCAATGGGTGTTGA
AGATAGATTTTCGGAGCATGGATCGAGGGAGGAGATTCTTTCTGAACTTTTTCTGGACAGCAGGGGTATTGAAAAAAGAA
TATTTGAACTGAGAGGTGAAAGAAATGCTAATAACGACCGAGTACGGAAAGATTGA

Upstream 100 bases:

>100_bases
GCAATAACTCCGGTTCCCGGAGGCGTAGGTATAGTAACTACGGCCATTCTTTTCAGACATTTCATGGTTTCTTCAAGGAG
AATGGTCGGGAGGCGATGAG

Downstream 100 bases:

>100_bases
AATCACGCTGCAGGCGATCGGGTCAATTGTAAAGAAAGTCGTTTCTGAATCCTACGGGCCTGTTAATGTAGGTGCCCCAC
AGCAGGGGTTTCTGGCAAAA

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]

Number of amino acids: Translated: 631; Mature: 631

Protein sequence:

>631_residues
MIEFDEVPLYKKIKGYSYPELEILAEEFRNYIANVVSKNTGHLASNLGTIELTFALYRVFDPEKDIIIWDTGHQAYSHKL
LTGRFKAFKTLRQRHGISGFTKRDESKYDVFGAGHVGTAIPAALGIEQALKLRNEKRNIVVVVGDGALTSGISLEALNQI
RELSSKIKIVVNDNGMSISRNVGSLSTKLNEFRLNPIYRELKEDLKSALETMRLSKIENILSKLKSGVKHSLLGGNIFED
LGLNYIGPINGHNIREMEGLFKMVKNFDEPFLIHVVTKKGAGLDYAEKDPTTFHSVSRIDPETGQKITQTNMVSYSRVFG
SVLAKLGELDPRIVAVTAAMPDGTGLAEFARKFPERFFDLGITEQLCTTFAAGIATKNLKPVFAVYSTFLQRSFDQLIHD
VALQRLPVVFAIDRAGIVGRDGPTHNGIFDIAYLSMIPNMRVLAPSNLQELANIVCTILSDEEISGPIAIRYPRQSEIAN
LEEILNSMMKINVWKWEKLFDGKEVAILAVGSMVSPAKQVAEKHGYTLYNCRSVKPLDEVTLAEVLKKHDLVVCIEEGVK
IGGFGSSVMLYASDHGFSTRVVAMGVEDRFSEHGSREEILSELFLDSRGIEKRIFELRGERNANNDRVRKD

Sequences:

>Translated_631_residues
MIEFDEVPLYKKIKGYSYPELEILAEEFRNYIANVVSKNTGHLASNLGTIELTFALYRVFDPEKDIIIWDTGHQAYSHKL
LTGRFKAFKTLRQRHGISGFTKRDESKYDVFGAGHVGTAIPAALGIEQALKLRNEKRNIVVVVGDGALTSGISLEALNQI
RELSSKIKIVVNDNGMSISRNVGSLSTKLNEFRLNPIYRELKEDLKSALETMRLSKIENILSKLKSGVKHSLLGGNIFED
LGLNYIGPINGHNIREMEGLFKMVKNFDEPFLIHVVTKKGAGLDYAEKDPTTFHSVSRIDPETGQKITQTNMVSYSRVFG
SVLAKLGELDPRIVAVTAAMPDGTGLAEFARKFPERFFDLGITEQLCTTFAAGIATKNLKPVFAVYSTFLQRSFDQLIHD
VALQRLPVVFAIDRAGIVGRDGPTHNGIFDIAYLSMIPNMRVLAPSNLQELANIVCTILSDEEISGPIAIRYPRQSEIAN
LEEILNSMMKINVWKWEKLFDGKEVAILAVGSMVSPAKQVAEKHGYTLYNCRSVKPLDEVTLAEVLKKHDLVVCIEEGVK
IGGFGSSVMLYASDHGFSTRVVAMGVEDRFSEHGSREEILSELFLDSRGIEKRIFELRGERNANNDRVRKD
>Mature_631_residues
MIEFDEVPLYKKIKGYSYPELEILAEEFRNYIANVVSKNTGHLASNLGTIELTFALYRVFDPEKDIIIWDTGHQAYSHKL
LTGRFKAFKTLRQRHGISGFTKRDESKYDVFGAGHVGTAIPAALGIEQALKLRNEKRNIVVVVGDGALTSGISLEALNQI
RELSSKIKIVVNDNGMSISRNVGSLSTKLNEFRLNPIYRELKEDLKSALETMRLSKIENILSKLKSGVKHSLLGGNIFED
LGLNYIGPINGHNIREMEGLFKMVKNFDEPFLIHVVTKKGAGLDYAEKDPTTFHSVSRIDPETGQKITQTNMVSYSRVFG
SVLAKLGELDPRIVAVTAAMPDGTGLAEFARKFPERFFDLGITEQLCTTFAAGIATKNLKPVFAVYSTFLQRSFDQLIHD
VALQRLPVVFAIDRAGIVGRDGPTHNGIFDIAYLSMIPNMRVLAPSNLQELANIVCTILSDEEISGPIAIRYPRQSEIAN
LEEILNSMMKINVWKWEKLFDGKEVAILAVGSMVSPAKQVAEKHGYTLYNCRSVKPLDEVTLAEVLKKHDLVVCIEEGVK
IGGFGSSVMLYASDHGFSTRVVAMGVEDRFSEHGSREEILSELFLDSRGIEKRIFELRGERNANNDRVRKD

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=315, Percent_Identity=23.8095238095238, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI4507521, Length=315, Percent_Identity=23.8095238095238, Blast_Score=74, Evalue=4e-13,
Organism=Escherichia coli, GI1786622, Length=595, Percent_Identity=41.6806722689076, Blast_Score=483, Evalue=1e-137,
Organism=Caenorhabditis elegans, GI17539652, Length=399, Percent_Identity=23.8095238095238, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24666278, Length=268, Percent_Identity=25.7462686567164, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI45551847, Length=642, Percent_Identity=23.5202492211838, Blast_Score=75, Evalue=2e-13,
Organism=Drosophila melanogaster, GI45550715, Length=642, Percent_Identity=23.5202492211838, Blast_Score=75, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24645119, Length=591, Percent_Identity=23.8578680203046, Blast_Score=70, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005477
- InterPro:   IPR011766
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 70395; Mature: 70395

Theoretical pI: Translated: 7.47; Mature: 7.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEFDEVPLYKKIKGYSYPELEILAEEFRNYIANVVSKNTGHLASNLGTIELTFALYRVF
CCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCEEHHHHHHHHC
DPEKDIIIWDTGHQAYSHKLLTGRFKAFKTLRQRHGISGFTKRDESKYDVFGAGHVGTAI
CCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCHHHHH
PAALGIEQALKLRNEKRNIVVVVGDGALTSGISLEALNQIRELSSKIKIVVNDNGMSISR
HHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCEEEEECCCCCEEEC
NVGSLSTKLNEFRLNPIYRELKEDLKSALETMRLSKIENILSKLKSGVKHSLLGGNIFED
CCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCHHHH
LGLNYIGPINGHNIREMEGLFKMVKNFDEPFLIHVVTKKGAGLDYAEKDPTTFHSVSRID
CCCCEECCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHCC
PETGQKITQTNMVSYSRVFGSVLAKLGELDPRIVAVTAAMPDGTGLAEFARKFPERFFDL
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHC
GITEQLCTTFAAGIATKNLKPVFAVYSTFLQRSFDQLIHDVALQRLPVVFAIDRAGIVGR
CCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCC
DGPTHNGIFDIAYLSMIPNMRVLAPSNLQELANIVCTILSDEEISGPIAIRYPRQSEIAN
CCCCCCCHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHH
LEEILNSMMKINVWKWEKLFDGKEVAILAVGSMVSPAKQVAEKHGYTLYNCRSVKPLDEV
HHHHHHHHHHCCCEEHHHHCCCCCEEEEEECCCCCHHHHHHHHCCCEEEECCCCCCHHHH
TLAEVLKKHDLVVCIEEGVKIGGFGSSVMLYASDHGFSTRVVAMGVEDRFSEHGSREEIL
HHHHHHHHCCEEEEEECCCEECCCCCEEEEEEECCCCCEEEEEECHHHHHHHCCCHHHHH
SELFLDSRGIEKRIFELRGERNANNDRVRKD
HHHHHCCCCHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MIEFDEVPLYKKIKGYSYPELEILAEEFRNYIANVVSKNTGHLASNLGTIELTFALYRVF
CCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCEEHHHHHHHHC
DPEKDIIIWDTGHQAYSHKLLTGRFKAFKTLRQRHGISGFTKRDESKYDVFGAGHVGTAI
CCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCHHHHH
PAALGIEQALKLRNEKRNIVVVVGDGALTSGISLEALNQIRELSSKIKIVVNDNGMSISR
HHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCEEEEECCCCCEEEC
NVGSLSTKLNEFRLNPIYRELKEDLKSALETMRLSKIENILSKLKSGVKHSLLGGNIFED
CCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCHHHH
LGLNYIGPINGHNIREMEGLFKMVKNFDEPFLIHVVTKKGAGLDYAEKDPTTFHSVSRID
CCCCEECCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHCC
PETGQKITQTNMVSYSRVFGSVLAKLGELDPRIVAVTAAMPDGTGLAEFARKFPERFFDL
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHC
GITEQLCTTFAAGIATKNLKPVFAVYSTFLQRSFDQLIHDVALQRLPVVFAIDRAGIVGR
CCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCC
DGPTHNGIFDIAYLSMIPNMRVLAPSNLQELANIVCTILSDEEISGPIAIRYPRQSEIAN
CCCCCCCHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHH
LEEILNSMMKINVWKWEKLFDGKEVAILAVGSMVSPAKQVAEKHGYTLYNCRSVKPLDEV
HHHHHHHHHHCCCEEHHHHCCCCCEEEEEECCCCCHHHHHHHHCCCEEEECCCCCCHHHH
TLAEVLKKHDLVVCIEEGVKIGGFGSSVMLYASDHGFSTRVVAMGVEDRFSEHGSREEIL
HHHHHHHHCCEEEEEECCCEECCCCCEEEEEEECCCCCEEEEEECHHHHHHHCCCHHHHH
SELFLDSRGIEKRIFELRGERNANNDRVRKD
HHHHHCCCCHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]