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The map label for this gene is ygeZ [C]

Identifier: 239618431

GI number: 239618431

Start: 2198879

End: 2200246

Strand: Direct

Name: ygeZ [C]

Synonym: Kole_2072

Alternate gene names: 239618431

Gene position: 2198879-2200246 (Clockwise)

Preceding gene: 239618430

Following gene: 239618432

Centisome position: 95.52

GC content: 43.2

Gene sequence:

>1368_bases
GTGAAATATGATCTTGTACTGATTGGCGGGGAGGTCTGCGATGGCGCAGATCTCTATGCTGCCAATTTGTATATTTCCGA
AGGAAAGATAGCGGATATAACTCCAAAGAATGCATATCATCCAGCCAGAGCGTCTCTGGACTGCTCTGGCCTTTTTATTC
TTCCAGGATTTATAGATCCGCACGTTCATCTTGGTTTAAGGCTCGGGCGTTATAGTTCAACCGATGATTTTTCTTCCGGC
TCTGACGCTGCTCTGGCGGGTGGTGTGACCACCATCTTCGATTTTACAGAGCCCATTTACGATTACGAAGGTTTCATGAA
GAATTTAACAGAAAGGCTAAAGGATGCTTCCGTATCCAAAATCGATTACGGGCTTCACATAACCCTTGGTGGAAATGTCA
AACTATCTCCTGAAGAGGTTTCGAAACTGGCTGTGGAAACAGGCTGTCCAACGATAAAAGTTTTTACAGCTTACGGTGAT
ACAAATAGAAGAACCGATGATGGATACCTTTACGAGCTGTTGAAGAGTTCCGGAAAAATAGGAAGCGTTGTAATGGTTCA
CGCGGAAAACGATGAACTTATAAAAATAAATTCGAAGAAATATCCGGGAACCTTCGAATATCTTTCTGATATCCGTGCAA
CTGAGAGTGAGATTGGAGCAGTAATAATGGTTGCTCTTCTTGCCACTAAGGCGAAGGGTCAGGCCTATATCGTTCATCTT
TCAAGCGGTGAAACGGTAAATTGGATTGAGAGTTTTGCTGTAATTAGCAGAGATAATATAGTATTTGAGACGTGTCCGCA
GTATCTAGCGCTGAACAAAAAACTTTTAAAAAGAAAAGACGGATATTTATATACATTCTGTCCACCGCTCAGAAGCGAAA
AAGAGAGTGAACTTCTGGTTCGTGCATTGAGAAAAGGATTCATCAGCACTGTTGGAACGGATCATTGTCCATTTACTGTA
GAAGAAAAAACAGAAAGTGACGGAAAGCTCGACTCGGTTCCGTACGGTATCGCTTCCCTTGGTATCACATATAGTGTGGT
TAACACGCTGCTTGGCGGGGATTTATCGAAGGTTGTTCGGCTACTCAGCAAAAACCCGGCGAAGTATATGGGGGTTTATC
CTGAAAAAGGATCACTCCTTCCCGGAACCGACGCCGATATTACTGTGGTTGATCCGAATGAGAGATTTACAGTGCAGGAT
CCTGCCTACGGTAAAGCTGAGTATTGGCCGTACAAAGATCTTGAACTGAAAGGTAGAGTCAAATATACATTATTAAGAGG
AAAACTCGCCTTCGACGGTTCGACCATCTTGCTGGATGAAGGAAATGGAAAGTTCCTGAAAAGAAGCGAATTTTTCTGGG
GGAGATAA

Upstream 100 bases:

>100_bases
ATGAAGTCATTGATGGTCCACAGTCAATCGTCATAGACGAAGCAGAAAACCGCCTGCACACCGCAAAAGCTGTTATGGCT
TTAACCATGGGTGGTAGGCC

Downstream 100 bases:

>100_bases
AAATGCTCATCAAAGACGTTTCGATTTTTACCAATAACGGAAGATACATTCCTGAAGGCTTTGTCAGGGTCGATAATGGA
AAAATAATCGAGATTGGCGA

Product: amidohydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MKYDLVLIGGEVCDGADLYAANLYISEGKIADITPKNAYHPARASLDCSGLFILPGFIDPHVHLGLRLGRYSSTDDFSSG
SDAALAGGVTTIFDFTEPIYDYEGFMKNLTERLKDASVSKIDYGLHITLGGNVKLSPEEVSKLAVETGCPTIKVFTAYGD
TNRRTDDGYLYELLKSSGKIGSVVMVHAENDELIKINSKKYPGTFEYLSDIRATESEIGAVIMVALLATKAKGQAYIVHL
SSGETVNWIESFAVISRDNIVFETCPQYLALNKKLLKRKDGYLYTFCPPLRSEKESELLVRALRKGFISTVGTDHCPFTV
EEKTESDGKLDSVPYGIASLGITYSVVNTLLGGDLSKVVRLLSKNPAKYMGVYPEKGSLLPGTDADITVVDPNERFTVQD
PAYGKAEYWPYKDLELKGRVKYTLLRGKLAFDGSTILLDEGNGKFLKRSEFFWGR

Sequences:

>Translated_455_residues
MKYDLVLIGGEVCDGADLYAANLYISEGKIADITPKNAYHPARASLDCSGLFILPGFIDPHVHLGLRLGRYSSTDDFSSG
SDAALAGGVTTIFDFTEPIYDYEGFMKNLTERLKDASVSKIDYGLHITLGGNVKLSPEEVSKLAVETGCPTIKVFTAYGD
TNRRTDDGYLYELLKSSGKIGSVVMVHAENDELIKINSKKYPGTFEYLSDIRATESEIGAVIMVALLATKAKGQAYIVHL
SSGETVNWIESFAVISRDNIVFETCPQYLALNKKLLKRKDGYLYTFCPPLRSEKESELLVRALRKGFISTVGTDHCPFTV
EEKTESDGKLDSVPYGIASLGITYSVVNTLLGGDLSKVVRLLSKNPAKYMGVYPEKGSLLPGTDADITVVDPNERFTVQD
PAYGKAEYWPYKDLELKGRVKYTLLRGKLAFDGSTILLDEGNGKFLKRSEFFWGR
>Mature_455_residues
MKYDLVLIGGEVCDGADLYAANLYISEGKIADITPKNAYHPARASLDCSGLFILPGFIDPHVHLGLRLGRYSSTDDFSSG
SDAALAGGVTTIFDFTEPIYDYEGFMKNLTERLKDASVSKIDYGLHITLGGNVKLSPEEVSKLAVETGCPTIKVFTAYGD
TNRRTDDGYLYELLKSSGKIGSVVMVHAENDELIKINSKKYPGTFEYLSDIRATESEIGAVIMVALLATKAKGQAYIVHL
SSGETVNWIESFAVISRDNIVFETCPQYLALNKKLLKRKDGYLYTFCPPLRSEKESELLVRALRKGFISTVGTDHCPFTV
EEKTESDGKLDSVPYGIASLGITYSVVNTLLGGDLSKVVRLLSKNPAKYMGVYPEKGSLLPGTDADITVVDPNERFTVQD
PAYGKAEYWPYKDLELKGRVKYTLLRGKLAFDGSTILLDEGNGKFLKRSEFFWGR

Specific function: Catalyzes the stereospecific hydrolysis of the cyclic amide bond of D-hydantoin. Has no activity on dihydropyrimidines [H]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19923821, Length=465, Percent_Identity=26.8817204301075, Blast_Score=155, Evalue=8e-38,
Organism=Homo sapiens, GI4503375, Length=471, Percent_Identity=28.4501061571125, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI4503379, Length=464, Percent_Identity=24.7844827586207, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI4503051, Length=468, Percent_Identity=26.2820512820513, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI190194363, Length=463, Percent_Identity=24.8380129589633, Blast_Score=132, Evalue=7e-31,
Organism=Homo sapiens, GI62422571, Length=468, Percent_Identity=26.2820512820513, Blast_Score=132, Evalue=8e-31,
Organism=Homo sapiens, GI4503377, Length=462, Percent_Identity=25.1082251082251, Blast_Score=128, Evalue=9e-30,
Organism=Escherichia coli, GI87082175, Length=439, Percent_Identity=28.7015945330296, Blast_Score=182, Evalue=4e-47,
Organism=Escherichia coli, GI1786722, Length=448, Percent_Identity=27.0089285714286, Blast_Score=120, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI71989490, Length=467, Percent_Identity=27.6231263383298, Blast_Score=158, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI17539558, Length=462, Percent_Identity=24.6753246753247, Blast_Score=131, Evalue=6e-31,
Organism=Saccharomyces cerevisiae, GI6322218, Length=402, Percent_Identity=30.3482587064677, Blast_Score=124, Evalue=3e-29,
Organism=Drosophila melanogaster, GI221377917, Length=474, Percent_Identity=28.6919831223629, Blast_Score=171, Evalue=1e-42,
Organism=Drosophila melanogaster, GI17137462, Length=454, Percent_Identity=28.6343612334802, Blast_Score=165, Evalue=6e-41,
Organism=Drosophila melanogaster, GI24644287, Length=328, Percent_Identity=30.1829268292683, Blast_Score=108, Evalue=7e-24,
Organism=Drosophila melanogaster, GI18859883, Length=403, Percent_Identity=28.287841191067, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24644289, Length=195, Percent_Identity=32.8205128205128, Blast_Score=99, Evalue=7e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011778
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: 3.-.-.- [C]

Molecular weight: Translated: 50114; Mature: 50114

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYDLVLIGGEVCDGADLYAANLYISEGKIADITPKNAYHPARASLDCSGLFILPGFIDP
CCEEEEEECCCCCCCCCEEEEEEEEECCEEEECCCCCCCCCCCCCCCCCCEEEECCCCCC
HVHLGLRLGRYSSTDDFSSGSDAALAGGVTTIFDFTEPIYDYEGFMKNLTERLKDASVSK
CEEEEEEECCCCCCCCCCCCCCCEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCE
IDYGLHITLGGNVKLSPEEVSKLAVETGCPTIKVFTAYGDTNRRTDDGYLYELLKSSGKI
EECEEEEEECCCEEECHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCHHHHHHHHCCCCC
GSVVMVHAENDELIKINSKKYPGTFEYLSDIRATESEIGAVIMVALLATKAKGQAYIVHL
CEEEEEEECCCCEEEECCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCEEEEEE
SSGETVNWIESFAVISRDNIVFETCPQYLALNKKLLKRKDGYLYTFCPPLRSEKESELLV
CCCCCHHHHHHHHEEECCCEEEHHCHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHH
RALRKGFISTVGTDHCPFTVEEKTESDGKLDSVPYGIASLGITYSVVNTLLGGDLSKVVR
HHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHH
LLSKNPAKYMGVYPEKGSLLPGTDADITVVDPNERFTVQDPAYGKAEYWPYKDLELKGRV
HHHCCCHHHEEECCCCCCCCCCCCCCEEEECCCCEEEECCCCCCCCCCCCCCCCEECCCE
KYTLLRGKLAFDGSTILLDEGNGKFLKRSEFFWGR
EEEEEEEEEEECCCEEEEECCCCCEEEECCCCCCC
>Mature Secondary Structure
MKYDLVLIGGEVCDGADLYAANLYISEGKIADITPKNAYHPARASLDCSGLFILPGFIDP
CCEEEEEECCCCCCCCCEEEEEEEEECCEEEECCCCCCCCCCCCCCCCCCEEEECCCCCC
HVHLGLRLGRYSSTDDFSSGSDAALAGGVTTIFDFTEPIYDYEGFMKNLTERLKDASVSK
CEEEEEEECCCCCCCCCCCCCCCEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCE
IDYGLHITLGGNVKLSPEEVSKLAVETGCPTIKVFTAYGDTNRRTDDGYLYELLKSSGKI
EECEEEEEECCCEEECHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCHHHHHHHHCCCCC
GSVVMVHAENDELIKINSKKYPGTFEYLSDIRATESEIGAVIMVALLATKAKGQAYIVHL
CEEEEEEECCCCEEEECCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCEEEEEE
SSGETVNWIESFAVISRDNIVFETCPQYLALNKKLLKRKDGYLYTFCPPLRSEKESELLV
CCCCCHHHHHHHHEEECCCEEEHHCHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHH
RALRKGFISTVGTDHCPFTVEEKTESDGKLDSVPYGIASLGITYSVVNTLLGGDLSKVVR
HHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHH
LLSKNPAKYMGVYPEKGSLLPGTDADITVVDPNERFTVQDPAYGKAEYWPYKDLELKGRV
HHHCCCHHHEEECCCCCCCCCCCCCCEEEECCCCEEEECCCCCCCCCCCCCCCCEECCCE
KYTLLRGKLAFDGSTILLDEGNGKFLKRSEFFWGR
EEEEEEEEEEECCCEEEEECCCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7765480 [H]