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The map label for this gene is pyrD [H]

Identifier: 239618433

GI number: 239618433

Start: 2201573

End: 2202658

Strand: Direct

Name: pyrD [H]

Synonym: Kole_2074

Alternate gene names: 239618433

Gene position: 2201573-2202658 (Clockwise)

Preceding gene: 239618432

Following gene: 239618434

Centisome position: 95.63

GC content: 44.94

Gene sequence:

>1086_bases
TTGGATCTCACAACGAAGATAGCCGGTCTGCAGCTTGCAAATCCGGTAATGCCCGCTTCAGGGCCGTTGACCGGGGACGA
CCAGAAGATGCTTGCCCTTACAGATTTTGGGCTTGGTGCCATGGTTACCAAGACGATATCTACAAAAGCTGCTGAGGTTC
CACGTCCCTGTATAATTGCAGGAAAAAACTATATTATGAATACCGAGTTGTGGACGGAATATCCACCTGAAAAGTGGAAA
GGTGAATTCATACCAAAATTCAGAGAAAAAAGCTCTCTTCCATTGATAGTCAGTCTGGGATACACCGTGGAAGATCTTGA
GGTCCTGGTACCAATGTTCGACGATCTTGCCGACGCTTTTGAGCTTTCCACACATTATGTGGCGGATGATCCAGAGCTCA
TGAAACATCTCATCAGGACGGTTAAAAAGCATACGGATAAACCTGTATTCCTGAAGTTTGATCCGTCGGTACCTGAACCT
GAGGTCATGGCAAAAGCAGTTGAAGAAGCTGGTGGGGATGGTATAGTTGCCATTAACTCTTTAGGACCGGGTTATCCACT
CTACCGCGAATTAAAATCGTCACCTCTAGGTAGCACACATGGCTTTGGCTGGATTTCCGGACCAGTGATCAAGCCAATTG
CTCTGGCGATGGTAAAACGGGTGGCTTCGAGCTGTAATTTGCCAATCATCGGTGTAGGCGGTATATCATCTGCTGATGAC
GTCATCGATTTTATTATGGCCGGTGCTTCCGCTGTTCAGCTTCTTTCAGGTGCTCTACTCTATGGAAAGAGCATCTACAA
AAAAATAATCGCTGATCTTCCAAAAAAATTAGAGGCACTTGGGTACAACAGTATAAATGAAATAAAAGGCCTTGCGACGA
ATTCTAATCCTGAGGTATCATACGAAAAACGAACACCGAAAATTGATCATTCCAAGTGTGTCAAATGTGGCGTGTGTGTT
GAAGTGTGTCCTTACTTTGCTTTGAGTATGGAAGAACAGGTTATTGTGGATGAGGAAGCCTGTTTTGGTTGTGGCCTATG
TCAGACCAAATGTCCAACAAAAGCCATCGGAGGTGTTCTTTTTTGA

Upstream 100 bases:

>100_bases
AAAAAGGTTGTCGGAGTATCTGAGGAGGAGCTCTACAAAGAAGCAAGAAAGCTTGCTGAAAAACTCTGGAAAAGGCTGTA
AAAGTATGGGAGGGATTAAA

Downstream 100 bases:

>100_bases
TTAAGTACAACTACTTGCTTCGGTGTATAAGCTGTGGAAAGGAATATTCACCAGAGGAAGTTGAATACACTTGCCCTGAT
TGCGGACCAAGACTGGGAAC

Product: dihydroorotate dehydrogenase family protein

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 361; Mature: 361

Protein sequence:

>361_residues
MDLTTKIAGLQLANPVMPASGPLTGDDQKMLALTDFGLGAMVTKTISTKAAEVPRPCIIAGKNYIMNTELWTEYPPEKWK
GEFIPKFREKSSLPLIVSLGYTVEDLEVLVPMFDDLADAFELSTHYVADDPELMKHLIRTVKKHTDKPVFLKFDPSVPEP
EVMAKAVEEAGGDGIVAINSLGPGYPLYRELKSSPLGSTHGFGWISGPVIKPIALAMVKRVASSCNLPIIGVGGISSADD
VIDFIMAGASAVQLLSGALLYGKSIYKKIIADLPKKLEALGYNSINEIKGLATNSNPEVSYEKRTPKIDHSKCVKCGVCV
EVCPYFALSMEEQVIVDEEACFGCGLCQTKCPTKAIGGVLF

Sequences:

>Translated_361_residues
MDLTTKIAGLQLANPVMPASGPLTGDDQKMLALTDFGLGAMVTKTISTKAAEVPRPCIIAGKNYIMNTELWTEYPPEKWK
GEFIPKFREKSSLPLIVSLGYTVEDLEVLVPMFDDLADAFELSTHYVADDPELMKHLIRTVKKHTDKPVFLKFDPSVPEP
EVMAKAVEEAGGDGIVAINSLGPGYPLYRELKSSPLGSTHGFGWISGPVIKPIALAMVKRVASSCNLPIIGVGGISSADD
VIDFIMAGASAVQLLSGALLYGKSIYKKIIADLPKKLEALGYNSINEIKGLATNSNPEVSYEKRTPKIDHSKCVKCGVCV
EVCPYFALSMEEQVIVDEEACFGCGLCQTKCPTKAIGGVLF
>Mature_361_residues
MDLTTKIAGLQLANPVMPASGPLTGDDQKMLALTDFGLGAMVTKTISTKAAEVPRPCIIAGKNYIMNTELWTEYPPEKWK
GEFIPKFREKSSLPLIVSLGYTVEDLEVLVPMFDDLADAFELSTHYVADDPELMKHLIRTVKKHTDKPVFLKFDPSVPEP
EVMAKAVEEAGGDGIVAINSLGPGYPLYRELKSSPLGSTHGFGWISGPVIKPIALAMVKRVASSCNLPIIGVGGISSADD
VIDFIMAGASAVQLLSGALLYGKSIYKKIIADLPKKLEALGYNSINEIKGLATNSNPEVSYEKRTPKIDHSKCVKCGVCV
EVCPYFALSMEEQVIVDEEACFGCGLCQTKCPTKAIGGVLF

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI119943098, Length=339, Percent_Identity=27.4336283185841, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI87082059, Length=392, Percent_Identity=27.5510204081633, Blast_Score=120, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI71984108, Length=465, Percent_Identity=24.5161290322581, Blast_Score=92, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6322633, Length=308, Percent_Identity=27.9220779220779, Blast_Score=83, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24640763, Length=318, Percent_Identity=27.6729559748428, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI18858217, Length=318, Percent_Identity=27.6729559748428, Blast_Score=92, Evalue=7e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.3.1 [H]

Molecular weight: Translated: 38920; Mature: 38920

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: PS00912 DHODEHASE_2 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLTTKIAGLQLANPVMPASGPLTGDDQKMLALTDFGLGAMVTKTISTKAAEVPRPCIIA
CCCCHHHCCEEECCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCEEEE
GKNYIMNTELWTEYPPEKWKGEFIPKFREKSSLPLIVSLGYTVEDLEVLVPMFDDLADAF
CCCEEEECHHHCCCCCHHCCCCCCCHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHH
ELSTHYVADDPELMKHLIRTVKKHTDKPVFLKFDPSVPEPEVMAKAVEEAGGDGIVAINS
HHCCCEECCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCEEEECC
LGPGYPLYRELKSSPLGSTHGFGWISGPVIKPIALAMVKRVASSCNLPIIGVGGISSADD
CCCCCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHH
VIDFIMAGASAVQLLSGALLYGKSIYKKIIADLPKKLEALGYNSINEIKGLATNSNPEVS
HHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCEE
YEKRTPKIDHSKCVKCGVCVEVCPYFALSMEEQVIVDEEACFGCGLCQTKCPTKAIGGVL
ECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHCCCCCCCCCCCHHHHCCCC
F
C
>Mature Secondary Structure
MDLTTKIAGLQLANPVMPASGPLTGDDQKMLALTDFGLGAMVTKTISTKAAEVPRPCIIA
CCCCHHHCCEEECCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCEEEE
GKNYIMNTELWTEYPPEKWKGEFIPKFREKSSLPLIVSLGYTVEDLEVLVPMFDDLADAF
CCCEEEECHHHCCCCCHHCCCCCCCHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHH
ELSTHYVADDPELMKHLIRTVKKHTDKPVFLKFDPSVPEPEVMAKAVEEAGGDGIVAINS
HHCCCEECCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCEEEECC
LGPGYPLYRELKSSPLGSTHGFGWISGPVIKPIALAMVKRVASSCNLPIIGVGGISSADD
CCCCCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHH
VIDFIMAGASAVQLLSGALLYGKSIYKKIIADLPKKLEALGYNSINEIKGLATNSNPEVS
HHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCEE
YEKRTPKIDHSKCVKCGVCVEVCPYFALSMEEQVIVDEEACFGCGLCQTKCPTKAIGGVL
ECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHCCCCCCCCCCCHHHHCCCC
F
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA