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The map label for this gene is ndhS [H]

Identifier: 239618435

GI number: 239618435

Start: 2203898

End: 2204368

Strand: Direct

Name: ndhS [H]

Synonym: Kole_2076

Alternate gene names: 239618435

Gene position: 2203898-2204368 (Clockwise)

Preceding gene: 239618434

Following gene: 239618436

Centisome position: 95.73

GC content: 45.22

Gene sequence:

>471_bases
ATGAAGATAAGCTTTAAGTTGAATGGTGAGCCCGTAGAAGTCGATATAAGGCCGGATATGCGGGTACTTGACTTTCTGAG
AGATGAAATGGGATTGACGGGAGTCAAAGAAGGTTGTGGTGAAGGAGAATGTGGTGCCTGTACCATCATAGTCGATGGGC
GTAACGTGCACTCATGCCTCATGCTTACCGTCGAACTTGATGGCAAAGATGTCTGGACTATTGAAGGATTGTCGAAGGAT
GGAAAACCACATCCTGTACAGGAAGCATTTATAGAAGCTGGTGGTGTGCAGTGTGGTTTCTGTACCCCCGGGATGATAAT
GTCGGCTAAGGTGTTGCTGGACAGAAATCCAAAACCGTCTGAGGAACAAATAAAAGAAGCCCTTGAGGGAAACCTTTGCA
GATGTACCGGTTACTACAAGATCATAAAGGCTGTTGAATTGGCATCTGAAAAACTGGAAAAGGGTGAATAA

Upstream 100 bases:

>100_bases
GTTACCGGAAATGGCCTTAAAGATTTGAAAGCACCTGCTCGGGTTCTCGAAGAGCTTAAAAAGCTTCCTGCTAACGTTGA
GAAAATCAGGGAGGGATTGG

Downstream 100 bases:

>100_bases
AAACGTGAAAACGGGGCTCGTTATACTGGCTGCAGGATCAGCAAAGCGGTTTGGTACCGATAAACTCCTGAAAGAGTTCG
ATGGTAAACCGCTGCTTCAG

Product: (2Fe-2S)-binding domain protein

Products: NA

Alternate protein names: NDH; Nicotinic acid hydroxylase small FeS subunit; NAH [H]

Number of amino acids: Translated: 156; Mature: 156

Protein sequence:

>156_residues
MKISFKLNGEPVEVDIRPDMRVLDFLRDEMGLTGVKEGCGEGECGACTIIVDGRNVHSCLMLTVELDGKDVWTIEGLSKD
GKPHPVQEAFIEAGGVQCGFCTPGMIMSAKVLLDRNPKPSEEQIKEALEGNLCRCTGYYKIIKAVELASEKLEKGE

Sequences:

>Translated_156_residues
MKISFKLNGEPVEVDIRPDMRVLDFLRDEMGLTGVKEGCGEGECGACTIIVDGRNVHSCLMLTVELDGKDVWTIEGLSKD
GKPHPVQEAFIEAGGVQCGFCTPGMIMSAKVLLDRNPKPSEEQIKEALEGNLCRCTGYYKIIKAVELASEKLEKGE
>Mature_156_residues
MKISFKLNGEPVEVDIRPDMRVLDFLRDEMGLTGVKEGCGEGECGACTIIVDGRNVHSCLMLTVELDGKDVWTIEGLSKD
GKPHPVQEAFIEAGGVQCGFCTPGMIMSAKVLLDRNPKPSEEQIKEALEGNLCRCTGYYKIIKAVELASEKLEKGE

Specific function: Catalyzes the hydroxylation of nicotinate to 6- hydroxynicotinate. Also active against 2-pyrazinecarboxylic acid, but inactive against other nicotinate analogs [H]

COG id: COG2080

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 2Fe-2S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=154, Percent_Identity=43.5064935064935, Blast_Score=100, Evalue=4e-22,
Organism=Homo sapiens, GI71773480, Length=152, Percent_Identity=44.7368421052632, Blast_Score=99, Evalue=2e-21,
Organism=Escherichia coli, GI1789232, Length=150, Percent_Identity=45.3333333333333, Blast_Score=131, Evalue=2e-32,
Organism=Escherichia coli, GI1786480, Length=166, Percent_Identity=39.7590361445783, Blast_Score=128, Evalue=2e-31,
Organism=Escherichia coli, GI1789246, Length=149, Percent_Identity=34.2281879194631, Blast_Score=80, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17540638, Length=154, Percent_Identity=45.4545454545455, Blast_Score=130, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17539860, Length=154, Percent_Identity=40.2597402597403, Blast_Score=125, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI32566215, Length=154, Percent_Identity=38.3116883116883, Blast_Score=122, Evalue=5e-29,
Organism=Drosophila melanogaster, GI17737937, Length=165, Percent_Identity=41.2121212121212, Blast_Score=117, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24647197, Length=161, Percent_Identity=37.888198757764, Blast_Score=110, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24647195, Length=161, Percent_Identity=37.888198757764, Blast_Score=110, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24647201, Length=155, Percent_Identity=36.7741935483871, Blast_Score=100, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24647199, Length=155, Percent_Identity=36.1290322580645, Blast_Score=98, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24647193, Length=155, Percent_Identity=35.4838709677419, Blast_Score=89, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002888
- InterPro:   IPR006058
- InterPro:   IPR012675
- InterPro:   IPR001041 [H]

Pfam domain/function: PF00111 Fer2; PF01799 Fer2_2 [H]

EC number: =1.17.1.5 [H]

Molecular weight: Translated: 17049; Mature: 17049

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.1 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
9.0 %Cys+Met (Translated Protein)
5.1 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
9.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKISFKLNGEPVEVDIRPDMRVLDFLRDEMGLTGVKEGCGEGECGACTIIVDGRNVHSCL
CEEEEEECCCEEEEEECCCHHHHHHHHHHCCCCCHHHCCCCCCCCEEEEEECCCCCCEEE
MLTVELDGKDVWTIEGLSKDGKPHPVQEAFIEAGGVQCGFCTPGMIMSAKVLLDRNPKPS
EEEEEECCCEEEEEECCCCCCCCCCHHHHHHHCCCCEEECCCCCHHHEEEEEECCCCCCC
EEQIKEALEGNLCRCTGYYKIIKAVELASEKLEKGE
HHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKISFKLNGEPVEVDIRPDMRVLDFLRDEMGLTGVKEGCGEGECGACTIIVDGRNVHSCL
CEEEEEECCCEEEEEECCCHHHHHHHHHHCCCCCHHHCCCCCCCCEEEEEECCCCCCEEE
MLTVELDGKDVWTIEGLSKDGKPHPVQEAFIEAGGVQCGFCTPGMIMSAKVLLDRNPKPS
EEEEEECCCEEEEEECCCCCCCCCCHHHHHHHCCCCEEECCCCCHHHEEEEEECCCCCCC
EEQIKEALEGNLCRCTGYYKIIKAVELASEKLEKGE
HHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA